MIC27_HUMAN
Evidence for PS localization
Functions
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed), (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MIC27_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.6410 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MIC27_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 51.2821 | 4 | yes |
| GO:0007005 | mitochondrion organization | 46.1538 | 5 | yes |
| GO:0061024 | membrane organization | 41.0256 | 4 | yes |
| GO:0007006 | mitochondrial membrane organization | 38.4615 | 5 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 30.7692 | 6 | yes |
| GO:0071702 | organic substance transport | 30.7692 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.2051 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 28.2051 | 4 | no |
| GO:0022607 | cellular component assembly | 28.2051 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.6410 | 4 | no |
| GO:0042407 | cristae formation | 23.0769 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.0769 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 23.0769 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0006811 | ion transport | 20.5128 | 4 | no |
| GO:0008104 | protein localization | 20.5128 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.5128 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 20.5128 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MIC27_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 5.1282 | 3 | no |
| DOID:700 | mitochondrial metabolism disease | 5.1282 | 3 | no |
| DOID:870 | neuropathy | 5.1282 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM11_HUMAN | [view interactions] | High throughput | no | no |
| T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMA7_HUMAN | [view interactions] | High throughput | no | no |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| MIC13_HUMAN | [view interactions] | High throughput | no | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| STAR7_HUMAN | [view interactions] | High throughput | no | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRDC_HUMAN | [view interactions] | High throughput | no | no |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| S39AC_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAR19_HUMAN | [view interactions] | High throughput | no | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSAP1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MIC10_HUMAN | [view interactions] | Computational | no | yes |
| TOM7_HUMAN | [view interactions] | Computational | no | no |
| CHC10_HUMAN | [view interactions] | Computational | no | yes |
| MFN1_HUMAN | [view interactions] | Computational | no | yes |
| TOM40_HUMAN | [view interactions] | Computational | no | yes |
| TOM70_HUMAN | [view interactions] | Computational | no | yes |