MIC25_HUMAN
Evidence for PS localization
Functions
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MIC25_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 23.3333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MIC25_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 56.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 46.6667 | 4 | no |
| GO:0007005 | mitochondrion organization | 43.3333 | 5 | yes |
| GO:0061024 | membrane organization | 43.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 36.6667 | 4 | no |
| GO:0007006 | mitochondrial membrane organization | 33.3333 | 5 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 33.3333 | 6 | yes |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0042407 | cristae formation | 23.3333 | 7 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.3333 | 6 | no |
| GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
| GO:0006974 | cellular response to DNA damage stimulus | 6.6667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MIC25_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 10.0000 | 3 | no |
| DOID:870 | neuropathy | 10.0000 | 4 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 6.6667 | 6 | no |
| DOID:440 | neuromuscular disease | 6.6667 | 5 | no |
| DOID:700 | mitochondrial metabolism disease | 6.6667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MIC19_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHC10_HUMAN | [view interactions] | Low throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
| MFS11_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| ERLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| S22AG_HUMAN | [view interactions] | High throughput | no | yes |
| CLC5A_HUMAN | [view interactions] | High throughput | no | no |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC13_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERH_HUMAN | [view interactions] | High throughput | no | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| INVS_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD244_HUMAN | [view interactions] | High throughput | no | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| PCNP_HUMAN | [view interactions] | High throughput | no | yes |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| TRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| GTR8_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| TOM70_HUMAN | [view interactions] | Computational | no | yes |
| MTX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TOM40_HUMAN | [view interactions] | Computational | no | yes |
| MTX3_HUMAN | [view interactions] | Computational | no | yes |
| MIC10_HUMAN | [view interactions] | Computational | no | yes |