NDUA8_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUA8_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 31.2500 | 5 | yes |
| GO:0046872 | metal ion binding | 29.1667 | 4 | no |
| GO:0003954 | NADH dehydrogenase activity | 25.0000 | 4 | yes |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 23.9583 | 5 | yes |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 23.9583 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 23.9583 | 4 | yes |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 23.9583 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 20.8333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUA8_HUMAN |
|---|---|---|---|---|
| GO:0015980 | energy derivation by oxidation of organic compounds | 34.3750 | 4 | yes |
| GO:0022900 | electron transport chain | 33.3333 | 4 | yes |
| GO:0009060 | aerobic respiration | 32.2917 | 6 | yes |
| GO:0022904 | respiratory electron transport chain | 32.2917 | 5 | yes |
| GO:0045333 | cellular respiration | 32.2917 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.2500 | 4 | yes |
| GO:0019646 | aerobic electron transport chain | 30.2083 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 29.1667 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 27.0833 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 27.0833 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.0417 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 23.9583 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.9583 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.9167 | 4 | no |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 21.8750 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 21.8750 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.8750 | 5 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 20.8333 | 6 | yes |
| GO:0010646 | regulation of cell communication | 20.8333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 20.8333 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.8333 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 20.8333 | 4 | no |
| GO:0010257 | NADH dehydrogenase complex assembly | 19.7917 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 19.7917 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NDUA8_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 3.1250 | 3 | no |
| DOID:870 | neuropathy | 3.1250 | 4 | no |
| DOID:700 | mitochondrial metabolism disease | 2.0833 | 3 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 2.0833 | 6 | no |
| DOID:440 | neuromuscular disease | 2.0833 | 5 | no |
| DOID:1289 | neurodegenerative disease | 2.0833 | 4 | no |
| DOID:3146 | lipid metabolism disorder | 2.0833 | 3 | no |
| DOID:331 | central nervous system disease | 2.0833 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
| NU2M_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
| NU6M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU5M_HUMAN | [view interactions] | Low throughput | no | no |
| NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAPL_HUMAN | [view interactions] | High throughput | no | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| MED1_HUMAN | [view interactions] | High throughput | no | no |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| C560_HUMAN | [view interactions] | High throughput | no | no |
| DMAC1_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSU1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| PGES2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUCR_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| GRPL2_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| CIA30_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| JOS2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| OPA3_HUMAN | [view interactions] | High throughput | no | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHSD_HUMAN | [view interactions] | Computational | no | yes |
| COX5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CX6B2_HUMAN | [view interactions] | Computational | no | no |
| RM27_HUMAN | [view interactions] | Computational | no | yes |
| RM21_HUMAN | [view interactions] | Computational | no | no |
| QCR9_HUMAN | [view interactions] | Computational | no | no |
| ICT1_HUMAN | [view interactions] | Computational | no | yes |
| QCR10_HUMAN | [view interactions] | Computational | no | no |
| CX6A2_HUMAN | [view interactions] | Computational | no | no |
| CYB_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| COX7C_HUMAN | [view interactions] | Computational | no | yes |
| COA6_HUMAN | [view interactions] | Computational | no | yes |
| QCR8_HUMAN | [view interactions] | Computational | no | yes |