Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NDUA8_HUMAN

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NDUA8_HUMAN
GO:0008324 monoatomic cation transmembrane transporter activity 32.6316 4 yes
GO:0015078 proton transmembrane transporter activity 32.6316 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 32.6316 4 yes
GO:0000166 nucleotide binding 32.6316 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 31.5789 4 yes
GO:0015399 primary active transmembrane transporter activity 29.4737 4 yes
GO:0043169 cation binding 29.4737 4 no
GO:0017076 purine nucleotide binding 28.4211 5 no
GO:0043168 anion binding 28.4211 4 no
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 27.3684 5 yes
GO:0046872 metal ion binding 27.3684 5 no
GO:0030554 adenyl nucleotide binding 24.2105 6 no
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22.1053 4 yes
GO:0032555 purine ribonucleotide binding 22.1053 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NDUA8_HUMAN
GO:0006796 phosphate-containing compound metabolic process 44.2105 4 yes
GO:0006753 nucleoside phosphate metabolic process 36.8421 4 yes
GO:0009117 nucleotide metabolic process 36.8421 5 yes
GO:0006163 purine nucleotide metabolic process 35.7895 5 yes
GO:0072521 purine-containing compound metabolic process 35.7895 4 yes
GO:0009150 purine ribonucleotide metabolic process 33.6842 6 yes
GO:0009259 ribonucleotide metabolic process 33.6842 5 yes
GO:0015980 energy derivation by oxidation of organic compounds 33.6842 4 yes
GO:0019693 ribose phosphate metabolic process 33.6842 4 yes
GO:0022900 electron transport chain 32.6316 4 yes
GO:0009060 aerobic respiration 31.5789 6 yes
GO:0022904 respiratory electron transport chain 31.5789 5 yes
GO:0045333 cellular respiration 31.5789 5 yes
GO:1901362 organic cyclic compound biosynthetic process 31.5789 4 yes
GO:0043933 protein-containing complex organization 30.5263 4 yes
GO:1901566 organonitrogen compound biosynthetic process 30.5263 4 yes
GO:0019646 aerobic electron transport chain 29.4737 6 yes
GO:0022607 cellular component assembly 29.4737 4 yes
GO:0009141 nucleoside triphosphate metabolic process 28.4211 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 28.4211 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 28.4211 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 28.4211 7 yes
GO:0034654 nucleobase-containing compound biosynthetic process 27.3684 4 yes
GO:0046034 ATP metabolic process 27.3684 7 yes
GO:1901137 carbohydrate derivative biosynthetic process 26.3158 4 yes
GO:0006996 organelle organization 26.3158 4 no
GO:0031323 regulation of cellular metabolic process 26.3158 4 no
GO:0006164 purine nucleotide biosynthetic process 25.2632 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 25.2632 7 yes
GO:0009165 nucleotide biosynthetic process 25.2632 6 yes
GO:0009260 ribonucleotide biosynthetic process 25.2632 6 yes
GO:0046390 ribose phosphate biosynthetic process 25.2632 5 yes
GO:0065003 protein-containing complex assembly 25.2632 5 yes
GO:0072522 purine-containing compound biosynthetic process 25.2632 5 yes
GO:0090407 organophosphate biosynthetic process 25.2632 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 25.2632 5 yes
GO:0048523 negative regulation of cellular process 25.2632 4 no
GO:0048522 positive regulation of cellular process 25.2632 4 no
GO:0080090 regulation of primary metabolic process 25.2632 4 no
GO:0051128 regulation of cellular component organization 24.2105 4 no
GO:0060255 regulation of macromolecule metabolic process 24.2105 4 no
GO:0006754 ATP biosynthetic process 22.1053 8 yes
GO:0009142 nucleoside triphosphate biosynthetic process 22.1053 6 yes
GO:0009145 purine nucleoside triphosphate biosynthetic process 22.1053 7 yes
GO:0009201 ribonucleoside triphosphate biosynthetic process 22.1053 7 yes
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 22.1053 8 yes
GO:0015986 proton motive force-driven ATP synthesis 22.1053 9 yes
GO:0042776 proton motive force-driven mitochondrial ATP synthesis 22.1053 10 yes
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 21.0526 7 yes
GO:0042981 regulation of apoptotic process 21.0526 5 no
GO:0043067 regulation of programmed cell death 21.0526 4 no
GO:0009893 positive regulation of metabolic process 21.0526 4 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0033108 mitochondrial respiratory chain complex assembly 20.0000 6 yes
GO:0010257 NADH dehydrogenase complex assembly 18.9474 6 yes
GO:0032981 mitochondrial respiratory chain complex I assembly 18.9474 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NDUBA_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS5_HUMAN [view interactions] Low throughput no yes
NDUAA_HUMAN [view entry] [view interactions] Low throughput yes yes
NU3M_HUMAN [view interactions] Low throughput no yes
NU6M_HUMAN [view interactions] Low throughput no no
NDUC1_HUMAN [view interactions] Low throughput no yes
NDUBB_HUMAN [view interactions] Low throughput no yes
NU2M_HUMAN [view interactions] Low throughput no no
NU4LM_HUMAN [view interactions] Low throughput no no
NDUAB_HUMAN [view interactions] Low throughput no no
NDUA1_HUMAN [view interactions] Low throughput no yes
NDUB3_HUMAN [view interactions] Low throughput no yes
NDUS2_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB1_HUMAN [view interactions] Low throughput no yes
NDUB6_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA3_HUMAN [view interactions] Low throughput no yes
NDUB8_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUC2_HUMAN [view interactions] Low throughput no yes
NU1M_HUMAN [view interactions] Low throughput no yes
NU4M_HUMAN [view interactions] Low throughput no yes
NU5M_HUMAN [view interactions] Low throughput no no
NDUB7_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB9_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB5_HUMAN [view interactions] Low throughput no yes
NDUS3_HUMAN [view entry] [view interactions] Low throughput yes yes
ACPM_HUMAN [view interactions] Low throughput no yes
NDUB4_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUAD_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUB2_HUMAN [view interactions] Low throughput no yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
ASPH_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6_HUMAN [view interactions] High throughput no yes
ODBA_HUMAN [view interactions] High throughput no yes
CX7A2_HUMAN [view interactions] High throughput no no
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
EMC2_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
TOM5_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5H_HUMAN [view interactions] High throughput no yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
ATPK_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
NDUCR_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ATPD_HUMAN [view interactions] High throughput no yes
ATP5J_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
GRPL2_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
OCAD1_HUMAN [view interactions] High throughput no yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RMND1_HUMAN [view interactions] High throughput no yes
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
SURF1_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
KBTB4_HUMAN [view interactions] High throughput no yes
TBCD4_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
NDUF3_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
ATM_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
KLC3_HUMAN [view interactions] High throughput no no
CNTRB_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
ECSIT_HUMAN [view interactions] High throughput no yes
NDUS8_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
JOS2_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
CIA30_HUMAN [view interactions] High throughput no yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
NDUF4_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OPA3_HUMAN [view interactions] High throughput no yes
FMC1_HUMAN [view interactions] High throughput no no
CHC10_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
SIM43_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
M3K10_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA6_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
SPRE1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI55_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
RBTN2_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
RNF31_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NDUV3_HUMAN [view interactions] High throughput no yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
WAPL_HUMAN [view interactions] High throughput no yes
CISD3_HUMAN [view interactions] High throughput no yes
COQ9_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
ATX3_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
FXRD1_HUMAN [view interactions] High throughput no no
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
MIDN_HUMAN [view interactions] High throughput no no
SMC5_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
CSN2_HUMAN [view interactions] High throughput no yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
GFI1B_HUMAN [view interactions] High throughput no no
LEO1_HUMAN [view interactions] High throughput no yes
SIN1_HUMAN [view interactions] High throughput no yes
MAX_HUMAN [view interactions] High throughput no yes
MED1_HUMAN [view interactions] High throughput no no
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
PRS10_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD6_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
C560_HUMAN [view interactions] High throughput no no
DMAC1_HUMAN [view interactions] High throughput no no
QCR7_HUMAN [view entry] [view interactions] High throughput yes yes
HAPR1_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
RSU1_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
PRDX3_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R3_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
COA3_HUMAN [view interactions] High throughput no yes
GBG5_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no