SUCA_HUMAN
Evidence for PS localization
Functions
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SUCA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 30.6667 | 4 | yes |
| GO:0043169 | cation binding | 29.3333 | 4 | no |
| GO:0046872 | metal ion binding | 29.3333 | 5 | no |
| GO:0043168 | anion binding | 28.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.3333 | 5 | no |
| GO:0003723 | RNA binding | 22.6667 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.6667 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.3333 | 6 | no |
| GO:0004774 | succinate-CoA ligase activity | 2.6667 | 5 | yes |
| GO:0004775 | succinate-CoA ligase (ADP-forming) activity | 2.6667 | 6 | yes |
| GO:0016878 | acid-thiol ligase activity | 2.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SUCA_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 37.3333 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 36.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 36.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0000 | 4 | no |
| GO:0006996 | organelle organization | 36.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 32.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.6667 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 29.3333 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 29.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.3333 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 28.0000 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 28.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 28.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 25.3333 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 25.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.0000 | 4 | no |
| GO:0009259 | ribonucleotide metabolic process | 22.6667 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 22.6667 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 22.6667 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.6667 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.6667 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 22.6667 | 5 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 21.3333 | 6 | yes |
| GO:0008104 | protein localization | 21.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.3333 | 6 | no |
| GO:1901565 | organonitrogen compound catabolic process | 18.6667 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 10.6667 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 10.6667 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 10.6667 | 5 | yes |
| GO:0006104 | succinyl-CoA metabolic process | 5.3333 | 4 | yes |
| GO:0006195 | purine nucleotide catabolic process | 4.0000 | 6 | yes |
| GO:0009154 | purine ribonucleotide catabolic process | 4.0000 | 6 | yes |
| GO:0009166 | nucleotide catabolic process | 4.0000 | 6 | yes |
| GO:0009261 | ribonucleotide catabolic process | 4.0000 | 5 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 4.0000 | 4 | yes |
| GO:0046434 | organophosphate catabolic process | 4.0000 | 4 | yes |
| GO:0072523 | purine-containing compound catabolic process | 4.0000 | 5 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 4.0000 | 4 | yes |
| GO:1901292 | nucleoside phosphate catabolic process | 4.0000 | 5 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 4.0000 | 4 | yes |
| GO:0033869 | nucleoside bisphosphate catabolic process | 2.6667 | 6 | yes |
| GO:0034031 | ribonucleoside bisphosphate catabolic process | 2.6667 | 7 | yes |
| GO:0034034 | purine nucleoside bisphosphate catabolic process | 2.6667 | 6 | yes |
| GO:0044273 | sulfur compound catabolic process | 2.6667 | 4 | yes |
| GO:1901289 | succinyl-CoA catabolic process | 2.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SUCB2_HUMAN | [view interactions] | Low throughput | no | no |
| SUCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBNL2_HUMAN | [view interactions] | High throughput | no | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ANT3_HUMAN | [view interactions] | High throughput | no | no |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| RPC3_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB1_HUMAN | [view interactions] | High throughput | no | no |
| FES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SMYD2_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ZNG1B_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AG_HUMAN | [view interactions] | High throughput | no | no |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSF2_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| CCS_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| NFU1_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| ORN_HUMAN | [view interactions] | High throughput | no | no |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |