SUCA_HUMAN
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SUCA_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 29.6296 | 4 | no |
GO:0003723 | RNA binding | 18.5185 | 4 | yes |
GO:0004774 | succinate-CoA ligase activity | 2.4691 | 5 | yes |
GO:0004775 | succinate-CoA ligase (ADP-forming) activity | 2.4691 | 6 | yes |
GO:0004776 | succinate-CoA ligase (GDP-forming) activity | 2.4691 | 6 | yes |
GO:0016878 | acid-thiol ligase activity | 2.4691 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SUCA_HUMAN |
---|---|---|---|---|
GO:0019752 | carboxylic acid metabolic process | 35.8025 | 5 | no |
GO:0043436 | oxoacid metabolic process | 35.8025 | 4 | no |
GO:0022607 | cellular component assembly | 32.0988 | 4 | no |
GO:0048522 | positive regulation of cellular process | 30.8642 | 4 | no |
GO:0006996 | organelle organization | 28.3951 | 4 | no |
GO:0048523 | negative regulation of cellular process | 27.1605 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 27.1605 | 4 | no |
GO:0043933 | protein-containing complex organization | 25.9259 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 24.6914 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 24.6914 | 4 | no |
GO:0065003 | protein-containing complex assembly | 23.4568 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 23.4568 | 4 | no |
GO:0010646 | regulation of cell communication | 22.2222 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
GO:0009060 | aerobic respiration | 20.9877 | 6 | no |
GO:0015980 | energy derivation by oxidation of organic compounds | 20.9877 | 4 | no |
GO:0022900 | electron transport chain | 20.9877 | 4 | no |
GO:0022904 | respiratory electron transport chain | 20.9877 | 5 | no |
GO:0045333 | cellular respiration | 20.9877 | 5 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SUCA_HUMAN |
---|---|---|---|---|
DOID:0050155 | sensory system disease | 2.4691 | 3 | no |
DOID:10584 | retinitis pigmentosa | 2.4691 | 7 | no |
DOID:5614 | eye disease | 2.4691 | 4 | no |
DOID:8466 | retinal degeneration | 2.4691 | 6 | no |
DOID:9799 | eye degenerative disease | 2.4691 | 5 | no |
DOID:0060286 | combined oxidative phosphorylation deficiency | 2.4691 | 4 | no |
DOID:700 | mitochondrial metabolism disease | 2.4691 | 3 | no |
DOID:331 | central nervous system disease | 2.4691 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SUCB2_HUMAN | [view interactions] | Low throughput | no | no |
SUCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLGT3_HUMAN | [view interactions] | High throughput | no | no |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACPM_HUMAN | [view interactions] | High throughput | no | yes |
MPPB_HUMAN | [view interactions] | High throughput | no | yes |
UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACSF2_HUMAN | [view interactions] | High throughput | no | no |
GCSH_HUMAN | [view interactions] | High throughput | no | yes |
CCS_HUMAN | [view interactions] | High throughput | no | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
GUAA_HUMAN | [view interactions] | High throughput | no | no |
MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
PPA6_HUMAN | [view interactions] | High throughput | no | no |
COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NNRE_HUMAN | [view interactions] | High throughput | no | yes |
NFU1_HUMAN | [view interactions] | High throughput | no | yes |
NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
NIT2_HUMAN | [view interactions] | High throughput | no | yes |
PREP_HUMAN | [view interactions] | High throughput | no | yes |
MPPA_HUMAN | [view interactions] | High throughput | no | yes |
IPYR_HUMAN | [view interactions] | High throughput | no | yes |
ORN_HUMAN | [view interactions] | High throughput | no | no |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPC2_HUMAN | [view interactions] | High throughput | no | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
ATPD_HUMAN | [view interactions] | High throughput | no | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
EFTS_HUMAN | [view interactions] | High throughput | no | no |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
MK14_HUMAN | [view interactions] | High throughput | no | yes |
MK11_HUMAN | [view interactions] | High throughput | no | yes |
CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
ANT3_HUMAN | [view interactions] | High throughput | no | no |
RPC3_HUMAN | [view interactions] | High throughput | no | yes |
SYAM_HUMAN | [view interactions] | High throughput | no | yes |
SYLM_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
SH2D3_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
B2L14_HUMAN | [view interactions] | High throughput | no | yes |
5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
EPHB1_HUMAN | [view interactions] | High throughput | no | no |
FES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRC_HUMAN | [view interactions] | High throughput | no | no |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANGI_HUMAN | [view interactions] | High throughput | no | no |
KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
OSMR_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
SMYD2_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
TR61B_HUMAN | [view interactions] | High throughput | no | yes |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
SETB1_HUMAN | [view interactions] | High throughput | no | yes |
CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
WDR36_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
MRP6_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
BRD1_HUMAN | [view interactions] | High throughput | no | yes |
SP100_HUMAN | [view interactions] | High throughput | no | no |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
CBWD2_HUMAN | [view interactions] | High throughput | no | no |
AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
SPOP_HUMAN | [view interactions] | High throughput | no | no |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
SBP1_HUMAN | [view interactions] | High throughput | no | no |
SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIF1_HUMAN | [view interactions] | High throughput | no | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S10AG_HUMAN | [view interactions] | High throughput | no | no |
SEPT9_HUMAN | [view interactions] | High throughput | no | no |
ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
SH3L3_HUMAN | [view interactions] | High throughput | no | no |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
ADRO_HUMAN | [view interactions] | High throughput | no | no |
GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
THIC_HUMAN | [view interactions] | Computational | no | yes |
ECHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUB8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5F1_HUMAN | [view interactions] | Computational | no | yes |
THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IDH3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACO12_HUMAN | [view interactions] | Computational | no | no |
DGUOK_HUMAN | [view interactions] | Computational | no | yes |
ACACB_HUMAN | [view interactions] | Computational | no | no |
MPCP_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DHSD_HUMAN | [view interactions] | Computational | no | yes |
ATP5H_HUMAN | [view interactions] | Computational | no | yes |
ACLY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MUTA_HUMAN | [view interactions] | Computational | no | yes |
HMGCL_HUMAN | [view interactions] | Computational | no | yes |
ODB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACS2L_HUMAN | [view interactions] | Computational | no | yes |
HMCS2_HUMAN | [view interactions] | Computational | no | no |
THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HMCS1_HUMAN | [view interactions] | Computational | no | yes |
C560_HUMAN | [view interactions] | Computational | no | no |
HMGC2_HUMAN | [view interactions] | Computational | no | no |
ACACA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DHTK1_HUMAN | [view interactions] | Computational | no | no |
OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
COX5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ODBB_HUMAN | [view interactions] | Computational | no | yes |
ACSA_HUMAN | [view interactions] | Computational | no | no |