Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FES_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FES_HUMAN
GO:0005524 ATP binding 34.2857 5 yes
GO:0017076 purine nucleotide binding 34.2857 4 yes
GO:0030554 adenyl nucleotide binding 34.2857 5 yes
GO:0032555 purine ribonucleotide binding 34.2857 4 yes
GO:0032559 adenyl ribonucleotide binding 34.2857 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.2857 4 yes
GO:0003723 RNA binding 34.2857 4 no
GO:0019900 kinase binding 22.8571 4 no
GO:0019901 protein kinase binding 22.8571 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 20.0000 4 yes
GO:0016301 kinase activity 20.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.0000 4 yes
GO:0004713 protein tyrosine kinase activity 17.1429 4 yes
GO:0008017 microtubule binding 14.2857 5 yes
GO:0015631 tubulin binding 14.2857 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 5.7143 5 yes
GO:0034987 immunoglobulin receptor binding 5.7143 4 yes
GO:0035091 phosphatidylinositol binding 5.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FES_HUMAN
GO:0048522 positive regulation of cellular process 62.8571 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0051128 regulation of cellular component organization 51.4286 4 yes
GO:0031323 regulation of cellular metabolic process 48.5714 4 no
GO:0051171 regulation of nitrogen compound metabolic process 48.5714 4 no
GO:0006996 organelle organization 45.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 45.7143 4 no
GO:0080090 regulation of primary metabolic process 45.7143 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0036211 protein modification process 40.0000 4 yes
GO:0043412 macromolecule modification 40.0000 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0045595 regulation of cell differentiation 37.1429 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.1429 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.1429 5 no
GO:0023056 positive regulation of signaling 37.1429 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.1429 5 no
GO:0051247 positive regulation of protein metabolic process 37.1429 6 no
GO:1902531 regulation of intracellular signal transduction 37.1429 5 no
GO:0006796 phosphate-containing compound metabolic process 34.2857 4 yes
GO:0031344 regulation of cell projection organization 34.2857 5 yes
GO:0051049 regulation of transport 34.2857 4 yes
GO:0051094 positive regulation of developmental process 34.2857 4 yes
GO:0051240 positive regulation of multicellular organismal process 34.2857 4 yes
GO:0071310 cellular response to organic substance 34.2857 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.2857 6 yes
GO:0009892 negative regulation of metabolic process 34.2857 4 no
GO:0009967 positive regulation of signal transduction 34.2857 5 no
GO:0010647 positive regulation of cell communication 34.2857 5 no
GO:0019220 regulation of phosphate metabolic process 34.2857 6 no
GO:0031325 positive regulation of cellular metabolic process 34.2857 5 no
GO:0042325 regulation of phosphorylation 34.2857 7 no
GO:0048584 positive regulation of response to stimulus 34.2857 4 no
GO:0051174 regulation of phosphorus metabolic process 34.2857 5 no
GO:0022607 cellular component assembly 34.2857 4 no
GO:0009889 regulation of biosynthetic process 34.2857 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.2857 5 no
GO:0030030 cell projection organization 34.2857 4 no
GO:0031326 regulation of cellular biosynthetic process 34.2857 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.4286 4 yes
GO:0010941 regulation of cell death 31.4286 4 no
GO:0031324 negative regulation of cellular metabolic process 31.4286 5 no
GO:0042981 regulation of apoptotic process 31.4286 6 no
GO:0043067 regulation of programmed cell death 31.4286 5 no
GO:0008104 protein localization 31.4286 4 no
GO:0060341 regulation of cellular localization 31.4286 4 no
GO:0016310 phosphorylation 28.5714 5 yes
GO:0030155 regulation of cell adhesion 28.5714 4 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0051130 positive regulation of cellular component organization 28.5714 5 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:2000145 regulation of cell motility 28.5714 4 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0051336 regulation of hydrolase activity 28.5714 4 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0006355 regulation of DNA-templated transcription 28.5714 6 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1903506 regulation of nucleic acid-templated transcription 28.5714 7 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0007010 cytoskeleton organization 25.7143 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 25.7143 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.7143 5 yes
GO:0010975 regulation of neuron projection development 25.7143 7 yes
GO:0033043 regulation of organelle organization 25.7143 5 yes
GO:0044087 regulation of cellular component biogenesis 25.7143 4 yes
GO:0045597 positive regulation of cell differentiation 25.7143 5 yes
GO:0050776 regulation of immune response 25.7143 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 25.7143 6 no
GO:0042327 positive regulation of phosphorylation 25.7143 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.7143 7 no
GO:0043085 positive regulation of catalytic activity 25.7143 4 no
GO:0043549 regulation of kinase activity 25.7143 5 no
GO:0051338 regulation of transferase activity 25.7143 4 no
GO:0051050 positive regulation of transport 25.7143 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.7143 5 no
GO:0006468 protein phosphorylation 22.8571 5 yes
GO:0018193 peptidyl-amino acid modification 22.8571 5 yes
GO:0031346 positive regulation of cell projection organization 22.8571 6 yes
GO:0051046 regulation of secretion 22.8571 5 yes
GO:1903530 regulation of secretion by cell 22.8571 4 yes
GO:0001934 positive regulation of protein phosphorylation 22.8571 8 no
GO:0031401 positive regulation of protein modification process 22.8571 7 no
GO:0048638 regulation of developmental growth 22.8571 4 no
GO:0065003 protein-containing complex assembly 22.8571 5 no
GO:0015031 protein transport 22.8571 4 no
GO:0071705 nitrogen compound transport 22.8571 4 no
GO:0080134 regulation of response to stress 22.8571 4 no
GO:0030334 regulation of cell migration 22.8571 5 no
GO:0008360 regulation of cell shape 20.0000 6 yes
GO:0014070 response to organic cyclic compound 20.0000 4 yes
GO:0022604 regulation of cell morphogenesis 20.0000 5 yes
GO:0050865 regulation of cell activation 20.0000 4 yes
GO:0051493 regulation of cytoskeleton organization 20.0000 6 yes
GO:1901701 cellular response to oxygen-containing compound 20.0000 4 yes
GO:0002684 positive regulation of immune system process 17.1429 4 yes
GO:0002694 regulation of leukocyte activation 17.1429 4 yes
GO:0060627 regulation of vesicle-mediated transport 17.1429 4 yes
GO:0018108 peptidyl-tyrosine phosphorylation 14.2857 6 yes
GO:0018212 peptidyl-tyrosine modification 14.2857 6 yes
GO:0032886 regulation of microtubule-based process 14.2857 4 yes
GO:0032970 regulation of actin filament-based process 14.2857 4 yes
GO:0033993 response to lipid 14.2857 4 yes
GO:0043254 regulation of protein-containing complex assembly 14.2857 5 yes
GO:0046777 protein autophosphorylation 14.2857 6 yes
GO:0071407 cellular response to organic cyclic compound 14.2857 5 yes
GO:1902903 regulation of supramolecular fiber organization 14.2857 5 yes
GO:0017157 regulation of exocytosis 11.4286 5 yes
GO:0032271 regulation of protein polymerization 11.4286 6 yes
GO:0032956 regulation of actin cytoskeleton organization 11.4286 5 yes
GO:0044089 positive regulation of cellular component biogenesis 11.4286 5 yes
GO:1903706 regulation of hemopoiesis 11.4286 4 yes
GO:0002697 regulation of immune effector process 8.5714 4 yes
GO:0002703 regulation of leukocyte mediated immunity 8.5714 5 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 8.5714 6 yes
GO:0010638 positive regulation of organelle organization 8.5714 6 yes
GO:0010976 positive regulation of neuron projection development 8.5714 7 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 8.5714 6 yes
GO:0031113 regulation of microtubule polymerization 8.5714 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 8.5714 6 yes
GO:0031667 response to nutrient levels 8.5714 4 yes
GO:0032273 positive regulation of protein polymerization 8.5714 7 yes
GO:0043300 regulation of leukocyte degranulation 8.5714 5 yes
GO:0045637 regulation of myeloid cell differentiation 8.5714 5 yes
GO:0045639 positive regulation of myeloid cell differentiation 8.5714 6 yes
GO:0051495 positive regulation of cytoskeleton organization 8.5714 7 yes
GO:0070507 regulation of microtubule cytoskeleton organization 8.5714 5 yes
GO:0071396 cellular response to lipid 8.5714 5 yes
GO:1902105 regulation of leukocyte differentiation 8.5714 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 8.5714 6 yes
GO:1903305 regulation of regulated secretory pathway 8.5714 6 yes
GO:2000249 regulation of actin cytoskeleton reorganization 8.5714 6 yes
GO:0001578 microtubule bundle formation 5.7143 4 yes
GO:0002699 positive regulation of immune effector process 5.7143 5 yes
GO:0002761 regulation of myeloid leukocyte differentiation 5.7143 6 yes
GO:0002763 positive regulation of myeloid leukocyte differentiation 5.7143 7 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 5.7143 7 yes
GO:0031116 positive regulation of microtubule polymerization 5.7143 7 yes
GO:0031669 cellular response to nutrient levels 5.7143 4 yes
GO:0031670 cellular response to nutrient 5.7143 4 yes
GO:0033003 regulation of mast cell activation 5.7143 5 yes
GO:0033006 regulation of mast cell activation involved in immune response 5.7143 5 yes
GO:0033273 response to vitamin 5.7143 4 yes
GO:0033280 response to vitamin D 5.7143 4 yes
GO:0043304 regulation of mast cell degranulation 5.7143 6 yes
GO:0045655 regulation of monocyte differentiation 5.7143 7 yes
GO:0045657 positive regulation of monocyte differentiation 5.7143 8 yes
GO:0071295 cellular response to vitamin 5.7143 5 yes
GO:0071305 cellular response to vitamin D 5.7143 5 yes
GO:1902107 positive regulation of leukocyte differentiation 5.7143 6 yes
GO:1903708 positive regulation of hemopoiesis 5.7143 5 yes
GO:2000251 positive regulation of actin cytoskeleton reorganization 5.7143 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
FES_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
HSH2D_HUMAN [view interactions] Low throughput no no
TIF1B_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
BCAR1_HUMAN [view interactions] Low throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
ZN746_HUMAN [view interactions] High throughput no no
ZN775_HUMAN [view interactions] High throughput no no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
ERP29_HUMAN [view interactions] High throughput no yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ERF1_HUMAN [view interactions] High throughput no yes
IF4H_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CSRP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDV3_HUMAN [view interactions] High throughput no no
POF1B_HUMAN [view interactions] High throughput no no
FBX50_HUMAN [view interactions] High throughput no no
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
PSD13_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
GAB1_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB3_HUMAN [view interactions] High throughput no yes
EPHA8_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR2_HUMAN [view interactions] High throughput no yes
MATK_HUMAN [view interactions] High throughput no yes
MERTK_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
PTK6_HUMAN [view interactions] High throughput no yes
PTK7_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PLXA2_HUMAN [view entry] [view interactions] Computational yes yes
IL4RA_HUMAN [view interactions] Computational no no
RRAS_HUMAN [view interactions] Computational no yes
PLXA1_HUMAN [view entry] [view interactions] Computational yes yes
DPYL2_HUMAN [view entry] [view interactions] Computational yes yes
JAK3_HUMAN [view interactions] Computational no no
IRS2_HUMAN [view interactions] Computational no yes
TIE2_HUMAN [view interactions] Computational no no
IL4_HUMAN [view interactions] Computational no no
VGFR2_HUMAN [view interactions] Computational no no
LIMK1_HUMAN [view interactions] Computational no yes
PLXA4_HUMAN [view entry] [view interactions] Computational yes no
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
PLXA3_HUMAN [view entry] [view interactions] Computational yes no
ANGP1_HUMAN [view interactions] Computational no no
ANGP2_HUMAN [view interactions] Computational no no
IL2RG_HUMAN [view interactions] Computational no no
DPYL5_HUMAN [view entry] [view interactions] Computational yes yes
JAK1_HUMAN [view interactions] Computational no yes
AMPH_HUMAN [view entry] [view interactions] Computational yes yes