Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FES_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FES_HUMAN
GO:0000166 nucleotide binding 46.4286 4 yes
GO:0043168 anion binding 46.4286 4 yes
GO:0005524 ATP binding 42.8571 5 yes
GO:0017076 purine nucleotide binding 42.8571 5 yes
GO:0030554 adenyl nucleotide binding 42.8571 6 yes
GO:0032555 purine ribonucleotide binding 42.8571 4 yes
GO:0032559 adenyl ribonucleotide binding 42.8571 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 yes
GO:0003723 RNA binding 42.8571 4 no
GO:0019900 kinase binding 32.1429 4 no
GO:0019901 protein kinase binding 32.1429 5 no
GO:0004713 protein tyrosine kinase activity 25.0000 4 yes
GO:0016301 kinase activity 25.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 yes
GO:0042803 protein homodimerization activity 21.4286 4 no
GO:0008017 microtubule binding 10.7143 5 yes
GO:0015631 tubulin binding 10.7143 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 7.1429 5 yes
GO:0034987 immunoglobulin receptor binding 7.1429 4 yes
GO:0035091 phosphatidylinositol binding 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FES_HUMAN
GO:0048522 positive regulation of cellular process 67.8571 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0009966 regulation of signal transduction 53.5714 4 no
GO:0010646 regulation of cell communication 53.5714 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0036211 protein modification process 46.4286 4 yes
GO:0043412 macromolecule modification 46.4286 4 yes
GO:0051049 regulation of transport 46.4286 4 yes
GO:0051128 regulation of cellular component organization 46.4286 4 yes
GO:0008104 protein localization 46.4286 4 no
GO:0010468 regulation of gene expression 46.4286 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.4286 5 no
GO:0022607 cellular component assembly 46.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0060341 regulation of cellular localization 39.2857 4 no
GO:1902531 regulation of intracellular signal transduction 39.2857 5 no
GO:0006355 regulation of DNA-templated transcription 39.2857 7 no
GO:0019220 regulation of phosphate metabolic process 39.2857 6 no
GO:0023056 positive regulation of signaling 39.2857 4 no
GO:0048584 positive regulation of response to stimulus 39.2857 4 no
GO:0051174 regulation of phosphorus metabolic process 39.2857 5 no
GO:0051252 regulation of RNA metabolic process 39.2857 5 no
GO:2001141 regulation of RNA biosynthetic process 39.2857 6 no
GO:0042981 regulation of apoptotic process 39.2857 5 no
GO:0043067 regulation of programmed cell death 39.2857 4 no
GO:0042127 regulation of cell population proliferation 35.7143 4 yes
GO:0009967 positive regulation of signal transduction 35.7143 5 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0010647 positive regulation of cell communication 35.7143 5 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0032880 regulation of protein localization 35.7143 5 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0016310 phosphorylation 32.1429 5 yes
GO:0045595 regulation of cell differentiation 32.1429 4 yes
GO:0051240 positive regulation of multicellular organismal process 32.1429 4 yes
GO:0009891 positive regulation of biosynthetic process 32.1429 5 no
GO:0009894 regulation of catabolic process 32.1429 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 32.1429 6 no
GO:0031328 positive regulation of cellular biosynthetic process 32.1429 6 no
GO:0071702 organic substance transport 32.1429 4 no
GO:0043933 protein-containing complex organization 32.1429 4 no
GO:0001934 positive regulation of protein phosphorylation 32.1429 8 no
GO:0010562 positive regulation of phosphorus metabolic process 32.1429 6 no
GO:0042327 positive regulation of phosphorylation 32.1429 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.1429 7 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0006468 protein phosphorylation 28.5714 5 yes
GO:0018193 peptidyl-amino acid modification 28.5714 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 yes
GO:0031344 regulation of cell projection organization 28.5714 5 yes
GO:0044087 regulation of cellular component biogenesis 28.5714 4 yes
GO:0051046 regulation of secretion 28.5714 5 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0071310 cellular response to organic substance 28.5714 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 yes
GO:1903530 regulation of secretion by cell 28.5714 4 yes
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0015031 protein transport 28.5714 4 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0051130 positive regulation of cellular component organization 25.0000 5 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0010975 regulation of neuron projection development 21.4286 7 yes
GO:0018108 peptidyl-tyrosine phosphorylation 21.4286 6 yes
GO:0018212 peptidyl-tyrosine modification 21.4286 6 yes
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 yes
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 yes
GO:0001817 regulation of cytokine production 21.4286 4 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0051253 negative regulation of RNA metabolic process 21.4286 6 no
GO:0097435 supramolecular fiber organization 21.4286 4 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:0002684 positive regulation of immune system process 17.8571 4 yes
GO:0014070 response to organic cyclic compound 17.8571 4 yes
GO:0031346 positive regulation of cell projection organization 17.8571 6 yes
GO:0032886 regulation of microtubule-based process 17.8571 4 yes
GO:0033043 regulation of organelle organization 17.8571 5 yes
GO:0043254 regulation of protein-containing complex assembly 17.8571 5 yes
GO:0045597 positive regulation of cell differentiation 17.8571 5 yes
GO:0046777 protein autophosphorylation 17.8571 6 yes
GO:0010976 positive regulation of neuron projection development 14.2857 7 yes
GO:0017157 regulation of exocytosis 14.2857 5 yes
GO:0030155 regulation of cell adhesion 14.2857 4 yes
GO:0032271 regulation of protein polymerization 14.2857 6 yes
GO:0033993 response to lipid 14.2857 4 yes
GO:0051493 regulation of cytoskeleton organization 14.2857 6 yes
GO:0060284 regulation of cell development 14.2857 5 yes
GO:1902903 regulation of supramolecular fiber organization 14.2857 5 yes
GO:1903706 regulation of hemopoiesis 14.2857 4 yes
GO:0002697 regulation of immune effector process 10.7143 4 yes
GO:0002703 regulation of leukocyte mediated immunity 10.7143 5 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 10.7143 6 yes
GO:0014855 striated muscle cell proliferation 10.7143 4 yes
GO:0022604 regulation of cell morphogenesis 10.7143 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 10.7143 6 yes
GO:0031113 regulation of microtubule polymerization 10.7143 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 10.7143 6 yes
GO:0032273 positive regulation of protein polymerization 10.7143 7 yes
GO:0043300 regulation of leukocyte degranulation 10.7143 5 yes
GO:0044089 positive regulation of cellular component biogenesis 10.7143 5 yes
GO:0045637 regulation of myeloid cell differentiation 10.7143 5 yes
GO:0045639 positive regulation of myeloid cell differentiation 10.7143 6 yes
GO:0060038 cardiac muscle cell proliferation 10.7143 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 10.7143 5 yes
GO:0071396 cellular response to lipid 10.7143 5 yes
GO:0071407 cellular response to organic cyclic compound 10.7143 5 yes
GO:1902105 regulation of leukocyte differentiation 10.7143 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 10.7143 6 yes
GO:1903305 regulation of regulated secretory pathway 10.7143 6 yes
GO:0001578 microtubule bundle formation 7.1429 4 yes
GO:0002761 regulation of myeloid leukocyte differentiation 7.1429 6 yes
GO:0002763 positive regulation of myeloid leukocyte differentiation 7.1429 7 yes
GO:0010638 positive regulation of organelle organization 7.1429 6 yes
GO:0010720 positive regulation of cell development 7.1429 6 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 7.1429 7 yes
GO:0031116 positive regulation of microtubule polymerization 7.1429 7 yes
GO:0031670 cellular response to nutrient 7.1429 4 yes
GO:0033273 response to vitamin 7.1429 4 yes
GO:0033280 response to vitamin D 7.1429 4 yes
GO:0043304 regulation of mast cell degranulation 7.1429 6 yes
GO:0045655 regulation of monocyte differentiation 7.1429 7 yes
GO:0045657 positive regulation of monocyte differentiation 7.1429 8 yes
GO:0051495 positive regulation of cytoskeleton organization 7.1429 7 yes
GO:0071295 cellular response to vitamin 7.1429 5 yes
GO:0071305 cellular response to vitamin D 7.1429 5 yes
GO:1902107 positive regulation of leukocyte differentiation 7.1429 6 yes
GO:1903708 positive regulation of hemopoiesis 7.1429 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
FES_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
HSH2D_HUMAN [view interactions] Low throughput no no
TIF1B_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
BCAR1_HUMAN [view interactions] Low throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
ZN746_HUMAN [view interactions] High throughput no no
ZN775_HUMAN [view interactions] High throughput no no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
CDV3_HUMAN [view interactions] High throughput no no
CSRP1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
IF4H_HUMAN [view interactions] High throughput no yes
ERF1_HUMAN [view interactions] High throughput no yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ERP29_HUMAN [view interactions] High throughput no yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
FBX50_HUMAN [view interactions] High throughput no no
POF1B_HUMAN [view interactions] High throughput no no
PSD13_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
GAB1_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB3_HUMAN [view interactions] High throughput no yes
EPHA8_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR2_HUMAN [view interactions] High throughput no yes
MATK_HUMAN [view interactions] High throughput no yes
MERTK_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
PTK6_HUMAN [view interactions] High throughput no yes
PTK7_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes