COF2_HUMAN
Evidence for PS localization
Functions
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COF2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 41.3043 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.4348 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.4348 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.2609 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0870 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.0870 | 5 | no |
| GO:0005524 | ATP binding | 23.9130 | 5 | no |
| GO:0019900 | kinase binding | 23.9130 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 4 | no |
| GO:0045296 | cadherin binding | 21.7391 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COF2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 60.8696 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 58.6957 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.5217 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.3478 | 4 | no |
| GO:0007010 | cytoskeleton organization | 43.4783 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 43.4783 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 41.3043 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 41.3043 | 6 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 36.9565 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 36.9565 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.9565 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 34.7826 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 32.6087 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.6087 | 5 | no |
| GO:0022607 | cellular component assembly | 32.6087 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.6087 | 4 | no |
| GO:0007015 | actin filament organization | 30.4348 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.4348 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0010941 | regulation of cell death | 28.2609 | 4 | no |
| GO:0032535 | regulation of cellular component size | 26.0870 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 5 | no |
| GO:0060548 | negative regulation of cell death | 26.0870 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.9130 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.9130 | 5 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 23.9130 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 23.9130 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 23.9130 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.9130 | 4 | no |
| GO:0008104 | protein localization | 23.9130 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.9130 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.9130 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.9130 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.9130 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.9130 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.9130 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.9130 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.9130 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.9130 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.9130 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.9130 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 21.7391 | 7 | yes |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | no |
| GO:0030030 | cell projection organization | 21.7391 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 19.5652 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 17.3913 | 4 | yes |
| GO:0008154 | actin polymerization or depolymerization | 15.2174 | 6 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 15.2174 | 7 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 15.2174 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 15.2174 | 6 | yes |
| GO:0022411 | cellular component disassembly | 13.0435 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 13.0435 | 5 | yes |
| GO:0030042 | actin filament depolymerization | 10.8696 | 7 | yes |
| GO:0030043 | actin filament fragmentation | 10.8696 | 8 | yes |
| GO:0045214 | sarcomere organization | 10.8696 | 5 | yes |
| GO:0051261 | protein depolymerization | 10.8696 | 6 | yes |
| GO:0060249 | anatomical structure homeostasis | 10.8696 | 4 | yes |
| GO:0060537 | muscle tissue development | 10.8696 | 4 | yes |
| GO:0030836 | positive regulation of actin filament depolymerization | 8.6957 | 7 | yes |
| GO:0043243 | positive regulation of protein-containing complex disassembly | 8.6957 | 6 | yes |
| GO:1901881 | positive regulation of protein depolymerization | 8.6957 | 7 | yes |
| GO:0007519 | skeletal muscle tissue development | 6.5217 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in COF2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.3478 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CSRP3_HUMAN | [view interactions] | Low throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| COMD3_HUMAN | [view interactions] | High throughput | no | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM7_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| HIRP3_HUMAN | [view interactions] | High throughput | no | no |
| PRDM7_HUMAN | [view interactions] | High throughput | no | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSH1_HUMAN | [view interactions] | Computational | no | yes |
| ACTS_HUMAN | [view interactions] | Computational | no | no |
| LIMK1_HUMAN | [view interactions] | Computational | no | yes |
| LIMK2_HUMAN | [view interactions] | Computational | no | yes |
| KBTBD_HUMAN | [view interactions] | Computational | no | no |
| SSH3_HUMAN | [view interactions] | Computational | no | yes |