IGSF8_HUMAN
Evidence for PS localization
Functions
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IGSF8_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 68.0000 | 4 | no |
| GO:0003729 | mRNA binding | 21.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IGSF8_HUMAN |
|---|---|---|---|---|
| GO:0009059 | macromolecule biosynthetic process | 49.0000 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 47.0000 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 47.0000 | 4 | no |
| GO:0006518 | peptide metabolic process | 44.0000 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 44.0000 | 4 | no |
| GO:0006412 | translation | 43.0000 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 43.0000 | 5 | no |
| GO:0043604 | amide biosynthetic process | 43.0000 | 5 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 43.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.0000 | 4 | no |
| GO:0002181 | cytoplasmic translation | 41.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.0000 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 34.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.0000 | 5 | no |
| GO:0016070 | RNA metabolic process | 31.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 31.0000 | 4 | no |
| GO:0006396 | RNA processing | 28.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 28.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 22.0000 | 4 | no |
| GO:0006996 | organelle organization | 21.0000 | 4 | no |
| GO:0007399 | nervous system development | 3.0000 | 4 | yes |
| GO:0007519 | skeletal muscle tissue development | 2.0000 | 5 | yes |
| GO:0060537 | muscle tissue development | 2.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in IGSF8_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 3.0000 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.0000 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD82_HUMAN | [view interactions] | Low throughput | no | no |
| CD81_HUMAN | [view interactions] | Low throughput | no | no |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1A_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIFCL_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| SMD1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YBOX2_HUMAN | [view interactions] | High throughput | no | no |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| RU2A_HUMAN | [view interactions] | High throughput | no | yes |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRSF8_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| TBE_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS30_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC14_HUMAN | [view interactions] | High throughput | no | yes |
| ADPRS_HUMAN | [view interactions] | High throughput | no | yes |
| DYH14_HUMAN | [view interactions] | High throughput | no | no |
| HBD_HUMAN | [view interactions] | High throughput | no | no |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| DGLB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| MBLC2_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| CD19_HUMAN | [view interactions] | High throughput | no | no |
| EFNB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFX3_HUMAN | [view interactions] | High throughput | no | yes |
| MMRN1_HUMAN | [view interactions] | High throughput | no | yes |
| TMX4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| CTLA4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| CLD19_HUMAN | [view interactions] | High throughput | no | no |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| NCDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGDC4_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| ACTH_HUMAN | [view interactions] | High throughput | no | no |
| CAYP1_HUMAN | [view interactions] | High throughput | no | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| CTL1_HUMAN | [view interactions] | High throughput | no | no |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| KR104_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| KRA24_HUMAN | [view interactions] | High throughput | no | no |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| KRA57_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH3_HUMAN | [view interactions] | High throughput | no | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB9_HUMAN | [view interactions] | High throughput | no | no |
| IBTK_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1M_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1N_HUMAN | [view interactions] | High throughput | no | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITA4_HUMAN | [view interactions] | Computational | no | no |