Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGSF8_HUMAN

GO
G2C
SynGO

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in IGSF8_HUMAN
GO:0003723 RNA binding 68.3168 4 no
GO:0003729 mRNA binding 23.7624 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in IGSF8_HUMAN
GO:0009059 macromolecule biosynthetic process 52.4752 4 no
GO:0006412 translation 42.5743 4 no
GO:1901566 organonitrogen compound biosynthetic process 42.5743 4 no
GO:0002181 cytoplasmic translation 41.5842 5 no
GO:0048522 positive regulation of cellular process 41.5842 4 no
GO:0060255 regulation of macromolecule metabolic process 41.5842 4 no
GO:0031323 regulation of cellular metabolic process 40.5941 4 no
GO:0080090 regulation of primary metabolic process 40.5941 4 no
GO:0009889 regulation of biosynthetic process 38.6139 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.6139 5 no
GO:0031326 regulation of cellular biosynthetic process 38.6139 5 no
GO:0010468 regulation of gene expression 36.6337 6 no
GO:0048523 negative regulation of cellular process 35.6436 4 no
GO:0090304 nucleic acid metabolic process 35.6436 4 no
GO:0016070 RNA metabolic process 31.6832 5 no
GO:0009893 positive regulation of metabolic process 30.6931 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.7129 5 no
GO:0022607 cellular component assembly 27.7228 4 no
GO:0006396 RNA processing 26.7327 6 no
GO:0031325 positive regulation of cellular metabolic process 26.7327 5 no
GO:0009892 negative regulation of metabolic process 26.7327 4 no
GO:0051128 regulation of cellular component organization 26.7327 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.7426 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.7426 5 no
GO:0051246 regulation of protein metabolic process 24.7525 5 no
GO:0009891 positive regulation of biosynthetic process 23.7624 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.7624 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.7624 6 no
GO:0051252 regulation of RNA metabolic process 23.7624 5 no
GO:0009890 negative regulation of biosynthetic process 22.7723 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.7723 6 no
GO:0031324 negative regulation of cellular metabolic process 22.7723 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.7723 6 no
GO:0006996 organelle organization 21.7822 4 no
GO:0010646 regulation of cell communication 20.7921 4 no
GO:0141188 nucleic acid catabolic process 20.7921 5 no
GO:0043933 protein-containing complex organization 20.7921 4 no
GO:0007399 nervous system development 2.9703 4 yes
GO:0007519 skeletal muscle tissue development 1.9802 5 yes
GO:0060537 muscle tissue development 1.9802 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
CD82_HUMAN [view interactions] Low throughput no no
CD81_HUMAN [view interactions] Low throughput no no
TBE_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
RS19_HUMAN [view entry] [view interactions] High throughput yes no
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
RL12_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
RL27_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RS4Y1_HUMAN [view interactions] High throughput no yes
RL30_HUMAN [view entry] [view interactions] High throughput yes yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RS30_HUMAN [view interactions] High throughput no yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
RL26L_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
RL26_HUMAN [view entry] [view interactions] High throughput yes yes
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
RL9_HUMAN [view entry] [view interactions] High throughput yes yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BE_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
TM160_HUMAN [view interactions] High throughput no no
EI2BD_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
DJC14_HUMAN [view interactions] High throughput no yes
ADPRS_HUMAN [view interactions] High throughput no yes
DYH14_HUMAN [view interactions] High throughput no no
HBD_HUMAN [view interactions] High throughput no no
HBA_HUMAN [view interactions] High throughput no no
DGLB_HUMAN [view interactions] High throughput no no
OCLN_HUMAN [view interactions] High throughput no no
MBLC2_HUMAN [view interactions] High throughput no yes
GDPD5_HUMAN [view interactions] High throughput no no
TMX1_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
CD19_HUMAN [view interactions] High throughput no no
EFNB3_HUMAN [view entry] [view interactions] High throughput yes yes
RFX3_HUMAN [view interactions] High throughput no yes
MMRN1_HUMAN [view interactions] High throughput no yes
TMX4_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
AT1B3_HUMAN [view interactions] High throughput no yes
CTLA4_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
IPPK_HUMAN [view interactions] High throughput no yes
CLGN_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
CLD19_HUMAN [view interactions] High throughput no no
KDSR_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
DQA1_HUMAN [view interactions] High throughput no yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
IGDC4_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
BSCL2_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
SCAM3_HUMAN [view interactions] High throughput no no
ACTH_HUMAN [view interactions] High throughput no no
CAYP1_HUMAN [view interactions] High throughput no no
CC50A_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CTL1_HUMAN [view interactions] High throughput no no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
TSN5_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
KR104_HUMAN [view interactions] High throughput no no
KR107_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
KR109_HUMAN [view interactions] High throughput no no
KRA11_HUMAN [view interactions] High throughput no no
KRA24_HUMAN [view interactions] High throughput no no
TGM1_HUMAN [view interactions] High throughput no no
KRA57_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
KR103_HUMAN [view interactions] High throughput no no
KR412_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
NUCL_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH3_HUMAN [view interactions] High throughput no no
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
SPB9_HUMAN [view interactions] High throughput no no
IBTK_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
H13_HUMAN [view interactions] High throughput no no
H12_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
H2B1J_HUMAN [view interactions] High throughput no yes
H2B1K_HUMAN [view interactions] High throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
H2B1O_HUMAN [view interactions] High throughput no yes
H2B1L_HUMAN [view interactions] High throughput no yes
H2B1M_HUMAN [view interactions] High throughput no yes
H2B1N_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
H2B1B_HUMAN [view interactions] High throughput no yes
H2B2F_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
RBBP4_HUMAN [view interactions] High throughput no yes
H2B1A_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
FRIL_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SART3_HUMAN [view interactions] High throughput no yes
EIF3L_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIFCL_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
SET_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX3_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
MCM5_HUMAN [view interactions] High throughput no no
ILF2_HUMAN [view interactions] High throughput no yes
AN32B_HUMAN [view interactions] High throughput no yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
SMD3_HUMAN [view interactions] High throughput no yes
PDCD4_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
SMD1_HUMAN [view interactions] High throughput no yes
SRSF3_HUMAN [view interactions] High throughput no yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
YBOX2_HUMAN [view interactions] High throughput no no
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3Y_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
SRP14_HUMAN [view interactions] High throughput no no
RSMB_HUMAN [view interactions] High throughput no yes
THOC4_HUMAN [view interactions] High throughput no no
EIF3G_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B3_HUMAN [view interactions] High throughput no yes
TCOF_HUMAN [view interactions] High throughput no yes
RU2A_HUMAN [view interactions] High throughput no yes
LSM3_HUMAN [view interactions] High throughput no yes
ELP1_HUMAN [view interactions] High throughput no yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP2_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF8_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB6_HUMAN [view entry] [view interactions] High throughput yes yes
TBA8_HUMAN [view interactions] High throughput no yes