Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBB6_HUMAN

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TBB6_HUMAN
GO:0017076 purine nucleotide binding 40.0000 4 yes
GO:0032555 purine ribonucleotide binding 38.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.5714 4 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0030554 adenyl nucleotide binding 28.5714 5 no
GO:0005524 ATP binding 27.1429 5 no
GO:0019901 protein kinase binding 27.1429 5 no
GO:0032559 adenyl ribonucleotide binding 27.1429 5 no
GO:0016462 pyrophosphatase activity 21.4286 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 yes
GO:0003723 RNA binding 21.4286 4 no
GO:0003924 GTPase activity 11.4286 7 yes
GO:0005525 GTP binding 11.4286 5 yes
GO:0019001 guanyl nucleotide binding 11.4286 5 yes
GO:0032561 guanyl ribonucleotide binding 11.4286 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBB6_HUMAN
GO:0031323 regulation of cellular metabolic process 67.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 65.7143 4 no
GO:0080090 regulation of primary metabolic process 64.2857 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.8571 4 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 55.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 52.8571 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0009966 regulation of signal transduction 48.5714 4 no
GO:0009889 regulation of biosynthetic process 48.5714 4 no
GO:0031326 regulation of cellular biosynthetic process 48.5714 5 no
GO:0006996 organelle organization 47.1429 4 yes
GO:0031325 positive regulation of cellular metabolic process 47.1429 5 no
GO:0010556 regulation of macromolecule biosynthetic process 47.1429 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.1429 5 no
GO:0010468 regulation of gene expression 45.7143 5 no
GO:0051246 regulation of protein metabolic process 44.2857 5 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0031399 regulation of protein modification process 41.4286 6 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010941 regulation of cell death 38.5714 4 no
GO:0051252 regulation of RNA metabolic process 38.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.1429 5 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0006355 regulation of DNA-templated transcription 35.7143 6 no
GO:1903506 regulation of nucleic acid-templated transcription 35.7143 7 no
GO:2001141 regulation of RNA biosynthetic process 35.7143 6 no
GO:0010648 negative regulation of cell communication 34.2857 5 no
GO:0023057 negative regulation of signaling 34.2857 4 no
GO:0031401 positive regulation of protein modification process 34.2857 7 no
GO:0042325 regulation of phosphorylation 34.2857 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.2857 5 no
GO:0048584 positive regulation of response to stimulus 32.8571 4 no
GO:0051338 regulation of transferase activity 32.8571 4 no
GO:0031324 negative regulation of cellular metabolic process 32.8571 5 no
GO:0043067 regulation of programmed cell death 32.8571 5 no
GO:0044087 regulation of cellular component biogenesis 32.8571 4 no
GO:0009968 negative regulation of signal transduction 31.4286 5 no
GO:0010647 positive regulation of cell communication 31.4286 5 no
GO:0023056 positive regulation of signaling 31.4286 4 no
GO:0048585 negative regulation of response to stimulus 31.4286 4 no
GO:0051130 positive regulation of cellular component organization 31.4286 5 no
GO:0042981 regulation of apoptotic process 31.4286 6 no
GO:0022607 cellular component assembly 31.4286 4 no
GO:0033043 regulation of organelle organization 31.4286 5 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0009891 positive regulation of biosynthetic process 30.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.0000 6 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0060548 negative regulation of cell death 28.5714 5 no
GO:0043085 positive regulation of catalytic activity 27.1429 4 no
GO:0008104 protein localization 27.1429 4 no
GO:0071702 organic substance transport 27.1429 4 no
GO:0071705 nitrogen compound transport 27.1429 4 no
GO:0043933 protein-containing complex organization 27.1429 4 no
GO:0007010 cytoskeleton organization 25.7143 5 yes
GO:0051248 negative regulation of protein metabolic process 25.7143 6 no
GO:0071310 cellular response to organic substance 25.7143 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.2857 6 no
GO:0036211 protein modification process 24.2857 4 no
GO:0042327 positive regulation of phosphorylation 24.2857 8 no
GO:0043408 regulation of MAPK cascade 24.2857 6 no
GO:0043412 macromolecule modification 24.2857 4 no
GO:0045859 regulation of protein kinase activity 24.2857 6 no
GO:0045937 positive regulation of phosphate metabolic process 24.2857 7 no
GO:0051129 negative regulation of cellular component organization 24.2857 5 no
GO:0051347 positive regulation of transferase activity 24.2857 5 no
GO:0043066 negative regulation of apoptotic process 24.2857 7 no
GO:0043069 negative regulation of programmed cell death 24.2857 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.2857 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.2857 6 no
GO:0080134 regulation of response to stress 22.8571 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.8571 6 no
GO:1902533 positive regulation of intracellular signal transduction 22.8571 6 no
GO:0051049 regulation of transport 22.8571 4 no
GO:0065003 protein-containing complex assembly 22.8571 5 no
GO:0010638 positive regulation of organelle organization 22.8571 6 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0009894 regulation of catabolic process 21.4286 4 no

Disease

Term Name % Distance from top the of the tree Annotated in TBB6_HUMAN
DOID:1289 neurodegenerative disease 2.8571 4 no
DOID:331 central nervous system disease 2.8571 3 no
DOID:0050686 organ system cancer 2.8571 3 no
DOID:120 female reproductive organ cancer 2.8571 5 no
DOID:193 reproductive organ cancer 2.8571 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRK2_HUMAN [view interactions] Low throughput no yes
FOCAD_HUMAN [view interactions] Low throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
ST1A1_HUMAN [view interactions] High throughput no no
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
SRXN1_HUMAN [view interactions] High throughput no no
SERC_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
KCC1D_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
NUCB2_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
FTM_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
SAV1_HUMAN [view interactions] High throughput no yes
DNJA4_HUMAN [view interactions] High throughput no yes
IRS4_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
ARAF_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R1_HUMAN [view interactions] High throughput no no
TOM40_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
IFT27_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC1_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
CNEP1_HUMAN [view interactions] High throughput no yes
CTDS2_HUMAN [view interactions] High throughput no yes
MTMR8_HUMAN [view interactions] High throughput no no
PPE2_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PEX14_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
DUX4_HUMAN [view interactions] High throughput no no
PPM1D_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TRI63_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
TYRO3_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ANGI_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
M3K1_HUMAN [view interactions] High throughput no yes
M3K3_HUMAN [view interactions] High throughput no no
NFKB2_HUMAN [view interactions] High throughput no yes
TNR1A_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LMBL1_HUMAN [view interactions] High throughput no no
5HT7R_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
KATL1_HUMAN [view interactions] High throughput no no
KATL2_HUMAN [view interactions] High throughput no yes
KTNB1_HUMAN [view interactions] High throughput no yes
NBEL2_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
CMKMT_HUMAN [view interactions] High throughput no no
F86B2_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
MET23_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
IGSF8_HUMAN [view entry] [view interactions] High throughput yes no
ICAM1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ASB10_HUMAN [view interactions] High throughput no no
PCSK9_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
KS6B2_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
MTMRB_HUMAN [view interactions] High throughput no no
PTN18_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CCND2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
MINY4_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
CCND1_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
UCHL3_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
S15A3_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ANR55_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
SP140_HUMAN [view interactions] High throughput no no
RMC1_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
TXNIP_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DJB12_HUMAN [view interactions] High throughput no yes
DNJB2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB8_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
DJC12_HUMAN [view interactions] High throughput no yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
DJC25_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
ISG15_HUMAN [view interactions] High throughput no no
UBP2_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
OSTM1_HUMAN [view interactions] High throughput no yes
CAYP1_HUMAN [view interactions] High throughput no no
SURF1_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TTC5_HUMAN [view interactions] High throughput no yes
I12R1_HUMAN [view interactions] High throughput no no
KLK5_HUMAN [view interactions] High throughput no no
MICB_HUMAN [view interactions] High throughput no no
BIG2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
EMAL4_HUMAN [view interactions] High throughput no yes
TMPS5_HUMAN [view interactions] High throughput no no
TNR6_HUMAN [view interactions] High throughput no no
ZMYM4_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
T11L1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
DPP4_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
ANTR1_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
BRD4_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
TTL_HUMAN [view interactions] Computational no no
VASH1_HUMAN [view interactions] Computational no yes
TBB8_HUMAN [view interactions] Computational no no
CHMP7_HUMAN [view interactions] Computational no yes
CHM4A_HUMAN [view interactions] Computational no no
TBA8_HUMAN [view interactions] Computational no yes
TBCA_HUMAN [view interactions] Computational no yes
TBA3E_HUMAN [view interactions] Computational no no
CHM2B_HUMAN [view entry] [view interactions] Computational yes yes
C2D1B_HUMAN [view interactions] Computational no yes
IST1_HUMAN [view interactions] Computational no yes
ARHG2_HUMAN [view entry] [view interactions] Computational yes yes
LEMD2_HUMAN [view interactions] Computational no yes
TBCE_HUMAN [view interactions] Computational no no
CHM2A_HUMAN [view interactions] Computational no yes
CHM4B_HUMAN [view entry] [view interactions] Computational yes yes
TBAL3_HUMAN [view interactions] Computational no no
CXA1_HUMAN [view entry] [view interactions] Computational yes yes
ARL2_HUMAN [view interactions] Computational no yes
CHMP6_HUMAN [view interactions] Computational no yes
TBCB_HUMAN [view entry] [view interactions] Computational yes yes
TBA3D_HUMAN [view interactions] Computational no no
TBA3C_HUMAN [view interactions] Computational no no
VASH2_HUMAN [view interactions] Computational no no
SVBP_HUMAN [view interactions] Computational no yes