5HT7R_HUMAN
Evidence for PS localization
Functions
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT7R_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 56.5217 | 4 | no |
| GO:0043168 | anion binding | 43.4783 | 4 | no |
| GO:0000166 | nucleotide binding | 41.3043 | 4 | no |
| GO:0017076 | purine nucleotide binding | 41.3043 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 41.3043 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 41.3043 | 4 | no |
| GO:0043169 | cation binding | 28.2609 | 4 | no |
| GO:0046872 | metal ion binding | 28.2609 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 23.9130 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.9130 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.9130 | 6 | no |
| GO:0005524 | ATP binding | 23.9130 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.9130 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.9130 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.9130 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.9130 | 4 | no |
| GO:0019843 | rRNA binding | 21.7391 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT7R_HUMAN |
|---|---|---|---|---|
| GO:0009059 | macromolecule biosynthetic process | 50.0000 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 41.3043 | 4 | no |
| GO:0006412 | translation | 39.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0002181 | cytoplasmic translation | 36.9565 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 36.9565 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.9565 | 4 | no |
| GO:0006996 | organelle organization | 34.7826 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6087 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.4348 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.2609 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2609 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.0870 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.0870 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.9130 | 4 | no |
| GO:0022607 | cellular component assembly | 23.9130 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.9130 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.9130 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 21.7391 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | no |
| GO:0006936 | muscle contraction | 6.5217 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHBT3_HUMAN | [view interactions] | Low throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| GASP1_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1D_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KMT5C_HUMAN | [view interactions] | High throughput | no | no |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYLK2_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP4_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |