5HT7R_HUMAN
Evidence for PS localization
Functions
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT7R_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 52.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 28.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.0000 | 6 | no |
| GO:0046872 | metal ion binding | 24.0000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 22.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 22.0000 | 4 | no |
| GO:0005524 | ATP binding | 22.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT7R_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 42.0000 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 42.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.0000 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 38.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.0000 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 38.0000 | 4 | no |
| GO:0006996 | organelle organization | 36.0000 | 4 | no |
| GO:0006412 | translation | 36.0000 | 4 | no |
| GO:0006518 | peptide metabolic process | 36.0000 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 36.0000 | 5 | no |
| GO:0043603 | cellular amide metabolic process | 36.0000 | 4 | no |
| GO:0043604 | amide biosynthetic process | 36.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.0000 | 5 | no |
| GO:0002181 | cytoplasmic translation | 34.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.0000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 26.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 24.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 24.0000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 24.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 22.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.0000 | 6 | no |
| GO:0003018 | vascular process in circulatory system | 4.0000 | 4 | yes |
| GO:0006936 | muscle contraction | 4.0000 | 4 | yes |
| GO:0035150 | regulation of tube size | 4.0000 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 4.0000 | 5 | yes |
| GO:0042310 | vasoconstriction | 4.0000 | 6 | yes |
| GO:0097746 | blood vessel diameter maintenance | 4.0000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT7R_HUMAN |
|---|---|---|---|---|
| DOID:0050563 | nonsyndromic deafness | 4.0000 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 4.0000 | 6 | no |
| DOID:2742 | auditory system disease | 4.0000 | 4 | no |
| DOID:0050700 | cardiomyopathy | 4.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.0000 | 5 | no |
| DOID:114 | heart disease | 4.0000 | 3 | no |
| DOID:2843 | long QT syndrome | 4.0000 | 6 | no |
| DOID:0050155 | sensory system disease | 4.0000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHBT3_HUMAN | [view interactions] | Low throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| GASP1_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1D_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KMT5C_HUMAN | [view interactions] | High throughput | no | no |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYLK2_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP4_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| GNAL_HUMAN | [view interactions] | Computational | no | yes |
| GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 5HT6R_HUMAN | [view interactions] | Computational | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |