MYH14_HUMAN
Evidence for PS localization
Functions
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 376 | Gly | Cys | Deafness,autosomaldominant,4A(DFNA4A) | - |
| 726 | Arg | Ser | Deafness,autosomaldominant,4A(DFNA4A) | - |
| 976 | Leu | Phe | Deafness,autosomaldominant,4A(DFNA4A) | - |
| 120 | Ser | Leu | Deafness,autosomaldominant,4A(DFNA4A) | - |
| 933 | Arg | Leu | Peripheralneuropathy,myopathy,hoarseness,andhearingloss(PNMHH) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYH14_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.0000 | 4 | no |
| GO:0045296 | cadherin binding | 23.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
| GO:0003779 | actin binding | 16.6667 | 4 | yes |
| GO:0005524 | ATP binding | 16.6667 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 16.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYH14_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.3333 | 4 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0036211 | protein modification process | 26.6667 | 4 | no |
| GO:0043412 | macromolecule modification | 26.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.3333 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 23.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.3333 | 5 | no |
| GO:0071702 | organic substance transport | 23.3333 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.0000 | 4 | yes |
| GO:0006936 | muscle contraction | 13.3333 | 4 | yes |
| GO:0007519 | skeletal muscle tissue development | 10.0000 | 5 | yes |
| GO:0031032 | actomyosin structure organization | 10.0000 | 4 | yes |
| GO:0060537 | muscle tissue development | 10.0000 | 4 | yes |
| GO:0001508 | action potential | 6.6667 | 4 | yes |
| GO:0008360 | regulation of cell shape | 6.6667 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 6.6667 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYH14_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 6.6667 | 3 | yes |
| DOID:0050563 | nonsyndromic deafness | 6.6667 | 5 | yes |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 6.6667 | 6 | yes |
| DOID:2742 | auditory system disease | 6.6667 | 4 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRPM7_HUMAN | [view interactions] | Low throughput | no | no |
| TRPM6_HUMAN | [view interactions] | Low throughput | no | no |
| BRCA2_HUMAN | [view interactions] | Low throughput | no | no |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| MYL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYL9_HUMAN | [view interactions] | High throughput | no | no |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| CEPT1_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| STAP2_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KLF10_HUMAN | [view interactions] | High throughput | no | no |
| ELK3_HUMAN | [view interactions] | High throughput | no | yes |
| IRF8_HUMAN | [view interactions] | High throughput | no | no |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| ZIC3_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| 5HT7R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| CG025_HUMAN | [view interactions] | High throughput | no | yes |
| SGK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| ETV5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNQ_HUMAN | [view interactions] | High throughput | no | yes |
| DNMT1_HUMAN | [view interactions] | High throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYL3_HUMAN | [view interactions] | High throughput | no | no |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| FCF1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFY21_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| CXCL6_HUMAN | [view interactions] | High throughput | no | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |