SORCN_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SORCN_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 5 | yes |
| GO:0005509 | calcium ion binding | 33.3333 | 6 | yes |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 20.8333 | 4 | no |
| GO:0042803 | protein homodimerization activity | 20.8333 | 4 | no |
| GO:0005524 | ATP binding | 20.8333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.8333 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.8333 | 5 | no |
| GO:0140297 | DNA-binding transcription factor binding | 16.6667 | 4 | yes |
| GO:0002020 | protease binding | 12.5000 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 12.5000 | 4 | yes |
| GO:0005246 | calcium channel regulator activity | 8.3333 | 5 | yes |
| GO:0099106 | ion channel regulator activity | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SORCN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.8333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | yes |
| GO:0051049 | regulation of transport | 45.8333 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 29.1667 | 4 | yes |
| GO:0051046 | regulation of secretion | 29.1667 | 5 | yes |
| GO:0051050 | positive regulation of transport | 29.1667 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 29.1667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 29.1667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.1667 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.1667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.1667 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.1667 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.1667 | 5 | no |
| GO:0071702 | organic substance transport | 29.1667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.1667 | 4 | no |
| GO:0022607 | cellular component assembly | 29.1667 | 4 | no |
| GO:0006811 | monoatomic ion transport | 25.0000 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 25.0000 | 5 | yes |
| GO:0006816 | calcium ion transport | 25.0000 | 7 | yes |
| GO:0006937 | regulation of muscle contraction | 25.0000 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 25.0000 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | yes |
| GO:0030001 | metal ion transport | 25.0000 | 6 | yes |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 25.0000 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 25.0000 | 5 | yes |
| GO:0044057 | regulation of system process | 25.0000 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 25.0000 | 7 | yes |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 25.0000 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 25.0000 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 25.0000 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0001508 | action potential | 20.8333 | 4 | yes |
| GO:0006942 | regulation of striated muscle contraction | 20.8333 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 20.8333 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 20.8333 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.8333 | 4 | yes |
| GO:0051051 | negative regulation of transport | 20.8333 | 4 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 20.8333 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 20.8333 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 20.8333 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 20.8333 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.8333 | 8 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.8333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.8333 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.8333 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0033365 | protein localization to organelle | 20.8333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.8333 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.8333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.8333 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 20.8333 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 20.8333 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.8333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | no |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 16.6667 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 16.6667 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 16.6667 | 6 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 16.6667 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 16.6667 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 16.6667 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 16.6667 | 5 | yes |
| GO:0051223 | regulation of protein transport | 16.6667 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 16.6667 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 16.6667 | 6 | yes |
| GO:0070201 | regulation of establishment of protein localization | 16.6667 | 6 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 16.6667 | 6 | yes |
| GO:1903115 | regulation of actin filament-based movement | 16.6667 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 16.6667 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 16.6667 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 16.6667 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 16.6667 | 7 | yes |
| GO:0002791 | regulation of peptide secretion | 12.5000 | 6 | yes |
| GO:0007507 | heart development | 12.5000 | 4 | yes |
| GO:0032410 | negative regulation of transporter activity | 12.5000 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 12.5000 | 5 | yes |
| GO:0045822 | negative regulation of heart contraction | 12.5000 | 6 | yes |
| GO:0050796 | regulation of insulin secretion | 12.5000 | 6 | yes |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12.5000 | 6 | yes |
| GO:0051284 | positive regulation of sequestering of calcium ion | 12.5000 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 12.5000 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 12.5000 | 5 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 12.5000 | 6 | yes |
| GO:1903523 | negative regulation of blood circulation | 12.5000 | 5 | yes |
| GO:0002793 | positive regulation of peptide secretion | 8.3333 | 6 | yes |
| GO:0006880 | intracellular sequestering of iron ion | 8.3333 | 4 | yes |
| GO:0007517 | muscle organ development | 8.3333 | 4 | yes |
| GO:0010459 | negative regulation of heart rate | 8.3333 | 4 | yes |
| GO:0010649 | regulation of cell communication by electrical coupling | 8.3333 | 5 | yes |
| GO:0032024 | positive regulation of insulin secretion | 8.3333 | 7 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 8.3333 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 8.3333 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 8.3333 | 6 | yes |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 8.3333 | 8 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 8.3333 | 5 | yes |
| GO:0045932 | negative regulation of muscle contraction | 8.3333 | 5 | yes |
| GO:0045988 | negative regulation of striated muscle contraction | 8.3333 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 8.3333 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 8.3333 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 8.3333 | 5 | yes |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 8.3333 | 6 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 8.3333 | 6 | yes |
| GO:0055118 | negative regulation of cardiac muscle contraction | 8.3333 | 7 | yes |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 8.3333 | 6 | yes |
| GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 8.3333 | 7 | yes |
| GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 8.3333 | 7 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 8.3333 | 6 | yes |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 8.3333 | 6 | yes |
| GO:1901077 | regulation of relaxation of muscle | 8.3333 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 8.3333 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 8.3333 | 8 | yes |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 8.3333 | 6 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 8.3333 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 8.3333 | 7 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 8.3333 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 8.3333 | 6 | yes |
| GO:2001258 | negative regulation of cation channel activity | 8.3333 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRAN_HUMAN | [view interactions] | Low throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AT2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1S_HUMAN | [view interactions] | Low throughput | no | no |
| RYR3_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| PRR13_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| GRIK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| PDE4C_HUMAN | [view interactions] | High throughput | no | no |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| HAUS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| NOL10_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSNA1_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |