SORCN_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SORCN_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 36.3636 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0005524 | ATP binding | 22.7273 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.7273 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0003723 | RNA binding | 22.7273 | 4 | no |
| GO:0140297 | DNA-binding transcription factor binding | 18.1818 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 13.6364 | 4 | yes |
| GO:0002020 | protease binding | 9.0909 | 4 | yes |
| GO:0005246 | calcium channel regulator activity | 9.0909 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SORCN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 45.4545 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.9091 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | yes |
| GO:0006996 | organelle organization | 31.8182 | 4 | no |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0006811 | ion transport | 31.8182 | 4 | yes |
| GO:0006812 | cation transport | 31.8182 | 5 | yes |
| GO:0010468 | regulation of gene expression | 31.8182 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 31.8182 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 31.8182 | 4 | yes |
| GO:0043269 | regulation of ion transport | 31.8182 | 5 | yes |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0006816 | calcium ion transport | 27.2727 | 7 | yes |
| GO:0006937 | regulation of muscle contraction | 27.2727 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 27.2727 | 6 | yes |
| GO:0030001 | metal ion transport | 27.2727 | 6 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 27.2727 | 5 | yes |
| GO:0044057 | regulation of system process | 27.2727 | 4 | yes |
| GO:0051046 | regulation of secretion | 27.2727 | 5 | yes |
| GO:0051050 | positive regulation of transport | 27.2727 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 27.2727 | 7 | yes |
| GO:0090257 | regulation of muscle system process | 27.2727 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 27.2727 | 7 | yes |
| GO:1903530 | regulation of secretion by cell | 27.2727 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 27.2727 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 22.7273 | 6 | yes |
| GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 22.7273 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7273 | 5 | no |
| GO:0010941 | regulation of cell death | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 5 | no |
| GO:0001508 | action potential | 22.7273 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 22.7273 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 22.7273 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 22.7273 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 22.7273 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | yes |
| GO:0043270 | positive regulation of ion transport | 22.7273 | 5 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 22.7273 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 22.7273 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 22.7273 | 7 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.7273 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 22.7273 | 5 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 18.1818 | 6 | yes |
| GO:0032880 | regulation of protein localization | 18.1818 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 18.1818 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 18.1818 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 18.1818 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 18.1818 | 5 | yes |
| GO:0051051 | negative regulation of transport | 18.1818 | 4 | yes |
| GO:0051100 | negative regulation of binding | 18.1818 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 18.1818 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 18.1818 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 18.1818 | 4 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 18.1818 | 6 | yes |
| GO:1903115 | regulation of actin filament-based movement | 18.1818 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 18.1818 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 18.1818 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 18.1818 | 7 | yes |
| GO:0007507 | heart development | 13.6364 | 4 | yes |
| GO:0032410 | negative regulation of transporter activity | 13.6364 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 13.6364 | 5 | yes |
| GO:0043271 | negative regulation of ion transport | 13.6364 | 5 | yes |
| GO:0045822 | negative regulation of heart contraction | 13.6364 | 6 | yes |
| GO:0046883 | regulation of hormone secretion | 13.6364 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 13.6364 | 5 | yes |
| GO:0051223 | regulation of protein transport | 13.6364 | 5 | yes |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 13.6364 | 6 | yes |
| GO:0051284 | positive regulation of sequestering of calcium ion | 13.6364 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 13.6364 | 6 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 13.6364 | 6 | yes |
| GO:1903523 | negative regulation of blood circulation | 13.6364 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 9.0909 | 6 | yes |
| GO:2001258 | negative regulation of cation channel activity | 9.0909 | 6 | yes |
| GO:0002791 | regulation of peptide secretion | 9.0909 | 6 | yes |
| GO:0002793 | positive regulation of peptide secretion | 9.0909 | 6 | yes |
| GO:0006880 | intracellular sequestering of iron ion | 9.0909 | 4 | yes |
| GO:0007517 | muscle organ development | 9.0909 | 4 | yes |
| GO:0010459 | negative regulation of heart rate | 9.0909 | 4 | yes |
| GO:0010649 | regulation of cell communication by electrical coupling | 9.0909 | 5 | yes |
| GO:0032024 | positive regulation of insulin secretion | 9.0909 | 7 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 9.0909 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 9.0909 | 5 | yes |
| GO:0034766 | negative regulation of ion transmembrane transport | 9.0909 | 6 | yes |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 9.0909 | 8 | yes |
| GO:0042994 | cytoplasmic sequestering of transcription factor | 9.0909 | 5 | yes |
| GO:0043392 | negative regulation of DNA binding | 9.0909 | 5 | yes |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | 9.0909 | 4 | yes |
| GO:0045932 | negative regulation of muscle contraction | 9.0909 | 5 | yes |
| GO:0045988 | negative regulation of striated muscle contraction | 9.0909 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 9.0909 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 9.0909 | 6 | yes |
| GO:0050796 | regulation of insulin secretion | 9.0909 | 6 | yes |
| GO:0051101 | regulation of DNA binding | 9.0909 | 4 | yes |
| GO:0051220 | cytoplasmic sequestering of protein | 9.0909 | 4 | yes |
| GO:0051222 | positive regulation of protein transport | 9.0909 | 5 | yes |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 9.0909 | 6 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 9.0909 | 6 | yes |
| GO:0055118 | negative regulation of cardiac muscle contraction | 9.0909 | 7 | yes |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 9.0909 | 6 | yes |
| GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 9.0909 | 7 | yes |
| GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 9.0909 | 7 | yes |
| GO:0090087 | regulation of peptide transport | 9.0909 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 9.0909 | 5 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 9.0909 | 6 | yes |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 9.0909 | 6 | yes |
| GO:1901077 | regulation of relaxation of muscle | 9.0909 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 9.0909 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 9.0909 | 8 | yes |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 9.0909 | 6 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 9.0909 | 7 | yes |
| GO:1903829 | positive regulation of protein localization | 9.0909 | 5 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 9.0909 | 7 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 9.0909 | 6 | yes |
| GO:2000677 | regulation of transcription regulatory region DNA binding | 9.0909 | 5 | yes |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding | 9.0909 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRAN_HUMAN | [view interactions] | Low throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1S_HUMAN | [view interactions] | Low throughput | no | no |
| RYR3_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| PRR13_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| PDE4C_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| HAUS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| NOL10_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSNA1_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |