KGUA_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed). Involved in the cGMP metabolism in photoreceptors . It may also have a role in the survival and growth progression of some tumors (PubMed). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KGUA_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.3158 | 4 | no |
| GO:0043169 | cation binding | 21.0526 | 4 | no |
| GO:0046872 | metal ion binding | 21.0526 | 5 | no |
| GO:0000166 | nucleotide binding | 15.7895 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 15.7895 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 15.7895 | 4 | yes |
| GO:0043168 | anion binding | 15.7895 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 10.5263 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 10.5263 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 10.5263 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KGUA_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.1053 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.1053 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.8421 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.8421 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.8421 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.5789 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 31.5789 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 31.5789 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 31.5789 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.3158 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010646 | regulation of cell communication | 26.3158 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.3158 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.0526 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.0526 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.0526 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 21.0526 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | no |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0006996 | organelle organization | 21.0526 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.0526 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 21.0526 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0006163 | purine nucleotide metabolic process | 15.7895 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 15.7895 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 15.7895 | 5 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 15.7895 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 15.7895 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 10.5263 | 6 | yes |
| GO:0009165 | nucleotide biosynthetic process | 10.5263 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 10.5263 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 10.5263 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 10.5263 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 10.5263 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBE2Z_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| D19L2_HUMAN | [view interactions] | High throughput | no | no |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MCEM1_HUMAN | [view interactions] | High throughput | no | no |
| CO054_HUMAN | [view interactions] | High throughput | no | no |
| CB068_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM2_HUMAN | [view interactions] | High throughput | no | no |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |