KGUA_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed). Involved in the cGMP metabolism in photoreceptors . It may also have a role in the survival and growth progression of some tumors (PubMed). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KGUA_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 40.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | yes |
| GO:0005524 | ATP binding | 24.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.0000 | 5 | yes |
| GO:0016301 | kinase activity | 20.0000 | 4 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 16.0000 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 16.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KGUA_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 44.0000 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 44.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 40.0000 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 40.0000 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 36.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 36.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0000 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 32.0000 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 32.0000 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 32.0000 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 32.0000 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 32.0000 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 32.0000 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 32.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 32.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.0000 | 4 | no |
| GO:0090407 | organophosphate biosynthetic process | 28.0000 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 24.0000 | 5 | yes |
| GO:0009165 | nucleotide biosynthetic process | 24.0000 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 24.0000 | 5 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 24.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.0000 | 5 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 24.0000 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 24.0000 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 24.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 24.0000 | 4 | no |
| GO:0006164 | purine nucleotide biosynthetic process | 20.0000 | 6 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 16.0000 | 6 | yes |
| GO:0009262 | deoxyribonucleotide metabolic process | 8.0000 | 4 | yes |
| GO:0009263 | deoxyribonucleotide biosynthetic process | 8.0000 | 5 | yes |
| GO:0009265 | 2-deoxyribonucleotide biosynthetic process | 8.0000 | 6 | yes |
| GO:0009394 | 2-deoxyribonucleotide metabolic process | 8.0000 | 5 | yes |
| GO:0019692 | deoxyribose phosphate metabolic process | 8.0000 | 4 | yes |
| GO:0046385 | deoxyribose phosphate biosynthetic process | 8.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBE2Z_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| D19L2_HUMAN | [view interactions] | High throughput | no | no |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MCEM1_HUMAN | [view interactions] | High throughput | no | no |
| CO054_HUMAN | [view interactions] | High throughput | no | no |
| CB068_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM2_HUMAN | [view interactions] | High throughput | no | no |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD9_HUMAN | [view interactions] | Computational | no | yes |
| GMPR1_HUMAN | [view interactions] | Computational | no | yes |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| APT_HUMAN | [view interactions] | Computational | no | yes |
| 5NT3B_HUMAN | [view interactions] | Computational | no | yes |
| KI13B_HUMAN | [view interactions] | Computational | no | yes |
| 5NT1A_HUMAN | [view interactions] | Computational | no | yes |
| RIR2_HUMAN | [view interactions] | Computational | no | no |
| PDE6C_HUMAN | [view interactions] | Computational | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDK5_HUMAN | [view interactions] | Computational | no | yes |
| NT5C_HUMAN | [view interactions] | Computational | no | yes |
| GUAA_HUMAN | [view interactions] | Computational | no | no |
| RIR2B_HUMAN | [view interactions] | Computational | no | yes |
| 5NTC_HUMAN | [view interactions] | Computational | no | yes |
| DCK_HUMAN | [view interactions] | Computational | no | no |
| NDKA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITPA_HUMAN | [view interactions] | Computational | no | yes |
| KPYM_HUMAN | [view interactions] | Computational | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ENTP8_HUMAN | [view interactions] | Computational | no | no |
| NDKM_HUMAN | [view interactions] | Computational | no | yes |
| NDK7_HUMAN | [view interactions] | Computational | no | yes |
| ENTP1_HUMAN | [view interactions] | Computational | no | yes |
| NDK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MESH1_HUMAN | [view interactions] | Computational | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NT5M_HUMAN | [view interactions] | Computational | no | yes |
| 5NT1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ENTP3_HUMAN | [view interactions] | Computational | no | no |
| RIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HPRT_HUMAN | [view interactions] | Computational | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DGUOK_HUMAN | [view interactions] | Computational | no | yes |