PSN2_HUMAN
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PSN2_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 31.0345 | 4 | no |
GO:0017076 | purine nucleotide binding | 31.0345 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 31.0345 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 31.0345 | 4 | no |
GO:0019900 | kinase binding | 24.1379 | 4 | no |
GO:0005524 | ATP binding | 24.1379 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 24.1379 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 24.1379 | 5 | no |
GO:0019901 | protein kinase binding | 20.6897 | 5 | no |
GO:0042803 | protein homodimerization activity | 20.6897 | 4 | no |
GO:0004175 | endopeptidase activity | 17.2414 | 4 | yes |
GO:0004190 | aspartic-type endopeptidase activity | 10.3448 | 5 | yes |
GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving | 10.3448 | 6 | yes |
GO:0070001 | aspartic-type peptidase activity | 10.3448 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PSN2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 79.3103 | 4 | no |
GO:0048523 | negative regulation of cellular process | 65.5172 | 4 | yes |
GO:0010646 | regulation of cell communication | 62.0690 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 58.6207 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 58.6207 | 4 | no |
GO:0051049 | regulation of transport | 51.7241 | 4 | yes |
GO:0009966 | regulation of signal transduction | 51.7241 | 4 | no |
GO:0010468 | regulation of gene expression | 51.7241 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.7241 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 51.7241 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 44.8276 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 44.8276 | 4 | no |
GO:0010647 | positive regulation of cell communication | 44.8276 | 5 | no |
GO:0023056 | positive regulation of signaling | 44.8276 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.8276 | 5 | no |
GO:0010941 | regulation of cell death | 41.3793 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 41.3793 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 41.3793 | 5 | yes |
GO:0008104 | protein localization | 41.3793 | 4 | no |
GO:0022607 | cellular component assembly | 41.3793 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 41.3793 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 37.9310 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.9310 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 37.9310 | 5 | no |
GO:0051094 | positive regulation of developmental process | 34.4828 | 4 | no |
GO:0009894 | regulation of catabolic process | 34.4828 | 4 | no |
GO:0043269 | regulation of ion transport | 34.4828 | 5 | yes |
GO:0060548 | negative regulation of cell death | 34.4828 | 5 | yes |
GO:0006996 | organelle organization | 34.4828 | 4 | no |
GO:0051050 | positive regulation of transport | 34.4828 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 34.4828 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 34.4828 | 5 | no |
GO:0060341 | regulation of cellular localization | 34.4828 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 34.4828 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.0345 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 31.0345 | 6 | no |
GO:0031329 | regulation of cellular catabolic process | 31.0345 | 5 | no |
GO:0036211 | protein modification process | 31.0345 | 4 | no |
GO:0043412 | macromolecule modification | 31.0345 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 31.0345 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 31.0345 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 31.0345 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 31.0345 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 31.0345 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.0345 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.0345 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 31.0345 | 5 | no |
GO:0032880 | regulation of protein localization | 31.0345 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 31.0345 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 31.0345 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
GO:0030030 | cell projection organization | 27.5862 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 27.5862 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 27.5862 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 27.5862 | 4 | yes |
GO:1904062 | regulation of cation transmembrane transport | 27.5862 | 6 | yes |
GO:0015031 | protein transport | 27.5862 | 4 | no |
GO:0016192 | vesicle-mediated transport | 27.5862 | 4 | no |
GO:0071702 | organic substance transport | 27.5862 | 4 | no |
GO:0071705 | nitrogen compound transport | 27.5862 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 27.5862 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 27.5862 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 27.5862 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 27.5862 | 6 | no |
GO:0030334 | regulation of cell migration | 27.5862 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.5862 | 4 | no |
GO:2000145 | regulation of cell motility | 27.5862 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 24.1379 | 4 | no |
GO:0010629 | negative regulation of gene expression | 24.1379 | 6 | no |
GO:0031344 | regulation of cell projection organization | 24.1379 | 5 | no |
GO:0042176 | regulation of protein catabolic process | 24.1379 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.1379 | 6 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 24.1379 | 6 | no |
GO:0045595 | regulation of cell differentiation | 24.1379 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 24.1379 | 4 | no |
GO:0080134 | regulation of response to stress | 24.1379 | 4 | no |
GO:0006915 | apoptotic process | 24.1379 | 4 | no |
GO:0071310 | cellular response to organic substance | 24.1379 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 24.1379 | 5 | no |
GO:0010648 | negative regulation of cell communication | 24.1379 | 5 | no |
GO:0023057 | negative regulation of signaling | 24.1379 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 24.1379 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 24.1379 | 4 | no |
GO:1903829 | positive regulation of protein localization | 24.1379 | 5 | no |
GO:0034330 | cell junction organization | 24.1379 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 24.1379 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.1379 | 6 | no |
GO:0031399 | regulation of protein modification process | 24.1379 | 6 | no |
GO:0042325 | regulation of phosphorylation | 24.1379 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.1379 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 24.1379 | 5 | no |
GO:0030162 | regulation of proteolysis | 20.6897 | 6 | no |
GO:0031175 | neuron projection development | 20.6897 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.6897 | 6 | no |
GO:0010975 | regulation of neuron projection development | 20.6897 | 7 | no |
GO:0031345 | negative regulation of cell projection organization | 20.6897 | 6 | no |
GO:0045597 | positive regulation of cell differentiation | 20.6897 | 5 | no |
GO:0060284 | regulation of cell development | 20.6897 | 5 | no |
GO:0006468 | protein phosphorylation | 20.6897 | 5 | no |
GO:0016310 | phosphorylation | 20.6897 | 5 | no |
GO:0006811 | ion transport | 20.6897 | 4 | yes |
GO:0007219 | Notch signaling pathway | 20.6897 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 20.6897 | 6 | yes |
GO:0006886 | intracellular protein transport | 20.6897 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 20.6897 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | no |
GO:0043270 | positive regulation of ion transport | 20.6897 | 5 | no |
GO:0007010 | cytoskeleton organization | 20.6897 | 5 | no |
GO:0010628 | positive regulation of gene expression | 20.6897 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 20.6897 | 6 | no |
GO:0009891 | positive regulation of biosynthetic process | 20.6897 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.6897 | 6 | no |
GO:0006508 | proteolysis | 17.2414 | 4 | yes |
GO:0006812 | cation transport | 17.2414 | 5 | yes |
GO:0006816 | calcium ion transport | 17.2414 | 7 | yes |
GO:0030001 | metal ion transport | 17.2414 | 6 | yes |
GO:0042982 | amyloid precursor protein metabolic process | 17.2414 | 4 | yes |
GO:0006509 | membrane protein ectodomain proteolysis | 13.7931 | 6 | yes |
GO:0016485 | protein processing | 13.7931 | 5 | yes |
GO:0033619 | membrane protein proteolysis | 13.7931 | 5 | yes |
GO:0042987 | amyloid precursor protein catabolic process | 13.7931 | 5 | yes |
GO:0051604 | protein maturation | 13.7931 | 4 | yes |
GO:0051924 | regulation of calcium ion transport | 13.7931 | 7 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 13.7931 | 7 | yes |
GO:0006518 | peptide metabolic process | 10.3448 | 4 | yes |
GO:0007220 | Notch receptor processing | 10.3448 | 4 | yes |
GO:0034205 | amyloid-beta formation | 10.3448 | 6 | yes |
GO:0043603 | cellular amide metabolic process | 10.3448 | 4 | yes |
GO:0050435 | amyloid-beta metabolic process | 10.3448 | 5 | yes |
GO:0110097 | regulation of calcium import into the mitochondrion | 6.8966 | 8 | yes |
GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering | 6.8966 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PSN2_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 10.3448 | 3 | no |
DOID:114 | heart disease | 6.8966 | 3 | no |
DOID:1289 | neurodegenerative disease | 6.8966 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FHL2_HUMAN | [view interactions] | Low throughput | no | yes |
FLNB_HUMAN | [view interactions] | Low throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
CIB1_HUMAN | [view interactions] | Low throughput | no | no |
SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ECSIT_HUMAN | [view interactions] | Low throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSEN_HUMAN | [view interactions] | Low throughput | no | no |
GFAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCIP4_HUMAN | [view interactions] | Low throughput | no | no |
APBA1_HUMAN | [view interactions] | Low throughput | no | no |
APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
APH1A_HUMAN | [view interactions] | Low throughput | no | yes |
NICA_HUMAN | [view interactions] | Low throughput | no | yes |
PEN2_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BCL2_HUMAN | [view interactions] | Low throughput | no | no |
ICAM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KC1A_HUMAN | [view interactions] | Low throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EID1_HUMAN | [view interactions] | High throughput | no | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
RN115_HUMAN | [view interactions] | High throughput | no | yes |
BI1_HUMAN | [view interactions] | High throughput | no | yes |
PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
MAST1_HUMAN | [view interactions] | High throughput | no | yes |
RNF32_HUMAN | [view interactions] | High throughput | no | no |
LIPG_HUMAN | [view interactions] | High throughput | no | no |
DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXL12_HUMAN | [view interactions] | High throughput | no | yes |
RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
MICA2_HUMAN | [view interactions] | High throughput | no | yes |
SOX14_HUMAN | [view interactions] | High throughput | no | no |
H31_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
MNDA_HUMAN | [view interactions] | High throughput | no | no |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
BAK_HUMAN | [view interactions] | High throughput | no | no |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
ELL2_HUMAN | [view interactions] | High throughput | no | no |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
SP6_HUMAN | [view interactions] | High throughput | no | no |
WDR61_HUMAN | [view interactions] | High throughput | no | yes |
FX4L6_HUMAN | [view interactions] | High throughput | no | no |
ARL16_HUMAN | [view interactions] | High throughput | no | no |
ZN366_HUMAN | [view interactions] | High throughput | no | yes |
ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
MR1L1_HUMAN | [view interactions] | High throughput | no | no |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
ZXDC_HUMAN | [view interactions] | High throughput | no | no |
DMB_HUMAN | [view interactions] | High throughput | no | no |
NOS3_HUMAN | [view interactions] | High throughput | no | no |
CEP55_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EVI5L_HUMAN | [view interactions] | High throughput | no | yes |
GCDH_HUMAN | [view interactions] | High throughput | no | yes |
IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
IFIT5_HUMAN | [view interactions] | High throughput | no | no |
OGA_HUMAN | [view interactions] | High throughput | no | yes |
SPC24_HUMAN | [view interactions] | High throughput | no | no |
AAMP_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHKA_HUMAN | [view interactions] | High throughput | no | yes |
ECD_HUMAN | [view interactions] | High throughput | no | yes |
HPS1_HUMAN | [view interactions] | High throughput | no | yes |
PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
APH1B_HUMAN | [view interactions] | High throughput | no | no |
NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
NOTC3_HUMAN | [view interactions] | High throughput | no | yes |
NOTC4_HUMAN | [view interactions] | High throughput | no | no |
TSN5_HUMAN | [view interactions] | High throughput | no | no |
DLK1_HUMAN | [view interactions] | High throughput | no | no |
NAR3_HUMAN | [view interactions] | High throughput | no | no |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
KIF22_HUMAN | [view interactions] | High throughput | no | no |
PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPL4_HUMAN | [view interactions] | High throughput | no | yes |
ALG5_HUMAN | [view interactions] | High throughput | no | yes |
IRF3_HUMAN | [view interactions] | High throughput | no | yes |
DNER_HUMAN | [view interactions] | Computational | no | yes |
TNR16_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DTX2_HUMAN | [view interactions] | Computational | no | yes |
E2AK3_HUMAN | [view interactions] | Computational | no | yes |
EPHB3_HUMAN | [view interactions] | Computational | no | yes |
EPHB1_HUMAN | [view interactions] | Computational | no | no |
CENPR_HUMAN | [view interactions] | Computational | no | yes |
DTX4_HUMAN | [view interactions] | Computational | no | yes |
DTX1_HUMAN | [view interactions] | Computational | no | yes |
ITPR3_HUMAN | [view interactions] | Computational | no | yes |
ITPR2_HUMAN | [view interactions] | Computational | no | yes |
ERN1_HUMAN | [view interactions] | Computational | no | yes |
BACE1_HUMAN | [view interactions] | Computational | no | yes |
NGF_HUMAN | [view interactions] | Computational | no | no |
APOE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHB4_HUMAN | [view interactions] | Computational | no | yes |
YBOX1_HUMAN | [view interactions] | Computational | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MFN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADA10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |