PSN2_HUMAN
Evidence for PS localization
Functions
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PSN2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 38.4615 | 4 | no |
| GO:0046872 | metal ion binding | 38.4615 | 5 | no |
| GO:0019900 | kinase binding | 30.7692 | 4 | no |
| GO:0043168 | anion binding | 26.9231 | 4 | no |
| GO:0019901 | protein kinase binding | 26.9231 | 5 | no |
| GO:0000166 | nucleotide binding | 23.0769 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.0769 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0004175 | endopeptidase activity | 15.3846 | 4 | yes |
| GO:0004190 | aspartic-type endopeptidase activity | 11.5385 | 5 | yes |
| GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving | 11.5385 | 6 | yes |
| GO:0070001 | aspartic-type peptidase activity | 11.5385 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PSN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 73.0769 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 61.5385 | 4 | yes |
| GO:0010646 | regulation of cell communication | 61.5385 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 57.6923 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.1538 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 46.1538 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | no |
| GO:0010468 | regulation of gene expression | 46.1538 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.1538 | 5 | no |
| GO:0023056 | positive regulation of signaling | 46.1538 | 4 | no |
| GO:0008104 | protein localization | 42.3077 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 42.3077 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 42.3077 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 42.3077 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 38.4615 | 6 | no |
| GO:0022607 | cellular component assembly | 38.4615 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 38.4615 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 38.4615 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 38.4615 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 38.4615 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
| GO:0009894 | regulation of catabolic process | 38.4615 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 38.4615 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 34.6154 | 5 | no |
| GO:0006996 | organelle organization | 34.6154 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 34.6154 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 34.6154 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 34.6154 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.6154 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.7692 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.7692 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 30.7692 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 30.7692 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.7692 | 5 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.7692 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 30.7692 | 4 | yes |
| GO:0006915 | apoptotic process | 30.7692 | 4 | no |
| GO:0036211 | protein modification process | 26.9231 | 4 | no |
| GO:0043412 | macromolecule modification | 26.9231 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.9231 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.9231 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.9231 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.9231 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.9231 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 26.9231 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 26.9231 | 6 | no |
| GO:0060284 | regulation of cell development | 26.9231 | 5 | no |
| GO:0070925 | organelle assembly | 26.9231 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.9231 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.9231 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 26.9231 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 26.9231 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.0769 | 8 | no |
| GO:0010628 | positive regulation of gene expression | 23.0769 | 7 | no |
| GO:0010720 | positive regulation of cell development | 23.0769 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 23.0769 | 5 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 23.0769 | 8 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 23.0769 | 7 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0015031 | protein transport | 23.0769 | 4 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.0769 | 5 | no |
| GO:0006811 | monoatomic ion transport | 23.0769 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 23.0769 | 5 | yes |
| GO:0006816 | calcium ion transport | 23.0769 | 7 | yes |
| GO:0007219 | Notch signaling pathway | 23.0769 | 4 | yes |
| GO:0030001 | metal ion transport | 23.0769 | 6 | yes |
| GO:0006508 | proteolysis | 19.2308 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 19.2308 | 6 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 19.2308 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 19.2308 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 19.2308 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 15.3846 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 15.3846 | 4 | yes |
| GO:0051604 | protein maturation | 15.3846 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 15.3846 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 15.3846 | 7 | yes |
| GO:0006509 | membrane protein ectodomain proteolysis | 11.5385 | 6 | yes |
| GO:0007220 | Notch receptor processing | 11.5385 | 4 | yes |
| GO:0016485 | protein processing | 11.5385 | 5 | yes |
| GO:0033619 | membrane protein proteolysis | 11.5385 | 5 | yes |
| GO:0034205 | amyloid-beta formation | 11.5385 | 4 | yes |
| GO:0042982 | amyloid precursor protein metabolic process | 11.5385 | 4 | yes |
| GO:0042987 | amyloid precursor protein catabolic process | 11.5385 | 5 | yes |
| GO:0110097 | regulation of calcium import into the mitochondrion | 7.6923 | 8 | yes |
| GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering | 7.6923 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FHL2_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNB_HUMAN | [view interactions] | Low throughput | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CIB1_HUMAN | [view interactions] | Low throughput | no | no |
| CSEN_HUMAN | [view interactions] | Low throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DOCK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECSIT_HUMAN | [view interactions] | Low throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GFAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCIP4_HUMAN | [view interactions] | Low throughput | no | no |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| APH1A_HUMAN | [view interactions] | Low throughput | no | yes |
| NICA_HUMAN | [view interactions] | Low throughput | no | yes |
| PEN2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| ICAM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| RN115_HUMAN | [view interactions] | High throughput | no | yes |
| BI1_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL12_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPF_HUMAN | [view interactions] | High throughput | no | no |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| MNDA_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| SOX14_HUMAN | [view interactions] | High throughput | no | no |
| MICA2_HUMAN | [view interactions] | High throughput | no | yes |
| PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ELL2_HUMAN | [view interactions] | High throughput | no | no |
| ZXDC_HUMAN | [view interactions] | High throughput | no | no |
| SP6_HUMAN | [view interactions] | High throughput | no | no |
| SKI8_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN366_HUMAN | [view interactions] | High throughput | no | yes |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| FX4L6_HUMAN | [view interactions] | High throughput | no | no |
| DMB_HUMAN | [view interactions] | High throughput | no | no |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVI5L_HUMAN | [view interactions] | High throughput | no | yes |
| GCDH_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT5_HUMAN | [view interactions] | High throughput | no | no |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| SPC24_HUMAN | [view interactions] | High throughput | no | no |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHKA_HUMAN | [view interactions] | High throughput | no | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| HPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APH1B_HUMAN | [view interactions] | High throughput | no | no |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC3_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC4_HUMAN | [view interactions] | High throughput | no | no |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| DLK1_HUMAN | [view interactions] | High throughput | no | no |
| NAR3_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| ALG5_HUMAN | [view interactions] | High throughput | no | yes |
| IRF3_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |