NEBL_HUMAN
Evidence for PS localization
Functions
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed). Isoform 2 might play a role in the assembly of focal adhesion (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NEBL_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 37.5000 | 4 | no |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0003779 | actin binding | 29.1667 | 4 | yes |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0015631 | tubulin binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NEBL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 58.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 54.1667 | 4 | no |
| GO:0008104 | protein localization | 54.1667 | 4 | no |
| GO:0006996 | organelle organization | 54.1667 | 4 | no |
| GO:0007010 | cytoskeleton organization | 54.1667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0030030 | cell projection organization | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.8333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.8333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 41.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 41.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.6667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 37.5000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 37.5000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 37.5000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 37.5000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 37.5000 | 4 | no |
| GO:0034330 | cell junction organization | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 33.3333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 29.1667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.1667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.1667 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 29.1667 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 29.1667 | 5 | no |
| GO:0023057 | negative regulation of signaling | 29.1667 | 4 | no |
| GO:0032880 | regulation of protein localization | 29.1667 | 5 | no |
| GO:0034329 | cell junction assembly | 29.1667 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 29.1667 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 29.1667 | 4 | no |
| GO:0060284 | regulation of cell development | 29.1667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.1667 | 4 | no |
| GO:2000145 | regulation of cell motility | 29.1667 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.1667 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 29.1667 | 4 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031175 | neuron projection development | 25.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0045216 | cell-cell junction organization | 25.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 25.0000 | 7 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.8333 | 5 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.8333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.8333 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:0007043 | cell-cell junction assembly | 20.8333 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 20.8333 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 20.8333 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 20.8333 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.8333 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.8333 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 20.8333 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.8333 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.8333 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
| GO:0009896 | positive regulation of catabolic process | 20.8333 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 20.8333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.8333 | 4 | no |
| GO:0001817 | regulation of cytokine production | 20.8333 | 4 | no |
| GO:0006915 | apoptotic process | 20.8333 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.8333 | 7 | no |
| GO:0007015 | actin filament organization | 16.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYPN_HUMAN | [view interactions] | Low throughput | no | no |
| XIRP2_HUMAN | [view interactions] | Low throughput | no | no |
| XIRP1_HUMAN | [view interactions] | Low throughput | no | no |
| ZYX_HUMAN | [view interactions] | Low throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| NUTM1_HUMAN | [view interactions] | High throughput | no | no |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| CC125_HUMAN | [view interactions] | High throughput | no | yes |
| ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| GOG6A_HUMAN | [view interactions] | High throughput | no | no |
| CEP70_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| CC136_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX26_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| NNRD_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| TAFA5_HUMAN | [view interactions] | High throughput | no | no |
| G0S2_HUMAN | [view interactions] | High throughput | no | no |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| GFRP_HUMAN | [view interactions] | High throughput | no | no |
| PRP16_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |