NEBL_HUMAN
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed). Isoform 2 might play a role in the assembly of focal adhesion (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NEBL_HUMAN |
---|---|---|---|---|
GO:0045296 | cadherin binding | 38.0952 | 4 | no |
GO:0019900 | kinase binding | 33.3333 | 4 | no |
GO:0003779 | actin binding | 28.5714 | 4 | yes |
GO:0015631 | tubulin binding | 23.8095 | 4 | no |
GO:0019901 | protein kinase binding | 23.8095 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NEBL_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 76.1905 | 4 | no |
GO:0048522 | positive regulation of cellular process | 71.4286 | 4 | no |
GO:0008104 | protein localization | 57.1429 | 4 | no |
GO:0006996 | organelle organization | 52.3810 | 4 | no |
GO:0007010 | cytoskeleton organization | 52.3810 | 5 | no |
GO:0010646 | regulation of cell communication | 52.3810 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 52.3810 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 52.3810 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | no |
GO:0051128 | regulation of cellular component organization | 52.3810 | 4 | no |
GO:0022607 | cellular component assembly | 52.3810 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 47.6190 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 47.6190 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 47.6190 | 5 | no |
GO:0034330 | cell junction organization | 47.6190 | 4 | no |
GO:0009894 | regulation of catabolic process | 42.8571 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 42.8571 | 4 | no |
GO:0051049 | regulation of transport | 42.8571 | 4 | no |
GO:0030030 | cell projection organization | 42.8571 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.0952 | 5 | no |
GO:0032880 | regulation of protein localization | 38.0952 | 5 | no |
GO:0033043 | regulation of organelle organization | 38.0952 | 5 | no |
GO:0060341 | regulation of cellular localization | 38.0952 | 4 | no |
GO:0010941 | regulation of cell death | 38.0952 | 4 | no |
GO:0042981 | regulation of apoptotic process | 38.0952 | 6 | no |
GO:0043067 | regulation of programmed cell death | 38.0952 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 38.0952 | 5 | no |
GO:0097435 | supramolecular fiber organization | 33.3333 | 4 | yes |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | no |
GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
GO:0060548 | negative regulation of cell death | 33.3333 | 5 | no |
GO:0034329 | cell junction assembly | 33.3333 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0030334 | regulation of cell migration | 28.5714 | 5 | no |
GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 28.5714 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 28.5714 | 6 | no |
GO:0051241 | negative regulation of multicellular organismal process | 28.5714 | 4 | no |
GO:0071702 | organic substance transport | 28.5714 | 4 | no |
GO:0016192 | vesicle-mediated transport | 28.5714 | 4 | no |
GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | no |
GO:0045216 | cell-cell junction organization | 28.5714 | 5 | no |
GO:0010243 | response to organonitrogen compound | 28.5714 | 4 | no |
GO:0014070 | response to organic cyclic compound | 28.5714 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 23.8095 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.8095 | 5 | no |
GO:0010628 | positive regulation of gene expression | 23.8095 | 6 | no |
GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.8095 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 23.8095 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 23.8095 | 5 | no |
GO:0042176 | regulation of protein catabolic process | 23.8095 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 23.8095 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.8095 | 6 | no |
GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 23.8095 | 4 | no |
GO:0071705 | nitrogen compound transport | 23.8095 | 4 | no |
GO:0060284 | regulation of cell development | 23.8095 | 5 | no |
GO:0060249 | anatomical structure homeostasis | 23.8095 | 4 | no |
GO:0043269 | regulation of ion transport | 23.8095 | 5 | no |
GO:0071407 | cellular response to organic cyclic compound | 23.8095 | 5 | no |
GO:0071417 | cellular response to organonitrogen compound | 23.8095 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 23.8095 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 23.8095 | 4 | no |
GO:0031175 | neuron projection development | 23.8095 | 6 | no |
GO:0007015 | actin filament organization | 14.2857 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NEBL_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 9.5238 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ZYX_HUMAN | [view interactions] | Low throughput | no | no |
MYPN_HUMAN | [view interactions] | Low throughput | no | no |
XIRP2_HUMAN | [view interactions] | Low throughput | no | no |
XIRP1_HUMAN | [view interactions] | Low throughput | no | no |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
KIFC3_HUMAN | [view interactions] | High throughput | no | no |
NNRD_HUMAN | [view interactions] | High throughput | no | yes |
PUR8_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
PCM1_HUMAN | [view interactions] | High throughput | no | yes |
TAFA5_HUMAN | [view interactions] | High throughput | no | no |
G0S2_HUMAN | [view interactions] | High throughput | no | no |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VASP_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
MED28_HUMAN | [view interactions] | High throughput | no | yes |
TMG4_HUMAN | [view interactions] | High throughput | no | yes |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
ZN764_HUMAN | [view interactions] | High throughput | no | no |
GFRP_HUMAN | [view interactions] | High throughput | no | no |
PRP16_HUMAN | [view interactions] | High throughput | no | yes |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI27_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
TRAF1_HUMAN | [view interactions] | High throughput | no | no |
NUTM1_HUMAN | [view interactions] | High throughput | no | no |
MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
FAM9B_HUMAN | [view interactions] | High throughput | no | no |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
CC125_HUMAN | [view interactions] | High throughput | no | yes |
ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
P55G_HUMAN | [view interactions] | High throughput | no | yes |
GOG6A_HUMAN | [view interactions] | High throughput | no | no |
CEP70_HUMAN | [view interactions] | High throughput | no | yes |
SYQ_HUMAN | [view interactions] | High throughput | no | yes |
CC136_HUMAN | [view interactions] | High throughput | no | yes |
GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GLE1_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MERL_HUMAN | [view interactions] | High throughput | no | yes |
PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PEX26_HUMAN | [view interactions] | High throughput | no | yes |
SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CE170_HUMAN | [view interactions] | High throughput | no | yes |