Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACTN3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACTN3_HUMAN
GO:0046872 metal ion binding 47.3684 4 yes
GO:0003779 actin binding 42.1053 4 yes
GO:0005509 calcium ion binding 26.3158 5 yes
GO:0003723 RNA binding 26.3158 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0140297 DNA-binding transcription factor binding 21.0526 4 no
GO:0045296 cadherin binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACTN3_HUMAN
GO:0048522 positive regulation of cellular process 73.6842 4 yes
GO:0006996 organelle organization 68.4211 4 yes
GO:0031323 regulation of cellular metabolic process 63.1579 4 yes
GO:0048523 negative regulation of cellular process 63.1579 4 yes
GO:0022607 cellular component assembly 57.8947 4 yes
GO:0010941 regulation of cell death 52.6316 4 yes
GO:0042981 regulation of apoptotic process 47.3684 6 yes
GO:0043067 regulation of programmed cell death 47.3684 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 yes
GO:0080090 regulation of primary metabolic process 47.3684 4 yes
GO:0008104 protein localization 47.3684 4 no
GO:0060255 regulation of macromolecule metabolic process 42.1053 4 no
GO:0051128 regulation of cellular component organization 42.1053 4 no
GO:0051049 regulation of transport 42.1053 4 no
GO:0007010 cytoskeleton organization 42.1053 5 yes
GO:0009893 positive regulation of metabolic process 42.1053 4 yes
GO:0009966 regulation of signal transduction 42.1053 4 yes
GO:0010646 regulation of cell communication 42.1053 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 yes
GO:0016192 vesicle-mediated transport 36.8421 4 no
GO:0015031 protein transport 36.8421 4 no
GO:0071702 organic substance transport 36.8421 4 no
GO:0071705 nitrogen compound transport 36.8421 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 yes
GO:0034330 cell junction organization 31.5789 4 yes
GO:0048585 negative regulation of response to stimulus 31.5789 4 yes
GO:1902531 regulation of intracellular signal transduction 31.5789 5 yes
GO:0010468 regulation of gene expression 31.5789 5 no
GO:0030030 cell projection organization 31.5789 4 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0060627 regulation of vesicle-mediated transport 31.5789 4 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 yes
GO:0034329 cell junction assembly 26.3158 5 yes
GO:0042325 regulation of phosphorylation 26.3158 7 yes
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 yes
GO:0051240 positive regulation of multicellular organismal process 26.3158 4 yes
GO:0055001 muscle cell development 26.3158 4 yes
GO:0009889 regulation of biosynthetic process 26.3158 4 no
GO:0010556 regulation of macromolecule biosynthetic process 26.3158 5 no
GO:0010604 positive regulation of macromolecule metabolic process 26.3158 5 no
GO:0031326 regulation of cellular biosynthetic process 26.3158 5 no
GO:0051246 regulation of protein metabolic process 26.3158 5 no
GO:0033043 regulation of organelle organization 26.3158 5 no
GO:0051493 regulation of cytoskeleton organization 26.3158 6 no
GO:0051726 regulation of cell cycle 26.3158 4 no
GO:0072657 protein localization to membrane 26.3158 4 no
GO:0009892 negative regulation of metabolic process 26.3158 4 yes
GO:0009894 regulation of catabolic process 26.3158 4 yes
GO:0009968 negative regulation of signal transduction 26.3158 5 yes
GO:0010648 negative regulation of cell communication 26.3158 5 yes
GO:0019220 regulation of phosphate metabolic process 26.3158 6 yes
GO:0023057 negative regulation of signaling 26.3158 4 yes
GO:0045595 regulation of cell differentiation 21.0526 4 yes
GO:0048041 focal adhesion assembly 21.0526 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 21.0526 5 yes
GO:0060284 regulation of cell development 21.0526 5 yes
GO:0150115 cell-substrate junction organization 21.0526 5 yes
GO:1902532 negative regulation of intracellular signal transduction 21.0526 6 yes
GO:2000026 regulation of multicellular organismal development 21.0526 4 yes
GO:0010628 positive regulation of gene expression 21.0526 6 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0032956 regulation of actin cytoskeleton organization 21.0526 5 no
GO:0032970 regulation of actin filament-based process 21.0526 4 no
GO:0044087 regulation of cellular component biogenesis 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0008285 negative regulation of cell population proliferation 21.0526 5 no
GO:0017157 regulation of exocytosis 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0042127 regulation of cell population proliferation 21.0526 4 no
GO:0043269 regulation of ion transport 21.0526 5 no
GO:0043270 positive regulation of ion transport 21.0526 5 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0051046 regulation of secretion 21.0526 5 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:0060548 negative regulation of cell death 21.0526 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.0526 7 no
GO:1903530 regulation of secretion by cell 21.0526 4 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0006886 intracellular protein transport 21.0526 4 no
GO:0016197 endosomal transport 21.0526 4 no
GO:0033365 protein localization to organelle 21.0526 5 no
GO:0072594 establishment of protein localization to organelle 21.0526 4 no
GO:0007044 cell-substrate junction assembly 21.0526 6 yes
GO:0042326 negative regulation of phosphorylation 15.7895 8 yes
GO:0044057 regulation of system process 15.7895 4 yes
GO:0045597 positive regulation of cell differentiation 15.7895 5 yes
GO:0045927 positive regulation of growth 15.7895 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 15.7895 6 yes
GO:0045936 negative regulation of phosphate metabolic process 15.7895 7 yes
GO:0051094 positive regulation of developmental process 15.7895 4 yes
GO:0051147 regulation of muscle cell differentiation 15.7895 5 yes
GO:0051149 positive regulation of muscle cell differentiation 15.7895 6 yes
GO:0051153 regulation of striated muscle cell differentiation 15.7895 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 15.7895 7 yes
GO:0051241 negative regulation of multicellular organismal process 15.7895 4 yes
GO:0006936 muscle contraction 15.7895 4 yes
GO:0009895 negative regulation of catabolic process 15.7895 5 yes
GO:0009896 positive regulation of catabolic process 15.7895 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 15.7895 6 yes
GO:0010720 positive regulation of cell development 15.7895 6 yes
GO:0030278 regulation of ossification 10.5263 4 yes
GO:0030500 regulation of bone mineralization 10.5263 5 yes
GO:0030501 positive regulation of bone mineralization 10.5263 6 yes
GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction 10.5263 10 yes
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction 10.5263 7 yes
GO:0043457 regulation of cellular respiration 10.5263 6 yes
GO:0043465 regulation of fermentation 10.5263 6 yes
GO:0043467 regulation of generation of precursor metabolites and energy 10.5263 5 yes
GO:0043470 regulation of carbohydrate catabolic process 10.5263 5 yes
GO:0043501 skeletal muscle adaptation 10.5263 4 yes
GO:0043502 regulation of muscle adaptation 10.5263 4 yes
GO:0045778 positive regulation of ossification 10.5263 5 yes
GO:0045820 negative regulation of glycolytic process 10.5263 6 yes
GO:0045912 negative regulation of carbohydrate metabolic process 10.5263 5 yes
GO:0045913 positive regulation of carbohydrate metabolic process 10.5263 5 yes
GO:0045933 positive regulation of muscle contraction 10.5263 5 yes
GO:0045980 negative regulation of nucleotide metabolic process 10.5263 6 yes
GO:0045989 positive regulation of striated muscle contraction 10.5263 6 yes
GO:0048631 regulation of skeletal muscle tissue growth 10.5263 5 yes
GO:0048633 positive regulation of skeletal muscle tissue growth 10.5263 6 yes
GO:0048638 regulation of developmental growth 10.5263 4 yes
GO:0048639 positive regulation of developmental growth 10.5263 5 yes
GO:0048641 regulation of skeletal muscle tissue development 10.5263 5 yes
GO:0048643 positive regulation of skeletal muscle tissue development 10.5263 6 yes
GO:0048742 regulation of skeletal muscle fiber development 10.5263 6 yes
GO:0048743 positive regulation of skeletal muscle fiber development 10.5263 7 yes
GO:0050848 regulation of calcium-mediated signaling 10.5263 6 yes
GO:0050849 negative regulation of calcium-mediated signaling 10.5263 7 yes
GO:0060349 bone morphogenesis 10.5263 4 yes
GO:0062012 regulation of small molecule metabolic process 10.5263 4 yes
GO:0062013 positive regulation of small molecule metabolic process 10.5263 5 yes
GO:0062014 negative regulation of small molecule metabolic process 10.5263 5 yes
GO:0070167 regulation of biomineral tissue development 10.5263 4 yes
GO:0070169 positive regulation of biomineral tissue development 10.5263 5 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 10.5263 8 yes
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 10.5263 9 yes
GO:0090257 regulation of muscle system process 10.5263 5 yes
GO:0090324 negative regulation of oxidative phosphorylation 10.5263 7 yes
GO:0106056 regulation of calcineurin-mediated signaling 10.5263 7 yes
GO:0106057 negative regulation of calcineurin-mediated signaling 10.5263 8 yes
GO:0110151 positive regulation of biomineralization 10.5263 4 yes
GO:0120163 negative regulation of cold-induced thermogenesis 10.5263 4 yes
GO:1900157 regulation of bone mineralization involved in bone maturation 10.5263 6 yes
GO:1900159 positive regulation of bone mineralization involved in bone maturation 10.5263 7 yes
GO:1900542 regulation of purine nucleotide metabolic process 10.5263 6 yes
GO:1900543 negative regulation of purine nucleotide metabolic process 10.5263 7 yes
GO:1901077 regulation of relaxation of muscle 10.5263 6 yes
GO:1901078 negative regulation of relaxation of muscle 10.5263 5 yes
GO:1901856 negative regulation of cellular respiration 10.5263 6 yes
GO:1901861 regulation of muscle tissue development 10.5263 4 yes
GO:1901863 positive regulation of muscle tissue development 10.5263 5 yes
GO:1903578 regulation of ATP metabolic process 10.5263 7 yes
GO:1903579 negative regulation of ATP metabolic process 10.5263 8 yes
GO:1903715 regulation of aerobic respiration 10.5263 7 yes
GO:1904023 regulation of glucose catabolic process to lactate via pyruvate 10.5263 6 yes
GO:1904025 positive regulation of glucose catabolic process to lactate via pyruvate 10.5263 6 yes
GO:0002082 regulation of oxidative phosphorylation 10.5263 8 yes
GO:0006109 regulation of carbohydrate metabolic process 10.5263 5 yes
GO:0006110 regulation of glycolytic process 10.5263 6 yes
GO:0006140 regulation of nucleotide metabolic process 10.5263 5 yes
GO:0006937 regulation of muscle contraction 10.5263 6 yes
GO:0006942 regulation of striated muscle contraction 10.5263 7 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 10.5263 5 yes
GO:0010676 positive regulation of cellular carbohydrate metabolic process 10.5263 6 yes
GO:0010677 negative regulation of cellular carbohydrate metabolic process 10.5263 6 yes
GO:0010830 regulation of myotube differentiation 10.5263 7 yes
GO:0010906 regulation of glucose metabolic process 10.5263 5 yes
GO:0010907 positive regulation of glucose metabolic process 10.5263 6 yes
GO:0014724 regulation of twitch skeletal muscle contraction 10.5263 9 yes
GO:0014728 regulation of the force of skeletal muscle contraction 10.5263 10 yes
GO:0014732 skeletal muscle atrophy 10.5263 5 yes
GO:0014733 regulation of skeletal muscle adaptation 10.5263 5 yes
GO:0014819 regulation of skeletal muscle contraction 10.5263 8 yes
GO:0014862 regulation of skeletal muscle contraction by chemo-mechanical energy conversion 10.5263 9 yes
GO:0014883 transition between fast and slow fiber 10.5263 6 yes
GO:0014891 striated muscle atrophy 10.5263 4 yes
GO:0014894 response to denervation involved in regulation of muscle adaptation 10.5263 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
F16P1_HUMAN [view interactions] Low throughput no no
MYPN_HUMAN [view interactions] Low throughput no no
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
NRAP_HUMAN [view interactions] Low throughput no no
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI32_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN3_HUMAN [view entry] [view interactions] Low throughput yes no
ACPM_HUMAN [view interactions] High throughput no yes
CXCL5_HUMAN [view interactions] High throughput no yes
IVD_HUMAN [view interactions] High throughput no yes
DDAH2_HUMAN [view interactions] High throughput no yes
ATP23_HUMAN [view interactions] High throughput no yes
K2C6C_HUMAN [view interactions] High throughput no no
ZN426_HUMAN [view interactions] High throughput no yes
SOLH1_HUMAN [view interactions] High throughput no no
ZN343_HUMAN [view interactions] High throughput no yes
CT085_HUMAN [view interactions] High throughput no no
ASB9_HUMAN [view interactions] High throughput no no
ECM1_HUMAN [view interactions] High throughput no no
PKHG2_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RB33B_HUMAN [view interactions] High throughput no no
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
TITIN_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
REL_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
NEBL_HUMAN [view entry] [view interactions] High throughput yes no
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
RN111_HUMAN [view interactions] High throughput no yes
CA094_HUMAN [view interactions] High throughput no no
KCTD6_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
PKP2_HUMAN [view interactions] High throughput no yes
LHX3_HUMAN [view interactions] High throughput no no
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYP2L_HUMAN [view interactions] High throughput no no
HXD12_HUMAN [view interactions] High throughput no no
AK17A_HUMAN [view interactions] High throughput no no
LRCC1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
T183A_HUMAN [view interactions] High throughput no no
MILK1_HUMAN [view interactions] High throughput no yes
ENTP6_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
RSH6A_HUMAN [view interactions] High throughput no no
GRM2A_HUMAN [view interactions] High throughput no no
K1C39_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
TSN33_HUMAN [view interactions] High throughput no no
LATS1_HUMAN [view interactions] High throughput no yes
ZSA5A_HUMAN [view interactions] High throughput no no
CE024_HUMAN [view interactions] High throughput no yes
CHTOP_HUMAN [view interactions] High throughput no yes
MTMR9_HUMAN [view interactions] High throughput no no
REL2_HUMAN [view interactions] High throughput no no
LACB2_HUMAN [view interactions] High throughput no yes
GPBP1_HUMAN [view interactions] High throughput no yes
MYH15_HUMAN [view interactions] High throughput no yes
MYH7_HUMAN [view interactions] High throughput no no
UBP42_HUMAN [view interactions] High throughput no no
AMPD1_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DUX1_HUMAN [view interactions] High throughput no no
DUX4C_HUMAN [view interactions] High throughput no no
ALMS1_HUMAN [view interactions] High throughput no no
CHLE_HUMAN [view interactions] High throughput no no
PDLI1_HUMAN [view interactions] High throughput no yes
ZN219_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RTP5_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
ODF3B_HUMAN [view interactions] High throughput no no
MYOZ1_HUMAN [view interactions] High throughput no no
MYOTI_HUMAN [view interactions] High throughput no no
C2CD6_HUMAN [view interactions] High throughput no no
MILK2_HUMAN [view interactions] High throughput no no
HSF2B_HUMAN [view interactions] High throughput no yes
CTG1B_HUMAN [view interactions] High throughput no no
NKAP1_HUMAN [view interactions] High throughput no yes
UBP2_HUMAN [view interactions] High throughput no yes
F90A1_HUMAN [view interactions] High throughput no no
MAGA6_HUMAN [view interactions] High throughput no no
TRI29_HUMAN [view interactions] High throughput no no
PO6F2_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PCCB_HUMAN [view interactions] High throughput no yes
GLIS2_HUMAN [view interactions] High throughput no no
PPR18_HUMAN [view interactions] High throughput no no
PTK6_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
CTDS1_HUMAN [view interactions] High throughput no no