ACTN3_HUMAN
Evidence for PS localization
Functions
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [ACTN3_HUMAN]
Isoform [D6RH00] alignment
Isoform [A0A087WSZ2] alignment
LOADING 86%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTN3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 56.5217 | 4 | yes |
| GO:0046872 | metal ion binding | 56.5217 | 5 | yes |
| GO:0003779 | actin binding | 34.7826 | 4 | yes |
| GO:0043168 | anion binding | 26.0870 | 4 | no |
| GO:0003723 | RNA binding | 26.0870 | 4 | no |
| GO:0005509 | calcium ion binding | 21.7391 | 6 | yes |
| GO:0000166 | nucleotide binding | 21.7391 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.7391 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0019900 | kinase binding | 21.7391 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
| GO:0140297 | DNA-binding transcription factor binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTN3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 73.9130 | 4 | yes |
| GO:0006996 | organelle organization | 65.2174 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 65.2174 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 65.2174 | 4 | yes |
| GO:0022607 | cellular component assembly | 56.5217 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.1739 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 52.1739 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 52.1739 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 52.1739 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.8261 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.4783 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.4783 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.4783 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.4783 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4783 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | no |
| GO:0007010 | cytoskeleton organization | 39.1304 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 39.1304 | 4 | yes |
| GO:0008104 | protein localization | 39.1304 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.1304 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 34.7826 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 34.7826 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| AMPD1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ASB9_HUMAN | [view interactions] | High throughput | no | no |
| ATP23_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | Low throughput | no | yes |
| CE024_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CHLE_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |