Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AA2AR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for adenosine . The activity of this receptor is mediated by G proteins which activate adenylyl cyclase . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AA2AR_HUMAN
GO:0043169 cation binding 50.0000 4 no
GO:0046872 metal ion binding 44.4444 5 no
GO:0005509 calcium ion binding 44.4444 6 no
GO:0004930 G protein-coupled receptor activity 33.3333 4 yes
GO:0001664 G protein-coupled receptor binding 27.7778 4 yes
GO:0003779 actin binding 22.2222 4 no
GO:0035254 glutamate receptor binding 22.2222 4 yes
GO:0019209 kinase activator activity 22.2222 4 no
GO:0019887 protein kinase regulator activity 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0030295 protein kinase activator activity 22.2222 5 no
GO:0031432 titin binding 22.2222 4 no
GO:0001609 G protein-coupled adenosine receptor activity 16.6667 5 yes
GO:0031802 type 5 metabotropic glutamate receptor binding 16.6667 6 yes
GO:0035256 G protein-coupled glutamate receptor binding 16.6667 5 yes
GO:0042805 actinin binding 11.1111 4 yes
GO:0051393 alpha-actinin binding 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AA2AR_HUMAN
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0009966 regulation of signal transduction 77.7778 4 yes
GO:0048523 negative regulation of cellular process 72.2222 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 yes
GO:0080090 regulation of primary metabolic process 61.1111 4 yes
GO:0023056 positive regulation of signaling 55.5556 4 yes
GO:0043269 regulation of monoatomic ion transport 55.5556 5 yes
GO:0048584 positive regulation of response to stimulus 55.5556 4 yes
GO:0051050 positive regulation of transport 55.5556 4 yes
GO:0009967 positive regulation of signal transduction 55.5556 5 yes
GO:0010647 positive regulation of cell communication 55.5556 5 yes
GO:0010959 regulation of metal ion transport 55.5556 6 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0051051 negative regulation of transport 44.4444 4 no
GO:0031326 regulation of cellular biosynthetic process 38.8889 5 yes
GO:0032880 regulation of protein localization 38.8889 5 yes
GO:0042981 regulation of apoptotic process 38.8889 5 yes
GO:0043067 regulation of programmed cell death 38.8889 4 yes
GO:0048585 negative regulation of response to stimulus 38.8889 4 yes
GO:0050804 modulation of chemical synaptic transmission 38.8889 5 yes
GO:0060341 regulation of cellular localization 38.8889 4 yes
GO:0099177 regulation of trans-synaptic signaling 38.8889 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0019220 regulation of phosphate metabolic process 38.8889 6 no
GO:0051174 regulation of phosphorus metabolic process 38.8889 5 no
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:0009889 regulation of biosynthetic process 38.8889 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.8889 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0051924 regulation of calcium ion transport 33.3333 7 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 33.3333 6 yes
GO:0098657 import into cell 33.3333 4 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 no
GO:0043270 positive regulation of monoatomic ion transport 33.3333 5 no
GO:0044057 regulation of system process 33.3333 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 33.3333 6 no
GO:0008104 protein localization 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 yes
GO:0014070 response to organic cyclic compound 27.7778 4 yes
GO:0032101 regulation of response to external stimulus 27.7778 4 yes
GO:0032102 negative regulation of response to external stimulus 27.7778 5 yes
GO:0050708 regulation of protein secretion 27.7778 5 yes
GO:0051047 positive regulation of secretion 27.7778 5 yes
GO:0051223 regulation of protein transport 27.7778 5 yes
GO:0051240 positive regulation of multicellular organismal process 27.7778 4 yes
GO:0051252 regulation of RNA metabolic process 27.7778 5 yes
GO:0051952 regulation of amine transport 27.7778 5 yes
GO:0070201 regulation of establishment of protein localization 27.7778 6 yes
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 yes
GO:0001932 regulation of protein phosphorylation 27.7778 7 no
GO:0006937 regulation of muscle contraction 27.7778 6 no
GO:0006942 regulation of striated muscle contraction 27.7778 7 no
GO:0008016 regulation of heart contraction 27.7778 6 no
GO:0010562 positive regulation of phosphorus metabolic process 27.7778 6 no
GO:0010563 negative regulation of phosphorus metabolic process 27.7778 6 no
GO:0010564 regulation of cell cycle process 27.7778 5 no
GO:0031324 negative regulation of cellular metabolic process 27.7778 5 no
GO:0031401 positive regulation of protein modification process 27.7778 7 no
GO:0032410 negative regulation of transporter activity 27.7778 4 no
GO:0032411 positive regulation of transporter activity 27.7778 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 27.7778 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 27.7778 5 no
GO:0032465 regulation of cytokinesis 27.7778 5 no
GO:0034763 negative regulation of transmembrane transport 27.7778 5 no
GO:0034764 positive regulation of transmembrane transport 27.7778 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 27.7778 6 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 27.7778 6 no
GO:0042325 regulation of phosphorylation 27.7778 7 no
GO:0043271 negative regulation of monoatomic ion transport 27.7778 5 no
GO:0045936 negative regulation of phosphate metabolic process 27.7778 7 no
GO:0045937 positive regulation of phosphate metabolic process 27.7778 7 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0051302 regulation of cell division 27.7778 4 no
GO:0051726 regulation of cell cycle 27.7778 4 no
GO:0090257 regulation of muscle system process 27.7778 5 no
GO:1903522 regulation of blood circulation 27.7778 5 no
GO:1904063 negative regulation of cation transmembrane transport 27.7778 7 no
GO:1904064 positive regulation of cation transmembrane transport 27.7778 7 no
GO:2001257 regulation of cation channel activity 27.7778 6 no
GO:0006996 organelle organization 27.7778 4 no
GO:0007010 cytoskeleton organization 27.7778 5 no
GO:0010648 negative regulation of cell communication 27.7778 5 no
GO:0023057 negative regulation of signaling 27.7778 4 no
GO:0034330 cell junction organization 27.7778 4 no
GO:0046903 secretion 27.7778 4 no
GO:0006355 regulation of DNA-templated transcription 27.7778 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 27.7778 4 yes
GO:0030030 cell projection organization 22.2222 4 yes
GO:0031347 regulation of defense response 22.2222 5 yes
GO:0031348 negative regulation of defense response 22.2222 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 22.2222 6 yes
GO:0042127 regulation of cell population proliferation 22.2222 4 yes
GO:0042749 regulation of circadian sleep/wake cycle 22.2222 4 yes
GO:0043279 response to alkaloid 22.2222 5 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 22.2222 5 yes
GO:0050433 regulation of catecholamine secretion 22.2222 5 yes
GO:0050795 regulation of behavior 22.2222 4 yes
GO:0050806 positive regulation of synaptic transmission 22.2222 5 yes
GO:0051588 regulation of neurotransmitter transport 22.2222 5 yes
GO:0060078 regulation of postsynaptic membrane potential 22.2222 4 yes
GO:0060079 excitatory postsynaptic potential 22.2222 5 yes
GO:0060134 prepulse inhibition 22.2222 6 yes
GO:0080134 regulation of response to stress 22.2222 4 yes
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 yes
GO:0099536 synaptic signaling 22.2222 4 yes
GO:0099537 trans-synaptic signaling 22.2222 5 yes
GO:1900271 regulation of long-term synaptic potentiation 22.2222 4 yes
GO:1903532 positive regulation of secretion by cell 22.2222 5 yes
GO:1903829 positive regulation of protein localization 22.2222 5 yes
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0035303 regulation of dephosphorylation 22.2222 7 no
GO:0035304 regulation of protein dephosphorylation 22.2222 7 no
GO:0035306 positive regulation of dephosphorylation 22.2222 8 no
GO:0035307 positive regulation of protein dephosphorylation 22.2222 8 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0050848 regulation of calcium-mediated signaling 22.2222 6 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051282 regulation of sequestering of calcium ion 22.2222 4 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051926 negative regulation of calcium ion transport 22.2222 6 no
GO:0055117 regulation of cardiac muscle contraction 22.2222 7 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 22.2222 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 22.2222 6 no
GO:1903169 regulation of calcium ion transmembrane transport 22.2222 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 22.2222 7 no
GO:2001258 negative regulation of cation channel activity 22.2222 6 no
GO:2001259 positive regulation of cation channel activity 22.2222 6 no
GO:0055001 muscle cell development 22.2222 4 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0050890 cognition 22.2222 4 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0034329 cell junction assembly 22.2222 5 no
GO:0051128 regulation of cellular component organization 22.2222 4 no
GO:0043266 regulation of potassium ion transport 22.2222 7 no
GO:0002683 negative regulation of immune system process 22.2222 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 22.2222 5 yes
GO:0007268 chemical synaptic transmission 22.2222 7 yes
GO:0008285 negative regulation of cell population proliferation 22.2222 5 yes
GO:0014074 response to purine-containing compound 16.6667 5 yes
GO:0014075 response to amine 16.6667 5 yes
GO:0030155 regulation of cell adhesion 16.6667 4 yes
GO:0032890 regulation of organic acid transport 16.6667 5 yes
GO:0035150 regulation of tube size 16.6667 4 yes
GO:0035296 regulation of tube diameter 16.6667 5 yes
GO:0035809 regulation of urine volume 16.6667 4 yes
GO:0035810 positive regulation of urine volume 16.6667 5 yes
GO:0042311 vasodilation 16.6667 6 yes
GO:0043066 negative regulation of apoptotic process 16.6667 6 yes
GO:0043069 negative regulation of programmed cell death 16.6667 5 yes
GO:0048812 neuron projection morphogenesis 16.6667 5 yes
GO:0050714 positive regulation of protein secretion 16.6667 6 yes
GO:0050727 regulation of inflammatory response 16.6667 5 yes
GO:0050728 negative regulation of inflammatory response 16.6667 6 yes
GO:0051222 positive regulation of protein transport 16.6667 5 yes
GO:0051590 positive regulation of neurotransmitter transport 16.6667 5 yes
GO:0051954 positive regulation of amine transport 16.6667 5 yes
GO:0051955 regulation of amino acid transport 16.6667 6 yes
GO:0097746 blood vessel diameter maintenance 16.6667 5 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 16.6667 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 16.6667 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 16.6667 5 yes
GO:1904951 positive regulation of establishment of protein localization 16.6667 6 yes
GO:0001975 response to amphetamine 16.6667 6 yes
GO:0003018 vascular process in circulatory system 16.6667 4 yes
GO:0006909 phagocytosis 16.6667 4 yes
GO:0006954 inflammatory response 16.6667 4 yes
GO:0007162 negative regulation of cell adhesion 16.6667 5 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 16.6667 4 yes
GO:0007600 sensory perception 16.6667 4 yes
GO:0014048 regulation of glutamate secretion 16.6667 5 yes
GO:0014056 regulation of acetylcholine secretion, neurotransmission 11.1111 6 yes
GO:0014057 positive regulation of acetylcholine secretion, neurotransmission 11.1111 6 yes
GO:0014061 regulation of norepinephrine secretion 11.1111 6 yes
GO:0022407 regulation of cell-cell adhesion 11.1111 5 yes
GO:0022408 negative regulation of cell-cell adhesion 11.1111 6 yes
GO:0031000 response to caffeine 11.1111 6 yes
GO:0032222 regulation of synaptic transmission, cholinergic 11.1111 6 yes
GO:0032224 positive regulation of synaptic transmission, cholinergic 11.1111 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 11.1111 6 yes
GO:0032892 positive regulation of organic acid transport 11.1111 5 yes
GO:0035249 synaptic transmission, glutamatergic 11.1111 8 yes
GO:0035588 G protein-coupled purinergic receptor signaling pathway 11.1111 4 yes
GO:0035590 purinergic nucleotide receptor signaling pathway 11.1111 4 yes
GO:0042753 positive regulation of circadian rhythm 11.1111 4 yes
GO:0042755 eating behavior 11.1111 4 yes
GO:0043065 positive regulation of apoptotic process 11.1111 6 yes
GO:0043068 positive regulation of programmed cell death 11.1111 5 yes
GO:0043116 negative regulation of vascular permeability 11.1111 4 yes
GO:0043523 regulation of neuron apoptotic process 11.1111 6 yes
GO:0043524 negative regulation of neuron apoptotic process 11.1111 7 yes
GO:0045938 positive regulation of circadian sleep/wake cycle, sleep 11.1111 5 yes
GO:0046634 regulation of alpha-beta T cell activation 11.1111 7 yes
GO:0046636 negative regulation of alpha-beta T cell activation 11.1111 8 yes
GO:0046928 regulation of neurotransmitter secretion 11.1111 5 yes
GO:0048143 astrocyte activation 11.1111 4 yes
GO:0048520 positive regulation of behavior 11.1111 5 yes
GO:0050863 regulation of T cell activation 11.1111 6 yes
GO:0050865 regulation of cell activation 11.1111 4 yes
GO:0050866 negative regulation of cell activation 11.1111 5 yes
GO:0050868 negative regulation of T cell activation 11.1111 7 yes
GO:0051249 regulation of lymphocyte activation 11.1111 5 yes
GO:0051250 negative regulation of lymphocyte activation 11.1111 6 yes
GO:0051881 regulation of mitochondrial membrane potential 11.1111 4 yes
GO:0051899 membrane depolarization 11.1111 4 yes
GO:0051957 positive regulation of amino acid transport 11.1111 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 11.1111 6 yes
GO:0060080 inhibitory postsynaptic potential 11.1111 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 11.1111 6 yes
GO:1903038 negative regulation of leukocyte cell-cell adhesion 11.1111 7 yes
GO:2001233 regulation of apoptotic signaling pathway 11.1111 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 11.1111 6 yes
GO:0001956 positive regulation of neurotransmitter secretion 11.1111 6 yes
GO:0001963 synaptic transmission, dopaminergic 11.1111 8 yes
GO:0001973 G protein-coupled adenosine receptor signaling pathway 11.1111 5 yes
GO:0002694 regulation of leukocyte activation 11.1111 4 yes
GO:0002695 negative regulation of leukocyte activation 11.1111 5 yes
GO:0006915 apoptotic process 11.1111 4 yes
GO:0006968 cellular defense response 11.1111 4 yes
GO:0007271 synaptic transmission, cholinergic 11.1111 8 yes
GO:0007417 central nervous system development 11.1111 4 yes
GO:0007599 hemostasis 11.1111 4 yes
GO:0008015 blood circulation 11.1111 4 yes
GO:0014049 positive regulation of glutamate secretion 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NAMPT_HUMAN [view interactions] Low throughput no no
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
NECA2_HUMAN [view entry] [view interactions] Low throughput yes yes
TSNAX_HUMAN [view interactions] Low throughput no yes
UBP4_HUMAN [view interactions] Low throughput no no
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
GPR37_HUMAN [view interactions] Low throughput no no
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
CNR1_HUMAN [view interactions] Low throughput no yes
AA2BR_HUMAN [view interactions] Low throughput no no
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN3_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
ADA_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
HRH3_HUMAN [view interactions] Low throughput no no
CD4_HUMAN [view interactions] Low throughput no no
BET1_HUMAN [view interactions] High throughput no no
PPM1J_HUMAN [view interactions] High throughput no yes
POZP3_HUMAN [view interactions] High throughput no no
CHIN_HUMAN [view interactions] High throughput no no
HNRH3_HUMAN [view interactions] High throughput no no
S2539_HUMAN [view interactions] High throughput no no
RHBD2_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
NADAP_HUMAN [view interactions] High throughput no yes
SPNS1_HUMAN [view interactions] High throughput no yes
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP1_HUMAN [view interactions] High throughput no yes