NECA2_HUMAN
Evidence for PS localization
Functions
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NECA2_HUMAN |
|---|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | 33.3333 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 23.8095 | 4 | yes |
| GO:0043169 | cation binding | 23.8095 | 4 | yes |
| GO:0046872 | metal ion binding | 23.8095 | 5 | yes |
| GO:0003723 | RNA binding | 23.8095 | 4 | no |
| GO:0031802 | type 5 metabotropic glutamate receptor binding | 19.0476 | 6 | yes |
| GO:0035256 | G protein-coupled glutamate receptor binding | 19.0476 | 5 | yes |
| GO:0031685 | adenosine receptor binding | 14.2857 | 5 | yes |
| GO:0031687 | A2A adenosine receptor binding | 14.2857 | 6 | yes |
| GO:0005509 | calcium ion binding | 9.5238 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NECA2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 76.1905 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 71.4286 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 71.4286 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 71.4286 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 71.4286 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 71.4286 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 71.4286 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | yes |
| GO:0010646 | regulation of cell communication | 57.1429 | 4 | yes |
| GO:0010468 | regulation of gene expression | 57.1429 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 52.3810 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 52.3810 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 42.8571 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | no |
| GO:0051049 | regulation of transport | 38.0952 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.0952 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
| GO:0031399 | regulation of protein modification process | 38.0952 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 38.0952 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 38.0952 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.0952 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 38.0952 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 38.0952 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 38.0952 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 38.0952 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0002090 | regulation of receptor internalization | 28.5714 | 7 | yes |
| GO:0030100 | regulation of endocytosis | 28.5714 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 28.5714 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | yes |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 28.5714 | 8 | no |
| GO:0006417 | regulation of translation | 28.5714 | 6 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 28.5714 | 7 | no |
| GO:0010629 | negative regulation of gene expression | 28.5714 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0030030 | cell projection organization | 28.5714 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | yes |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | yes |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.8095 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.8095 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.8095 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.8095 | 6 | no |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.8095 | 4 | no |
| GO:0017148 | negative regulation of translation | 23.8095 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 23.8095 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8095 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.8095 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.8095 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.8095 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 23.8095 | 4 | no |
| GO:0051046 | regulation of secretion | 23.8095 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.8095 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 23.8095 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 19.0476 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 19.0476 | 7 | yes |
| GO:0051051 | negative regulation of transport | 19.0476 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 19.0476 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 19.0476 | 5 | yes |
| GO:0002091 | negative regulation of receptor internalization | 14.2857 | 7 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 14.2857 | 5 | yes |
| GO:0010559 | regulation of glycoprotein biosynthetic process | 14.2857 | 6 | yes |
| GO:0045806 | negative regulation of endocytosis | 14.2857 | 5 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 14.2857 | 6 | yes |
| GO:1900449 | regulation of glutamate receptor signaling pathway | 14.2857 | 5 | yes |
| GO:1903018 | regulation of glycoprotein metabolic process | 14.2857 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 14.2857 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 14.2857 | 6 | yes |
| GO:0042984 | regulation of amyloid precursor protein biosynthetic process | 9.5238 | 7 | yes |
| GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway | 9.5238 | 6 | yes |
| GO:0060167 | regulation of adenosine receptor signaling pathway | 9.5238 | 6 | yes |
| GO:0060168 | positive regulation of adenosine receptor signaling pathway | 9.5238 | 7 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 9.5238 | 7 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 9.5238 | 8 | yes |
| GO:1900451 | positive regulation of glutamate receptor signaling pathway | 9.5238 | 6 | yes |
| GO:1904020 | regulation of G protein-coupled receptor internalization | 9.5238 | 6 | yes |
| GO:1904021 | negative regulation of G protein-coupled receptor internalization | 9.5238 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| TRI59_HUMAN | [view interactions] | High throughput | no | no |
| NECA3_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| ISCU_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC121_HUMAN | [view interactions] | High throughput | no | no |
| ATL2_HUMAN | [view interactions] | High throughput | no | no |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| NECA1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPO_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGC6L_HUMAN | [view interactions] | High throughput | no | no |
| TEX11_HUMAN | [view interactions] | High throughput | no | no |
| GTPBA_HUMAN | [view interactions] | High throughput | no | yes |
| NECA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCOR3_HUMAN | [view interactions] | High throughput | no | yes |
| KANL1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| CAN3_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| NOC4L_HUMAN | [view interactions] | High throughput | no | no |
| MED14_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| DGCR6_HUMAN | [view interactions] | High throughput | no | no |
| INPP_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| BEX3_HUMAN | [view interactions] | High throughput | no | yes |
| NIP7_HUMAN | [view interactions] | High throughput | no | yes |
| AIRIM_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CARD9_HUMAN | [view interactions] | High throughput | no | no |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| GCC1_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD4_HUMAN | [view interactions] | High throughput | no | no |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD3_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| CC153_HUMAN | [view interactions] | High throughput | no | no |
| SRCRL_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCG_HUMAN | [view interactions] | High throughput | no | yes |
| EAF2_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL1_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRD1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| INT10_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR9_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| MTCL2_HUMAN | [view interactions] | High throughput | no | yes |
| MSGN1_HUMAN | [view interactions] | High throughput | no | no |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| PUS10_HUMAN | [view interactions] | High throughput | no | yes |
| CAGE1_HUMAN | [view interactions] | High throughput | no | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| MYPOP_HUMAN | [view interactions] | High throughput | no | no |
| TRIMM_HUMAN | [view interactions] | High throughput | no | no |