Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAN1_HUMAN

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed, PubMed). Proteolytically cleaves CTBP1 at Asn-375, Gly-387 and His-409 (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CAN1_HUMAN
GO:0003723 RNA binding 32.8358 4 no
GO:0000166 nucleotide binding 28.3582 4 no
GO:0043168 anion binding 28.3582 4 no
GO:0017076 purine nucleotide binding 26.8657 5 no
GO:0032555 purine ribonucleotide binding 25.3731 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8806 4 no
GO:0030554 adenyl nucleotide binding 22.3881 6 no
GO:0032559 adenyl ribonucleotide binding 20.8955 5 no
GO:0019900 kinase binding 20.8955 4 no
GO:0019901 protein kinase binding 20.8955 5 no
GO:0043169 cation binding 19.4030 4 yes
GO:0046872 metal ion binding 19.4030 5 yes
GO:0004175 endopeptidase activity 5.9701 4 yes
GO:0005509 calcium ion binding 5.9701 6 yes
GO:0004197 cysteine-type endopeptidase activity 4.4776 5 yes
GO:0008234 cysteine-type peptidase activity 4.4776 4 yes
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2.9851 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CAN1_HUMAN
GO:0048522 positive regulation of cellular process 64.1791 4 yes
GO:0048523 negative regulation of cellular process 59.7015 4 no
GO:0031323 regulation of cellular metabolic process 56.7164 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.2239 4 no
GO:0080090 regulation of primary metabolic process 52.2388 4 no
GO:0010646 regulation of cell communication 47.7612 4 yes
GO:0051128 regulation of cellular component organization 47.7612 4 no
GO:0009889 regulation of biosynthetic process 44.7761 4 no
GO:0009893 positive regulation of metabolic process 44.7761 4 no
GO:0010468 regulation of gene expression 44.7761 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.7761 5 no
GO:0031326 regulation of cellular biosynthetic process 44.7761 5 no
GO:0051246 regulation of protein metabolic process 44.7761 5 no
GO:0051049 regulation of transport 43.2836 4 yes
GO:0006996 organelle organization 43.2836 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.7910 5 no
GO:0031325 positive regulation of cellular metabolic process 41.7910 5 no
GO:0009966 regulation of signal transduction 38.8060 4 yes
GO:0051247 positive regulation of protein metabolic process 37.3134 6 no
GO:0009892 negative regulation of metabolic process 35.8209 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.8209 5 no
GO:0071310 cellular response to organic substance 35.8209 4 no
GO:0009894 regulation of catabolic process 32.8358 4 yes
GO:0009891 positive regulation of biosynthetic process 32.8358 5 no
GO:0031328 positive regulation of cellular biosynthetic process 32.8358 6 no
GO:0031324 negative regulation of cellular metabolic process 32.8358 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.3433 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.3433 5 no
GO:0042981 regulation of apoptotic process 31.3433 5 no
GO:0043067 regulation of programmed cell death 31.3433 4 no
GO:0051252 regulation of RNA metabolic process 31.3433 5 no
GO:0033043 regulation of organelle organization 31.3433 5 no
GO:0022607 cellular component assembly 31.3433 4 no
GO:0010647 positive regulation of cell communication 29.8507 5 no
GO:0023056 positive regulation of signaling 29.8507 4 no
GO:0006355 regulation of DNA-templated transcription 28.3582 7 no
GO:1902531 regulation of intracellular signal transduction 28.3582 5 no
GO:2001141 regulation of RNA biosynthetic process 28.3582 6 no
GO:0009890 negative regulation of biosynthetic process 28.3582 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.3582 6 no
GO:0010628 positive regulation of gene expression 28.3582 7 no
GO:0031327 negative regulation of cellular biosynthetic process 28.3582 6 no
GO:0051050 positive regulation of transport 28.3582 4 no
GO:0006796 phosphate-containing compound metabolic process 26.8657 4 no
GO:0043412 macromolecule modification 26.8657 4 no
GO:0009967 positive regulation of signal transduction 26.8657 5 no
GO:0048584 positive regulation of response to stimulus 26.8657 4 no
GO:0060341 regulation of cellular localization 26.8657 4 no
GO:0036211 protein modification process 25.3731 4 no
GO:0008104 protein localization 25.3731 4 no
GO:0010629 negative regulation of gene expression 25.3731 7 no
GO:0032880 regulation of protein localization 25.3731 5 no
GO:0051248 negative regulation of protein metabolic process 23.8806 6 no
GO:0080134 regulation of response to stress 23.8806 4 no
GO:0031399 regulation of protein modification process 23.8806 6 no
GO:0051130 positive regulation of cellular component organization 23.8806 5 no
GO:0007010 cytoskeleton organization 23.8806 5 no
GO:0045595 regulation of cell differentiation 22.3881 4 no
GO:0051094 positive regulation of developmental process 22.3881 4 no
GO:0051240 positive regulation of multicellular organismal process 22.3881 4 no
GO:0043933 protein-containing complex organization 22.3881 4 no
GO:0044087 regulation of cellular component biogenesis 22.3881 4 no
GO:0043066 negative regulation of apoptotic process 20.8955 6 no
GO:0043069 negative regulation of programmed cell death 20.8955 5 no
GO:0048585 negative regulation of response to stimulus 20.8955 4 no
GO:0019220 regulation of phosphate metabolic process 20.8955 6 no
GO:0051174 regulation of phosphorus metabolic process 20.8955 5 no
GO:0009896 positive regulation of catabolic process 20.8955 5 no
GO:0051129 negative regulation of cellular component organization 20.8955 5 no
GO:0042127 regulation of cell population proliferation 19.4030 4 yes
GO:0009057 macromolecule catabolic process 17.9104 4 yes
GO:0031329 regulation of cellular catabolic process 17.9104 5 yes
GO:0006508 proteolysis 16.4179 4 yes
GO:0034762 regulation of transmembrane transport 16.4179 4 yes
GO:0010506 regulation of autophagy 14.9254 6 yes
GO:0008284 positive regulation of cell population proliferation 10.4478 5 yes
GO:0016241 regulation of macroautophagy 7.4627 7 yes
GO:0022898 regulation of transmembrane transporter activity 5.9701 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 5.9701 5 yes
GO:0043112 receptor metabolic process 2.9851 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 2.9851 4 yes
GO:2000310 regulation of NMDA receptor activity 2.9851 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CPNS1_HUMAN [view interactions] Low throughput no yes
ICAL_HUMAN [view interactions] Low throughput no yes
CFTR_HUMAN [view interactions] Low throughput no no
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TIRAP_HUMAN [view interactions] Low throughput no no
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
PSN2_HUMAN [view entry] [view interactions] Low throughput yes no
FANCA_HUMAN [view interactions] Low throughput no no
FANCG_HUMAN [view interactions] Low throughput no yes
FANCC_HUMAN [view interactions] Low throughput no yes
PALB2_HUMAN [view interactions] Low throughput no yes
GAS2_HUMAN [view interactions] Low throughput no no
RAD21_HUMAN [view interactions] Low throughput no yes
HIF1A_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
NMT1_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
CPEB3_HUMAN [view entry] [view interactions] Low throughput yes no
PTN5_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATG5_HUMAN [view entry] [view interactions] Low throughput yes no
ATX3_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
GBP2_HUMAN [view interactions] High throughput no yes
PSF2_HUMAN [view interactions] High throughput no no
PSF3_HUMAN [view interactions] High throughput no yes
AGAL_HUMAN [view interactions] High throughput no yes
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
MVD1_HUMAN [view interactions] High throughput no yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
MA2A1_HUMAN [view interactions] High throughput no no
EIF2A_HUMAN [view interactions] High throughput no yes
HNRPR_HUMAN [view interactions] High throughput no yes
NIT1_HUMAN [view interactions] High throughput no yes
MTREX_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
BID_HUMAN [view interactions] High throughput no no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
MESD_HUMAN [view interactions] High throughput no yes
SDF2_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
UGGG1_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
SYDC_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
METK2_HUMAN [view interactions] High throughput no no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
GARS_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
SYQ_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SYMC_HUMAN [view interactions] High throughput no yes
EPIPL_HUMAN [view entry] [view interactions] High throughput yes no
RAN_HUMAN [view entry] [view interactions] High throughput yes no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AIMP2_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
ERO1A_HUMAN [view interactions] High throughput no yes
MAT2B_HUMAN [view interactions] High throughput no yes
SYLC_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RBBP7_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
CLC4G_HUMAN [view interactions] High throughput no no
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
RU17_HUMAN [view interactions] High throughput no yes
COG1_HUMAN [view interactions] High throughput no yes
DPOA2_HUMAN [view interactions] High throughput no yes
SYCM_HUMAN [view interactions] High throughput no yes
KTNA1_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
ZIC1_HUMAN [view interactions] High throughput no yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
NEST_HUMAN [view interactions] High throughput no no
FNTB_HUMAN [view interactions] High throughput no no
TRIPC_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
RP9_HUMAN [view interactions] High throughput no yes
C99L2_HUMAN [view interactions] High throughput no yes
CPNS2_HUMAN [view interactions] High throughput no no
CAN8_HUMAN [view interactions] High throughput no no
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
HTRA4_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
BAD_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
PAR1_HUMAN [view entry] [view interactions] High throughput yes yes
CE164_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
SH3BG_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
TINAL_HUMAN [view interactions] High throughput no no
CREG1_HUMAN [view interactions] High throughput no no
ECHM_HUMAN [view interactions] High throughput no yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
SLIT3_HUMAN [view interactions] High throughput no yes
ALAT1_HUMAN [view interactions] High throughput no no
CATC_HUMAN [view interactions] High throughput no yes
PTGDS_HUMAN [view interactions] High throughput no yes
TLE5_HUMAN [view interactions] High throughput no no
NF2L1_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
MYPC3_HUMAN [view interactions] High throughput no no
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
CO1A1_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
EED_HUMAN [view interactions] High throughput no yes
KNG1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
FXL12_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
CD109_HUMAN [view interactions] High throughput no no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FNTA_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIP4_HUMAN [view interactions] High throughput no yes
TGFB1_HUMAN [view interactions] High throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
REQU_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
PD1L1_HUMAN [view interactions] High throughput no no
EDEM1_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
SIA7F_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
ZC3H4_HUMAN [view interactions] High throughput no yes
PRC2C_HUMAN [view interactions] High throughput no yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
PP1RA_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
WDR33_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
CAN3_HUMAN [view interactions] High throughput no no
S22A1_HUMAN [view interactions] High throughput no yes
ASSY_HUMAN [view interactions] High throughput no yes
5MP1_HUMAN [view interactions] High throughput no no
BCCIP_HUMAN [view interactions] High throughput no no
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
GNS_HUMAN [view interactions] High throughput no yes
LDH6B_HUMAN [view interactions] High throughput no no
PEPD_HUMAN [view interactions] High throughput no yes
PUR4_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] High throughput no no
P4R3B_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
CASP7_HUMAN [view interactions] High throughput no no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes