MP2K1_HUMAN
Evidence for PS localization
Functions
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001022 | DOC_MAPK_gen_1 | DOC | 3 | 11 | - |
| ELMI001022 | DOC_MAPK_gen_1 | DOC | 3 | 11 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MP2K1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.2281 | 4 | yes |
| GO:0000166 | nucleotide binding | 39.4737 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 39.4737 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.7193 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 37.7193 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 32.4561 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.7018 | 5 | yes |
| GO:0005524 | ATP binding | 30.7018 | 5 | yes |
| GO:0003723 | RNA binding | 28.9474 | 4 | no |
| GO:0019900 | kinase binding | 28.0702 | 4 | no |
| GO:0019901 | protein kinase binding | 27.1930 | 5 | no |
| GO:0043169 | cation binding | 23.6842 | 4 | no |
| GO:0046872 | metal ion binding | 23.6842 | 5 | no |
| GO:0045296 | cadherin binding | 21.0526 | 4 | no |
| GO:0016301 | kinase activity | 20.1754 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.1754 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 14.0351 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 14.0351 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 12.2807 | 4 | yes |
| GO:0019209 | kinase activator activity | 7.0175 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 7.0175 | 5 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.1404 | 4 | yes |
| GO:0043539 | protein serine/threonine kinase activator activity | 4.3860 | 6 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 4.3860 | 4 | yes |
| GO:0005078 | MAP-kinase scaffold activity | 4.3860 | 4 | yes |
| GO:0004708 | MAP kinase kinase activity | 3.5088 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.9298 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.1754 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 69.2982 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 68.4211 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 65.7895 | 4 | yes |
| GO:0010646 | regulation of cell communication | 59.6491 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 57.8947 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 57.0175 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 56.1404 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 56.1404 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 55.2632 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.5088 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 51.7544 | 4 | yes |
| GO:0010468 | regulation of gene expression | 51.7544 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 49.1228 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 43.8596 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 42.1053 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 42.1053 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 41.2281 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 41.2281 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 40.3509 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 40.3509 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.4737 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 39.4737 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 39.4737 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 37.7193 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 37.7193 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 37.7193 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 37.7193 | 5 | yes |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.8421 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 35.9649 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 35.0877 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 35.0877 | 6 | yes |
| GO:0008104 | protein localization | 35.0877 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 35.0877 | 7 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 34.2105 | 6 | yes |
| GO:0051049 | regulation of transport | 34.2105 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 34.2105 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 32.4561 | 5 | no |
| GO:0023057 | negative regulation of signaling | 32.4561 | 4 | no |
| GO:0036211 | protein modification process | 31.5789 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 31.5789 | 7 | yes |
| GO:0043412 | macromolecule modification | 31.5789 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 31.5789 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 31.5789 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.7018 | 4 | yes |
| GO:0006996 | organelle organization | 30.7018 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 30.7018 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 30.7018 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 30.7018 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.8246 | 7 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 29.8246 | 4 | yes |
| GO:0080134 | regulation of response to stress | 28.9474 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 28.0702 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.0702 | 5 | yes |
| GO:0032880 | regulation of protein localization | 28.0702 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.1930 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.1930 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.1930 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 26.3158 | 4 | yes |
| GO:2000145 | regulation of cell motility | 26.3158 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.5614 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.5614 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 24.5614 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 23.6842 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.6842 | 7 | yes |
| GO:0051094 | positive regulation of developmental process | 23.6842 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 23.6842 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.6842 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.6842 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 23.6842 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 22.8070 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 22.8070 | 8 | yes |
| GO:0043408 | regulation of MAPK cascade | 22.8070 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 22.8070 | 6 | no |
| GO:0030334 | regulation of cell migration | 22.8070 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.9298 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 21.9298 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 21.9298 | 4 | yes |
| GO:0016310 | phosphorylation | 21.0526 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 21.0526 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.0526 | 8 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.1754 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.1754 | 7 | yes |
| GO:0090304 | nucleic acid metabolic process | 20.1754 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.1754 | 8 | no |
| GO:0071705 | nitrogen compound transport | 20.1754 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 20.1754 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.1754 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 20.1754 | 4 | no |
| GO:0006468 | protein phosphorylation | 19.2982 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.4211 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 18.4211 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 18.4211 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 17.5439 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 16.6667 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 16.6667 | 6 | yes |
| GO:0060284 | regulation of cell development | 16.6667 | 5 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 16.6667 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 15.7895 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 14.9123 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 14.9123 | 5 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 14.9123 | 7 | yes |
| GO:0033674 | positive regulation of kinase activity | 14.0351 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 14.0351 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 13.1579 | 7 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 13.1579 | 7 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 12.2807 | 7 | yes |
| GO:0038127 | ERBB signaling pathway | 11.4035 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 11.4035 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 11.4035 | 5 | yes |
| GO:0000165 | MAPK cascade | 11.4035 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 11.4035 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 10.5263 | 6 | yes |
| GO:0048732 | gland development | 10.5263 | 4 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 10.5263 | 7 | yes |
| GO:1903034 | regulation of response to wounding | 10.5263 | 5 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 9.6491 | 8 | yes |
| GO:0042552 | myelination | 8.7719 | 4 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8.7719 | 8 | yes |
| GO:0007507 | heart development | 8.7719 | 4 | yes |
| GO:0021782 | glial cell development | 7.8947 | 4 | yes |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 7.8947 | 6 | yes |
| GO:0014044 | Schwann cell development | 7.0175 | 5 | yes |
| GO:0038128 | ERBB2 signaling pathway | 7.0175 | 7 | yes |
| GO:0050769 | positive regulation of neurogenesis | 7.0175 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 7.0175 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 7.0175 | 5 | yes |
| GO:0010001 | glial cell differentiation | 7.0175 | 4 | yes |
| GO:0030878 | thyroid gland development | 6.1404 | 5 | yes |
| GO:0038129 | ERBB3 signaling pathway | 6.1404 | 7 | yes |
| GO:0038133 | ERBB2-ERBB3 signaling pathway | 6.1404 | 8 | yes |
| GO:0048534 | hematopoietic or lymphoid organ development | 6.1404 | 4 | yes |
| GO:0048538 | thymus development | 6.1404 | 5 | yes |
| GO:0070371 | ERK1 and ERK2 cascade | 6.1404 | 6 | yes |
| GO:0048679 | regulation of axon regeneration | 5.2632 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 5.2632 | 6 | yes |
| GO:0070570 | regulation of neuron projection regeneration | 5.2632 | 4 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 5.2632 | 5 | yes |
| GO:0030855 | epithelial cell differentiation | 4.3860 | 4 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 4.3860 | 6 | yes |
| GO:0048708 | astrocyte differentiation | 4.3860 | 5 | yes |
| GO:0060020 | Bergmann glial cell differentiation | 4.3860 | 6 | yes |
| GO:0060440 | trachea formation | 4.3860 | 4 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 4.3860 | 5 | yes |
| GO:0090170 | regulation of Golgi inheritance | 4.3860 | 7 | yes |
| GO:1903358 | regulation of Golgi organization | 4.3860 | 6 | yes |
| GO:0030182 | neuron differentiation | 3.5088 | 4 | yes |
| GO:0044342 | type B pancreatic cell proliferation | 2.6316 | 4 | yes |
| GO:0060502 | epithelial cell proliferation involved in lung morphogenesis | 2.6316 | 4 | yes |
| GO:0060674 | placenta blood vessel development | 2.6316 | 4 | yes |
| GO:0030216 | keratinocyte differentiation | 1.7544 | 6 | yes |
| GO:0035987 | endodermal cell differentiation | 1.7544 | 4 | yes |
| GO:1903224 | regulation of endodermal cell differentiation | 1.7544 | 5 | yes |
| GO:1903226 | positive regulation of endodermal cell differentiation | 1.7544 | 6 | yes |
| GO:0009913 | epidermal cell differentiation | 1.7544 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| PSD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VRK2_HUMAN | [view interactions] | Low throughput | no | no |
| M3K8_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIEA_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LTOR3_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LTOR2_HUMAN | [view interactions] | Low throughput | no | yes |
| VAV_HUMAN | [view interactions] | Low throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEK10_HUMAN | [view interactions] | Low throughput | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WDR83_HUMAN | [view interactions] | Low throughput | no | yes |
| LSP1_HUMAN | [view interactions] | Low throughput | no | no |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| MYOD1_HUMAN | [view interactions] | Low throughput | no | no |
| NF2L2_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MABP1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSME3_HUMAN | [view interactions] | Low throughput | no | yes |
| UROK_HUMAN | [view interactions] | Low throughput | no | no |
| M3K4_HUMAN | [view interactions] | Low throughput | no | yes |
| BRAF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRIB1_HUMAN | [view interactions] | Low throughput | no | no |
| KAT7_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEBP4_HUMAN | [view interactions] | Low throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARAF_HUMAN | [view interactions] | Low throughput | no | yes |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN277_HUMAN | [view interactions] | High throughput | no | no |
| ERAP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| NOP58_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3B_HUMAN | [view interactions] | High throughput | no | no |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| MOB2_HUMAN | [view interactions] | High throughput | no | no |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NAT10_HUMAN | [view interactions] | High throughput | no | yes |
| GNL3_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| UCRIL_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| H10_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM3_HUMAN | [view interactions] | High throughput | no | yes |
| U3IP2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAT1_HUMAN | [view interactions] | High throughput | no | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT4_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC27_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| MLH3_HUMAN | [view interactions] | High throughput | no | no |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| DCOR_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRL_HUMAN | [view interactions] | High throughput | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TLR2_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCP11_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRAP_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNAS9_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYH1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| CD006_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BSPRY_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| RB40B_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MXRA7_HUMAN | [view interactions] | High throughput | no | yes |
| HEXB_HUMAN | [view interactions] | High throughput | no | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| LSHR_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| BLM_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD5_HUMAN | [view interactions] | High throughput | no | no |
| MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPS2_HUMAN | [view interactions] | High throughput | no | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |