MP2K1_HUMAN
Evidence for PS localization
Functions
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001022 | DOC_MAPK_gen_1 | DOC | 3 | 11 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MP2K1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.3459 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.3459 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.3459 | 4 | yes |
| GO:0019900 | kinase binding | 33.0827 | 4 | no |
| GO:0019901 | protein kinase binding | 32.3308 | 5 | no |
| GO:0005524 | ATP binding | 30.8271 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 30.8271 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.8271 | 5 | yes |
| GO:0003723 | RNA binding | 26.3158 | 4 | no |
| GO:0016301 | kinase activity | 24.0602 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 24.0602 | 4 | yes |
| GO:0046872 | metal ion binding | 23.3083 | 4 | no |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 21.0526 | 4 | yes |
| GO:0045296 | cadherin binding | 21.0526 | 4 | no |
| GO:0004674 | protein serine/threonine kinase activity | 18.0451 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 18.0451 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 13.5338 | 4 | yes |
| GO:0019209 | kinase activator activity | 8.2707 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 8.2707 | 5 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.7669 | 4 | yes |
| GO:0004708 | MAP kinase kinase activity | 4.5113 | 5 | yes |
| GO:0043539 | protein serine/threonine kinase activator activity | 4.5113 | 6 | yes |
| GO:0005078 | MAP-kinase scaffold activity | 3.7594 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.1805 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 69.9248 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 68.4211 | 4 | yes |
| GO:0010646 | regulation of cell communication | 66.1654 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 65.4135 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 64.6617 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.6541 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 60.9023 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.1353 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.1353 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 52.6316 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.8797 | 5 | yes |
| GO:0010468 | regulation of gene expression | 50.3759 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 47.3684 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 45.1128 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 45.1128 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 43.6090 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 43.6090 | 4 | no |
| GO:0010941 | regulation of cell death | 42.8571 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 41.3534 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.6015 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 39.8496 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 39.8496 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 39.8496 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 39.8496 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 39.0977 | 6 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 37.5940 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 37.5940 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 37.5940 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 37.5940 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 36.8421 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 36.8421 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 36.0902 | 4 | yes |
| GO:0051049 | regulation of transport | 36.0902 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 36.0902 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 35.3383 | 5 | yes |
| GO:0036211 | protein modification process | 35.3383 | 4 | yes |
| GO:0043412 | macromolecule modification | 35.3383 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 33.0827 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 33.0827 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 33.0827 | 6 | yes |
| GO:0006996 | organelle organization | 32.3308 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 32.3308 | 7 | yes |
| GO:0045595 | regulation of cell differentiation | 32.3308 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 31.5789 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.5789 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.8271 | 4 | no |
| GO:0060548 | negative regulation of cell death | 30.0752 | 5 | no |
| GO:0071310 | cellular response to organic substance | 30.0752 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 29.3233 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 29.3233 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.3233 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 29.3233 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 29.3233 | 5 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 28.5714 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 27.8195 | 5 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 27.8195 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 27.8195 | 7 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.0677 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 27.0677 | 8 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 26.3158 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.3158 | 6 | yes |
| GO:0080134 | regulation of response to stress | 26.3158 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.3158 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.5639 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 25.5639 | 7 | yes |
| GO:0042127 | regulation of cell population proliferation | 25.5639 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.8120 | 6 | yes |
| GO:0016310 | phosphorylation | 24.8120 | 5 | yes |
| GO:0043549 | regulation of kinase activity | 24.8120 | 5 | yes |
| GO:0032880 | regulation of protein localization | 24.0602 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.0602 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.0602 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.0602 | 8 | yes |
| GO:0051726 | regulation of cell cycle | 23.3083 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 23.3083 | 4 | no |
| GO:0006468 | protein phosphorylation | 23.3083 | 5 | yes |
| GO:0071702 | organic substance transport | 22.5564 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.5564 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.5564 | 6 | yes |
| GO:0045859 | regulation of protein kinase activity | 22.5564 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.8045 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 21.8045 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.8045 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 21.8045 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.8045 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 21.8045 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.0526 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.0526 | 6 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 20.3008 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.3008 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.3008 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 20.3008 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 18.7970 | 6 | yes |
| GO:0033674 | positive regulation of kinase activity | 18.0451 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 17.2932 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 16.5414 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 16.5414 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 16.5414 | 7 | yes |
| GO:0080135 | regulation of cellular response to stress | 16.5414 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 16.5414 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 16.5414 | 8 | yes |
| GO:0010975 | regulation of neuron projection development | 15.7895 | 7 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 15.7895 | 7 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 15.7895 | 7 | yes |
| GO:0060284 | regulation of cell development | 15.0376 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 14.2857 | 4 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 14.2857 | 7 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 12.7820 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 12.7820 | 7 | yes |
| GO:0000165 | MAPK cascade | 10.5263 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 10.5263 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 10.5263 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 10.5263 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 10.5263 | 5 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10.5263 | 8 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 9.7744 | 8 | yes |
| GO:1903034 | regulation of response to wounding | 9.0226 | 5 | yes |
| GO:0010001 | glial cell differentiation | 7.5188 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 7.5188 | 6 | yes |
| GO:0048732 | gland development | 7.5188 | 4 | yes |
| GO:0007507 | heart development | 6.0150 | 4 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 6.0150 | 6 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 6.0150 | 5 | yes |
| GO:0030182 | neuron differentiation | 5.2632 | 4 | yes |
| GO:0070371 | ERK1 and ERK2 cascade | 5.2632 | 5 | yes |
| GO:0048534 | hematopoietic or lymphoid organ development | 4.5113 | 4 | yes |
| GO:0048708 | astrocyte differentiation | 4.5113 | 5 | yes |
| GO:1903649 | regulation of cytoplasmic transport | 4.5113 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 4.5113 | 5 | yes |
| GO:0030878 | thyroid gland development | 3.7594 | 5 | yes |
| GO:0048538 | thymus development | 3.7594 | 5 | yes |
| GO:0048679 | regulation of axon regeneration | 3.7594 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 3.7594 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 3.7594 | 5 | yes |
| GO:0060020 | Bergmann glial cell differentiation | 3.7594 | 6 | yes |
| GO:0060147 | regulation of post-transcriptional gene silencing | 3.7594 | 6 | yes |
| GO:0060964 | regulation of miRNA-mediated gene silencing | 3.7594 | 8 | yes |
| GO:0060966 | regulation of gene silencing by RNA | 3.7594 | 6 | yes |
| GO:0070570 | regulation of neuron projection regeneration | 3.7594 | 4 | yes |
| GO:0090170 | regulation of Golgi inheritance | 3.7594 | 7 | yes |
| GO:1900368 | regulation of post-transcriptional gene silencing by RNA | 3.7594 | 7 | yes |
| GO:1903358 | regulation of Golgi organization | 3.7594 | 6 | yes |
| GO:0030855 | epithelial cell differentiation | 3.0075 | 4 | yes |
| GO:0060148 | positive regulation of post-transcriptional gene silencing | 3.0075 | 4 | yes |
| GO:0060440 | trachea formation | 3.0075 | 4 | yes |
| GO:0070920 | regulation of production of small RNA involved in gene silencing by RNA | 3.0075 | 6 | yes |
| GO:1900370 | positive regulation of post-transcriptional gene silencing by RNA | 3.0075 | 5 | yes |
| GO:1903798 | regulation of miRNA maturation | 3.0075 | 7 | yes |
| GO:2000637 | positive regulation of miRNA-mediated gene silencing | 3.0075 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 2.2556 | 6 | yes |
| GO:0060674 | placenta blood vessel development | 2.2556 | 4 | yes |
| GO:1903800 | positive regulation of miRNA maturation | 2.2556 | 7 | yes |
| GO:0009913 | epidermal cell differentiation | 1.5038 | 5 | yes |
| GO:0030216 | keratinocyte differentiation | 1.5038 | 6 | yes |
| GO:0060502 | epithelial cell proliferation involved in lung morphogenesis | 1.5038 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K1_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.0075 | 3 | no |
| DOID:0060038 | specific developmental disorder | 1.5038 | 3 | no |
| DOID:1059 | intellectual disability | 1.5038 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 1.5038 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 1.5038 | 6 | no |
| DOID:440 | neuromuscular disease | 1.5038 | 5 | no |
| DOID:574 | peripheral nervous system disease | 1.5038 | 3 | no |
| DOID:870 | neuropathy | 1.5038 | 4 | no |
| DOID:10534 | stomach cancer | 1.5038 | 5 | no |
| DOID:120 | female reproductive organ cancer | 1.5038 | 5 | no |
| DOID:193 | reproductive organ cancer | 1.5038 | 4 | no |
| DOID:3119 | gastrointestinal system cancer | 1.5038 | 4 | no |
| DOID:114 | heart disease | 1.5038 | 3 | no |
| DOID:612 | primary immunodeficiency disease | 1.5038 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VRK2_HUMAN | [view interactions] | Low throughput | no | no |
| M3K8_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIEA_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LTOR3_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LTOR2_HUMAN | [view interactions] | Low throughput | no | yes |
| VAV_HUMAN | [view interactions] | Low throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEK10_HUMAN | [view interactions] | Low throughput | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WDR83_HUMAN | [view interactions] | Low throughput | no | yes |
| LSP1_HUMAN | [view interactions] | Low throughput | no | no |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| MYOD1_HUMAN | [view interactions] | Low throughput | no | no |
| NF2L2_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MABP1_HUMAN | [view interactions] | Low throughput | no | yes |
| UROK_HUMAN | [view interactions] | Low throughput | no | no |
| M3K4_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAT7_HUMAN | [view interactions] | Low throughput | no | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| BRAF_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRIB1_HUMAN | [view interactions] | Low throughput | no | no |
| TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEBP4_HUMAN | [view interactions] | Low throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARAF_HUMAN | [view interactions] | Low throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| PSD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC27_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| MLH3_HUMAN | [view interactions] | High throughput | no | no |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| DCOR_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRL_HUMAN | [view interactions] | High throughput | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TLR2_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCP11_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRAP_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNAS9_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYH1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| CD006_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BSPRY_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| RB40B_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MXRA7_HUMAN | [view interactions] | High throughput | no | yes |
| HEXB_HUMAN | [view interactions] | High throughput | no | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| BLM_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD5_HUMAN | [view interactions] | High throughput | no | no |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN277_HUMAN | [view interactions] | High throughput | no | no |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| UCRIL_HUMAN | [view interactions] | High throughput | no | no |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| U3IP2_HUMAN | [view interactions] | High throughput | no | yes |
| NPM3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H10_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GNL3_HUMAN | [view interactions] | High throughput | no | yes |
| NAT10_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| NOP58_HUMAN | [view interactions] | High throughput | no | yes |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| ITA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| FAT1_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THRB_HUMAN | [view interactions] | Computational | no | no |
| PI3R6_HUMAN | [view interactions] | Computational | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAK6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD5R1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GAB1_HUMAN | [view interactions] | Computational | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 1433S_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCL11_HUMAN | [view interactions] | Computational | no | no |
| IL6RA_HUMAN | [view interactions] | Computational | no | no |
| EFNB1_HUMAN | [view interactions] | Computational | no | yes |
| IL2RB_HUMAN | [view interactions] | Computational | no | no |
| IL2RA_HUMAN | [view interactions] | Computational | no | no |
| GAB2_HUMAN | [view interactions] | Computational | no | yes |
| NCOR2_HUMAN | [view interactions] | Computational | no | yes |
| M3K7_HUMAN | [view interactions] | Computational | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2AAB_HUMAN | [view interactions] | Computational | no | yes |
| MP2K4_HUMAN | [view interactions] | Computational | no | yes |
| PP2AB_HUMAN | [view interactions] | Computational | no | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| JAK3_HUMAN | [view interactions] | Computational | no | no |
| PK3CG_HUMAN | [view interactions] | Computational | no | yes |
| TYK2_HUMAN | [view interactions] | Computational | no | no |
| JUN_HUMAN | [view interactions] | Computational | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| JAK1_HUMAN | [view interactions] | Computational | no | yes |
| MOS_HUMAN | [view interactions] | Computational | no | no |
| NET1_HUMAN | [view interactions] | Computational | no | no |
| NRG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IL6RB_HUMAN | [view interactions] | Computational | no | no |
| 2ABB_HUMAN | [view interactions] | Computational | no | yes |
| ANGT_HUMAN | [view interactions] | Computational | no | no |
| EPHB1_HUMAN | [view interactions] | Computational | no | no |
| CDK1_HUMAN | [view interactions] | Computational | no | no |
| IL2_HUMAN | [view interactions] | Computational | no | no |
| PAK4_HUMAN | [view interactions] | Computational | no | yes |
| DCC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERBB3_HUMAN | [view interactions] | Computational | no | yes |
| PA24A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| MK13_HUMAN | [view interactions] | Computational | no | yes |
| IL6_HUMAN | [view interactions] | Computational | no | no |
| FOXM1_HUMAN | [view interactions] | Computational | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TAB1_HUMAN | [view interactions] | Computational | no | yes |
| PAK5_HUMAN | [view interactions] | Computational | no | yes |
| KAPCG_HUMAN | [view interactions] | Computational | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GLI2_HUMAN | [view interactions] | Computational | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAK3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IL2RG_HUMAN | [view interactions] | Computational | no | no |
| RUSC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK09_HUMAN | [view interactions] | Computational | no | yes |
| MK12_HUMAN | [view interactions] | Computational | no | no |
| B2L11_HUMAN | [view interactions] | Computational | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SHH_HUMAN | [view interactions] | Computational | no | no |
| SDF1_HUMAN | [view interactions] | Computational | no | no |