CD9_HUMAN
Evidence for PS localization
Functions
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed, PubMed, PubMed). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion . In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration . In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption . Acts as a receptor for PSG17 . Involved in platelet activation and aggregation (PubMed). Regulates paranodal junction formation . Involved in cell adhesion, cell motility and tumor metastasis (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CD9_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.4167 | 4 | no |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 31.2500 | 5 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 20.8333 | 4 | no |
| GO:0042803 | protein homodimerization activity | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CD9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.0833 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.9167 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.9167 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 45.8333 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.7500 | 5 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.6667 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 39.5833 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 35.4167 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.4167 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
| GO:0030334 | regulation of cell migration | 29.1667 | 5 | yes |
| GO:2000145 | regulation of cell motility | 29.1667 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.1667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.1667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.1667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.0833 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.0833 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.0833 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.0833 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.0833 | 4 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 22.9167 | 4 | yes |
| GO:0098657 | import into cell | 22.9167 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.9167 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.9167 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.9167 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9167 | 6 | no |
| GO:0006811 | monoatomic ion transport | 22.9167 | 4 | no |
| GO:0030030 | cell projection organization | 22.9167 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.9167 | 5 | no |
| GO:0008104 | protein localization | 22.9167 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.9167 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.9167 | 7 | no |
| GO:0051050 | positive regulation of transport | 22.9167 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.9167 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.9167 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.9167 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 20.8333 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.8333 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0006812 | monoatomic cation transport | 20.8333 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 20.8333 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 20.8333 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.8333 | 7 | no |
| GO:0006996 | organelle organization | 20.8333 | 4 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8333 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.8333 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8333 | 7 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.8333 | 6 | no |
| GO:0034330 | cell junction organization | 18.7500 | 4 | yes |
| GO:0061024 | membrane organization | 18.7500 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 16.6667 | 4 | yes |
| GO:1903034 | regulation of response to wounding | 16.6667 | 5 | yes |
| GO:0034329 | cell junction assembly | 14.5833 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 14.5833 | 4 | yes |
| GO:0045216 | cell-cell junction organization | 12.5000 | 5 | yes |
| GO:0050865 | regulation of cell activation | 12.5000 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 12.5000 | 5 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 10.4167 | 5 | yes |
| GO:0061041 | regulation of wound healing | 10.4167 | 6 | yes |
| GO:0006898 | receptor-mediated endocytosis | 10.4167 | 4 | yes |
| GO:0007043 | cell-cell junction assembly | 10.4167 | 6 | yes |
| GO:0031623 | receptor internalization | 8.3333 | 5 | yes |
| GO:0061025 | membrane fusion | 8.3333 | 5 | yes |
| GO:0007009 | plasma membrane organization | 8.3333 | 5 | yes |
| GO:0010543 | regulation of platelet activation | 8.3333 | 5 | yes |
| GO:0030913 | paranodal junction assembly | 6.2500 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 6.2500 | 5 | yes |
| GO:0034110 | regulation of homotypic cell-cell adhesion | 6.2500 | 6 | yes |
| GO:0061045 | negative regulation of wound healing | 6.2500 | 6 | yes |
| GO:0071404 | cellular response to low-density lipoprotein particle stimulus | 6.2500 | 4 | yes |
| GO:0071675 | regulation of mononuclear cell migration | 6.2500 | 5 | yes |
| GO:0090330 | regulation of platelet aggregation | 6.2500 | 6 | yes |
| GO:1903035 | negative regulation of response to wounding | 6.2500 | 5 | yes |
| GO:0002685 | regulation of leukocyte migration | 6.2500 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 6.2500 | 5 | yes |
| GO:0007520 | myoblast fusion | 6.2500 | 4 | yes |
| GO:0014905 | myoblast fusion involved in skeletal muscle regeneration | 4.1667 | 5 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 4.1667 | 6 | yes |
| GO:0030193 | regulation of blood coagulation | 4.1667 | 4 | yes |
| GO:0030195 | negative regulation of blood coagulation | 4.1667 | 5 | yes |
| GO:0034111 | negative regulation of homotypic cell-cell adhesion | 4.1667 | 7 | yes |
| GO:0035036 | sperm-egg recognition | 4.1667 | 4 | yes |
| GO:0045026 | plasma membrane fusion | 4.1667 | 6 | yes |
| GO:0050818 | regulation of coagulation | 4.1667 | 4 | yes |
| GO:0050819 | negative regulation of coagulation | 4.1667 | 5 | yes |
| GO:0050866 | negative regulation of cell activation | 4.1667 | 5 | yes |
| GO:0090331 | negative regulation of platelet aggregation | 4.1667 | 7 | yes |
| GO:1900047 | negative regulation of hemostasis | 4.1667 | 4 | yes |
| GO:1905521 | regulation of macrophage migration | 4.1667 | 6 | yes |
| GO:0008347 | glial cell migration | 4.1667 | 4 | yes |
| GO:0010544 | negative regulation of platelet activation | 4.1667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FPRP_HUMAN | [view interactions] | Low throughput | no | yes |
| CD63_HUMAN | [view interactions] | Low throughput | no | no |
| CD19_HUMAN | [view interactions] | Low throughput | no | no |
| ITA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD82_HUMAN | [view interactions] | Low throughput | no | no |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| MCP_HUMAN | [view interactions] | Low throughput | no | no |
| TSN4_HUMAN | [view interactions] | Low throughput | no | no |
| CD53_HUMAN | [view interactions] | Low throughput | no | yes |
| CD36_HUMAN | [view interactions] | Low throughput | no | no |
| SERPH_HUMAN | [view interactions] | Low throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LG3BP_HUMAN | [view interactions] | Low throughput | no | no |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S22A2_HUMAN | [view interactions] | Low throughput | no | no |
| ACE2_HUMAN | [view interactions] | Low throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD81_HUMAN | [view interactions] | Low throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA17_HUMAN | [view interactions] | Low throughput | no | yes |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN9_HUMAN | [view interactions] | High throughput | no | yes |
| CD151_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD166_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2_HUMAN | [view interactions] | High throughput | no | yes |
| TSN14_HUMAN | [view interactions] | High throughput | no | no |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| FWCH2_HUMAN | [view interactions] | High throughput | no | no |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| CTL1_HUMAN | [view interactions] | High throughput | no | no |
| GALK1_HUMAN | [view interactions] | High throughput | no | yes |
| LR74A_HUMAN | [view interactions] | High throughput | no | no |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| IGLL1_HUMAN | [view interactions] | High throughput | no | no |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNNM4_HUMAN | [view interactions] | High throughput | no | yes |
| ROBO1_HUMAN | [view interactions] | High throughput | no | yes |
| SDK2_HUMAN | [view interactions] | High throughput | no | no |
| CTL2_HUMAN | [view interactions] | High throughput | no | no |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| ACVR1_HUMAN | [view interactions] | High throughput | no | yes |
| MDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CELR2_HUMAN | [view interactions] | High throughput | no | no |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRG1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| MRC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYOF_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PCDB5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| NECT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP4_HUMAN | [view interactions] | High throughput | no | no |
| CLN8_HUMAN | [view interactions] | High throughput | no | no |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| IGDC4_HUMAN | [view interactions] | High throughput | no | yes |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| NSA2_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| S22A1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN2_HUMAN | [view interactions] | High throughput | no | no |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| MMP14_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DGLB_HUMAN | [view interactions] | High throughput | no | no |
| S39AE_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF3_HUMAN | [view interactions] | High throughput | no | yes |
| CD276_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT8_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCAM_HUMAN | [view interactions] | High throughput | no | yes |
| TEN3_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |