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CD9_HUMAN

GO
G2C
SynGO

Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed, PubMed, PubMed). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion . In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration . In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption . Acts as a receptor for PSG17 . Involved in platelet activation and aggregation (PubMed). Regulates paranodal junction formation . Involved in cell adhesion, cell motility and tumor metastasis (PubMed, PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CD9_HUMAN
GO:0046872 metal ion binding 34.0909 4 no
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0008324 cation transmembrane transporter activity 22.7273 4 no
GO:0022890 inorganic cation transmembrane transporter activity 22.7273 4 no
GO:0005524 ATP binding 20.4545 5 no
GO:0030554 adenyl nucleotide binding 20.4545 5 no
GO:0032559 adenyl ribonucleotide binding 20.4545 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CD9_HUMAN
GO:0048522 positive regulation of cellular process 59.0909 4 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0048523 negative regulation of cellular process 43.1818 4 yes
GO:0031323 regulation of cellular metabolic process 40.9091 4 no
GO:0010646 regulation of cell communication 38.6364 4 no
GO:0080090 regulation of primary metabolic process 38.6364 4 no
GO:0010468 regulation of gene expression 38.6364 5 no
GO:0051171 regulation of nitrogen compound metabolic process 34.0909 4 no
GO:0051049 regulation of transport 34.0909 4 no
GO:0022607 cellular component assembly 31.8182 4 yes
GO:0042127 regulation of cell population proliferation 31.8182 4 yes
GO:0009966 regulation of signal transduction 31.8182 4 no
GO:0030334 regulation of cell migration 29.5455 5 yes
GO:2000145 regulation of cell motility 29.5455 4 yes
GO:0009893 positive regulation of metabolic process 29.5455 4 no
GO:0060341 regulation of cellular localization 29.5455 4 no
GO:0080134 regulation of response to stress 27.2727 4 yes
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0051128 regulation of cellular component organization 27.2727 4 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:2000026 regulation of multicellular organismal development 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0032101 regulation of response to external stimulus 25.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.7273 4 no
GO:0030030 cell projection organization 22.7273 4 no
GO:0043085 positive regulation of catalytic activity 22.7273 4 no
GO:0051094 positive regulation of developmental process 22.7273 4 no
GO:0071310 cellular response to organic substance 22.7273 4 no
GO:1902531 regulation of intracellular signal transduction 22.7273 5 no
GO:0006811 ion transport 22.7273 4 no
GO:0009889 regulation of biosynthetic process 22.7273 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:0031326 regulation of cellular biosynthetic process 22.7273 5 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:0008284 positive regulation of cell population proliferation 22.7273 5 no
GO:0010647 positive regulation of cell communication 22.7273 5 no
GO:0023056 positive regulation of signaling 22.7273 4 no
GO:0010243 response to organonitrogen compound 20.4545 4 yes
GO:0030155 regulation of cell adhesion 20.4545 4 yes
GO:0034330 cell junction organization 20.4545 4 yes
GO:0048585 negative regulation of response to stimulus 20.4545 4 yes
GO:0001932 regulation of protein phosphorylation 20.4545 7 no
GO:0006996 organelle organization 20.4545 4 no
GO:0019220 regulation of phosphate metabolic process 20.4545 6 no
GO:0031399 regulation of protein modification process 20.4545 6 no
GO:0042325 regulation of phosphorylation 20.4545 7 no
GO:0051130 positive regulation of cellular component organization 20.4545 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.4545 5 no
GO:0051174 regulation of phosphorus metabolic process 20.4545 5 no
GO:0051247 positive regulation of protein metabolic process 20.4545 6 no
GO:1905475 regulation of protein localization to membrane 20.4545 6 no
GO:0006812 cation transport 20.4545 5 no
GO:0048878 chemical homeostasis 20.4545 4 no
GO:1903829 positive regulation of protein localization 20.4545 5 no
GO:0040017 positive regulation of locomotion 20.4545 4 no
GO:0016192 vesicle-mediated transport 18.1818 4 yes
GO:0061024 membrane organization 18.1818 4 yes
GO:1903034 regulation of response to wounding 18.1818 5 yes
GO:0034329 cell junction assembly 15.9091 5 yes
GO:0051241 negative regulation of multicellular organismal process 15.9091 4 yes
GO:0045216 cell-cell junction organization 13.6364 5 yes
GO:0008285 negative regulation of cell population proliferation 13.6364 5 yes
GO:0050865 regulation of cell activation 11.3636 4 yes
GO:0061041 regulation of wound healing 11.3636 6 yes
GO:0006897 endocytosis 11.3636 5 yes
GO:0007043 cell-cell junction assembly 11.3636 6 yes
GO:0061025 membrane fusion 9.0909 5 yes
GO:0006898 receptor-mediated endocytosis 9.0909 6 yes
GO:0007009 plasma membrane organization 9.0909 5 yes
GO:0010543 regulation of platelet activation 6.8182 5 yes
GO:0022407 regulation of cell-cell adhesion 6.8182 5 yes
GO:0030913 paranodal junction assembly 6.8182 4 yes
GO:0031623 receptor internalization 6.8182 7 yes
GO:0032102 negative regulation of response to external stimulus 6.8182 5 yes
GO:0034110 regulation of homotypic cell-cell adhesion 6.8182 6 yes
GO:0061045 negative regulation of wound healing 6.8182 6 yes
GO:0071404 cellular response to low-density lipoprotein particle stimulus 6.8182 4 yes
GO:0090330 regulation of platelet aggregation 6.8182 6 yes
GO:1903035 negative regulation of response to wounding 6.8182 5 yes
GO:0002685 regulation of leukocyte migration 6.8182 4 yes
GO:0007162 negative regulation of cell adhesion 6.8182 5 yes
GO:0007520 myoblast fusion 6.8182 4 yes
GO:0010544 negative regulation of platelet activation 4.5455 6 yes
GO:0014905 myoblast fusion involved in skeletal muscle regeneration 4.5455 5 yes
GO:0022408 negative regulation of cell-cell adhesion 4.5455 6 yes
GO:0030193 regulation of blood coagulation 4.5455 4 yes
GO:0030195 negative regulation of blood coagulation 4.5455 5 yes
GO:0034111 negative regulation of homotypic cell-cell adhesion 4.5455 7 yes
GO:0045026 plasma membrane fusion 4.5455 6 yes
GO:0050818 regulation of coagulation 4.5455 4 yes
GO:0050819 negative regulation of coagulation 4.5455 5 yes
GO:0050866 negative regulation of cell activation 4.5455 5 yes
GO:0090331 negative regulation of platelet aggregation 4.5455 7 yes
GO:1900047 negative regulation of hemostasis 4.5455 4 yes
GO:1905521 regulation of macrophage migration 4.5455 5 yes
GO:0008347 glial cell migration 4.5455 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in CD9_HUMAN
DOID:331 central nervous system disease 6.8182 3 no
DOID:1289 neurodegenerative disease 4.5455 4 no
DOID:231 motor neuron disease 4.5455 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IGSF8_HUMAN [view entry] [view interactions] Low throughput yes no
FPRP_HUMAN [view interactions] Low throughput no yes
ITA3_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
ADA17_HUMAN [view interactions] Low throughput no yes
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
ADA10_HUMAN [view entry] [view interactions] Low throughput yes yes
CD81_HUMAN [view interactions] Low throughput no no
CD19_HUMAN [view interactions] Low throughput no no
CD63_HUMAN [view interactions] Low throughput no no
CD82_HUMAN [view interactions] Low throughput no no
ITA5_HUMAN [view entry] [view interactions] Low throughput yes no
KIT_HUMAN [view interactions] Low throughput no no
MCP_HUMAN [view interactions] Low throughput no no
TSN4_HUMAN [view interactions] Low throughput no no
CD53_HUMAN [view interactions] Low throughput no yes
CD36_HUMAN [view interactions] Low throughput no no
SERPH_HUMAN [view interactions] Low throughput no no
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
LG3BP_HUMAN [view interactions] Low throughput no no
S22A2_HUMAN [view interactions] Low throughput no no
MMP14_HUMAN [view interactions] High throughput no yes
TSN9_HUMAN [view interactions] High throughput no yes
CD166_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
CD151_HUMAN [view interactions] High throughput no no
CD44_HUMAN [view interactions] High throughput no yes
TSN5_HUMAN [view interactions] High throughput no no
AT1B3_HUMAN [view interactions] High throughput no yes
TEN3_HUMAN [view interactions] High throughput no yes
BCAM_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
4F2_HUMAN [view entry] [view interactions] High throughput yes no
TFR1_HUMAN [view interactions] High throughput no yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
MOT8_HUMAN [view interactions] High throughput no no
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
CD276_HUMAN [view interactions] High throughput no yes
IGSF3_HUMAN [view interactions] High throughput no yes
S39AE_HUMAN [view interactions] High throughput no yes
DGLB_HUMAN [view entry] [view interactions] High throughput yes no
TEN2_HUMAN [view entry] [view interactions] High throughput yes no
STX3_HUMAN [view entry] [view interactions] High throughput yes no
PGFRB_HUMAN [view interactions] High throughput no yes
ITA6_HUMAN [view interactions] High throughput no yes
AGRL2_HUMAN [view entry] [view interactions] High throughput yes no
TSN15_HUMAN [view interactions] High throughput no yes
ITA2_HUMAN [view interactions] High throughput no yes
TSN14_HUMAN [view interactions] High throughput no no
MK07_HUMAN [view interactions] High throughput no yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
M1IP1_HUMAN [view interactions] High throughput no yes
FWCH2_HUMAN [view interactions] High throughput no no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
NEP_HUMAN [view interactions] High throughput no no
LR74A_HUMAN [view interactions] High throughput no no
CTL1_HUMAN [view interactions] High throughput no no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
IGLL1_HUMAN [view interactions] High throughput no no
DRB1_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
GALK1_HUMAN [view interactions] High throughput no yes
MYOF_HUMAN [view interactions] High throughput no yes
ATP7A_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
NECT3_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB2_HUMAN [view interactions] High throughput no yes
PCDB5_HUMAN [view interactions] High throughput no no
MRC2_HUMAN [view interactions] High throughput no yes
LCAP_HUMAN [view interactions] High throughput no yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
F234A_HUMAN [view interactions] High throughput no yes
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
AGRG1_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
CXAR_HUMAN [view interactions] High throughput no yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
CELR2_HUMAN [view interactions] High throughput no no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
MDR1_HUMAN [view entry] [view interactions] High throughput yes no
ACVR1_HUMAN [view interactions] High throughput no yes
AT133_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
STX2_HUMAN [view interactions] High throughput no no
LAT1_HUMAN [view interactions] High throughput no yes
CTL2_HUMAN [view interactions] High throughput no no
SDK2_HUMAN [view interactions] High throughput no no
ROBO1_HUMAN [view interactions] High throughput no yes
CNNM4_HUMAN [view interactions] High throughput no yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
AGRE5_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
ODFP4_HUMAN [view interactions] High throughput no no
CLN8_HUMAN [view interactions] High throughput no no
VKOR1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
VATB1_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
RNF4_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
SRRT_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
TSN1_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
ACHB2_HUMAN [view entry] [view interactions] High throughput yes no
SPSB4_HUMAN [view interactions] High throughput no no
IGDC4_HUMAN [view interactions] High throughput no yes
TSN2_HUMAN [view interactions] High throughput no no
NSA2_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
S22A1_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] Computational yes yes
ITA2B_HUMAN [view interactions] Computational no no
ADAM2_HUMAN [view interactions] Computational no no
IZUM1_HUMAN [view interactions] Computational no no
EGF_HUMAN [view interactions] Computational no no
PDPN_HUMAN [view interactions] Computational no no
EPCAM_HUMAN [view interactions] Computational no no
ICAM1_HUMAN [view interactions] Computational no no
HBEGF_HUMAN [view interactions] Computational no no
PDIA1_HUMAN [view interactions] Computational no yes