Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MDR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Translocates drugs and phospholipids across the membrane (PubMed, PubMed, PubMed). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MDR1_HUMAN
GO:0000166 nucleotide binding 30.7692 4 yes
GO:0017076 purine nucleotide binding 30.7692 5 yes
GO:0043169 cation binding 30.7692 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0016462 pyrophosphatase activity 23.0769 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.0769 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.0769 6 yes
GO:0032555 purine ribonucleotide binding 23.0769 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 yes
GO:0043168 anion binding 23.0769 4 yes
GO:0030554 adenyl nucleotide binding 15.3846 6 yes
GO:0031625 ubiquitin protein ligase binding 15.3846 5 yes
GO:0044389 ubiquitin-like protein ligase binding 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MDR1_HUMAN
GO:0048522 positive regulation of cellular process 53.8462 4 yes
GO:0071702 organic substance transport 46.1538 4 yes
GO:0071705 nitrogen compound transport 46.1538 4 yes
GO:0006996 organelle organization 46.1538 4 no
GO:0008104 protein localization 46.1538 4 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0030030 cell projection organization 38.4615 4 no
GO:0033365 protein localization to organelle 38.4615 5 no
GO:0015031 protein transport 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0051049 regulation of transport 30.7692 4 yes
GO:0022607 cellular component assembly 30.7692 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 no
GO:0006886 intracellular protein transport 30.7692 4 no
GO:0072594 establishment of protein localization to organelle 30.7692 4 no
GO:0098657 import into cell 30.7692 4 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0036211 protein modification process 30.7692 4 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0043412 macromolecule modification 30.7692 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0009966 regulation of signal transduction 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010646 regulation of cell communication 30.7692 4 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 23.0769 5 yes
GO:0034762 regulation of transmembrane transport 23.0769 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 23.0769 5 yes
GO:0043269 regulation of monoatomic ion transport 23.0769 5 yes
GO:0061024 membrane organization 23.0769 4 yes
GO:0080134 regulation of response to stress 23.0769 4 yes
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0006898 receptor-mediated endocytosis 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0008285 negative regulation of cell population proliferation 23.0769 5 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0045892 negative regulation of DNA-templated transcription 23.0769 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051253 negative regulation of RNA metabolic process 23.0769 6 no
GO:1902679 negative regulation of RNA biosynthetic process 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0006508 proteolysis 23.0769 4 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0016567 protein ubiquitination 23.0769 8 no
GO:0019941 modification-dependent protein catabolic process 23.0769 6 no
GO:0032446 protein modification by small protein conjugation 23.0769 7 no
GO:0043632 modification-dependent macromolecule catabolic process 23.0769 5 no
GO:0043687 post-translational protein modification 23.0769 5 no
GO:0051603 proteolysis involved in protein catabolic process 23.0769 5 no
GO:0070647 protein modification by small protein conjugation or removal 23.0769 6 no
GO:0051050 positive regulation of transport 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RING2_HUMAN [view interactions] Low throughput no yes
LAP4B_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
PSB8_HUMAN [view interactions] Low throughput no yes
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
DHX9_HUMAN [view interactions] Low throughput no yes
PIM1_HUMAN [view interactions] Low throughput no yes
FBX15_HUMAN [view interactions] Low throughput no no
UBA7_HUMAN [view interactions] Low throughput no yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
MARH8_HUMAN [view interactions] Low throughput no no
UBP7_HUMAN [view interactions] Low throughput no yes
SP3_HUMAN [view interactions] Low throughput no no
SP1_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
TBP_HUMAN [view interactions] Low throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
CD4_HUMAN [view interactions] High throughput no no
BCCIP_HUMAN [view interactions] High throughput no no
SIN1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
FXL13_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
TM169_HUMAN [view interactions] High throughput no yes
T2R19_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
BCL2_HUMAN [view interactions] High throughput no no
MARH1_HUMAN [view interactions] High throughput no yes
LEG9B_HUMAN [view interactions] High throughput no no
CCR6_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
EDAR_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIDN_HUMAN [view interactions] High throughput no no
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LEG9_HUMAN [view interactions] High throughput no yes