MDR1_HUMAN
Evidence for PS localization
Functions
Translocates drugs and phospholipids across the membrane (PubMed, PubMed, PubMed). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MDR1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | yes |
| GO:0046872 | metal ion binding | 27.2727 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 18.1818 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 18.1818 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MDR1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | yes |
| GO:0071702 | organic substance transport | 54.5455 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 54.5455 | 4 | yes |
| GO:0006996 | organelle organization | 54.5455 | 4 | no |
| GO:0008104 | protein localization | 54.5455 | 4 | no |
| GO:0015031 | protein transport | 45.4545 | 4 | no |
| GO:0030030 | cell projection organization | 45.4545 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | no |
| GO:0051049 | regulation of transport | 36.3636 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 36.3636 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 36.3636 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 36.3636 | 4 | no |
| GO:0023056 | positive regulation of signaling | 36.3636 | 4 | no |
| GO:0033365 | protein localization to organelle | 36.3636 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.3636 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 36.3636 | 6 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.3636 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 36.3636 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 27.2727 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 27.2727 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 27.2727 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 27.2727 | 5 | yes |
| GO:0043269 | regulation of ion transport | 27.2727 | 5 | yes |
| GO:0061024 | membrane organization | 27.2727 | 4 | yes |
| GO:0006508 | proteolysis | 27.2727 | 4 | no |
| GO:0006886 | intracellular protein transport | 27.2727 | 4 | no |
| GO:0006897 | endocytosis | 27.2727 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 27.2727 | 6 | no |
| GO:0009057 | macromolecule catabolic process | 27.2727 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0019941 | modification-dependent protein catabolic process | 27.2727 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 27.2727 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 27.2727 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.2727 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 27.2727 | 5 | no |
| GO:0072594 | establishment of protein localization to organelle | 27.2727 | 4 | no |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | no |
| GO:0010941 | regulation of cell death | 27.2727 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 27.2727 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 5 | no |
| GO:0051050 | positive regulation of transport | 18.1818 | 4 | yes |
| GO:0080134 | regulation of response to stress | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RING2_HUMAN | [view interactions] | Low throughput | no | yes |
| LAP4B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| PSB8_HUMAN | [view interactions] | Low throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | Low throughput | no | yes |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| FBX15_HUMAN | [view interactions] | Low throughput | no | no |
| UBA7_HUMAN | [view interactions] | Low throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARH8_HUMAN | [view interactions] | Low throughput | no | no |
| SP3_HUMAN | [view interactions] | Low throughput | no | no |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBP_HUMAN | [view interactions] | Low throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DRC6_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| TM169_HUMAN | [view interactions] | High throughput | no | yes |
| T2R19_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCL2_HUMAN | [view interactions] | High throughput | no | no |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9B_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| EDAR_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CP3A5_HUMAN | [view interactions] | Computational | no | no |
| RFA1_HUMAN | [view interactions] | Computational | no | yes |
| SO1B1_HUMAN | [view interactions] | Computational | no | no |
| MDR3_HUMAN | [view interactions] | Computational | no | no |
| P53_HUMAN | [view interactions] | Computational | no | no |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| RT07_HUMAN | [view interactions] | Computational | no | yes |
| EP300_HUMAN | [view interactions] | Computational | no | yes |
| TAF1_HUMAN | [view interactions] | Computational | no | yes |