Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NECT3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NECT3_HUMAN
GO:0017076 purine nucleotide binding 56.0000 4 no
GO:0032555 purine ribonucleotide binding 52.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 52.0000 4 no
GO:0003924 GTPase activity 40.0000 7 no
GO:0005525 GTP binding 40.0000 5 no
GO:0016462 pyrophosphatase activity 40.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 40.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 40.0000 6 no
GO:0019001 guanyl nucleotide binding 40.0000 5 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 40.0000 5 no
GO:0032561 guanyl ribonucleotide binding 40.0000 5 no
GO:0042803 protein homodimerization activity 16.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NECT3_HUMAN
GO:0048522 positive regulation of cellular process 72.0000 4 no
GO:0033043 regulation of organelle organization 64.0000 5 no
GO:0051128 regulation of cellular component organization 64.0000 4 no
GO:0006996 organelle organization 60.0000 4 no
GO:0048523 negative regulation of cellular process 56.0000 4 no
GO:0031323 regulation of cellular metabolic process 52.0000 4 no
GO:0044087 regulation of cellular component biogenesis 52.0000 4 no
GO:0051493 regulation of cytoskeleton organization 52.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 52.0000 4 no
GO:0007010 cytoskeleton organization 48.0000 5 no
GO:0009893 positive regulation of metabolic process 48.0000 4 no
GO:0010646 regulation of cell communication 48.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 48.0000 4 no
GO:0080090 regulation of primary metabolic process 48.0000 4 no
GO:0022607 cellular component assembly 48.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 44.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 44.0000 5 no
GO:0032970 regulation of actin filament-based process 44.0000 4 no
GO:0042127 regulation of cell population proliferation 44.0000 4 no
GO:0048584 positive regulation of response to stimulus 44.0000 4 no
GO:0007264 small GTPase mediated signal transduction 44.0000 4 no
GO:0030030 cell projection organization 44.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0010941 regulation of cell death 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0007265 Ras protein signal transduction 40.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 40.0000 4 no
GO:0022604 regulation of cell morphogenesis 40.0000 5 no
GO:0030334 regulation of cell migration 40.0000 5 no
GO:2000145 regulation of cell motility 40.0000 4 no
GO:0008104 protein localization 36.0000 4 yes
GO:0008284 positive regulation of cell population proliferation 36.0000 5 no
GO:0009967 positive regulation of signal transduction 36.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 36.0000 6 no
GO:0010647 positive regulation of cell communication 36.0000 5 no
GO:0019220 regulation of phosphate metabolic process 36.0000 6 no
GO:0023056 positive regulation of signaling 36.0000 4 no
GO:0030155 regulation of cell adhesion 36.0000 4 no
GO:0031344 regulation of cell projection organization 36.0000 5 no
GO:0031399 regulation of protein modification process 36.0000 6 no
GO:0042325 regulation of phosphorylation 36.0000 7 no
GO:0042327 positive regulation of phosphorylation 36.0000 8 no
GO:0042981 regulation of apoptotic process 36.0000 6 no
GO:0043067 regulation of programmed cell death 36.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 36.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 36.0000 5 no
GO:0051246 regulation of protein metabolic process 36.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.0000 6 no
GO:1902531 regulation of intracellular signal transduction 36.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 36.0000 6 no
GO:0007015 actin filament organization 36.0000 5 no
GO:0051049 regulation of transport 36.0000 4 no
GO:0097435 supramolecular fiber organization 36.0000 4 no
GO:0001932 regulation of protein phosphorylation 32.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 32.0000 8 no
GO:0002684 positive regulation of immune system process 32.0000 4 no
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0016192 vesicle-mediated transport 32.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.0000 5 no
GO:0031401 positive regulation of protein modification process 32.0000 7 no
GO:0044089 positive regulation of cellular component biogenesis 32.0000 5 no
GO:0051129 negative regulation of cellular component organization 32.0000 5 no
GO:0051247 positive regulation of protein metabolic process 32.0000 6 no
GO:0060548 negative regulation of cell death 32.0000 5 no
GO:0030335 positive regulation of cell migration 32.0000 6 no
GO:0040017 positive regulation of locomotion 32.0000 4 no
GO:0045595 regulation of cell differentiation 32.0000 4 no
GO:0051094 positive regulation of developmental process 32.0000 4 no
GO:0061024 membrane organization 32.0000 4 no
GO:2000147 positive regulation of cell motility 32.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 32.0000 5 no
GO:0031346 positive regulation of cell projection organization 28.0000 6 no
GO:0043066 negative regulation of apoptotic process 28.0000 7 no
GO:0043069 negative regulation of programmed cell death 28.0000 6 no
GO:0060491 regulation of cell projection assembly 28.0000 5 no
GO:0008360 regulation of cell shape 28.0000 6 no
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0010810 regulation of cell-substrate adhesion 28.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 28.0000 4 no
GO:0051726 regulation of cell cycle 28.0000 4 no
GO:0080134 regulation of response to stress 28.0000 4 no
GO:0032880 regulation of protein localization 28.0000 5 no
GO:0051050 positive regulation of transport 28.0000 4 no
GO:0060341 regulation of cellular localization 28.0000 4 no
GO:0072657 protein localization to membrane 24.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 24.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 24.0000 5 no
GO:0045785 positive regulation of cell adhesion 24.0000 5 no
GO:0050776 regulation of immune response 24.0000 4 no
GO:0071310 cellular response to organic substance 24.0000 4 no
GO:0110053 regulation of actin filament organization 24.0000 6 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 24.0000 6 no
GO:1901214 regulation of neuron death 24.0000 5 no
GO:1902903 regulation of supramolecular fiber organization 24.0000 5 no
GO:0002685 regulation of leukocyte migration 24.0000 4 no
GO:0006355 regulation of DNA-templated transcription 24.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 24.0000 5 no
GO:0010638 positive regulation of organelle organization 24.0000 6 no
GO:0030865 cortical cytoskeleton organization 24.0000 6 no
GO:0043085 positive regulation of catalytic activity 24.0000 4 no
GO:0045597 positive regulation of cell differentiation 24.0000 5 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 24.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 24.0000 6 no
GO:0031175 neuron projection development 24.0000 6 no
GO:0032101 regulation of response to external stimulus 24.0000 4 no
GO:0030031 cell projection assembly 24.0000 5 no
GO:0051223 regulation of protein transport 24.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 24.0000 4 no
GO:0070201 regulation of establishment of protein localization 24.0000 6 no
GO:1903829 positive regulation of protein localization 24.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 24.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 24.0000 4 no
GO:0090150 establishment of protein localization to membrane 16.0000 4 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 12.0000 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 12.0000 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 12.0000 4 yes
GO:1902414 protein localization to cell junction 12.0000 5 yes
GO:1990778 protein localization to cell periphery 12.0000 5 yes
GO:0007286 spermatid development 8.0000 4 yes
GO:0061951 establishment of protein localization to plasma membrane 8.0000 5 yes
GO:0072659 protein localization to plasma membrane 8.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AFAD_HUMAN [view interactions] Low throughput no yes
PARD3_HUMAN [view interactions] Low throughput no yes
NECT2_HUMAN [view interactions] Low throughput no no
NECT3_HUMAN [view entry] [view interactions] Low throughput yes yes
NECT1_HUMAN [view interactions] Low throughput no yes
PVR_HUMAN [view interactions] Low throughput no yes
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
SOCS1_HUMAN [view interactions] Low throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
MD2L1_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
SPAST_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
NLRP3_HUMAN [view interactions] High throughput no yes
ERR2_HUMAN [view interactions] High throughput no no
PDK1_HUMAN [view interactions] High throughput no yes
P4R3A_HUMAN [view interactions] High throughput no yes
CNDG2_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
CD81_HUMAN [view interactions] High throughput no no
KR109_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
KR107_HUMAN [view interactions] High throughput no no
RGS20_HUMAN [view interactions] High throughput no no
KRA42_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
TIGIT_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KR103_HUMAN [view interactions] High throughput no no
OTX1_HUMAN [view interactions] High throughput no no
KRA11_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
KRA41_HUMAN [view interactions] High throughput no no
KR511_HUMAN [view interactions] High throughput no no
KRA93_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
KRA59_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
SDF2_HUMAN [view interactions] High throughput no no
ASPH_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
COEA1_HUMAN [view interactions] High throughput no no
MAK_HUMAN [view interactions] High throughput no no
ERO1B_HUMAN [view interactions] High throughput no yes
INP5K_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
HFE_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
T106A_HUMAN [view interactions] High throughput no no
PCDB3_HUMAN [view interactions] High throughput no no
BTNL2_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
CSPG4_HUMAN [view interactions] Computational no yes
P85A_HUMAN [view interactions] Computational no yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
CLD1_HUMAN [view interactions] Computational no no
CADM3_HUMAN [view interactions] Computational no no
CADM1_HUMAN [view entry] [view interactions] Computational yes no
JAM1_HUMAN [view interactions] Computational no yes
PTPRM_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no