DAAM1_HUMAN
Evidence for PS localization
Functions
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed, PubMed). Involved in the organization of the subapical actin network in multiciliated epithelial cells . Together with DAAM2, required for myocardial maturation and sarcomere assembly . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DAAM1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 48.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 48.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 48.0000 | 4 | no |
| GO:0043168 | anion binding | 48.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.0000 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 36.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.0000 | 6 | no |
| GO:0005525 | GTP binding | 36.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 36.0000 | 6 | no |
| GO:0019900 | kinase binding | 36.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 36.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 36.0000 | 5 | no |
| GO:0031267 | small GTPase binding | 32.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 32.0000 | 4 | yes |
| GO:0003924 | GTPase activity | 32.0000 | 7 | no |
| GO:0003779 | actin binding | 28.0000 | 4 | yes |
| GO:0043169 | cation binding | 24.0000 | 4 | no |
| GO:0046872 | metal ion binding | 24.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DAAM1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 60.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 60.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 52.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.0000 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 36.0000 | 4 | no |
| GO:0030030 | cell projection organization | 36.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 36.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 36.0000 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 32.0000 | 4 | no |
| GO:0016055 | Wnt signaling pathway | 32.0000 | 4 | yes |
| GO:0007015 | actin filament organization | 32.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 32.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 32.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.0000 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 32.0000 | 4 | no |
| GO:0051049 | regulation of transport | 32.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.0000 | 4 | no |
| GO:0008104 | protein localization | 28.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.0000 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 28.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 28.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 28.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 24.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
| GO:0034330 | cell junction organization | 24.0000 | 4 | no |
| GO:0035567 | non-canonical Wnt signaling pathway | 24.0000 | 5 | yes |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 24.0000 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 24.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.0000 | 4 | no |
| GO:0030031 | cell projection assembly | 24.0000 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 24.0000 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 24.0000 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 24.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.0000 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 24.0000 | 6 | no |
| GO:2000147 | positive regulation of cell motility | 24.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | no |
| GO:0030865 | cortical cytoskeleton organization | 24.0000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARHGJ_HUMAN | [view interactions] | Low throughput | no | no |
| INTU_HUMAN | [view interactions] | Low throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | Low throughput | no | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMBP_HUMAN | [view interactions] | High throughput | no | no |
| B3GT4_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| GPN3_HUMAN | [view interactions] | High throughput | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| CMAP3_HUMAN | [view interactions] | High throughput | no | no |
| FXL16_HUMAN | [view interactions] | High throughput | no | yes |
| SEHL2_HUMAN | [view interactions] | High throughput | no | no |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| FXL14_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| SPX3_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| CA198_HUMAN | [view interactions] | High throughput | no | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA074_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| CBPQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| DAAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| FHDC1_HUMAN | [view interactions] | High throughput | no | no |
| FMN1_HUMAN | [view interactions] | High throughput | no | no |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMRC_HUMAN | [view interactions] | High throughput | no | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |