Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DAAM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed, PubMed). Involved in the organization of the subapical actin network in multiciliated epithelial cells . Together with DAAM2, required for myocardial maturation and sarcomere assembly . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DAAM1_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 45.8333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 45.8333 4 no
GO:0016462 pyrophosphatase activity 41.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 41.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 41.6667 6 no
GO:0019900 kinase binding 41.6667 4 no
GO:0019901 protein kinase binding 41.6667 5 no
GO:0031267 small GTPase binding 37.5000 5 yes
GO:0051020 GTPase binding 37.5000 4 yes
GO:0003924 GTPase activity 37.5000 7 no
GO:0005525 GTP binding 37.5000 5 no
GO:0019001 guanyl nucleotide binding 37.5000 5 no
GO:0032561 guanyl ribonucleotide binding 37.5000 5 no
GO:0003779 actin binding 33.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DAAM1_HUMAN
GO:0006996 organelle organization 75.0000 4 yes
GO:0007010 cytoskeleton organization 75.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 62.5000 4 yes
GO:0048522 positive regulation of cellular process 54.1667 4 no
GO:0022604 regulation of cell morphogenesis 54.1667 5 no
GO:0022607 cellular component assembly 54.1667 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0051128 regulation of cellular component organization 45.8333 4 no
GO:0030030 cell projection organization 45.8333 4 no
GO:0033043 regulation of organelle organization 41.6667 5 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0008360 regulation of cell shape 41.6667 6 no
GO:0030334 regulation of cell migration 37.5000 5 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0032956 regulation of actin cytoskeleton organization 37.5000 5 no
GO:0032970 regulation of actin filament-based process 37.5000 4 no
GO:0051493 regulation of cytoskeleton organization 37.5000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:2000145 regulation of cell motility 37.5000 4 no
GO:0097435 supramolecular fiber organization 37.5000 4 no
GO:0016055 Wnt signaling pathway 37.5000 5 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 37.5000 4 yes
GO:0030865 cortical cytoskeleton organization 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0007015 actin filament organization 33.3333 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 29.1667 5 no
GO:0051130 positive regulation of cellular component organization 29.1667 5 no
GO:0007264 small GTPase mediated signal transduction 29.1667 4 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0051094 positive regulation of developmental process 29.1667 4 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0051246 regulation of protein metabolic process 29.1667 5 no
GO:0008104 protein localization 29.1667 4 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0060341 regulation of cellular localization 29.1667 4 no
GO:0035567 non-canonical Wnt signaling pathway 29.1667 6 yes
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 29.1667 7 yes
GO:0090175 regulation of establishment of planar polarity 29.1667 6 yes
GO:2000027 regulation of animal organ morphogenesis 29.1667 5 yes
GO:0009966 regulation of signal transduction 29.1667 4 no
GO:0009889 regulation of biosynthetic process 29.1667 4 no
GO:0010468 regulation of gene expression 29.1667 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0002685 regulation of leukocyte migration 25.0000 4 no
GO:0007265 Ras protein signal transduction 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0030031 cell projection assembly 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0043254 regulation of protein-containing complex assembly 20.8333 5 no
GO:0044089 positive regulation of cellular component biogenesis 20.8333 5 no
GO:0050808 synapse organization 20.8333 5 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0110053 regulation of actin filament organization 20.8333 6 no
GO:1902903 regulation of supramolecular fiber organization 20.8333 5 no
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0002009 morphogenesis of an epithelium 20.8333 4 no
GO:0009891 positive regulation of biosynthetic process 20.8333 5 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0010324 membrane invagination 20.8333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0010562 positive regulation of phosphorus metabolic process 20.8333 6 no
GO:0010810 regulation of cell-substrate adhesion 20.8333 5 no
GO:0010941 regulation of cell death 20.8333 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8333 6 no
GO:0040013 negative regulation of locomotion 20.8333 4 no
GO:0042327 positive regulation of phosphorylation 20.8333 8 no
GO:0042981 regulation of apoptotic process 20.8333 6 no
GO:0043067 regulation of programmed cell death 20.8333 5 no
GO:0043549 regulation of kinase activity 20.8333 5 no
GO:0045216 cell-cell junction organization 20.8333 5 no
GO:0045785 positive regulation of cell adhesion 20.8333 5 no
GO:0045937 positive regulation of phosphate metabolic process 20.8333 7 no
GO:0051241 negative regulation of multicellular organismal process 20.8333 4 no
GO:0051338 regulation of transferase activity 20.8333 4 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0099024 plasma membrane invagination 20.8333 6 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:0007411 axon guidance 20.8333 8 no
GO:0032101 regulation of response to external stimulus 20.8333 4 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:0097485 neuron projection guidance 20.8333 7 no
GO:0060284 regulation of cell development 20.8333 5 no
GO:0016192 vesicle-mediated transport 20.8333 4 no
GO:0051336 regulation of hydrolase activity 20.8333 4 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:0010632 regulation of epithelial cell migration 20.8333 4 no
GO:0010638 positive regulation of organelle organization 20.8333 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARHGJ_HUMAN [view interactions] Low throughput no no
INTU_HUMAN [view interactions] Low throughput no yes
NPHP4_HUMAN [view interactions] Low throughput no yes
DVL2_HUMAN [view interactions] Low throughput no yes
DAAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
FBP1L_HUMAN [view interactions] Low throughput no yes
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
FNBP1_HUMAN [view interactions] High throughput no yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
NEP_HUMAN [view interactions] High throughput no no
AMBP_HUMAN [view interactions] High throughput no no
B3GT4_HUMAN [view interactions] High throughput no yes
CBX5_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
GPN3_HUMAN [view interactions] High throughput no yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
T185A_HUMAN [view interactions] High throughput no no
PIFO_HUMAN [view interactions] High throughput no no
FXL16_HUMAN [view interactions] High throughput no yes
SEHL2_HUMAN [view interactions] High throughput no no
RNBP6_HUMAN [view interactions] High throughput no yes
FXL14_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC6_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
SPX3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
CA074_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
GPR12_HUMAN [view interactions] High throughput no no
CBPQ_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOV_HUMAN [view interactions] High throughput no no
CHK2_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
DAAM2_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
FHDC1_HUMAN [view interactions] High throughput no no
FMN1_HUMAN [view interactions] High throughput no no
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
FMNL3_HUMAN [view entry] [view interactions] High throughput yes yes
MTMRC_HUMAN [view interactions] High throughput no yes
PDE6B_HUMAN [view interactions] High throughput no no
PRP18_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] Computational yes yes
SRRM4_HUMAN [view interactions] Computational no no
FZD3_HUMAN [view interactions] Computational no yes
WNT5B_HUMAN [view interactions] Computational no no
FZD7_HUMAN [view interactions] Computational no yes
DVL3_HUMAN [view interactions] Computational no yes
FZD6_HUMAN [view interactions] Computational no yes
WNT11_HUMAN [view interactions] Computational no no
ARHGB_HUMAN [view interactions] Computational no yes
WNT5A_HUMAN [view entry] [view interactions] Computational yes no