Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMNL2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002333 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMNL2_HUMAN
GO:0017076 purine nucleotide binding 44.4444 4 no
GO:0032555 purine ribonucleotide binding 40.7407 4 no
GO:0035639 purine ribonucleoside triphosphate binding 40.7407 4 no
GO:0003924 GTPase activity 33.3333 7 no
GO:0005525 GTP binding 33.3333 5 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0019001 guanyl nucleotide binding 33.3333 5 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0003779 actin binding 25.9259 4 yes
GO:0031267 small GTPase binding 25.9259 5 yes
GO:0051020 GTPase binding 25.9259 4 yes
GO:0019003 GDP binding 25.9259 4 no
GO:0045296 cadherin binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FMNL2_HUMAN
GO:0048522 positive regulation of cellular process 70.3704 4 no
GO:0006996 organelle organization 62.9630 4 yes
GO:0048523 negative regulation of cellular process 59.2593 4 no
GO:0051128 regulation of cellular component organization 59.2593 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0007010 cytoskeleton organization 51.8519 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 51.8519 4 no
GO:0080090 regulation of primary metabolic process 51.8519 4 no
GO:0031323 regulation of cellular metabolic process 48.1481 4 no
GO:0051130 positive regulation of cellular component organization 48.1481 5 no
GO:0010646 regulation of cell communication 48.1481 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0016192 vesicle-mediated transport 44.4444 4 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0030334 regulation of cell migration 40.7407 5 no
GO:2000145 regulation of cell motility 40.7407 4 no
GO:0010468 regulation of gene expression 40.7407 5 no
GO:0033043 regulation of organelle organization 40.7407 5 no
GO:0009966 regulation of signal transduction 40.7407 4 no
GO:0010647 positive regulation of cell communication 40.7407 5 no
GO:0023056 positive regulation of signaling 40.7407 4 no
GO:0031325 positive regulation of cellular metabolic process 40.7407 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.7407 5 no
GO:0022603 regulation of anatomical structure morphogenesis 37.0370 4 yes
GO:0019220 regulation of phosphate metabolic process 37.0370 6 no
GO:0042325 regulation of phosphorylation 37.0370 7 no
GO:0051174 regulation of phosphorus metabolic process 37.0370 5 no
GO:0009967 positive regulation of signal transduction 37.0370 5 no
GO:0022607 cellular component assembly 37.0370 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0032956 regulation of actin cytoskeleton organization 33.3333 5 no
GO:0032970 regulation of actin filament-based process 33.3333 4 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:1902903 regulation of supramolecular fiber organization 33.3333 5 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0022604 regulation of cell morphogenesis 29.6296 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.6296 5 no
GO:0030155 regulation of cell adhesion 29.6296 4 no
GO:0031346 positive regulation of cell projection organization 29.6296 6 no
GO:0051129 negative regulation of cellular component organization 29.6296 5 no
GO:0060491 regulation of cell projection assembly 29.6296 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 29.6296 6 no
GO:0009889 regulation of biosynthetic process 29.6296 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.6296 5 no
GO:0031326 regulation of cellular biosynthetic process 29.6296 5 no
GO:0044089 positive regulation of cellular component biogenesis 29.6296 5 no
GO:0001934 positive regulation of protein phosphorylation 29.6296 8 no
GO:0031401 positive regulation of protein modification process 29.6296 7 no
GO:0042981 regulation of apoptotic process 29.6296 6 no
GO:0043067 regulation of programmed cell death 29.6296 5 no
GO:0071310 cellular response to organic substance 29.6296 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.6296 6 no
GO:0120036 plasma membrane bounded cell projection organization 29.6296 5 no
GO:0051050 positive regulation of transport 29.6296 4 no
GO:0060627 regulation of vesicle-mediated transport 29.6296 4 no
GO:0030865 cortical cytoskeleton organization 25.9259 6 yes
GO:0043085 positive regulation of catalytic activity 25.9259 4 no
GO:0043549 regulation of kinase activity 25.9259 5 no
GO:0051093 negative regulation of developmental process 25.9259 4 no
GO:0051338 regulation of transferase activity 25.9259 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.9259 5 no
GO:0034330 cell junction organization 25.9259 4 no
GO:0043254 regulation of protein-containing complex assembly 25.9259 5 no
GO:0051252 regulation of RNA metabolic process 25.9259 5 no
GO:0110053 regulation of actin filament organization 25.9259 6 no
GO:1902905 positive regulation of supramolecular fiber organization 25.9259 6 no
GO:0015031 protein transport 25.9259 4 no
GO:0007264 small GTPase mediated signal transduction 25.9259 4 no
GO:0007265 Ras protein signal transduction 25.9259 5 no
GO:0010628 positive regulation of gene expression 25.9259 6 no
GO:0030162 regulation of proteolysis 25.9259 6 no
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 no
GO:1901214 regulation of neuron death 25.9259 5 no
GO:0080134 regulation of response to stress 25.9259 4 no
GO:0030100 regulation of endocytosis 25.9259 5 no
GO:0008360 regulation of cell shape 22.2222 6 yes
GO:0010632 regulation of epithelial cell migration 22.2222 4 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0045596 negative regulation of cell differentiation 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0051495 positive regulation of cytoskeleton organization 22.2222 7 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0002684 positive regulation of immune system process 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0016055 Wnt signaling pathway 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 22.2222 4 no
GO:0006897 endocytosis 22.2222 5 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:0030866 cortical actin cytoskeleton organization 14.8148 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
SPB4_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
DR9C7_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no
INVO_HUMAN [view interactions] High throughput no no
S1A7A_HUMAN [view interactions] High throughput no no
NGAL_HUMAN [view interactions] High throughput no no
FMNL3_HUMAN [view entry] [view interactions] High throughput yes yes
POF1B_HUMAN [view interactions] High throughput no no
CRIP2_HUMAN [view entry] [view interactions] High throughput yes no
KAD4_HUMAN [view interactions] High throughput no yes
SPRY4_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM2_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no
PDE6B_HUMAN [view interactions] High throughput no no
PRP18_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP3_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
PR40A_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
NPHP3_HUMAN [view interactions] High throughput no yes
PNMA1_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
THIOM_HUMAN [view interactions] High throughput no yes
NECA1_HUMAN [view interactions] High throughput no yes
SUOX_HUMAN [view interactions] High throughput no no
MIPO1_HUMAN [view interactions] High throughput no yes
K1C27_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
U119A_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes