Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMNL2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002333 MOD_NMyristoyl MOD 1 7 -
ELMI002333 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMNL2_HUMAN
GO:0043168 anion binding 40.6250 4 no
GO:0000166 nucleotide binding 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0003924 GTPase activity 28.1250 7 no
GO:0005525 GTP binding 28.1250 5 no
GO:0016462 pyrophosphatase activity 28.1250 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.1250 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.1250 6 no
GO:0019001 guanyl nucleotide binding 28.1250 6 no
GO:0032561 guanyl ribonucleotide binding 28.1250 5 no
GO:0003779 actin binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0031267 small GTPase binding 21.8750 5 yes
GO:0051020 GTPase binding 21.8750 4 yes
GO:0045296 cadherin binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FMNL2_HUMAN
GO:0048522 positive regulation of cellular process 65.6250 4 no
GO:0006996 organelle organization 65.6250 4 yes
GO:0051128 regulation of cellular component organization 59.3750 4 no
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0010646 regulation of cell communication 56.2500 4 no
GO:0060255 regulation of macromolecule metabolic process 53.1250 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0022607 cellular component assembly 46.8750 4 no
GO:0009893 positive regulation of metabolic process 46.8750 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.8750 5 no
GO:0031323 regulation of cellular metabolic process 46.8750 4 no
GO:2000145 regulation of cell motility 43.7500 4 no
GO:0044087 regulation of cellular component biogenesis 43.7500 4 no
GO:0007010 cytoskeleton organization 43.7500 5 yes
GO:0009889 regulation of biosynthetic process 43.7500 4 no
GO:0009966 regulation of signal transduction 43.7500 4 no
GO:0010468 regulation of gene expression 43.7500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.7500 5 no
GO:0031326 regulation of cellular biosynthetic process 43.7500 5 no
GO:0048584 positive regulation of response to stimulus 40.6250 4 no
GO:0051130 positive regulation of cellular component organization 40.6250 5 no
GO:0051246 regulation of protein metabolic process 40.6250 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.6250 6 no
GO:0071702 organic substance transport 40.6250 4 no
GO:0010647 positive regulation of cell communication 40.6250 5 no
GO:0023056 positive regulation of signaling 40.6250 4 no
GO:0030334 regulation of cell migration 40.6250 5 no
GO:0031325 positive regulation of cellular metabolic process 40.6250 5 no
GO:0031344 regulation of cell projection organization 40.6250 5 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0051049 regulation of transport 34.3750 4 no
GO:0051247 positive regulation of protein metabolic process 34.3750 6 no
GO:2000147 positive regulation of cell motility 34.3750 5 no
GO:0030030 cell projection organization 34.3750 4 no
GO:0030335 positive regulation of cell migration 34.3750 6 no
GO:0040017 positive regulation of locomotion 34.3750 4 no
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0042981 regulation of apoptotic process 31.2500 5 no
GO:0043067 regulation of programmed cell death 31.2500 4 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:1902533 positive regulation of intracellular signal transduction 31.2500 6 no
GO:0009891 positive regulation of biosynthetic process 31.2500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0051129 negative regulation of cellular component organization 31.2500 5 no
GO:0141124 intracellular signaling cassette 31.2500 4 no
GO:0032970 regulation of actin filament-based process 31.2500 4 no
GO:0033043 regulation of organelle organization 31.2500 5 no
GO:1902903 regulation of supramolecular fiber organization 31.2500 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 yes
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0045595 regulation of cell differentiation 28.1250 4 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:0032956 regulation of actin cytoskeleton organization 28.1250 5 no
GO:0051493 regulation of cytoskeleton organization 28.1250 6 no
GO:0034330 cell junction organization 28.1250 4 no
GO:0050804 modulation of chemical synaptic transmission 28.1250 5 no
GO:0099177 regulation of trans-synaptic signaling 28.1250 4 no
GO:0015031 protein transport 28.1250 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.1250 5 no
GO:0031346 positive regulation of cell projection organization 28.1250 6 no
GO:0031401 positive regulation of protein modification process 28.1250 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0110053 regulation of actin filament organization 25.0000 6 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no
GO:0007264 small GTPase-mediated signal transduction 25.0000 5 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0098657 import into cell 25.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0043408 regulation of MAPK cascade 21.8750 6 no
GO:0051241 negative regulation of multicellular organismal process 21.8750 4 no
GO:0060284 regulation of cell development 21.8750 5 no
GO:0071310 cellular response to organic substance 21.8750 4 no
GO:0043066 negative regulation of apoptotic process 21.8750 6 no
GO:0043069 negative regulation of programmed cell death 21.8750 5 no
GO:0043523 regulation of neuron apoptotic process 21.8750 6 no
GO:0030100 regulation of endocytosis 21.8750 5 no
GO:0097435 supramolecular fiber organization 21.8750 4 no
GO:1902905 positive regulation of supramolecular fiber organization 21.8750 6 no
GO:0051050 positive regulation of transport 21.8750 4 no
GO:0031175 neuron projection development 21.8750 6 no
GO:0022604 regulation of cell morphogenesis 18.7500 5 yes
GO:0030865 cortical cytoskeleton organization 15.6250 6 yes
GO:0030866 cortical actin cytoskeleton organization 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] High throughput no no
WRP73_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NRIP1_HUMAN [view interactions] High throughput no yes
PKNX1_HUMAN [view interactions] High throughput no yes
TTC3_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
KCNK3_HUMAN [view interactions] High throughput no no
NPHP3_HUMAN [view interactions] High throughput no yes
PNMA1_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
THIOM_HUMAN [view interactions] High throughput no yes
NECA1_HUMAN [view interactions] High throughput no yes
SUOX_HUMAN [view interactions] High throughput no no
MIPO1_HUMAN [view interactions] High throughput no yes
K1C27_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
U119A_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
SPB4_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
DR9C7_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no
INVO_HUMAN [view interactions] High throughput no no
S1A7A_HUMAN [view interactions] High throughput no no
NGAL_HUMAN [view interactions] High throughput no no
FMNL3_HUMAN [view entry] [view interactions] High throughput yes yes
POF1B_HUMAN [view interactions] High throughput no no
CRIP2_HUMAN [view entry] [view interactions] High throughput yes no
KAD4_HUMAN [view interactions] High throughput no yes
SPRY4_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM2_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no
PDE6B_HUMAN [view interactions] High throughput no no
PRP18_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP3_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
ARL3_HUMAN [view interactions] High throughput no yes