AACT_HUMAN
Evidence for PS localization
Functions
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AACT_HUMAN has binary interactions with 21 proteins
Isoforms
Interacting regions
Canonical [AACT_HUMAN]
Isoform [P01011-2] alignment
Isoform [P01011-3] alignment
Isoform [G3V595] alignment
Isoform [G3V3A0] alignment
Isoform [A0A087WY93] alignment
LOADING 39%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AACT_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.3636 | 4 | no |
| GO:0000166 | nucleotide binding | 31.8182 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.2727 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0003677 | DNA binding | 22.7273 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.7273 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | no |
| GO:0004866 | endopeptidase inhibitor activity | 13.6364 | 5 | yes |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 13.6364 | 6 | yes |
| GO:0030414 | peptidase inhibitor activity | 13.6364 | 4 | yes |
| GO:0061135 | endopeptidase regulator activity | 13.6364 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AACT_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0043933 | protein-containing complex organization | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 40.9091 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.8182 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.8182 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 31.8182 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.8182 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.8182 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.8182 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 27.2727 | 5 | no |
| GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.2727 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| A1AG1_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AACT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADH1B_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| CATG_HUMAN | [view interactions] | High throughput | no | no |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| CERU_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COE2_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| CXB5_HUMAN | [view interactions] | High throughput | no | no |