AACT_HUMAN
Evidence for PS localization
Functions
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AACT_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.3636 | 4 | no |
| GO:0000166 | nucleotide binding | 31.8182 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.2727 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0003677 | DNA binding | 22.7273 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.7273 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | no |
| GO:0004866 | endopeptidase inhibitor activity | 13.6364 | 5 | yes |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 13.6364 | 6 | yes |
| GO:0030414 | peptidase inhibitor activity | 13.6364 | 4 | yes |
| GO:0061135 | endopeptidase regulator activity | 13.6364 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AACT_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0043933 | protein-containing complex organization | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 40.9091 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.8182 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.8182 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 31.8182 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.8182 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.8182 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.8182 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 27.2727 | 5 | no |
| GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.2727 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.2727 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
| GO:0015031 | protein transport | 27.2727 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.7273 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.7273 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 22.7273 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.7273 | 4 | no |
| GO:0051049 | regulation of transport | 22.7273 | 4 | no |
| GO:0001817 | regulation of cytokine production | 22.7273 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.7273 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.7273 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.7273 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 22.7273 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.7273 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.7273 | 6 | no |
| GO:0033365 | protein localization to organelle | 22.7273 | 5 | no |
| GO:0055080 | monoatomic cation homeostasis | 22.7273 | 4 | no |
| GO:0019216 | regulation of lipid metabolic process | 13.6364 | 5 | yes |
| GO:0001894 | tissue homeostasis | 9.0909 | 4 | yes |
| GO:0002526 | acute inflammatory response | 9.0909 | 5 | yes |
| GO:0006953 | acute-phase response | 9.0909 | 6 | yes |
| GO:0006954 | inflammatory response | 9.0909 | 4 | yes |
| GO:0010669 | epithelial structure maintenance | 9.0909 | 5 | yes |
| GO:0030277 | maintenance of gastrointestinal epithelium | 9.0909 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DNJC1_HUMAN | [view interactions] | Low throughput | no | yes |
| KLK3_HUMAN | [view interactions] | Low throughput | no | no |
| KLK13_HUMAN | [view interactions] | Low throughput | no | no |
| KLK2_HUMAN | [view interactions] | Low throughput | no | no |
| ELNE_HUMAN | [view interactions] | Low throughput | no | no |
| AACT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RPA12_HUMAN | [view interactions] | High throughput | no | yes |
| MRP5_HUMAN | [view interactions] | High throughput | no | no |
| LAMC3_HUMAN | [view interactions] | High throughput | no | no |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| DDX31_HUMAN | [view interactions] | High throughput | no | no |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADH1B_HUMAN | [view interactions] | High throughput | no | no |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| SGCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| GDPD1_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| PHAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| SENP2_HUMAN | [view interactions] | High throughput | no | yes |
| VTDB_HUMAN | [view interactions] | High throughput | no | yes |
| CERU_HUMAN | [view interactions] | High throughput | no | no |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMO_HUMAN | [view interactions] | High throughput | no | no |
| A1AG1_HUMAN | [view interactions] | High throughput | no | no |
| PROL4_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| STAT_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HPT_HUMAN | [view interactions] | High throughput | no | no |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| LCN1_HUMAN | [view interactions] | High throughput | no | no |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| MED24_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| KLH11_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| T176B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN674_HUMAN | [view interactions] | High throughput | no | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| CXB5_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| F227B_HUMAN | [view interactions] | High throughput | no | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| COE2_HUMAN | [view interactions] | High throughput | no | no |
| TSSP_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| PLD5_HUMAN | [view interactions] | High throughput | no | no |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
| PCP4_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| THA10_HUMAN | [view interactions] | High throughput | no | no |
| SFXN4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSTL1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| NECT2_HUMAN | [view interactions] | High throughput | no | no |
| CATG_HUMAN | [view interactions] | High throughput | no | no |
| RN115_HUMAN | [view interactions] | High throughput | no | yes |
| G6PT1_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| PDE6D_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT3_HUMAN | [view interactions] | High throughput | no | yes |
| SH23A_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| MOGT3_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| NFAM1_HUMAN | [view interactions] | High throughput | no | yes |
| CIR1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPA12_HUMAN | [view interactions] | High throughput | no | no |
| FA5_HUMAN | [view interactions] | High throughput | no | no |
| THBG_HUMAN | [view interactions] | High throughput | no | no |
| SPI2_HUMAN | [view interactions] | High throughput | no | no |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |