Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AACT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AACT_HUMAN
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0003677 DNA binding 23.8095 4 yes
GO:0030554 adenyl nucleotide binding 23.8095 5 no
GO:0032559 adenyl ribonucleotide binding 23.8095 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8095 4 no
GO:0004866 endopeptidase inhibitor activity 14.2857 5 yes
GO:0004867 serine-type endopeptidase inhibitor activity 14.2857 6 yes
GO:0030414 peptidase inhibitor activity 14.2857 4 yes
GO:0061135 endopeptidase regulator activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AACT_HUMAN
GO:0060255 regulation of macromolecule metabolic process 47.6190 4 yes
GO:0048522 positive regulation of cellular process 47.6190 4 no
GO:0051171 regulation of nitrogen compound metabolic process 42.8571 4 yes
GO:0051246 regulation of protein metabolic process 42.8571 5 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0031323 regulation of cellular metabolic process 38.0952 4 no
GO:0043933 protein-containing complex organization 38.0952 4 no
GO:0051240 positive regulation of multicellular organismal process 38.0952 4 no
GO:0010646 regulation of cell communication 38.0952 4 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0030162 regulation of proteolysis 28.5714 6 yes
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0048878 chemical homeostasis 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0009892 negative regulation of metabolic process 23.8095 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 23.8095 5 yes
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0044087 regulation of cellular component biogenesis 23.8095 4 no
GO:0050801 ion homeostasis 23.8095 5 no
GO:0055080 cation homeostasis 23.8095 6 no
GO:0098771 inorganic ion homeostasis 23.8095 6 no
GO:0001817 regulation of cytokine production 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010468 regulation of gene expression 23.8095 5 no
GO:0010628 positive regulation of gene expression 23.8095 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:0031325 positive regulation of cellular metabolic process 23.8095 5 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.8095 6 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0031329 regulation of cellular catabolic process 23.8095 5 no
GO:0051049 regulation of transport 23.8095 4 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0019216 regulation of lipid metabolic process 19.0476 5 yes
GO:0051336 regulation of hydrolase activity 19.0476 4 yes
GO:0052547 regulation of peptidase activity 19.0476 5 yes
GO:0052548 regulation of endopeptidase activity 19.0476 6 yes
GO:0051248 negative regulation of protein metabolic process 14.2857 6 yes
GO:0001894 tissue homeostasis 9.5238 5 yes
GO:0002526 acute inflammatory response 9.5238 5 yes
GO:0006953 acute-phase response 9.5238 6 yes
GO:0006954 inflammatory response 9.5238 4 yes
GO:0010466 negative regulation of peptidase activity 9.5238 6 yes
GO:0010669 epithelial structure maintenance 9.5238 6 yes
GO:0010951 negative regulation of endopeptidase activity 9.5238 7 yes
GO:0030277 maintenance of gastrointestinal epithelium 9.5238 4 yes
GO:0043086 negative regulation of catalytic activity 9.5238 4 yes
GO:0045861 negative regulation of proteolysis 9.5238 7 yes
GO:0051346 negative regulation of hydrolase activity 9.5238 5 yes
GO:0060249 anatomical structure homeostasis 9.5238 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in AACT_HUMAN
DOID:0060286 combined oxidative phosphorylation deficiency 9.5238 4 no
DOID:700 mitochondrial metabolism disease 9.5238 3 no
DOID:331 central nervous system disease 9.5238 3 no
DOID:936 brain disease 9.5238 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLK13_HUMAN [view interactions] Low throughput no no
KLK2_HUMAN [view interactions] Low throughput no no
ELNE_HUMAN [view interactions] Low throughput no no
AACT_HUMAN [view entry] [view interactions] Low throughput yes no
DNJC1_HUMAN [view interactions] Low throughput no yes
KLK3_HUMAN [view interactions] Low throughput no no
T176B_HUMAN [view interactions] High throughput no yes
ZN674_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
CXB5_HUMAN [view interactions] High throughput no no
GABPA_HUMAN [view interactions] High throughput no no
F227B_HUMAN [view interactions] High throughput no yes
GBG8_HUMAN [view interactions] High throughput no no
COE2_HUMAN [view interactions] High throughput no no
TSSP_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
PLD5_HUMAN [view interactions] High throughput no no
EMC4_HUMAN [view interactions] High throughput no yes
UBE2U_HUMAN [view interactions] High throughput no no
MATN2_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
ZDHC6_HUMAN [view interactions] High throughput no no
PCP4_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
CCNC_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
THA10_HUMAN [view interactions] High throughput no no
SFXN4_HUMAN [view interactions] High throughput no yes
TRI41_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
PHF11_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
FSTL1_HUMAN [view interactions] High throughput no yes
EGFL8_HUMAN [view interactions] High throughput no no
NECT2_HUMAN [view interactions] High throughput no no
CATG_HUMAN [view interactions] High throughput no no
RN115_HUMAN [view interactions] High throughput no yes
G6PT1_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
PDE6D_HUMAN [view interactions] High throughput no yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
SG1D1_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
APTX_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
NUDT3_HUMAN [view interactions] High throughput no yes
SH23A_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
MOGT3_HUMAN [view interactions] High throughput no yes
PLCA_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
NFAM1_HUMAN [view interactions] High throughput no yes
CIR1_HUMAN [view interactions] High throughput no yes
P2RX6_HUMAN [view entry] [view interactions] High throughput yes no
UPK1A_HUMAN [view interactions] High throughput no no
TGO1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
SPA12_HUMAN [view interactions] High throughput no no
FA5_HUMAN [view interactions] High throughput no no
THBG_HUMAN [view interactions] High throughput no no
SPI2_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
RPA12_HUMAN [view interactions] High throughput no yes
MRP5_HUMAN [view interactions] High throughput no no
LAMC3_HUMAN [view interactions] High throughput no no
TB22B_HUMAN [view interactions] High throughput no no
DDX31_HUMAN [view interactions] High throughput no no
ZIC1_HUMAN [view interactions] High throughput no yes
SHCAF_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ADH1B_HUMAN [view interactions] High throughput no no
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
CASP6_HUMAN [view interactions] High throughput no no
SHLB1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NSD2_HUMAN [view interactions] High throughput no yes
SGCD_HUMAN [view entry] [view interactions] High throughput yes no
PSA3_HUMAN [view interactions] High throughput no no
VATB1_HUMAN [view interactions] High throughput no no
GDPD1_HUMAN [view interactions] High throughput no no
DD19B_HUMAN [view interactions] High throughput no yes
PHAF1_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
MPI_HUMAN [view interactions] High throughput no yes
CDK15_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
FGF11_HUMAN [view interactions] High throughput no no
SENP2_HUMAN [view interactions] High throughput no yes
VTDB_HUMAN [view interactions] High throughput no yes
CERU_HUMAN [view interactions] High throughput no no
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
HEMO_HUMAN [view interactions] High throughput no no
A1AG1_HUMAN [view interactions] High throughput no no
PROL4_HUMAN [view interactions] High throughput no no
A1AT_HUMAN [view interactions] High throughput no no
STAT_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
HPT_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
LCN1_HUMAN [view interactions] High throughput no no
HBB_HUMAN [view interactions] High throughput no no
MED24_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX60_HUMAN [view interactions] High throughput no no
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
ELOA2_HUMAN [view interactions] High throughput no yes
KLH11_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
STX17_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] Computational no yes