DAAM2_HUMAN
Evidence for PS localization
Functions
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DAAM2_HUMAN |
|---|---|---|---|---|
| GO:0031267 | small GTPase binding | 60.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 60.0000 | 4 | yes |
| GO:0003779 | actin binding | 50.0000 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DAAM2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 90.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 70.0000 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 70.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 50.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 40.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | yes |
| GO:0016055 | Wnt signaling pathway | 40.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 40.0000 | 4 | yes |
| GO:0008360 | regulation of cell shape | 40.0000 | 6 | no |
| GO:0030865 | cortical cytoskeleton organization | 40.0000 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 30.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 30.0000 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 30.0000 | 4 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 30.0000 | 4 | no |
| GO:0035567 | non-canonical Wnt signaling pathway | 30.0000 | 6 | no |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 30.0000 | 7 | no |
| GO:0090175 | regulation of establishment of planar polarity | 30.0000 | 6 | no |
| GO:2000027 | regulation of animal organ morphogenesis | 30.0000 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0030162 | regulation of proteolysis | 30.0000 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0032990 | cell part morphogenesis | 30.0000 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 30.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0043549 | regulation of kinase activity | 30.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 30.0000 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 30.0000 | 7 | no |
| GO:0048858 | cell projection morphogenesis | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 30.0000 | 6 | no |
| GO:0001667 | ameboidal-type cell migration | 20.0000 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 20.0000 | 6 | yes |
| GO:0010631 | epithelial cell migration | 20.0000 | 5 | yes |
| GO:0030832 | regulation of actin filament length | 20.0000 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 20.0000 | 7 | yes |
| GO:0032271 | regulation of protein polymerization | 20.0000 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 20.0000 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 20.0000 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 20.0000 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 20.0000 | 6 | yes |
| GO:0110053 | regulation of actin filament organization | 20.0000 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CD320_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| PRAME_HUMAN | [view interactions] | High throughput | no | no |
| AVR2A_HUMAN | [view interactions] | High throughput | no | yes |
| SG2A1_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| RBY1A_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| RBY1F_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| KR101_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| TY3H_HUMAN | [view interactions] | High throughput | no | no |
| KCIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NF2IP_HUMAN | [view interactions] | High throughput | no | no |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| FHDC1_HUMAN | [view interactions] | High throughput | no | no |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | Computational | no | yes |
| DVL3_HUMAN | [view interactions] | Computational | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DVL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |