DAAM2_HUMAN
Evidence for PS localization
Functions
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DAAM2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 50.0000 | 4 | yes |
| GO:0031267 | small GTPase binding | 50.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 50.0000 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 40.0000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 30.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DAAM2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 70.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 50.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 40.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0016055 | Wnt signaling pathway | 30.0000 | 4 | yes |
| GO:0030334 | regulation of cell migration | 30.0000 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 30.0000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 30.0000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 30.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 30.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 30.0000 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 30.0000 | 5 | yes |
| GO:0030865 | cortical cytoskeleton organization | 30.0000 | 6 | no |
| GO:0030866 | cortical actin cytoskeleton organization | 30.0000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.0000 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0006508 | proteolysis | 30.0000 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 30.0000 | 4 | no |
| GO:0016567 | protein ubiquitination | 30.0000 | 8 | no |
| GO:0019941 | modification-dependent protein catabolic process | 30.0000 | 6 | no |
| GO:0032446 | protein modification by small protein conjugation | 30.0000 | 7 | no |
| GO:0036211 | protein modification process | 30.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 30.0000 | 5 | no |
| GO:0043687 | post-translational protein modification | 30.0000 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 30.0000 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 30.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 20.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 20.0000 | 4 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 20.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 20.0000 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 20.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 20.0000 | 5 | yes |
| GO:0060284 | regulation of cell development | 20.0000 | 5 | yes |
| GO:2000050 | regulation of non-canonical Wnt signaling pathway | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| SG2A1_HUMAN | [view interactions] | High throughput | no | no |
| AVR2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRAME_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CD320_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| RBY1A_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| RBY1F_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| KR101_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| TY3H_HUMAN | [view interactions] | High throughput | no | no |
| KCIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NF2IP_HUMAN | [view interactions] | High throughput | no | no |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| FHDC1_HUMAN | [view interactions] | High throughput | no | no |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |