Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMNL3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis . In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMNL3_HUMAN
GO:0003779 actin binding 47.3684 4 yes
GO:0031267 small GTPase binding 36.8421 5 yes
GO:0051020 GTPase binding 36.8421 4 yes
GO:0000166 nucleotide binding 31.5789 4 no
GO:0017076 purine nucleotide binding 31.5789 5 no
GO:0032555 purine ribonucleotide binding 31.5789 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.5789 4 no
GO:0043168 anion binding 31.5789 4 no
GO:0019900 kinase binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FMNL3_HUMAN
GO:0006996 organelle organization 68.4211 4 yes
GO:0007010 cytoskeleton organization 57.8947 5 yes
GO:0022607 cellular component assembly 52.6316 4 yes
GO:0048522 positive regulation of cellular process 52.6316 4 no
GO:0009966 regulation of signal transduction 47.3684 4 no
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0048584 positive regulation of response to stimulus 47.3684 4 no
GO:0048523 negative regulation of cellular process 47.3684 4 no
GO:0051128 regulation of cellular component organization 47.3684 4 no
GO:0009967 positive regulation of signal transduction 42.1053 5 no
GO:0010647 positive regulation of cell communication 42.1053 5 no
GO:0023056 positive regulation of signaling 42.1053 4 no
GO:0030030 cell projection organization 36.8421 4 yes
GO:0060255 regulation of macromolecule metabolic process 36.8421 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:0030334 regulation of cell migration 36.8421 5 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0051130 positive regulation of cellular component organization 36.8421 5 no
GO:2000145 regulation of cell motility 36.8421 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.5789 4 yes
GO:0120036 plasma membrane bounded cell projection organization 31.5789 5 yes
GO:0009893 positive regulation of metabolic process 31.5789 4 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0031323 regulation of cellular metabolic process 31.5789 4 no
GO:0031344 regulation of cell projection organization 31.5789 5 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0097435 supramolecular fiber organization 31.5789 4 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 no
GO:0022604 regulation of cell morphogenesis 26.3158 5 yes
GO:0030031 cell projection assembly 26.3158 5 yes
GO:0008104 protein localization 26.3158 4 no
GO:0009889 regulation of biosynthetic process 26.3158 4 no
GO:0010564 regulation of cell cycle process 26.3158 5 no
GO:0051726 regulation of cell cycle 26.3158 4 no
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0002684 positive regulation of immune system process 26.3158 4 no
GO:0007015 actin filament organization 26.3158 5 no
GO:0010604 positive regulation of macromolecule metabolic process 26.3158 5 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0030155 regulation of cell adhesion 26.3158 4 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0042981 regulation of apoptotic process 26.3158 5 no
GO:0043067 regulation of programmed cell death 26.3158 4 no
GO:0045595 regulation of cell differentiation 26.3158 4 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:1902903 regulation of supramolecular fiber organization 26.3158 5 no
GO:0030335 positive regulation of cell migration 26.3158 6 no
GO:0040017 positive regulation of locomotion 26.3158 4 no
GO:2000147 positive regulation of cell motility 26.3158 5 no
GO:0030865 cortical cytoskeleton organization 21.0526 6 yes
GO:0030866 cortical actin cytoskeleton organization 21.0526 4 yes
GO:0046847 filopodium assembly 21.0526 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 21.0526 6 yes
GO:0001667 ameboidal-type cell migration 21.0526 4 no
GO:0009892 negative regulation of metabolic process 21.0526 4 no
GO:0034097 response to cytokine 21.0526 4 no
GO:0045787 positive regulation of cell cycle 21.0526 5 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0090068 positive regulation of cell cycle process 21.0526 6 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0002694 regulation of leukocyte activation 21.0526 4 no
GO:0006915 apoptotic process 21.0526 4 no
GO:0010468 regulation of gene expression 21.0526 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.0526 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0010810 regulation of cell-substrate adhesion 21.0526 5 no
GO:0031325 positive regulation of cellular metabolic process 21.0526 5 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0031346 positive regulation of cell projection organization 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0032956 regulation of actin cytoskeleton organization 21.0526 5 no
GO:0032970 regulation of actin filament-based process 21.0526 4 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0036211 protein modification process 21.0526 4 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.0526 5 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:0050865 regulation of cell activation 21.0526 4 no
GO:0051046 regulation of secretion 21.0526 5 no
GO:0051247 positive regulation of protein metabolic process 21.0526 6 no
GO:0051493 regulation of cytoskeleton organization 21.0526 6 no
GO:0110053 regulation of actin filament organization 21.0526 6 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:1902905 positive regulation of supramolecular fiber organization 21.0526 6 no
GO:0048812 neuron projection morphogenesis 21.0526 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.0526 4 no
GO:0016055 Wnt signaling pathway 21.0526 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0034329 cell junction assembly 21.0526 5 no
GO:0034330 cell junction organization 21.0526 4 no
GO:0042127 regulation of cell population proliferation 21.0526 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
FMNL1_HUMAN [view entry] [view interactions] Low throughput yes no
PR40A_HUMAN [view interactions] Low throughput no no
FMNL3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
H14_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
8ODP_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT7B_HUMAN [view interactions] High throughput no no
UBXN7_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
PLAK2_HUMAN [view interactions] High throughput no no
MAP2_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
TREX2_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD1_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
NAA11_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM2_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
CSRP3_HUMAN [view interactions] High throughput no no
DIAP1_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
FHDC1_HUMAN [view interactions] High throughput no no
FMN1_HUMAN [view interactions] High throughput no no
PRP18_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes