Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMNL3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis . In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMNL3_HUMAN
GO:0003779 actin binding 52.9412 4 yes
GO:0031267 small GTPase binding 41.1765 5 yes
GO:0051020 GTPase binding 41.1765 4 yes
GO:0017076 purine nucleotide binding 29.4118 4 no
GO:0032555 purine ribonucleotide binding 29.4118 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in FMNL3_HUMAN
GO:0006996 organelle organization 76.4706 4 yes
GO:0007010 cytoskeleton organization 64.7059 5 yes
GO:0048522 positive regulation of cellular process 58.8235 4 no
GO:0022603 regulation of anatomical structure morphogenesis 52.9412 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0022604 regulation of cell morphogenesis 47.0588 5 yes
GO:0031323 regulation of cellular metabolic process 47.0588 4 no
GO:0048584 positive regulation of response to stimulus 47.0588 4 no
GO:0051049 regulation of transport 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0010646 regulation of cell communication 47.0588 4 no
GO:0022607 cellular component assembly 41.1765 4 no
GO:0051128 regulation of cellular component organization 41.1765 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0080090 regulation of primary metabolic process 41.1765 4 no
GO:0009967 positive regulation of signal transduction 41.1765 5 no
GO:0010647 positive regulation of cell communication 41.1765 5 no
GO:0023056 positive regulation of signaling 41.1765 4 no
GO:0008360 regulation of cell shape 35.2941 6 yes
GO:0030865 cortical cytoskeleton organization 35.2941 6 yes
GO:0030030 cell projection organization 35.2941 4 no
GO:0031344 regulation of cell projection organization 35.2941 5 no
GO:0060627 regulation of vesicle-mediated transport 35.2941 4 no
GO:0009893 positive regulation of metabolic process 35.2941 4 no
GO:0031325 positive regulation of cellular metabolic process 35.2941 5 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0033043 regulation of organelle organization 29.4118 5 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0051130 positive regulation of cellular component organization 29.4118 5 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0097435 supramolecular fiber organization 29.4118 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 no
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 no
GO:1903829 positive regulation of protein localization 29.4118 5 no
GO:0032990 cell part morphogenesis 29.4118 4 no
GO:0043085 positive regulation of catalytic activity 29.4118 4 no
GO:0048812 neuron projection morphogenesis 29.4118 7 no
GO:0048858 cell projection morphogenesis 29.4118 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 29.4118 6 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0009889 regulation of biosynthetic process 29.4118 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0031326 regulation of cellular biosynthetic process 29.4118 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0010941 regulation of cell death 29.4118 4 no
GO:0042981 regulation of apoptotic process 29.4118 6 no
GO:0043067 regulation of programmed cell death 29.4118 5 no
GO:0010564 regulation of cell cycle process 29.4118 5 no
GO:0051246 regulation of protein metabolic process 29.4118 5 no
GO:0051726 regulation of cell cycle 29.4118 4 no
GO:0019220 regulation of phosphate metabolic process 29.4118 6 no
GO:0042325 regulation of phosphorylation 29.4118 7 no
GO:0051174 regulation of phosphorus metabolic process 29.4118 5 no
GO:0045595 regulation of cell differentiation 29.4118 4 no
GO:0030866 cortical actin cytoskeleton organization 23.5294 4 yes
GO:0002684 positive regulation of immune system process 23.5294 4 no
GO:0007015 actin filament organization 23.5294 5 no
GO:0030155 regulation of cell adhesion 23.5294 4 no
GO:0030334 regulation of cell migration 23.5294 5 no
GO:0031175 neuron projection development 23.5294 6 no
GO:0032956 regulation of actin cytoskeleton organization 23.5294 5 no
GO:0032970 regulation of actin filament-based process 23.5294 4 no
GO:0042127 regulation of cell population proliferation 23.5294 4 no
GO:0050865 regulation of cell activation 23.5294 4 no
GO:0051046 regulation of secretion 23.5294 5 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0051222 positive regulation of protein transport 23.5294 5 no
GO:0051223 regulation of protein transport 23.5294 5 no
GO:0051493 regulation of cytoskeleton organization 23.5294 6 no
GO:0061024 membrane organization 23.5294 4 no
GO:0070201 regulation of establishment of protein localization 23.5294 6 no
GO:1904951 positive regulation of establishment of protein localization 23.5294 6 no
GO:2000145 regulation of cell motility 23.5294 4 no
GO:0006355 regulation of DNA-templated transcription 23.5294 6 no
GO:0008104 protein localization 23.5294 4 no
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0010468 regulation of gene expression 23.5294 5 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:1903506 regulation of nucleic acid-templated transcription 23.5294 7 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0001667 ameboidal-type cell migration 23.5294 4 no
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0034097 response to cytokine 23.5294 4 no
GO:0045787 positive regulation of cell cycle 23.5294 5 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0090068 positive regulation of cell cycle process 23.5294 6 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0033674 positive regulation of kinase activity 23.5294 6 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0051338 regulation of transferase activity 23.5294 4 no
GO:0051347 positive regulation of transferase activity 23.5294 5 no
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0010942 positive regulation of cell death 23.5294 5 no
GO:0043065 positive regulation of apoptotic process 23.5294 7 no
GO:0043068 positive regulation of programmed cell death 23.5294 6 no
GO:1902903 regulation of supramolecular fiber organization 23.5294 5 no
GO:0016055 Wnt signaling pathway 23.5294 5 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 23.5294 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FMNL1_HUMAN [view entry] [view interactions] Low throughput yes no
PR40A_HUMAN [view interactions] Low throughput no yes
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
FMNL3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
H32_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
8ODP_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
BRAF_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
UBXN7_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
AKAP2_HUMAN [view interactions] High throughput no no
MAP2_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
TREX2_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD1_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
NAA11_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM2_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
CSRP3_HUMAN [view interactions] High throughput no no
DIAP1_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
FHDC1_HUMAN [view interactions] High throughput no no
FMN1_HUMAN [view interactions] High throughput no no
PRP18_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] Computational no no
RHOC_HUMAN [view interactions] Computational no no