VATH_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system . Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATH_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.1905 | 5 | no |
| GO:0043168 | anion binding | 26.1905 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 21.4286 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 21.4286 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 21.4286 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 21.4286 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.4286 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.4286 | 6 | no |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATH_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 54.7619 | 4 | yes |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0009894 | regulation of catabolic process | 40.4762 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.4762 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.4762 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.0952 | 4 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.7143 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 33.3333 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 30.9524 | 4 | yes |
| GO:0010506 | regulation of autophagy | 30.9524 | 6 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 30.9524 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 30.9524 | 4 | yes |
| GO:0008104 | protein localization | 30.9524 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.9524 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.9524 | 5 | no |
| GO:0006811 | monoatomic ion transport | 28.5714 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0006812 | monoatomic cation transport | 26.1905 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.1905 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.1905 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.1905 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.1905 | 5 | no |
| GO:0016241 | regulation of macroautophagy | 23.8095 | 7 | yes |
| GO:0097401 | synaptic vesicle lumen acidification | 23.8095 | 4 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 23.8095 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 23.8095 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 23.8095 | 5 | yes |
| GO:0050890 | cognition | 23.8095 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.8095 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
| GO:0051452 | intracellular pH reduction | 21.4286 | 4 | yes |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0007035 | vacuolar acidification | 19.0476 | 5 | yes |
| GO:0098657 | import into cell | 14.2857 | 4 | yes |
| GO:0007042 | lysosomal lumen acidification | 11.9048 | 5 | yes |
| GO:0035751 | regulation of lysosomal lumen pH | 11.9048 | 4 | yes |
| GO:0048388 | endosomal lumen acidification | 11.9048 | 5 | yes |
| GO:0061795 | Golgi lumen acidification | 9.5238 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX9_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| PP12C_HUMAN | [view interactions] | High throughput | no | yes |
| SNPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| FACC1_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRP1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR4_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GML_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| ITAD_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP3_HUMAN | [view interactions] | High throughput | no | no |
| GMPPB_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| WDR44_HUMAN | [view interactions] | High throughput | no | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |