VATH_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system . Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATH_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 27.0270 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 27.0270 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 27.0270 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 27.0270 | 4 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 24.3243 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 24.3243 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 24.3243 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 24.3243 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 24.3243 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.3243 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3243 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATH_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 54.0541 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 40.5405 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 37.8378 | 5 | yes |
| GO:0006996 | organelle organization | 37.8378 | 4 | no |
| GO:0010506 | regulation of autophagy | 35.1351 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 35.1351 | 7 | yes |
| GO:0048522 | positive regulation of cellular process | 35.1351 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.4324 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.4324 | 4 | no |
| GO:0022607 | cellular component assembly | 29.7297 | 4 | no |
| GO:0008104 | protein localization | 29.7297 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 27.0270 | 4 | no |
| GO:0006811 | ion transport | 24.3243 | 4 | yes |
| GO:0006873 | cellular ion homeostasis | 24.3243 | 4 | yes |
| GO:0030003 | cellular cation homeostasis | 24.3243 | 5 | yes |
| GO:0048878 | chemical homeostasis | 24.3243 | 4 | yes |
| GO:0050801 | ion homeostasis | 24.3243 | 5 | yes |
| GO:0055080 | cation homeostasis | 24.3243 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 24.3243 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 24.3243 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 24.3243 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 24.3243 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 24.3243 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.3243 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 24.3243 | 4 | no |
| GO:0006812 | cation transport | 21.6216 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.6216 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.6216 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.6216 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.6216 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.6216 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.6216 | 5 | no |
| GO:0071702 | organic substance transport | 21.6216 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 18.9189 | 4 | yes |
| GO:0098655 | cation transmembrane transport | 18.9189 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 18.9189 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 18.9189 | 5 | yes |
| GO:1902600 | proton transmembrane transport | 18.9189 | 6 | yes |
| GO:0006885 | regulation of pH | 16.2162 | 8 | yes |
| GO:0030004 | cellular monovalent inorganic cation homeostasis | 16.2162 | 6 | yes |
| GO:0030641 | regulation of cellular pH | 16.2162 | 7 | yes |
| GO:0051452 | intracellular pH reduction | 16.2162 | 9 | yes |
| GO:0051453 | regulation of intracellular pH | 16.2162 | 8 | yes |
| GO:0055067 | monovalent inorganic cation homeostasis | 16.2162 | 7 | yes |
| GO:0007035 | vacuolar acidification | 13.5135 | 10 | yes |
| GO:0006897 | endocytosis | 8.1081 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VATH_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 5.4054 | 6 | no |
| DOID:440 | neuromuscular disease | 5.4054 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.4054 | 3 | no |
| DOID:870 | neuropathy | 5.4054 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX9_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| PP12C_HUMAN | [view interactions] | High throughput | no | yes |
| SNPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| FACC1_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRP1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR4_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| GML_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| ITAD_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP3_HUMAN | [view interactions] | High throughput | no | no |
| GMPPB_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| WDR44_HUMAN | [view interactions] | High throughput | no | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| VAS1_HUMAN | [view interactions] | Computational | no | yes |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CC115_HUMAN | [view interactions] | Computational | no | no |
| ATP5L_HUMAN | [view interactions] | Computational | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATP5I_HUMAN | [view interactions] | Computational | no | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| VPP4_HUMAN | [view interactions] | Computational | no | no |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| ATPG_HUMAN | [view interactions] | Computational | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5H_HUMAN | [view interactions] | Computational | no | yes |
| ATPK_HUMAN | [view interactions] | Computational | no | yes |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| VPP2_HUMAN | [view interactions] | Computational | no | yes |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| ATP6_HUMAN | [view interactions] | Computational | no | no |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| ATPA_HUMAN | [view interactions] | Computational | no | yes |
| MIO_HUMAN | [view interactions] | Computational | no | yes |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATPO_HUMAN | [view interactions] | Computational | no | yes |
| VPP3_HUMAN | [view interactions] | Computational | no | no |
| ATPB_HUMAN | [view interactions] | Computational | no | yes |
| TM199_HUMAN | [view interactions] | Computational | no | yes |
| ATP5E_HUMAN | [view interactions] | Computational | no | no |
| VATC2_HUMAN | [view interactions] | Computational | no | yes |
| ATP8_HUMAN | [view interactions] | Computational | no | no |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| ATPD_HUMAN | [view interactions] | Computational | no | yes |
| VATL_HUMAN | [view interactions] | Computational | no | no |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |