VPP1_HUMAN
Evidence for PS localization
Functions
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPP1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 24.2424 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 22.7273 | 4 | yes |
| GO:0000166 | nucleotide binding | 22.7273 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.7273 | 5 | no |
| GO:0043168 | anion binding | 22.7273 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.2121 | 4 | no |
| GO:0043169 | cation binding | 21.2121 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 16.6667 | 5 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 16.6667 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 15.1515 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 15.1515 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 15.1515 | 4 | yes |
| GO:0051117 | ATPase binding | 7.5758 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPP1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 48.4848 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 40.9091 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.3939 | 4 | no |
| GO:0006996 | organelle organization | 39.3939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.8788 | 4 | no |
| GO:0009894 | regulation of catabolic process | 34.8485 | 4 | yes |
| GO:0008104 | protein localization | 34.8485 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.8485 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.3030 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.7879 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.7879 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0006811 | monoatomic ion transport | 25.7576 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 25.7576 | 5 | yes |
| GO:0010506 | regulation of autophagy | 25.7576 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 25.7576 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.7576 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.7576 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.2424 | 4 | no |
| GO:0071702 | organic substance transport | 24.2424 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.2424 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.2424 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2424 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.7273 | 4 | no |
| GO:0030030 | cell projection organization | 22.7273 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7273 | 5 | no |
| GO:0098662 | inorganic cation transmembrane transport | 21.2121 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 21.2121 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0071705 | nitrogen compound transport | 21.2121 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
| GO:0098657 | import into cell | 21.2121 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.2121 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.2121 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.2121 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 19.6970 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 19.6970 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 19.6970 | 4 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 19.6970 | 4 | yes |
| GO:0016241 | regulation of macroautophagy | 18.1818 | 7 | yes |
| GO:0097401 | synaptic vesicle lumen acidification | 16.6667 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 16.6667 | 5 | yes |
| GO:0051452 | intracellular pH reduction | 12.1212 | 4 | yes |
| GO:0007035 | vacuolar acidification | 10.6061 | 5 | yes |
| GO:0007042 | lysosomal lumen acidification | 7.5758 | 5 | yes |
| GO:0035751 | regulation of lysosomal lumen pH | 7.5758 | 4 | yes |
| GO:0048388 | endosomal lumen acidification | 7.5758 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | Low throughput | no | no |
| VA0E1_HUMAN | [view interactions] | Low throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CATD_HUMAN | [view interactions] | Low throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| VATC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATF_HUMAN | [view interactions] | Low throughput | no | yes |
| VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VA0E2_HUMAN | [view interactions] | Low throughput | no | no |
| VATO_HUMAN | [view interactions] | Low throughput | no | no |
| RNK_HUMAN | [view interactions] | Low throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZD10_HUMAN | [view interactions] | High throughput | no | no |
| F131B_HUMAN | [view interactions] | High throughput | no | no |
| BCAM_HUMAN | [view interactions] | High throughput | no | yes |
| PI2R_HUMAN | [view interactions] | High throughput | no | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MEAK7_HUMAN | [view interactions] | High throughput | no | yes |
| TM199_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| S35D3_HUMAN | [view interactions] | High throughput | no | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN267_HUMAN | [view interactions] | High throughput | no | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| HRH1_HUMAN | [view interactions] | High throughput | no | no |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| MKS3_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| MUC1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| NPT2B_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| RN128_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| S26A4_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| GPC5D_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
| SFT2A_HUMAN | [view interactions] | High throughput | no | no |
| MYADM_HUMAN | [view interactions] | High throughput | no | no |
| UT1_HUMAN | [view interactions] | High throughput | no | no |
| CC115_HUMAN | [view interactions] | High throughput | no | no |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP5_HUMAN | [view interactions] | High throughput | no | no |
| BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
| M4A12_HUMAN | [view interactions] | High throughput | no | no |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB_HUMAN | [view interactions] | High throughput | no | yes |
| EMP3_HUMAN | [view interactions] | High throughput | no | no |
| MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| TBD_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| S35F2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| RM46_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |