VPP1_HUMAN
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VPP1_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 25.4545 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 25.4545 | 4 | yes |
GO:0017076 | purine nucleotide binding | 21.8182 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 21.8182 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 21.8182 | 4 | no |
GO:0015078 | proton transmembrane transporter activity | 20.0000 | 5 | yes |
GO:0051117 | ATPase binding | 9.0909 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VPP1_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 49.0909 | 4 | yes |
GO:0022607 | cellular component assembly | 41.8182 | 4 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
GO:0009894 | regulation of catabolic process | 38.1818 | 4 | yes |
GO:0006996 | organelle organization | 38.1818 | 4 | no |
GO:0016192 | vesicle-mediated transport | 36.3636 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 34.5455 | 5 | yes |
GO:0051049 | regulation of transport | 34.5455 | 4 | no |
GO:0010646 | regulation of cell communication | 34.5455 | 4 | no |
GO:0008104 | protein localization | 32.7273 | 4 | no |
GO:0048523 | negative regulation of cellular process | 32.7273 | 4 | no |
GO:0010506 | regulation of autophagy | 30.9091 | 6 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 30.9091 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.2727 | 4 | no |
GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
GO:0016241 | regulation of macroautophagy | 25.4545 | 7 | yes |
GO:0006811 | ion transport | 25.4545 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.4545 | 5 | no |
GO:0071702 | organic substance transport | 25.4545 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 25.4545 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.4545 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.4545 | 5 | no |
GO:0030030 | cell projection organization | 25.4545 | 4 | no |
GO:0010647 | positive regulation of cell communication | 25.4545 | 5 | no |
GO:0048878 | chemical homeostasis | 23.6364 | 4 | yes |
GO:0006812 | cation transport | 23.6364 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 23.6364 | 4 | no |
GO:0032880 | regulation of protein localization | 23.6364 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 23.6364 | 4 | no |
GO:0060341 | regulation of cellular localization | 23.6364 | 4 | no |
GO:0071705 | nitrogen compound transport | 23.6364 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.6364 | 4 | no |
GO:0015031 | protein transport | 21.8182 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 21.8182 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.8182 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.8182 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.8182 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 21.8182 | 4 | no |
GO:0006873 | cellular ion homeostasis | 18.1818 | 4 | yes |
GO:0030003 | cellular cation homeostasis | 18.1818 | 5 | yes |
GO:0050801 | ion homeostasis | 18.1818 | 5 | yes |
GO:0055080 | cation homeostasis | 18.1818 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 18.1818 | 6 | yes |
GO:0006885 | regulation of pH | 9.0909 | 8 | yes |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 9.0909 | 6 | yes |
GO:0030641 | regulation of cellular pH | 9.0909 | 7 | yes |
GO:0051452 | intracellular pH reduction | 9.0909 | 9 | yes |
GO:0051453 | regulation of intracellular pH | 9.0909 | 8 | yes |
GO:0055067 | monovalent inorganic cation homeostasis | 9.0909 | 7 | yes |
GO:0007035 | vacuolar acidification | 7.2727 | 10 | yes |
GO:1901998 | toxin transport | 3.6364 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VA0D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATB1_HUMAN | [view interactions] | Low throughput | no | no |
VA0E1_HUMAN | [view interactions] | Low throughput | no | no |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CATD_HUMAN | [view interactions] | Low throughput | no | yes |
VATO_HUMAN | [view interactions] | Low throughput | no | no |
VATG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATL_HUMAN | [view interactions] | Low throughput | no | no |
VATC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATF_HUMAN | [view interactions] | Low throughput | no | yes |
VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VA0E2_HUMAN | [view interactions] | Low throughput | no | no |
RNK_HUMAN | [view interactions] | Low throughput | no | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
TFG_HUMAN | [view interactions] | High throughput | no | yes |
CD2AP_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAST_HUMAN | [view interactions] | High throughput | no | yes |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGRG5_HUMAN | [view interactions] | High throughput | no | no |
HXB5_HUMAN | [view interactions] | High throughput | no | no |
CD4_HUMAN | [view interactions] | High throughput | no | no |
CSCL1_HUMAN | [view interactions] | High throughput | no | no |
RN19B_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FZD10_HUMAN | [view interactions] | High throughput | no | no |
F131B_HUMAN | [view interactions] | High throughput | no | no |
BCAM_HUMAN | [view interactions] | High throughput | no | yes |
PI2R_HUMAN | [view interactions] | High throughput | no | no |
T185A_HUMAN | [view interactions] | High throughput | no | no |
VPP2_HUMAN | [view interactions] | High throughput | no | yes |
MEAK7_HUMAN | [view interactions] | High throughput | no | yes |
TM199_HUMAN | [view interactions] | High throughput | no | yes |
NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
SERC2_HUMAN | [view interactions] | High throughput | no | yes |
VA0D2_HUMAN | [view interactions] | High throughput | no | no |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
S35D3_HUMAN | [view interactions] | High throughput | no | no |
KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
CLIC1_HUMAN | [view interactions] | High throughput | no | no |
SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN267_HUMAN | [view interactions] | High throughput | no | yes |
SEH1_HUMAN | [view interactions] | High throughput | no | no |
HRH1_HUMAN | [view interactions] | High throughput | no | no |
MKS3_HUMAN | [view interactions] | High throughput | no | no |
TECT3_HUMAN | [view interactions] | High throughput | no | yes |
TM216_HUMAN | [view interactions] | High throughput | no | no |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STB5L_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
DQA1_HUMAN | [view interactions] | High throughput | no | yes |
MUC1_HUMAN | [view interactions] | High throughput | no | no |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
CEA21_HUMAN | [view interactions] | High throughput | no | yes |
GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
K2013_HUMAN | [view interactions] | High throughput | no | yes |
NPT2B_HUMAN | [view interactions] | High throughput | no | no |
MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RGS20_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
RN128_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
S26A4_HUMAN | [view interactions] | High throughput | no | no |
LEG1_HUMAN | [view interactions] | High throughput | no | yes |
CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VPP3_HUMAN | [view interactions] | High throughput | no | no |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
VMA21_HUMAN | [view interactions] | High throughput | no | no |
GPC5D_HUMAN | [view interactions] | High throughput | no | yes |
SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
SFT2A_HUMAN | [view interactions] | High throughput | no | no |
MYADM_HUMAN | [view interactions] | High throughput | no | no |
UT1_HUMAN | [view interactions] | High throughput | no | no |
CC115_HUMAN | [view interactions] | High throughput | no | no |
ARHG1_HUMAN | [view interactions] | High throughput | no | no |
ZDH23_HUMAN | [view interactions] | High throughput | no | no |
LEG3_HUMAN | [view interactions] | High throughput | no | yes |
FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AQP5_HUMAN | [view interactions] | High throughput | no | no |
BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
M4A12_HUMAN | [view interactions] | High throughput | no | no |
SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PUS7_HUMAN | [view interactions] | High throughput | no | yes |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLCB_HUMAN | [view interactions] | High throughput | no | yes |
EMP3_HUMAN | [view interactions] | High throughput | no | no |
MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SBDS_HUMAN | [view interactions] | High throughput | no | yes |
ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
CUED1_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
T2EB_HUMAN | [view interactions] | High throughput | no | yes |
TBD_HUMAN | [view interactions] | High throughput | no | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
S35F2_HUMAN | [view interactions] | High throughput | no | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
RM50_HUMAN | [view interactions] | High throughput | no | yes |
RM46_HUMAN | [view interactions] | High throughput | no | yes |
SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
RM44_HUMAN | [view interactions] | High throughput | no | yes |
NONO_HUMAN | [view interactions] | High throughput | no | yes |
RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM6_HUMAN | [view interactions] | High throughput | no | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |
DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
VPP4_HUMAN | [view interactions] | Computational | no | no |
VATG3_HUMAN | [view interactions] | Computational | no | no |
AT5G3_HUMAN | [view interactions] | Computational | no | no |
VATC2_HUMAN | [view interactions] | Computational | no | yes |
VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |