VATG1_HUMAN
Evidence for PS localization
Functions
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATG1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 31.2500 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 31.2500 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 31.2500 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 31.2500 | 4 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 28.1250 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 28.1250 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 28.1250 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 28.1250 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 12.5000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 12.5000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 12.5000 | 6 | yes |
| GO:0051117 | ATPase binding | 9.3750 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATG1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 46.8750 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 40.6250 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 40.6250 | 4 | no |
| GO:0010506 | regulation of autophagy | 37.5000 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 34.3750 | 7 | yes |
| GO:0016192 | vesicle-mediated transport | 31.2500 | 4 | no |
| GO:0006996 | organelle organization | 31.2500 | 4 | no |
| GO:0008104 | protein localization | 31.2500 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 28.1250 | 4 | yes |
| GO:0030003 | cellular cation homeostasis | 28.1250 | 5 | yes |
| GO:0048878 | chemical homeostasis | 28.1250 | 4 | yes |
| GO:0050801 | ion homeostasis | 28.1250 | 5 | yes |
| GO:0055080 | cation homeostasis | 28.1250 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 28.1250 | 6 | yes |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.8750 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 21.8750 | 4 | no |
| GO:0006811 | ion transport | 21.8750 | 4 | no |
| GO:0006812 | cation transport | 21.8750 | 5 | no |
| GO:0098655 | cation transmembrane transport | 21.8750 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 21.8750 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 21.8750 | 5 | no |
| GO:1902600 | proton transmembrane transport | 21.8750 | 6 | no |
| GO:0015031 | protein transport | 21.8750 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 21.8750 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.8750 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.8750 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.8750 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 21.8750 | 4 | no |
| GO:0006875 | cellular metal ion homeostasis | 12.5000 | 6 | yes |
| GO:0046916 | cellular transition metal ion homeostasis | 12.5000 | 7 | yes |
| GO:0055065 | metal ion homeostasis | 12.5000 | 7 | yes |
| GO:0055076 | transition metal ion homeostasis | 12.5000 | 8 | yes |
| GO:0006879 | cellular iron ion homeostasis | 9.3750 | 8 | yes |
| GO:0036295 | cellular response to increased oxygen levels | 9.3750 | 5 | yes |
| GO:0036296 | response to increased oxygen levels | 9.3750 | 4 | yes |
| GO:0055072 | iron ion homeostasis | 9.3750 | 9 | yes |
| GO:0071453 | cellular response to oxygen levels | 9.3750 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VATG1_HUMAN |
|---|---|---|---|---|
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 6.2500 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 6.2500 | 6 | no |
| DOID:440 | neuromuscular disease | 6.2500 | 5 | no |
| DOID:574 | peripheral nervous system disease | 6.2500 | 3 | no |
| DOID:870 | neuropathy | 6.2500 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| UBQL2_HUMAN | [view interactions] | Low throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYB5_HUMAN | [view interactions] | High throughput | no | no |
| VATE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B2L11_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| BTBD9_HUMAN | [view interactions] | High throughput | no | yes |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| DACH2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX15_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| LDOC1_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| KLH18_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA3_HUMAN | [view interactions] | High throughput | no | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| VATG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBTP2_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| S35A1_HUMAN | [view interactions] | High throughput | no | no |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS72_HUMAN | [view interactions] | High throughput | no | no |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| VPP2_HUMAN | [view interactions] | Computational | no | yes |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| MIO_HUMAN | [view interactions] | Computational | no | yes |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| VPP3_HUMAN | [view interactions] | Computational | no | no |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| VPP4_HUMAN | [view interactions] | Computational | no | no |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |