VATG1_HUMAN
Evidence for PS localization
Functions
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATG1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 30.5556 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 30.5556 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 30.5556 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 30.5556 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.5556 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 30.5556 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 30.5556 | 4 | yes |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 19.4444 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 19.4444 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 19.4444 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 11.1111 | 7 | yes |
| GO:0051117 | ATPase binding | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATG1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 63.8889 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 44.4444 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 38.8889 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:0010506 | regulation of autophagy | 36.1111 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.1111 | 5 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 33.3333 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 33.3333 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 33.3333 | 4 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0006811 | monoatomic ion transport | 30.5556 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 30.5556 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 30.5556 | 7 | yes |
| GO:0097401 | synaptic vesicle lumen acidification | 30.5556 | 4 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 30.5556 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 30.5556 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 30.5556 | 5 | yes |
| GO:0008104 | protein localization | 30.5556 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.5556 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 30.5556 | 4 | no |
| GO:0071702 | organic substance transport | 27.7778 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.7778 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.7778 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051452 | intracellular pH reduction | 25.0000 | 4 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.2222 | 6 | no |
| GO:0033365 | protein localization to organelle | 22.2222 | 5 | no |
| GO:0007035 | vacuolar acidification | 22.2222 | 5 | no |
| GO:0006879 | intracellular iron ion homeostasis | 8.3333 | 4 | yes |
| GO:0036295 | cellular response to increased oxygen levels | 8.3333 | 5 | yes |
| GO:0036296 | response to increased oxygen levels | 8.3333 | 4 | yes |
| GO:0071453 | cellular response to oxygen levels | 8.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| UBQL2_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B2L11_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD9_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| DACH2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX15_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| LDOC1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| KLH18_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA3_HUMAN | [view interactions] | High throughput | no | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| VATG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBTP2_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| S35A1_HUMAN | [view interactions] | High throughput | no | no |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS72_HUMAN | [view interactions] | High throughput | no | no |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| VATG3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYB5_HUMAN | [view interactions] | High throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |