Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VATE2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VATE2_HUMAN
GO:0008324 monoatomic cation transmembrane transporter activity 83.3333 4 yes
GO:0015078 proton transmembrane transporter activity 83.3333 5 yes
GO:0015399 primary active transmembrane transporter activity 83.3333 4 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 83.3333 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 83.3333 4 yes
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 83.3333 4 yes
GO:0046961 proton-transporting ATPase activity, rotational mechanism 83.3333 4 yes
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0016887 ATP hydrolysis activity 33.3333 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in VATE2_HUMAN
GO:0009894 regulation of catabolic process 100.0000 4 yes
GO:0010506 regulation of autophagy 100.0000 6 yes
GO:0031323 regulation of cellular metabolic process 100.0000 4 yes
GO:0031329 regulation of cellular catabolic process 100.0000 5 yes
GO:0016241 regulation of macroautophagy 83.3333 7 yes
GO:0006811 monoatomic ion transport 66.6667 4 no
GO:0006812 monoatomic cation transport 66.6667 5 no
GO:0097401 synaptic vesicle lumen acidification 66.6667 4 no
GO:0098655 monoatomic cation transmembrane transport 66.6667 4 no
GO:0098662 inorganic cation transmembrane transport 66.6667 4 no
GO:1902600 proton transmembrane transport 66.6667 5 no
GO:0006873 intracellular monoatomic ion homeostasis 50.0000 4 no
GO:0030003 intracellular monoatomic cation homeostasis 50.0000 5 no
GO:0055080 monoatomic cation homeostasis 50.0000 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007035 vacuolar acidification 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0051452 intracellular pH reduction 33.3333 4 no
GO:0070925 organelle assembly 33.3333 5 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
VATC2_HUMAN [view interactions] High throughput no yes
VATB1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
BBLN_HUMAN [view interactions] High throughput no yes
VATG2_HUMAN [view entry] [view interactions] High throughput yes yes
RASFA_HUMAN [view interactions] High throughput no no
MESD_HUMAN [view interactions] High throughput no yes
SPAG6_HUMAN [view interactions] High throughput no no
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes