VATE2_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATE2_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 71.4286 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 71.4286 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 71.4286 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 71.4286 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 64.2857 | 4 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 64.2857 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 64.2857 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 64.2857 | 4 | yes |
| GO:0051117 | ATPase binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATE2_HUMAN |
|---|---|---|---|---|
| GO:0009894 | regulation of catabolic process | 85.7143 | 4 | yes |
| GO:0010506 | regulation of autophagy | 85.7143 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 85.7143 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 85.7143 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 78.5714 | 7 | yes |
| GO:0006811 | ion transport | 50.0000 | 4 | no |
| GO:0006812 | cation transport | 50.0000 | 5 | no |
| GO:0098655 | cation transmembrane transport | 50.0000 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 50.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 50.0000 | 5 | no |
| GO:1902600 | proton transmembrane transport | 50.0000 | 6 | no |
| GO:0006873 | cellular ion homeostasis | 35.7143 | 4 | no |
| GO:0030003 | cellular cation homeostasis | 35.7143 | 5 | no |
| GO:0048878 | chemical homeostasis | 35.7143 | 4 | no |
| GO:0050801 | ion homeostasis | 35.7143 | 5 | no |
| GO:0055080 | cation homeostasis | 35.7143 | 6 | no |
| GO:0098771 | inorganic ion homeostasis | 35.7143 | 6 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0006885 | regulation of pH | 21.4286 | 8 | no |
| GO:0007035 | vacuolar acidification | 21.4286 | 10 | no |
| GO:0030004 | cellular monovalent inorganic cation homeostasis | 21.4286 | 6 | no |
| GO:0030641 | regulation of cellular pH | 21.4286 | 7 | no |
| GO:0051452 | intracellular pH reduction | 21.4286 | 9 | no |
| GO:0051453 | regulation of intracellular pH | 21.4286 | 8 | no |
| GO:0055067 | monovalent inorganic cation homeostasis | 21.4286 | 7 | no |
| GO:0006875 | cellular metal ion homeostasis | 21.4286 | 6 | no |
| GO:0006879 | cellular iron ion homeostasis | 21.4286 | 8 | no |
| GO:0036295 | cellular response to increased oxygen levels | 21.4286 | 5 | no |
| GO:0036296 | response to increased oxygen levels | 21.4286 | 4 | no |
| GO:0046916 | cellular transition metal ion homeostasis | 21.4286 | 7 | no |
| GO:0055065 | metal ion homeostasis | 21.4286 | 7 | no |
| GO:0055072 | iron ion homeostasis | 21.4286 | 9 | no |
| GO:0055076 | transition metal ion homeostasis | 21.4286 | 8 | no |
| GO:0071453 | cellular response to oxygen levels | 21.4286 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 21.4286 | 4 | no |
| GO:0022607 | cellular component assembly | 21.4286 | 4 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0070925 | organelle assembly | 21.4286 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:0008104 | protein localization | 21.4286 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.4286 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| VATG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASFA_HUMAN | [view interactions] | High throughput | no | no |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIO_HUMAN | [view interactions] | Computational | no | yes |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| VPP2_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| VPP3_HUMAN | [view interactions] | Computational | no | no |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| VATH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| VA0D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| VATL_HUMAN | [view interactions] | Computational | no | no |
| VPP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| VAS1_HUMAN | [view interactions] | Computational | no | yes |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| VPP4_HUMAN | [view interactions] | Computational | no | no |
| VATC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| VATF_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |