Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBC24_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May act as a GTPase-activating protein for Rab family protein(s) (PubMed, PubMed). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed). Involved in the regulation of synaptic vesicle trafficking (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TBC24_HUMAN
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no
GO:0005096 GTPase activator activity 21.4286 4 yes
GO:0030695 GTPase regulator activity 21.4286 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 21.4286 4 no
GO:0015078 proton transmembrane transporter activity 21.4286 5 no
GO:0015399 primary active transmembrane transporter activity 21.4286 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 21.4286 4 no
GO:0022890 inorganic cation transmembrane transporter activity 21.4286 4 no
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 21.4286 4 no
GO:0046961 proton-transporting ATPase activity, rotational mechanism 21.4286 4 no
GO:0017124 SH3 domain binding 21.4286 4 no
GO:0016462 pyrophosphatase activity 21.4286 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in TBC24_HUMAN
GO:0009966 regulation of signal transduction 71.4286 4 yes
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048523 negative regulation of cellular process 64.2857 4 yes
GO:1902531 regulation of intracellular signal transduction 64.2857 5 no
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 yes
GO:0010647 positive regulation of cell communication 42.8571 5 yes
GO:0023056 positive regulation of signaling 42.8571 4 yes
GO:0030030 cell projection organization 42.8571 4 yes
GO:0031344 regulation of cell projection organization 42.8571 5 yes
GO:0031399 regulation of protein modification process 42.8571 6 yes
GO:0048584 positive regulation of response to stimulus 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0051130 positive regulation of cellular component organization 42.8571 5 yes
GO:0051246 regulation of protein metabolic process 42.8571 5 yes
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 yes
GO:0022607 cellular component assembly 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 yes
GO:0120036 plasma membrane bounded cell projection organization 35.7143 5 yes
GO:0006996 organelle organization 35.7143 4 no
GO:0009894 regulation of catabolic process 35.7143 4 no
GO:0009889 regulation of biosynthetic process 35.7143 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0009968 negative regulation of signal transduction 35.7143 5 no
GO:0010468 regulation of gene expression 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0010648 negative regulation of cell communication 35.7143 5 no
GO:0023057 negative regulation of signaling 35.7143 4 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0032880 regulation of protein localization 35.7143 5 no
GO:0042981 regulation of apoptotic process 35.7143 5 no
GO:0043066 negative regulation of apoptotic process 35.7143 6 no
GO:0043067 regulation of programmed cell death 35.7143 4 no
GO:0043069 negative regulation of programmed cell death 35.7143 5 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0060341 regulation of cellular localization 35.7143 4 no
GO:0070201 regulation of establishment of protein localization 35.7143 6 no
GO:1903829 positive regulation of protein localization 35.7143 5 no
GO:0043408 regulation of MAPK cascade 35.7143 6 no
GO:1902533 positive regulation of intracellular signal transduction 35.7143 6 no
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0030334 regulation of cell migration 28.5714 5 yes
GO:0030335 positive regulation of cell migration 28.5714 6 yes
GO:0031346 positive regulation of cell projection organization 28.5714 6 yes
GO:0031400 negative regulation of protein modification process 28.5714 7 yes
GO:0040017 positive regulation of locomotion 28.5714 4 yes
GO:0051248 negative regulation of protein metabolic process 28.5714 6 yes
GO:0080134 regulation of response to stress 28.5714 4 yes
GO:0098657 import into cell 28.5714 4 yes
GO:2000145 regulation of cell motility 28.5714 4 yes
GO:2000147 positive regulation of cell motility 28.5714 5 yes
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0010506 regulation of autophagy 28.5714 6 no
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0055080 monoatomic cation homeostasis 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043523 regulation of neuron apoptotic process 28.5714 6 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:1902532 negative regulation of intracellular signal transduction 28.5714 6 no
GO:1904951 positive regulation of establishment of protein localization 28.5714 6 no
GO:1905475 regulation of protein localization to membrane 28.5714 6 no
GO:1905477 positive regulation of protein localization to membrane 28.5714 6 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 28.5714 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 yes
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 yes
GO:0006811 monoatomic ion transport 21.4286 4 no
GO:0006812 monoatomic cation transport 21.4286 5 no
GO:0016241 regulation of macroautophagy 21.4286 7 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0097401 synaptic vesicle lumen acidification 21.4286 4 no
GO:0098655 monoatomic cation transmembrane transport 21.4286 4 no
GO:0098662 inorganic cation transmembrane transport 21.4286 4 no
GO:1902600 proton transmembrane transport 21.4286 5 no
GO:0001817 regulation of cytokine production 21.4286 4 no
GO:0001933 negative regulation of protein phosphorylation 21.4286 8 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0010038 response to metal ion 21.4286 4 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0031345 negative regulation of cell projection organization 21.4286 6 no
GO:0031648 protein destabilization 21.4286 4 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043954 cellular component maintenance 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0050890 cognition 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1903533 regulation of protein targeting 21.4286 7 no
GO:1904375 regulation of protein localization to cell periphery 21.4286 6 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0006508 proteolysis 21.4286 4 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010628 positive regulation of gene expression 21.4286 7 no
GO:0010638 positive regulation of organelle organization 21.4286 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0032956 regulation of actin cytoskeleton organization 21.4286 5 no
GO:0032970 regulation of actin filament-based process 21.4286 4 no
GO:0043524 negative regulation of neuron apoptotic process 21.4286 7 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0050708 regulation of protein secretion 21.4286 5 no
GO:0051046 regulation of secretion 21.4286 5 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051093 negative regulation of developmental process 21.4286 4 no
GO:0051223 regulation of protein transport 21.4286 5 no
GO:0051493 regulation of cytoskeleton organization 21.4286 6 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:1903530 regulation of secretion by cell 21.4286 4 no
GO:0008284 positive regulation of cell population proliferation 21.4286 5 no
GO:0007264 small GTPase-mediated signal transduction 21.4286 5 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.4286 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.4286 5 no
GO:0022604 regulation of cell morphogenesis 14.2857 5 yes
GO:0031175 neuron projection development 14.2857 6 yes
GO:0034599 cellular response to oxidative stress 14.2857 4 yes
GO:0044057 regulation of system process 14.2857 4 yes
GO:0045595 regulation of cell differentiation 14.2857 4 yes
GO:0048488 synaptic vesicle endocytosis 14.2857 5 yes
GO:0050767 regulation of neurogenesis 14.2857 6 yes
GO:0050773 regulation of dendrite development 14.2857 4 yes
GO:0051094 positive regulation of developmental process 14.2857 4 yes
GO:0051960 regulation of nervous system development 14.2857 5 yes
GO:0060284 regulation of cell development 14.2857 5 yes
GO:0062197 cellular response to chemical stress 14.2857 4 yes
GO:0080135 regulation of cellular response to stress 14.2857 4 yes
GO:0140238 presynaptic endocytosis 14.2857 4 yes
GO:1900407 regulation of cellular response to oxidative stress 14.2857 5 yes
GO:1902882 regulation of response to oxidative stress 14.2857 5 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
IKBA_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
RASF8_HUMAN [view interactions] High throughput no yes
TET5A_HUMAN [view interactions] High throughput no yes
CCN1_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
S1PR4_HUMAN [view interactions] High throughput no no
SC6A5_HUMAN [view interactions] High throughput no no
TLR1_HUMAN [view interactions] High throughput no no
ACBD7_HUMAN [view interactions] High throughput no no
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
DHSD_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
PO3F1_HUMAN [view interactions] High throughput no no
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
GPAT1_HUMAN [view interactions] High throughput no no
ADAT3_HUMAN [view interactions] High throughput no no
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
TCAL2_HUMAN [view interactions] High throughput no no
OR5H1_HUMAN [view interactions] High throughput no no
VATB1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
FBW1A_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes