Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBC24_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May act as a GTPase-activating protein for Rab family protein(s) (PubMed, PubMed). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed). Involved in the regulation of synaptic vesicle trafficking (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TBC24_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0008324 cation transmembrane transporter activity 25.0000 4 no
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 25.0000 5 no
GO:0015078 proton transmembrane transporter activity 25.0000 5 no
GO:0015399 primary active transmembrane transporter activity 25.0000 4 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0022853 active ion transmembrane transporter activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 25.0000 4 no
GO:0046961 proton-transporting ATPase activity, rotational mechanism 25.0000 4 no
GO:0030695 GTPase regulator activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBC24_HUMAN
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0009966 regulation of signal transduction 58.3333 4 no
GO:0010646 regulation of cell communication 58.3333 4 no
GO:0048522 positive regulation of cellular process 58.3333 4 no
GO:1902531 regulation of intracellular signal transduction 58.3333 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0030030 cell projection organization 41.6667 4 yes
GO:0071310 cellular response to organic substance 41.6667 4 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0031401 positive regulation of protein modification process 41.6667 7 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 yes
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051222 positive regulation of protein transport 33.3333 5 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:1904951 positive regulation of establishment of protein localization 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0060548 negative regulation of cell death 33.3333 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0016241 regulation of macroautophagy 25.0000 7 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 no
GO:1904375 regulation of protein localization to cell periphery 25.0000 6 no
GO:1905475 regulation of protein localization to membrane 25.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043410 positive regulation of MAPK cascade 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
IKBA_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
RASF8_HUMAN [view interactions] High throughput no yes
TET5A_HUMAN [view interactions] High throughput no yes
CCN1_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
S1PR4_HUMAN [view interactions] High throughput no no
SC6A5_HUMAN [view interactions] High throughput no no
TLR1_HUMAN [view interactions] High throughput no no
ACBD7_HUMAN [view interactions] High throughput no no
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
DHSD_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
PO3F1_HUMAN [view interactions] High throughput no no
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
GPAT1_HUMAN [view interactions] High throughput no no
ADAT3_HUMAN [view interactions] High throughput no no
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
TCAL2_HUMAN [view interactions] High throughput no no
OR5H1_HUMAN [view interactions] High throughput no no
VATB1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no