VPS28_HUMAN
Evidence for PS localization
Functions
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS28_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.5789 | 4 | no |
| GO:0000166 | nucleotide binding | 26.3158 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.3158 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.3158 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.6842 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.6842 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | no |
| GO:0043130 | ubiquitin binding | 5.2632 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS28_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 47.3684 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 47.3684 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.3684 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.7368 | 4 | yes |
| GO:0008104 | protein localization | 39.4737 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.4737 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.4737 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.2105 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.2105 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.5789 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 31.5789 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | yes |
| GO:0051049 | regulation of transport | 28.9474 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.9474 | 5 | yes |
| GO:0071702 | organic substance transport | 28.9474 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 28.9474 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.3158 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.3158 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.3158 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 23.6842 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.6842 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.6842 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 23.6842 | 6 | yes |
| GO:0071705 | nitrogen compound transport | 23.6842 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 23.6842 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.6842 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.6842 | 5 | no |
| GO:0015031 | protein transport | 21.0526 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | yes |
| GO:0061024 | membrane organization | 21.0526 | 4 | yes |
| GO:0070925 | organelle assembly | 21.0526 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.0526 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0007034 | vacuolar transport | 18.4211 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 18.4211 | 5 | yes |
| GO:0051050 | positive regulation of transport | 18.4211 | 4 | yes |
| GO:0006886 | intracellular protein transport | 15.7895 | 4 | yes |
| GO:0032880 | regulation of protein localization | 15.7895 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 15.7895 | 4 | yes |
| GO:0006508 | proteolysis | 13.1579 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 13.1579 | 5 | yes |
| GO:0016050 | vesicle organization | 13.1579 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 13.1579 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 13.1579 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 13.1579 | 5 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 13.1579 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 13.1579 | 6 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 13.1579 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 13.1579 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 10.5263 | 7 | yes |
| GO:0007032 | endosome organization | 10.5263 | 6 | yes |
| GO:0016236 | macroautophagy | 10.5263 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 10.5263 | 9 | yes |
| GO:0031400 | negative regulation of protein modification process | 10.5263 | 7 | yes |
| GO:0033365 | protein localization to organelle | 10.5263 | 5 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 10.5263 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 10.5263 | 5 | yes |
| GO:0051223 | regulation of protein transport | 10.5263 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 10.5263 | 6 | yes |
| GO:1901873 | regulation of post-translational protein modification | 10.5263 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 10.5263 | 8 | yes |
| GO:1903829 | positive regulation of protein localization | 10.5263 | 5 | yes |
| GO:0031397 | negative regulation of protein ubiquitination | 7.8947 | 10 | yes |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 7.8947 | 4 | yes |
| GO:0036257 | multivesicular body organization | 7.8947 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 7.8947 | 6 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 7.8947 | 8 | yes |
| GO:0072594 | establishment of protein localization to organelle | 7.8947 | 4 | yes |
| GO:0072665 | protein localization to vacuole | 7.8947 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 7.8947 | 5 | yes |
| GO:0090148 | membrane fission | 7.8947 | 5 | yes |
| GO:1901874 | negative regulation of post-translational protein modification | 7.8947 | 8 | yes |
| GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 7.8947 | 9 | yes |
| GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway | 5.2632 | 4 | yes |
| GO:0043328 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 5.2632 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 5.2632 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 5.2632 | 6 | yes |
| GO:2000395 | regulation of ubiquitin-dependent endocytosis | 5.2632 | 6 | yes |
| GO:2000397 | positive regulation of ubiquitin-dependent endocytosis | 5.2632 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VP37A_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DFFB_HUMAN | [view interactions] | Low throughput | no | yes |
| DFFA_HUMAN | [view interactions] | Low throughput | no | yes |
| AKTIP_HUMAN | [view interactions] | Low throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNF8_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS25_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS36_HUMAN | [view interactions] | Low throughput | no | yes |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| VP37C_HUMAN | [view interactions] | Low throughput | no | yes |
| MLKL_HUMAN | [view interactions] | Low throughput | no | no |
| VP37B_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MB12A_HUMAN | [view interactions] | Low throughput | no | yes |
| VP37D_HUMAN | [view interactions] | High throughput | no | no |
| PCP2_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| MB12B_HUMAN | [view interactions] | High throughput | no | no |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| EVG1_HUMAN | [view interactions] | High throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| GO45_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAXO1_HUMAN | [view interactions] | High throughput | no | no |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| CARD9_HUMAN | [view interactions] | High throughput | no | no |
| RASF5_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRDE2_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUOX_HUMAN | [view interactions] | High throughput | no | no |
| SHC3_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| AB17A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ2A_HUMAN | [view interactions] | High throughput | no | no |
| CUTA_HUMAN | [view interactions] | High throughput | no | yes |
| E41LB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| KNL1_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| IL1B_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CP2J2_HUMAN | [view interactions] | High throughput | no | no |
| ACY1_HUMAN | [view interactions] | High throughput | no | no |
| F227B_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKIL_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| CE57L_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| PAR6B_HUMAN | [view interactions] | High throughput | no | no |
| SGO2_HUMAN | [view interactions] | High throughput | no | no |
| HBE_HUMAN | [view interactions] | High throughput | no | no |
| PGBM_HUMAN | [view interactions] | High throughput | no | no |
| UMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CB069_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX36_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| S35F6_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| MUC13_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBP_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| TAF10_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| ARRD1_HUMAN | [view interactions] | High throughput | no | yes |
| STXB4_HUMAN | [view interactions] | High throughput | no | yes |