Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AB17A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed). Has depalmitoylating activity towards NRAS (PubMed). Has depalmitoylating activity towards DLG4/PSD95 (PubMed). May have depalmitoylating activity towards MAP6 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AB17A_HUMAN
GO:0000166 nucleotide binding 46.6667 4 no
GO:0017076 purine nucleotide binding 46.6667 5 no
GO:0032555 purine ribonucleotide binding 46.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 46.6667 4 no
GO:0043168 anion binding 46.6667 4 no
GO:0005524 ATP binding 40.0000 5 no
GO:0030554 adenyl nucleotide binding 40.0000 6 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0003723 RNA binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0016887 ATP hydrolysis activity 33.3333 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0031625 ubiquitin protein ligase binding 26.6667 5 no
GO:0044389 ubiquitin-like protein ligase binding 26.6667 4 no
GO:0016790 thiolester hydrolase activity 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AB17A_HUMAN
GO:0051128 regulation of cellular component organization 86.6667 4 yes
GO:0032880 regulation of protein localization 66.6667 5 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0060341 regulation of cellular localization 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:1903829 positive regulation of protein localization 53.3333 5 yes
GO:0009889 regulation of biosynthetic process 53.3333 4 no
GO:0009893 positive regulation of metabolic process 53.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 53.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 53.3333 5 no
GO:0022607 cellular component assembly 53.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 53.3333 5 no
GO:0048523 negative regulation of cellular process 46.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 46.6667 5 no
GO:0043933 protein-containing complex organization 46.6667 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.6667 5 no
GO:0051130 positive regulation of cellular component organization 46.6667 5 no
GO:0070201 regulation of establishment of protein localization 46.6667 6 no
GO:0008104 protein localization 40.0000 4 yes
GO:0036211 protein modification process 40.0000 4 yes
GO:0043412 macromolecule modification 40.0000 4 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0065003 protein-containing complex assembly 40.0000 5 no
GO:0033043 regulation of organelle organization 40.0000 5 no
GO:0051052 regulation of DNA metabolic process 40.0000 5 no
GO:1904951 positive regulation of establishment of protein localization 40.0000 6 no
GO:0009057 macromolecule catabolic process 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0032204 regulation of telomere maintenance 33.3333 6 no
GO:0032210 regulation of telomere maintenance via telomerase 33.3333 7 no
GO:0033044 regulation of chromosome organization 33.3333 6 no
GO:1900180 regulation of protein localization to nucleus 33.3333 6 no
GO:1900182 positive regulation of protein localization to nucleus 33.3333 6 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 33.3333 7 no
GO:2000278 regulation of DNA biosynthetic process 33.3333 6 no
GO:0050807 regulation of synapse organization 26.6667 5 yes
GO:0015031 protein transport 26.6667 4 no
GO:0031324 negative regulation of cellular metabolic process 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0071702 organic substance transport 26.6667 4 no
GO:0071705 nitrogen compound transport 26.6667 4 no
GO:0032206 positive regulation of telomere maintenance 26.6667 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 26.6667 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0050821 protein stabilization 26.6667 4 no
GO:0051054 positive regulation of DNA metabolic process 26.6667 6 no
GO:0070202 regulation of establishment of protein localization to chromosome 26.6667 7 no
GO:0070203 regulation of establishment of protein localization to telomere 26.6667 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 26.6667 8 no
GO:1904814 regulation of protein localization to chromosome, telomeric region 26.6667 6 no
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 26.6667 6 no
GO:1904851 positive regulation of establishment of protein localization to telomere 26.6667 7 no
GO:1904869 regulation of protein localization to Cajal body 26.6667 7 no
GO:1904871 positive regulation of protein localization to Cajal body 26.6667 7 no
GO:1904872 regulation of telomerase RNA localization to Cajal body 26.6667 4 no
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 26.6667 4 no
GO:2000573 positive regulation of DNA biosynthetic process 26.6667 7 no
GO:2001252 positive regulation of chromosome organization 26.6667 7 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0050890 cognition 26.6667 4 no
GO:0051049 regulation of transport 26.6667 4 no
GO:0051129 negative regulation of cellular component organization 26.6667 5 no
GO:0051338 regulation of transferase activity 26.6667 4 no
GO:0051347 positive regulation of transferase activity 26.6667 5 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0030163 protein catabolic process 20.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 20.0000 4 yes
GO:0002084 protein depalmitoylation 13.3333 6 yes
GO:0035601 protein deacylation 13.3333 5 yes
GO:0042157 lipoprotein metabolic process 13.3333 4 yes
GO:0042159 lipoprotein catabolic process 13.3333 5 yes
GO:0072657 protein localization to membrane 13.3333 4 yes
GO:0098732 macromolecule deacylation 13.3333 5 yes
GO:0098734 macromolecule depalmitoylation 13.3333 6 yes
GO:0099175 regulation of postsynapse organization 13.3333 6 yes
GO:1902816 regulation of protein localization to microtubule 13.3333 6 yes
GO:1902817 negative regulation of protein localization to microtubule 13.3333 6 yes
GO:1903828 negative regulation of protein localization 13.3333 5 yes
GO:1905666 regulation of protein localization to endosome 13.3333 6 yes
GO:1905668 positive regulation of protein localization to endosome 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNIP1_HUMAN [view interactions] High throughput no yes
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF1_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
RGS20_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
KRA59_HUMAN [view interactions] High throughput no no
BIRC2_HUMAN [view interactions] High throughput no yes
PNMA1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
HXA1_HUMAN [view interactions] High throughput no no
HPGDS_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PLS4_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
DYT2B_HUMAN [view interactions] High throughput no no
C5AR2_HUMAN [view interactions] High throughput no yes
LPAR6_HUMAN [view interactions] High throughput no no
APJ_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
CHM4A_HUMAN [view interactions] High throughput no no
GPR12_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
CCZ1_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
DD19B_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG4_HUMAN [view interactions] High throughput no no
AVR2A_HUMAN [view interactions] High throughput no yes
AB17C_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
JIP4_HUMAN [view interactions] High throughput no yes
PKHH3_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no