Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AB17A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed). Has depalmitoylating activity towards NRAS (PubMed). Has depalmitoylating activity towards DLG4/PSD95 (PubMed). May have depalmitoylating activity towards MAP6 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AB17A_HUMAN
GO:0017076 purine nucleotide binding 55.5556 4 no
GO:0032555 purine ribonucleotide binding 55.5556 4 no
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0005524 ATP binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0016887 ATP hydrolysis activity 27.7778 7 no
GO:0003723 RNA binding 27.7778 4 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0005525 GTP binding 22.2222 5 no
GO:0019001 guanyl nucleotide binding 22.2222 5 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0016790 thiolester hydrolase activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AB17A_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0051128 regulation of cellular component organization 77.7778 4 yes
GO:0032880 regulation of protein localization 66.6667 5 yes
GO:0060341 regulation of cellular localization 66.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 61.1111 4 no
GO:0010604 positive regulation of macromolecule metabolic process 61.1111 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 61.1111 5 no
GO:0031323 regulation of cellular metabolic process 61.1111 4 no
GO:1903829 positive regulation of protein localization 55.5556 5 yes
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0070201 regulation of establishment of protein localization 44.4444 6 no
GO:0031328 positive regulation of cellular biosynthetic process 38.8889 6 no
GO:0033043 regulation of organelle organization 38.8889 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 38.8889 6 no
GO:0006996 organelle organization 38.8889 4 no
GO:0031399 regulation of protein modification process 38.8889 6 no
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:1904951 positive regulation of establishment of protein localization 38.8889 6 no
GO:0043933 protein-containing complex organization 38.8889 4 no
GO:0009891 positive regulation of biosynthetic process 38.8889 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 38.8889 6 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0051052 regulation of DNA metabolic process 33.3333 5 no
GO:0008104 protein localization 33.3333 4 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0032204 regulation of telomere maintenance 27.7778 6 no
GO:0032210 regulation of telomere maintenance via telomerase 27.7778 7 no
GO:0033044 regulation of chromosome organization 27.7778 6 no
GO:0051054 positive regulation of DNA metabolic process 27.7778 6 no
GO:1900180 regulation of protein localization to nucleus 27.7778 6 no
GO:1900182 positive regulation of protein localization to nucleus 27.7778 6 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 27.7778 7 no
GO:2000278 regulation of DNA biosynthetic process 27.7778 6 no
GO:2000573 positive regulation of DNA biosynthetic process 27.7778 7 no
GO:0010468 regulation of gene expression 27.7778 5 no
GO:0009057 macromolecule catabolic process 27.7778 4 yes
GO:0050807 regulation of synapse organization 27.7778 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 no
GO:0016192 vesicle-mediated transport 27.7778 4 no
GO:0051049 regulation of transport 27.7778 4 no
GO:0009966 regulation of signal transduction 27.7778 4 no
GO:0010646 regulation of cell communication 27.7778 4 no
GO:0031401 positive regulation of protein modification process 27.7778 7 no
GO:0043085 positive regulation of catalytic activity 27.7778 4 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0051347 positive regulation of transferase activity 27.7778 5 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0032206 positive regulation of telomere maintenance 22.2222 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 22.2222 8 no
GO:0050821 protein stabilization 22.2222 4 no
GO:0070202 regulation of establishment of protein localization to chromosome 22.2222 7 no
GO:0070203 regulation of establishment of protein localization to telomere 22.2222 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 22.2222 8 no
GO:1904814 regulation of protein localization to chromosome, telomeric region 22.2222 6 no
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 22.2222 6 no
GO:1904851 positive regulation of establishment of protein localization to telomere 22.2222 7 no
GO:1904869 regulation of protein localization to Cajal body 22.2222 7 no
GO:1904871 positive regulation of protein localization to Cajal body 22.2222 7 no
GO:1904872 regulation of telomerase RNA localization to Cajal body 22.2222 4 no
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 22.2222 4 no
GO:2001252 positive regulation of chromosome organization 22.2222 7 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0030163 protein catabolic process 16.6667 4 yes
GO:0099175 regulation of postsynapse organization 16.6667 6 yes
GO:1901565 organonitrogen compound catabolic process 16.6667 4 yes
GO:0002084 protein depalmitoylation 11.1111 6 yes
GO:0035601 protein deacylation 11.1111 5 yes
GO:0042157 lipoprotein metabolic process 11.1111 4 yes
GO:0042159 lipoprotein catabolic process 11.1111 5 yes
GO:0072657 protein localization to membrane 11.1111 4 yes
GO:0098732 macromolecule deacylation 11.1111 5 yes
GO:0098734 macromolecule depalmitoylation 11.1111 6 yes
GO:1902816 regulation of protein localization to microtubule 11.1111 6 yes
GO:1902817 negative regulation of protein localization to microtubule 11.1111 6 yes
GO:1903828 negative regulation of protein localization 11.1111 5 yes
GO:1905666 regulation of protein localization to endosome 11.1111 6 yes
GO:1905668 positive regulation of protein localization to endosome 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNIP1_HUMAN [view interactions] High throughput no yes
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF1_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
RGS20_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
KRA59_HUMAN [view interactions] High throughput no no
BIRC2_HUMAN [view interactions] High throughput no yes
PNMA1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
HXA1_HUMAN [view interactions] High throughput no no
HPGDS_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PLS4_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
DYT2B_HUMAN [view interactions] High throughput no no
C5AR2_HUMAN [view interactions] High throughput no yes
LPAR6_HUMAN [view interactions] High throughput no no
APJ_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
CHM4A_HUMAN [view interactions] High throughput no no
GPR12_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
CCZ1_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
DD19B_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG4_HUMAN [view interactions] High throughput no no
AVR2A_HUMAN [view interactions] High throughput no yes
AB17C_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
JIP4_HUMAN [view interactions] High throughput no yes
PKHH3_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] Computational yes no
RASH_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no