Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AB17C_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AB17C_HUMAN
GO:0016462 pyrophosphatase activity 44.4444 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 44.4444 4 no
GO:0017076 purine nucleotide binding 44.4444 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 44.4444 6 no
GO:0032555 purine ribonucleotide binding 44.4444 4 no
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 no
GO:0003924 GTPase activity 33.3333 7 no
GO:0005525 GTP binding 33.3333 5 no
GO:0019001 guanyl nucleotide binding 33.3333 5 no
GO:0019003 GDP binding 33.3333 4 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0016790 thiolester hydrolase activity 22.2222 4 yes
GO:0015631 tubulin binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AB17C_HUMAN
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0048523 negative regulation of cellular process 77.7778 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0010941 regulation of cell death 55.5556 4 no
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0023056 positive regulation of signaling 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0031399 regulation of protein modification process 55.5556 6 no
GO:0042981 regulation of apoptotic process 55.5556 6 no
GO:0043067 regulation of programmed cell death 55.5556 5 no
GO:0048584 positive regulation of response to stimulus 55.5556 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0010646 regulation of cell communication 55.5556 4 no
GO:0010647 positive regulation of cell communication 55.5556 5 no
GO:0016192 vesicle-mediated transport 44.4444 4 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043066 negative regulation of apoptotic process 44.4444 7 no
GO:0043069 negative regulation of programmed cell death 44.4444 6 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 no
GO:0044089 positive regulation of cellular component biogenesis 44.4444 5 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0051336 regulation of hydrolase activity 44.4444 4 no
GO:0060548 negative regulation of cell death 44.4444 5 no
GO:0010562 positive regulation of phosphorus metabolic process 44.4444 6 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0031401 positive regulation of protein modification process 44.4444 7 no
GO:0045937 positive regulation of phosphate metabolic process 44.4444 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051247 positive regulation of protein metabolic process 44.4444 6 no
GO:0032880 regulation of protein localization 44.4444 5 yes
GO:0050807 regulation of synapse organization 44.4444 5 yes
GO:0060341 regulation of cellular localization 44.4444 4 yes
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0006996 organelle organization 44.4444 4 no
GO:0009967 positive regulation of signal transduction 44.4444 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0031331 positive regulation of cellular catabolic process 33.3333 6 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0000165 MAPK cascade 33.3333 4 no
GO:0007264 small GTPase mediated signal transduction 33.3333 4 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043523 regulation of neuron apoptotic process 33.3333 6 no
GO:0043524 negative regulation of neuron apoptotic process 33.3333 7 no
GO:0048168 regulation of neuronal synaptic plasticity 33.3333 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:1901214 regulation of neuron death 33.3333 5 no
GO:1901215 negative regulation of neuron death 33.3333 6 no
GO:0009057 macromolecule catabolic process 33.3333 4 yes
GO:0030163 protein catabolic process 33.3333 4 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:1901565 organonitrogen compound catabolic process 33.3333 4 yes
GO:1903829 positive regulation of protein localization 33.3333 5 yes
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009896 positive regulation of catabolic process 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0031648 protein destabilization 22.2222 4 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034764 positive regulation of transmembrane transport 22.2222 5 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0034767 positive regulation of ion transmembrane transport 22.2222 6 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0043270 positive regulation of ion transport 22.2222 5 no
GO:0048193 Golgi vesicle transport 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 22.2222 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 22.2222 6 no
GO:0051282 regulation of sequestering of calcium ion 22.2222 4 no
GO:0051650 establishment of vesicle localization 22.2222 4 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0051928 positive regulation of calcium ion transport 22.2222 6 no
GO:0060491 regulation of cell projection assembly 22.2222 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:1902850 microtubule cytoskeleton organization involved in mitosis 22.2222 4 no
GO:1903169 regulation of calcium ion transmembrane transport 22.2222 7 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:1904064 positive regulation of cation transmembrane transport 22.2222 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 22.2222 7 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 no
GO:0008104 protein localization 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0006897 endocytosis 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010517 regulation of phospholipase activity 22.2222 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051346 negative regulation of hydrolase activity 22.2222 5 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0060191 regulation of lipase activity 22.2222 5 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 22.2222 8 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0006508 proteolysis 22.2222 4 no
GO:0002082 regulation of oxidative phosphorylation 22.2222 8 no
GO:0006140 regulation of nucleotide metabolic process 22.2222 5 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 10 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010950 positive regulation of endopeptidase activity 22.2222 7 no
GO:0010952 positive regulation of peptidase activity 22.2222 6 no
GO:0019438 aromatic compound biosynthetic process 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0030808 regulation of nucleotide biosynthetic process 22.2222 6 no
GO:0031334 positive regulation of protein-containing complex assembly 22.2222 6 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 9 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 8 no
GO:0043457 regulation of cellular respiration 22.2222 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 22.2222 4 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0052547 regulation of peptidase activity 22.2222 5 no
GO:0052548 regulation of endopeptidase activity 22.2222 6 no
GO:0062012 regulation of small molecule metabolic process 22.2222 4 no
GO:0062013 positive regulation of small molecule metabolic process 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:1900371 regulation of purine nucleotide biosynthetic process 22.2222 7 no
GO:1900542 regulation of purine nucleotide metabolic process 22.2222 6 no
GO:1901362 organic cyclic compound biosynthetic process 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1903715 regulation of aerobic respiration 22.2222 7 no
GO:2000116 regulation of cysteine-type endopeptidase activity 22.2222 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 22.2222 8 no
GO:0002084 protein depalmitoylation 22.2222 6 yes
GO:0035601 protein deacylation 22.2222 5 yes
GO:0042157 lipoprotein metabolic process 22.2222 4 yes
GO:0042159 lipoprotein catabolic process 22.2222 5 yes
GO:0098732 macromolecule deacylation 22.2222 5 yes
GO:0098734 macromolecule depalmitoylation 22.2222 6 yes
GO:0099175 regulation of postsynapse organization 22.2222 6 yes
GO:1902816 regulation of protein localization to microtubule 22.2222 6 yes
GO:1902817 negative regulation of protein localization to microtubule 22.2222 6 yes
GO:1903828 negative regulation of protein localization 22.2222 5 yes
GO:1905666 regulation of protein localization to endosome 22.2222 6 yes
GO:1905668 positive regulation of protein localization to endosome 22.2222 6 yes
GO:0007612 learning 22.2222 4 no
GO:0010506 regulation of autophagy 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A2MG_HUMAN [view interactions] High throughput no yes
TOR1A_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
PAHX_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
PEX26_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
AB17A_HUMAN [view entry] [view interactions] High throughput yes yes
MFD4A_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
CAN5_HUMAN [view entry] [view interactions] High throughput yes yes
CAN6_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no
RASK_HUMAN [view entry] [view interactions] Computational yes no