Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AB17C_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AB17C_HUMAN
GO:0016790 thiolester hydrolase activity 33.3333 4 yes
GO:0015631 tubulin binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AB17C_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0048523 negative regulation of cellular process 83.3333 4 yes
GO:0051128 regulation of cellular component organization 83.3333 4 yes
GO:0032880 regulation of protein localization 66.6667 5 yes
GO:0050807 regulation of synapse organization 66.6667 5 yes
GO:0060341 regulation of cellular localization 66.6667 4 yes
GO:0009057 macromolecule catabolic process 50.0000 4 yes
GO:0030163 protein catabolic process 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 50.0000 4 yes
GO:1903828 negative regulation of protein localization 50.0000 5 yes
GO:1903829 positive regulation of protein localization 50.0000 5 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0009896 positive regulation of catabolic process 50.0000 5 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0042981 regulation of apoptotic process 50.0000 5 no
GO:0043067 regulation of programmed cell death 50.0000 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 50.0000 5 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051336 regulation of hydrolase activity 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0002084 protein depalmitoylation 33.3333 6 yes
GO:0035601 protein deacylation 33.3333 5 yes
GO:0042157 lipoprotein metabolic process 33.3333 4 yes
GO:0042159 lipoprotein catabolic process 33.3333 5 yes
GO:0098732 macromolecule deacylation 33.3333 5 yes
GO:0098734 macromolecule depalmitoylation 33.3333 6 yes
GO:0099175 regulation of postsynapse organization 33.3333 6 yes
GO:1902816 regulation of protein localization to microtubule 33.3333 6 yes
GO:1902817 negative regulation of protein localization to microtubule 33.3333 6 yes
GO:1905666 regulation of protein localization to endosome 33.3333 6 yes
GO:1905668 positive regulation of protein localization to endosome 33.3333 6 yes
GO:0008104 protein localization 33.3333 4 no
GO:0006508 proteolysis 33.3333 4 no
GO:0002082 regulation of oxidative phosphorylation 33.3333 8 no
GO:0006140 regulation of nucleotide metabolic process 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 10 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010950 positive regulation of endopeptidase activity 33.3333 7 no
GO:0010952 positive regulation of peptidase activity 33.3333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0030808 regulation of nucleotide biosynthetic process 33.3333 5 no
GO:0031334 positive regulation of protein-containing complex assembly 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 no
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 9 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 8 no
GO:0043457 regulation of cellular respiration 33.3333 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0052547 regulation of peptidase activity 33.3333 5 no
GO:0052548 regulation of endopeptidase activity 33.3333 6 no
GO:0062012 regulation of small molecule metabolic process 33.3333 4 no
GO:0062013 positive regulation of small molecule metabolic process 33.3333 5 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:1900371 regulation of purine nucleotide biosynthetic process 33.3333 6 no
GO:1900542 regulation of purine nucleotide metabolic process 33.3333 6 no
GO:1901362 organic cyclic compound biosynthetic process 33.3333 4 no
GO:1902850 microtubule cytoskeleton organization involved in mitosis 33.3333 4 no
GO:1903715 regulation of aerobic respiration 33.3333 7 no
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 33.3333 8 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006915 apoptotic process 33.3333 4 no
GO:0010506 regulation of autophagy 33.3333 6 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0010959 regulation of metal ion transport 33.3333 6 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0031331 positive regulation of cellular catabolic process 33.3333 6 no
GO:0031648 protein destabilization 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034764 positive regulation of transmembrane transport 33.3333 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043065 positive regulation of apoptotic process 33.3333 6 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043068 positive regulation of programmed cell death 33.3333 5 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043269 regulation of monoatomic ion transport 33.3333 5 no
GO:0043270 positive regulation of monoatomic ion transport 33.3333 5 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 33.3333 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 33.3333 6 no
GO:0051282 regulation of sequestering of calcium ion 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051650 establishment of vesicle localization 33.3333 4 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0051928 positive regulation of calcium ion transport 33.3333 6 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 33.3333 6 no
GO:1904064 positive regulation of cation transmembrane transport 33.3333 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 33.3333 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A2MG_HUMAN [view interactions] High throughput no yes
TOR1A_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
PAHX_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
PEX26_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
AB17A_HUMAN [view entry] [view interactions] High throughput yes yes
MFD4A_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
CAN5_HUMAN [view entry] [view interactions] High throughput yes yes
CAN6_HUMAN [view interactions] High throughput no no