PDE2A_HUMAN
Evidence for PS localization
Functions
Regulates mitochondrial cAMP levels and respiration . Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
![](/static/images/legend1.gif)
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
![](/static/images/legend2.gif)
Network
Isoforms
Interacting regions
Canonical [PDE2A_HUMAN]
Isoform [O00408-2] alignment
Isoform [O00408-3] alignment
Isoform [O00408-4] alignment
Isoform [O00408-5] alignment
Isoform [O00408-6] alignment
Isoform [H0YGL2] alignment
Isoform [H0YG13] alignment
Isoform [H0YFL1] alignment
Isoform [C9JPD5] alignment
Isoform [H7C009] alignment
Isoform [E9PEF1] alignment
Isoform [F5GXX2] alignment
Isoform [F5H5P8] alignment
Isoform [F5H2V7] alignment
Isoform [F5H2Z0] alignment
Isoform [F5H2R8] alignment
Isoform [F5H3Z7] alignment
Isoform [F5H143] alignment
Isoform [F5H130] alignment
Isoform [F5H1D7] alignment
LOADING 47%
![](/static/images/legend3.gif)
Disease-causing germline mutations
No data found.
Linear motifs
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI002310 | MOD_NMyristoyl | MOD | 1 | 7 | - |
ELMI002310 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PDE2A_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 36.1111 | 4 | yes |
GO:0046872 | metal ion binding | 36.1111 | 5 | yes |
GO:0042803 | protein homodimerization activity | 27.7778 | 4 | yes |
GO:0043168 | anion binding | 25.0000 | 4 | yes |
GO:0000166 | nucleotide binding | 22.2222 | 4 | yes |
GO:0017076 | purine nucleotide binding | 22.2222 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | yes |
GO:0032555 | purine ribonucleotide binding | 16.6667 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
GO:0008270 | zinc ion binding | 11.1111 | 7 | yes |
GO:0046914 | transition metal ion binding | 11.1111 | 6 | yes |
GO:0000287 | magnesium ion binding | 5.5556 | 6 | yes |
GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 5.5556 | 6 | yes |
GO:0004114 | 3,5-cyclic-nucleotide phosphodiesterase activity | 5.5556 | 7 | yes |
GO:0004115 | 3,5-cyclic-AMP phosphodiesterase activity | 5.5556 | 8 | yes |
GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | 5.5556 | 8 | yes |
GO:0008081 | phosphoric diester hydrolase activity | 5.5556 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 5.5556 | 6 | yes |
GO:0030551 | cyclic nucleotide binding | 5.5556 | 5 | yes |
GO:0030552 | cAMP binding | 5.5556 | 5 | yes |
GO:0030553 | cGMP binding | 5.5556 | 5 | yes |
GO:0030911 | TPR domain binding | 5.5556 | 4 | yes |
GO:0032561 | guanyl ribonucleotide binding | 5.5556 | 5 | yes |
GO:0042301 | phosphate ion binding | 5.5556 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 5.5556 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PDE2A_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 55.5556 | 4 | yes |
GO:0010646 | regulation of cell communication | 47.2222 | 4 | yes |
GO:0006996 | organelle organization | 47.2222 | 4 | no |
GO:0008104 | protein localization | 47.2222 | 4 | no |
GO:0009966 | regulation of signal transduction | 44.4444 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 38.8889 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 36.1111 | 4 | yes |
GO:0071702 | organic substance transport | 36.1111 | 4 | no |
GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 30.5556 | 4 | yes |
GO:0033043 | regulation of organelle organization | 30.5556 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 30.5556 | 5 | yes |
GO:0051049 | regulation of transport | 30.5556 | 4 | no |
GO:0010647 | positive regulation of cell communication | 30.5556 | 5 | no |
GO:0023056 | positive regulation of signaling | 30.5556 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | yes |
GO:0010468 | regulation of gene expression | 27.7778 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
A2MG_HUMAN | [view interactions] | High throughput | no | yes |
ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
AIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
APAF_HUMAN | [view interactions] | High throughput | no | no |
AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG3_HUMAN | [view interactions] | High throughput | no | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
ATP9B_HUMAN | [view interactions] | High throughput | no | yes |
B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CAV2_HUMAN | [view interactions] | High throughput | no | no |
CC127_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COBA1_HUMAN | [view interactions] | High throughput | no | no |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
COX15_HUMAN | [view interactions] | High throughput | no | yes |
CP20A_HUMAN | [view interactions] | High throughput | no | yes |