Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE2A_HUMAN

Regulates mitochondrial cAMP levels and respiration . Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed). [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI002310 MOD_NMyristoyl MOD 1 7 -
ELMI002310 MOD_NMyristoyl MOD 1 7 -

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE2A_HUMAN
GO:0043169 cation binding 36.1111 4 yes
GO:0046872 metal ion binding 36.1111 5 yes
GO:0042803 protein homodimerization activity 27.7778 4 yes
GO:0043168 anion binding 25.0000 4 yes
GO:0000166 nucleotide binding 22.2222 4 yes
GO:0017076 purine nucleotide binding 22.2222 5 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 yes
GO:0032555 purine ribonucleotide binding 16.6667 4 yes
GO:0032559 adenyl ribonucleotide binding 16.6667 5 yes
GO:0008270 zinc ion binding 11.1111 7 yes
GO:0046914 transition metal ion binding 11.1111 6 yes
GO:0000287 magnesium ion binding 5.5556 6 yes
GO:0004112 cyclic-nucleotide phosphodiesterase activity 5.5556 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 5.5556 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 5.5556 8 yes
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 5.5556 8 yes
GO:0008081 phosphoric diester hydrolase activity 5.5556 5 yes
GO:0019001 guanyl nucleotide binding 5.5556 6 yes
GO:0030551 cyclic nucleotide binding 5.5556 5 yes
GO:0030552 cAMP binding 5.5556 5 yes
GO:0030553 cGMP binding 5.5556 5 yes
GO:0030911 TPR domain binding 5.5556 4 yes
GO:0032561 guanyl ribonucleotide binding 5.5556 5 yes
GO:0042301 phosphate ion binding 5.5556 5 yes
GO:0042578 phosphoric ester hydrolase activity 5.5556 4 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 5.5556 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDE2A_HUMAN
GO:0048522 positive regulation of cellular process 55.5556 4 yes
GO:0010646 regulation of cell communication 47.2222 4 yes
GO:0006996 organelle organization 47.2222 4 no
GO:0008104 protein localization 47.2222 4 no
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0051128 regulation of cellular component organization 44.4444 4 yes
GO:0031323 regulation of cellular metabolic process 38.8889 4 yes
GO:0048523 negative regulation of cellular process 38.8889 4 yes
GO:0060255 regulation of macromolecule metabolic process 38.8889 4 yes
GO:0080090 regulation of primary metabolic process 38.8889 4 yes
GO:0048584 positive regulation of response to stimulus 36.1111 4 yes
GO:0071702 organic substance transport 36.1111 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0009893 positive regulation of metabolic process 30.5556 4 yes
GO:0033043 regulation of organelle organization 30.5556 5 yes
GO:1902531 regulation of intracellular signal transduction 30.5556 5 yes
GO:0051049 regulation of transport 30.5556 4 no
GO:0010647 positive regulation of cell communication 30.5556 5 no
GO:0023056 positive regulation of signaling 30.5556 4 no
GO:0009889 regulation of biosynthetic process 27.7778 4 yes
GO:0010468 regulation of gene expression 27.7778 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 yes
GO:0031325 positive regulation of cellular metabolic process 27.7778 5 yes
GO:0031326 regulation of cellular biosynthetic process 27.7778 5 yes
GO:0051252 regulation of RNA metabolic process 27.7778 5 yes
GO:0033365 protein localization to organelle 27.7778 5 no
GO:0061024 membrane organization 27.7778 4 no
GO:0009967 positive regulation of signal transduction 27.7778 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 yes
GO:0007005 mitochondrion organization 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 yes
GO:0071310 cellular response to organic substance 22.2222 4 yes
GO:0015031 protein transport 22.2222 4 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0009890 negative regulation of biosynthetic process 19.4444 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 19.4444 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 19.4444 6 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 19.4444 5 yes
GO:0051253 negative regulation of RNA metabolic process 19.4444 6 yes
GO:0009891 positive regulation of biosynthetic process 16.6667 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 16.6667 6 yes
GO:0010628 positive regulation of gene expression 16.6667 7 yes
GO:0031328 positive regulation of cellular biosynthetic process 16.6667 6 yes
GO:0045892 negative regulation of DNA-templated transcription 16.6667 8 yes
GO:0080134 regulation of response to stress 16.6667 4 yes
GO:0141124 intracellular signaling cassette 16.6667 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 16.6667 7 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 13.8889 9 yes
GO:0006357 regulation of transcription by RNA polymerase II 13.8889 8 yes
GO:0009968 negative regulation of signal transduction 13.8889 5 yes
GO:0010648 negative regulation of cell communication 13.8889 5 yes
GO:0010821 regulation of mitochondrion organization 13.8889 6 yes
GO:0023057 negative regulation of signaling 13.8889 4 yes
GO:0034097 response to cytokine 13.8889 4 yes
GO:0048585 negative regulation of response to stimulus 13.8889 4 yes
GO:0071345 cellular response to cytokine stimulus 13.8889 5 yes
GO:1901701 cellular response to oxygen-containing compound 13.8889 4 yes
GO:0006163 purine nucleotide metabolic process 11.1111 5 yes
GO:0006753 nucleoside phosphate metabolic process 11.1111 4 yes
GO:0009117 nucleotide metabolic process 11.1111 5 yes
GO:0010243 response to organonitrogen compound 11.1111 4 yes
GO:0032101 regulation of response to external stimulus 11.1111 4 yes
GO:0032103 positive regulation of response to external stimulus 11.1111 5 yes
GO:0071417 cellular response to organonitrogen compound 11.1111 4 yes
GO:0072521 purine-containing compound metabolic process 11.1111 4 yes
GO:1901699 cellular response to nitrogen compound 11.1111 4 yes
GO:0002521 leukocyte differentiation 8.3333 4 yes
GO:0002573 myeloid leukocyte differentiation 8.3333 5 yes
GO:0003018 vascular process in circulatory system 8.3333 4 yes
GO:0009150 purine ribonucleotide metabolic process 8.3333 6 yes
GO:0009259 ribonucleotide metabolic process 8.3333 5 yes
GO:0014070 response to organic cyclic compound 8.3333 4 yes
GO:0019693 ribose phosphate metabolic process 8.3333 4 yes
GO:0030099 myeloid cell differentiation 8.3333 4 yes
GO:0031347 regulation of defense response 8.3333 5 yes
GO:0031349 positive regulation of defense response 8.3333 5 yes
GO:0071363 cellular response to growth factor stimulus 8.3333 4 yes
GO:0071407 cellular response to organic cyclic compound 8.3333 5 yes
GO:0071466 cellular response to xenobiotic stimulus 8.3333 4 yes
GO:1901565 organonitrogen compound catabolic process 8.3333 4 yes
GO:1902532 negative regulation of intracellular signal transduction 8.3333 6 yes
GO:0001885 endothelial cell development 5.5556 5 yes
GO:0002064 epithelial cell development 5.5556 4 yes
GO:0003281 ventricular septum development 5.5556 4 yes
GO:0006195 purine nucleotide catabolic process 5.5556 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 5.5556 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 5.5556 5 yes
GO:0009154 purine ribonucleotide catabolic process 5.5556 6 yes
GO:0009166 nucleotide catabolic process 5.5556 6 yes
GO:0009187 cyclic nucleotide metabolic process 5.5556 6 yes
GO:0009214 cyclic nucleotide catabolic process 5.5556 7 yes
GO:0009261 ribonucleotide catabolic process 5.5556 5 yes
GO:0010752 regulation of cGMP-mediated signaling 5.5556 6 yes
GO:0010754 negative regulation of cGMP-mediated signaling 5.5556 7 yes
GO:0014074 response to purine-containing compound 5.5556 5 yes
GO:0019933 cAMP-mediated signaling 5.5556 5 yes
GO:0019934 cGMP-mediated signaling 5.5556 5 yes
GO:0030224 monocyte differentiation 5.5556 6 yes
GO:0034655 nucleobase-containing compound catabolic process 5.5556 4 yes
GO:0035904 aorta development 5.5556 5 yes
GO:0036005 response to macrophage colony-stimulating factor 5.5556 5 yes
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 5.5556 6 yes
GO:0043116 negative regulation of vascular permeability 5.5556 4 yes
GO:0043117 positive regulation of vascular permeability 5.5556 4 yes
GO:0043949 regulation of cAMP-mediated signaling 5.5556 6 yes
GO:0043951 negative regulation of cAMP-mediated signaling 5.5556 7 yes
GO:0046068 cGMP metabolic process 5.5556 7 yes
GO:0046069 cGMP catabolic process 5.5556 7 yes
GO:0046434 organophosphate catabolic process 5.5556 4 yes
GO:0046683 response to organophosphorus 5.5556 4 yes
GO:0050727 regulation of inflammatory response 5.5556 5 yes
GO:0050729 positive regulation of inflammatory response 5.5556 6 yes
GO:0051591 response to cAMP 5.5556 4 yes
GO:0052652 cyclic purine nucleotide metabolic process 5.5556 6 yes
GO:0060840 artery development 5.5556 4 yes
GO:0061028 establishment of endothelial barrier 5.5556 6 yes
GO:0070305 response to cGMP 5.5556 4 yes
GO:0071260 cellular response to mechanical stimulus 5.5556 4 yes
GO:0071320 cellular response to cAMP 5.5556 5 yes
GO:0071321 cellular response to cGMP 5.5556 5 yes
GO:0071559 response to transforming growth factor beta 5.5556 4 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 5.5556 5 yes
GO:0072523 purine-containing compound catabolic process 5.5556 5 yes
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus 5.5556 6 yes
GO:0097012 response to granulocyte macrophage colony-stimulating factor 5.5556 5 yes
GO:1901136 carbohydrate derivative catabolic process 5.5556 4 yes
GO:1901292 nucleoside phosphate catabolic process 5.5556 5 yes
GO:1901361 organic cyclic compound catabolic process 5.5556 4 yes
GO:1903131 mononuclear cell differentiation 5.5556 5 yes
GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine 5.5556 5 yes
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine 5.5556 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
AIP_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE2A_HUMAN [view entry] [view interactions] Low throughput yes yes
FADS3_HUMAN [view interactions] High throughput no no
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
S35A3_HUMAN [view interactions] High throughput no yes
MCAT_HUMAN [view interactions] High throughput no yes
COBA1_HUMAN [view interactions] High throughput no no
ATG3_HUMAN [view interactions] High throughput no yes
ORML3_HUMAN [view interactions] High throughput no no
MBOA5_HUMAN [view interactions] High throughput no no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
PP4P2_HUMAN [view interactions] High throughput no yes
TTC1_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
SMRCD_HUMAN [view interactions] High throughput no yes
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
PDES1_HUMAN [view interactions] High throughput no no
ERGI1_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
S12A4_HUMAN [view interactions] High throughput no yes
CP20A_HUMAN [view interactions] High throughput no yes
PTH2_HUMAN [view interactions] High throughput no yes
PLS3_HUMAN [view interactions] High throughput no yes
FADS2_HUMAN [view interactions] High throughput no yes
ITCH_HUMAN [view interactions] High throughput no yes
MRP1_HUMAN [view interactions] High throughput no no
GBA1_HUMAN [view interactions] High throughput no yes
TMED5_HUMAN [view interactions] High throughput no yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA3_HUMAN [view entry] [view interactions] High throughput yes yes
TMX3_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
TM165_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
GOT1B_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
APAF_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
STEA3_HUMAN [view interactions] High throughput no yes
B2CL1_HUMAN [view interactions] High throughput no yes
MRP5_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
GALT1_HUMAN [view interactions] High throughput no yes
MARC2_HUMAN [view interactions] High throughput no no
Z3H7B_HUMAN [view interactions] High throughput no no
COX15_HUMAN [view interactions] High throughput no yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
UB2G2_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
PRAF2_HUMAN [view entry] [view interactions] High throughput yes yes
STX10_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
MK11_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
OBI1_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
SLX4I_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
S38A7_HUMAN [view interactions] High throughput no yes
UXS1_HUMAN [view interactions] High throughput no yes
ABCBA_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
STX16_HUMAN [view interactions] High throughput no yes
A2MG_HUMAN [view interactions] High throughput no yes
CHMP5_HUMAN [view interactions] High throughput no yes
TOM1_HUMAN [view interactions] High throughput no yes
CC127_HUMAN [view entry] [view interactions] High throughput yes yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
DAZP2_HUMAN [view interactions] High throughput no no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
ATP9B_HUMAN [view interactions] High throughput no yes
RDH13_HUMAN [view interactions] High throughput no no
RELL1_HUMAN [view interactions] High throughput no yes
TMED1_HUMAN [view interactions] High throughput no yes
GL8D1_HUMAN [view interactions] High throughput no yes
HS2ST_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RN121_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
VP37C_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
MON2_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
CHM2A_HUMAN [view interactions] High throughput no yes
MFS10_HUMAN [view interactions] High throughput no yes
RNF26_HUMAN [view interactions] High throughput no yes
MYH2_HUMAN [view interactions] High throughput no yes
CAV2_HUMAN [view interactions] High throughput no no
PEX2_HUMAN [view interactions] High throughput no yes
FUT8_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
S12A6_HUMAN [view interactions] High throughput no yes
PACC1_HUMAN [view interactions] High throughput no no
PPM1L_HUMAN [view interactions] High throughput no yes
MB12B_HUMAN [view interactions] High throughput no no