Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRUN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002936 LIG_KLC1_WD_1 LIG 1136 1145 -
ELMI002936 LIG_KLC1_WD_1 LIG 1136 1145 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PRUN2_HUMAN
GO:0000166 nucleotide binding 46.1538 4 no
GO:0017076 purine nucleotide binding 46.1538 5 no
GO:0030554 adenyl nucleotide binding 46.1538 6 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0032559 adenyl ribonucleotide binding 38.4615 5 no
GO:0043168 anion binding 38.4615 4 no
GO:0005524 ATP binding 34.6154 5 no
GO:0035639 purine ribonucleoside triphosphate binding 34.6154 4 no
GO:0003723 RNA binding 34.6154 4 no
GO:0042803 protein homodimerization activity 30.7692 4 no
GO:0016462 pyrophosphatase activity 15.3846 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 15.3846 4 yes
GO:0043169 cation binding 15.3846 4 yes
GO:0046872 metal ion binding 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PRUN2_HUMAN
GO:0031323 regulation of cellular metabolic process 65.3846 4 no
GO:0060255 regulation of macromolecule metabolic process 65.3846 4 no
GO:0080090 regulation of primary metabolic process 65.3846 4 no
GO:0009889 regulation of biosynthetic process 61.5385 4 no
GO:0010468 regulation of gene expression 61.5385 6 no
GO:0010556 regulation of macromolecule biosynthetic process 61.5385 5 no
GO:0031326 regulation of cellular biosynthetic process 61.5385 5 no
GO:0048523 negative regulation of cellular process 57.6923 4 no
GO:0009893 positive regulation of metabolic process 53.8462 4 no
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0051246 regulation of protein metabolic process 53.8462 5 no
GO:0009892 negative regulation of metabolic process 46.1538 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.1538 5 no
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 no
GO:0031324 negative regulation of cellular metabolic process 46.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.3077 5 no
GO:0042981 regulation of apoptotic process 42.3077 5 no
GO:0043067 regulation of programmed cell death 42.3077 4 no
GO:0006996 organelle organization 38.4615 4 no
GO:0009890 negative regulation of biosynthetic process 38.4615 5 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.4615 6 no
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0031327 negative regulation of cellular biosynthetic process 38.4615 6 no
GO:0051240 positive regulation of multicellular organismal process 38.4615 4 no
GO:0071310 cellular response to organic substance 38.4615 4 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0048585 negative regulation of response to stimulus 38.4615 4 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0051128 regulation of cellular component organization 38.4615 4 no
GO:0051252 regulation of RNA metabolic process 34.6154 5 no
GO:0043066 negative regulation of apoptotic process 34.6154 6 no
GO:0043069 negative regulation of programmed cell death 34.6154 5 no
GO:0009891 positive regulation of biosynthetic process 34.6154 5 no
GO:0009894 regulation of catabolic process 34.6154 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 34.6154 6 no
GO:0031328 positive regulation of cellular biosynthetic process 34.6154 6 no
GO:0051248 negative regulation of protein metabolic process 34.6154 6 no
GO:1902531 regulation of intracellular signal transduction 34.6154 5 no
GO:0001932 regulation of protein phosphorylation 34.6154 7 no
GO:0009968 negative regulation of signal transduction 34.6154 5 no
GO:0010648 negative regulation of cell communication 34.6154 5 no
GO:0019220 regulation of phosphate metabolic process 34.6154 6 no
GO:0023057 negative regulation of signaling 34.6154 4 no
GO:0032101 regulation of response to external stimulus 34.6154 4 no
GO:0042325 regulation of phosphorylation 34.6154 7 no
GO:0051174 regulation of phosphorus metabolic process 34.6154 5 no
GO:0051247 positive regulation of protein metabolic process 34.6154 6 no
GO:0080134 regulation of response to stress 34.6154 4 no
GO:0071363 cellular response to growth factor stimulus 30.7692 4 no
GO:0006796 phosphate-containing compound metabolic process 30.7692 4 no
GO:0010628 positive regulation of gene expression 30.7692 7 no
GO:0010243 response to organonitrogen compound 30.7692 4 no
GO:0031347 regulation of defense response 30.7692 5 no
GO:0071702 organic substance transport 30.7692 4 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 no
GO:1902532 negative regulation of intracellular signal transduction 26.9231 6 no
GO:0006355 regulation of DNA-templated transcription 26.9231 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 26.9231 5 no
GO:2001141 regulation of RNA biosynthetic process 26.9231 6 no
GO:0008104 protein localization 26.9231 4 no
GO:0009059 macromolecule biosynthetic process 26.9231 4 no
GO:0015031 protein transport 26.9231 4 no
GO:0022607 cellular component assembly 26.9231 4 no
GO:0007010 cytoskeleton organization 26.9231 5 no
GO:0010629 negative regulation of gene expression 26.9231 7 no
GO:0030162 regulation of proteolysis 26.9231 6 no
GO:0036211 protein modification process 26.9231 4 no
GO:0043412 macromolecule modification 26.9231 4 no
GO:0051336 regulation of hydrolase activity 26.9231 4 no
GO:0002684 positive regulation of immune system process 26.9231 4 no
GO:0031344 regulation of cell projection organization 26.9231 5 no
GO:0031401 positive regulation of protein modification process 26.9231 7 no
GO:0032103 positive regulation of response to external stimulus 26.9231 5 no
GO:0043549 regulation of kinase activity 26.9231 5 no
GO:0045859 regulation of protein kinase activity 26.9231 6 no
GO:0050776 regulation of immune response 26.9231 4 no
GO:0051338 regulation of transferase activity 26.9231 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.9231 6 no
GO:1903037 regulation of leukocyte cell-cell adhesion 23.0769 6 no
GO:1903039 positive regulation of leukocyte cell-cell adhesion 23.0769 7 no
GO:0051253 negative regulation of RNA metabolic process 23.0769 6 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:2001233 regulation of apoptotic signaling pathway 23.0769 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 23.0769 6 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0006915 apoptotic process 23.0769 4 yes
GO:0001817 regulation of cytokine production 23.0769 4 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010647 positive regulation of cell communication 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0034097 response to cytokine 23.0769 4 no
GO:0043086 negative regulation of catalytic activity 23.0769 4 no
GO:0052547 regulation of peptidase activity 23.0769 5 no
GO:0052548 regulation of endopeptidase activity 23.0769 6 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0002694 regulation of leukocyte activation 23.0769 4 no
GO:0002696 positive regulation of leukocyte activation 23.0769 5 no
GO:0002831 regulation of response to biotic stimulus 23.0769 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.0769 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0022407 regulation of cell-cell adhesion 23.0769 5 no
GO:0022409 positive regulation of cell-cell adhesion 23.0769 6 no
GO:0030155 regulation of cell adhesion 23.0769 4 no
GO:0031349 positive regulation of defense response 23.0769 5 no
GO:0033993 response to lipid 23.0769 4 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0045088 regulation of innate immune response 23.0769 5 no
GO:0045785 positive regulation of cell adhesion 23.0769 5 no
GO:0045862 positive regulation of proteolysis 23.0769 7 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0050778 positive regulation of immune response 23.0769 5 no
GO:0050863 regulation of T cell activation 23.0769 6 no
GO:0050865 regulation of cell activation 23.0769 4 no
GO:0050867 positive regulation of cell activation 23.0769 5 no
GO:0050870 positive regulation of T cell activation 23.0769 7 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0051249 regulation of lymphocyte activation 23.0769 5 no
GO:0051251 positive regulation of lymphocyte activation 23.0769 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCL2_HUMAN [view interactions] Low throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
ZMYM1_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
APLP1_HUMAN [view interactions] High throughput no yes
NDUV3_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2K_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
PECA1_HUMAN [view interactions] High throughput no no
TTHY_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
KLF11_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
RCN3_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
UBCP1_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
DRA_HUMAN [view interactions] High throughput no no
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF2A_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
DHRS3_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
WSB2_HUMAN [view interactions] High throughput no yes