Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRUN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002936 LIG_KLC1_WD_1 LIG 1136 1145 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PRUN2_HUMAN
GO:0017076 purine nucleotide binding 34.4828 4 no
GO:0030554 adenyl nucleotide binding 34.4828 5 no
GO:0032555 purine ribonucleotide binding 34.4828 4 no
GO:0032559 adenyl ribonucleotide binding 34.4828 5 no
GO:0005524 ATP binding 31.0345 5 no
GO:0035639 purine ribonucleoside triphosphate binding 31.0345 4 no
GO:0003723 RNA binding 31.0345 4 no
GO:0042803 protein homodimerization activity 27.5862 4 no
GO:0015631 tubulin binding 20.6897 4 no
GO:0045296 cadherin binding 20.6897 4 no
GO:0046872 metal ion binding 17.2414 4 yes
GO:0016462 pyrophosphatase activity 10.3448 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 10.3448 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PRUN2_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 62.0690 4 no
GO:0060255 regulation of macromolecule metabolic process 62.0690 4 no
GO:0080090 regulation of primary metabolic process 62.0690 4 no
GO:0009893 positive regulation of metabolic process 55.1724 4 no
GO:0010468 regulation of gene expression 55.1724 5 no
GO:0031323 regulation of cellular metabolic process 55.1724 4 no
GO:0051246 regulation of protein metabolic process 55.1724 5 no
GO:0048523 negative regulation of cellular process 51.7241 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.2759 5 no
GO:0006996 organelle organization 44.8276 4 no
GO:0009889 regulation of biosynthetic process 44.8276 4 no
GO:0031326 regulation of cellular biosynthetic process 44.8276 5 no
GO:0009892 negative regulation of metabolic process 41.3793 4 no
GO:0010556 regulation of macromolecule biosynthetic process 41.3793 5 no
GO:0010605 negative regulation of macromolecule metabolic process 41.3793 5 no
GO:0031324 negative regulation of cellular metabolic process 41.3793 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 41.3793 5 no
GO:0048522 positive regulation of cellular process 41.3793 4 no
GO:0071310 cellular response to organic substance 41.3793 4 no
GO:0009966 regulation of signal transduction 37.9310 4 no
GO:0010646 regulation of cell communication 37.9310 4 no
GO:0010941 regulation of cell death 37.9310 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.9310 5 no
GO:0031399 regulation of protein modification process 37.9310 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.9310 5 no
GO:0051247 positive regulation of protein metabolic process 37.9310 6 no
GO:0022607 cellular component assembly 34.4828 4 no
GO:0042981 regulation of apoptotic process 34.4828 6 no
GO:0043067 regulation of programmed cell death 34.4828 5 no
GO:0048585 negative regulation of response to stimulus 34.4828 4 no
GO:0051252 regulation of RNA metabolic process 34.4828 5 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0051128 regulation of cellular component organization 34.4828 4 no
GO:0048584 positive regulation of response to stimulus 34.4828 4 no
GO:0010243 response to organonitrogen compound 31.0345 4 no
GO:0043933 protein-containing complex organization 31.0345 4 no
GO:1901701 cellular response to oxygen-containing compound 31.0345 4 no
GO:0051049 regulation of transport 31.0345 4 no
GO:0060548 negative regulation of cell death 31.0345 5 no
GO:0080134 regulation of response to stress 31.0345 4 no
GO:0001932 regulation of protein phosphorylation 31.0345 7 no
GO:0009894 regulation of catabolic process 31.0345 4 no
GO:0019220 regulation of phosphate metabolic process 31.0345 6 no
GO:0042325 regulation of phosphorylation 31.0345 7 no
GO:0051174 regulation of phosphorus metabolic process 31.0345 5 no
GO:0051248 negative regulation of protein metabolic process 31.0345 6 no
GO:0071702 organic substance transport 31.0345 4 no
GO:0071705 nitrogen compound transport 31.0345 4 no
GO:0006355 regulation of DNA-templated transcription 27.5862 6 no
GO:0009890 negative regulation of biosynthetic process 27.5862 5 no
GO:0009968 negative regulation of signal transduction 27.5862 5 no
GO:0010648 negative regulation of cell communication 27.5862 5 no
GO:0023057 negative regulation of signaling 27.5862 4 no
GO:0031327 negative regulation of cellular biosynthetic process 27.5862 6 no
GO:0031401 positive regulation of protein modification process 27.5862 7 no
GO:0043066 negative regulation of apoptotic process 27.5862 7 no
GO:0043069 negative regulation of programmed cell death 27.5862 6 no
GO:1903506 regulation of nucleic acid-templated transcription 27.5862 7 no
GO:2001141 regulation of RNA biosynthetic process 27.5862 6 no
GO:0008104 protein localization 27.5862 4 no
GO:0010628 positive regulation of gene expression 27.5862 6 no
GO:0015031 protein transport 27.5862 4 no
GO:0031325 positive regulation of cellular metabolic process 27.5862 5 no
GO:0051240 positive regulation of multicellular organismal process 27.5862 4 no
GO:0051336 regulation of hydrolase activity 27.5862 4 no
GO:0065003 protein-containing complex assembly 27.5862 5 no
GO:0007010 cytoskeleton organization 27.5862 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 24.1379 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 24.1379 6 no
GO:0051253 negative regulation of RNA metabolic process 24.1379 6 no
GO:0002684 positive regulation of immune system process 24.1379 4 no
GO:0006796 phosphate-containing compound metabolic process 24.1379 4 no
GO:0006886 intracellular protein transport 24.1379 4 no
GO:0030162 regulation of proteolysis 24.1379 6 no
GO:0036211 protein modification process 24.1379 4 no
GO:0043086 negative regulation of catalytic activity 24.1379 4 no
GO:0043412 macromolecule modification 24.1379 4 no
GO:0043549 regulation of kinase activity 24.1379 5 no
GO:0045859 regulation of protein kinase activity 24.1379 6 no
GO:0051338 regulation of transferase activity 24.1379 4 no
GO:0052547 regulation of peptidase activity 24.1379 5 no
GO:0052548 regulation of endopeptidase activity 24.1379 6 no
GO:0070848 response to growth factor 24.1379 4 no
GO:0071363 cellular response to growth factor stimulus 24.1379 5 no
GO:0032101 regulation of response to external stimulus 24.1379 4 no
GO:0016192 vesicle-mediated transport 24.1379 4 no
GO:0045892 negative regulation of DNA-templated transcription 20.6897 7 no
GO:0051050 positive regulation of transport 20.6897 4 no
GO:1902532 negative regulation of intracellular signal transduction 20.6897 6 no
GO:1902679 negative regulation of RNA biosynthetic process 20.6897 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 20.6897 8 no
GO:0001934 positive regulation of protein phosphorylation 20.6897 8 no
GO:0002694 regulation of leukocyte activation 20.6897 4 no
GO:0002696 positive regulation of leukocyte activation 20.6897 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.6897 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 20.6897 5 no
GO:0009059 macromolecule biosynthetic process 20.6897 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.6897 6 no
GO:0010629 negative regulation of gene expression 20.6897 6 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0022407 regulation of cell-cell adhesion 20.6897 5 no
GO:0022409 positive regulation of cell-cell adhesion 20.6897 6 no
GO:0030155 regulation of cell adhesion 20.6897 4 no
GO:0031329 regulation of cellular catabolic process 20.6897 5 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0031400 negative regulation of protein modification process 20.6897 7 no
GO:0033993 response to lipid 20.6897 4 no
GO:0042327 positive regulation of phosphorylation 20.6897 8 no
GO:0043085 positive regulation of catalytic activity 20.6897 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 20.6897 4 no
GO:0045785 positive regulation of cell adhesion 20.6897 5 no
GO:0045937 positive regulation of phosphate metabolic process 20.6897 7 no
GO:0050863 regulation of T cell activation 20.6897 6 no
GO:0050865 regulation of cell activation 20.6897 4 no
GO:0050867 positive regulation of cell activation 20.6897 5 no
GO:0050870 positive regulation of T cell activation 20.6897 7 no
GO:0051249 regulation of lymphocyte activation 20.6897 5 no
GO:0051251 positive regulation of lymphocyte activation 20.6897 6 no
GO:0060341 regulation of cellular localization 20.6897 4 no
GO:0071417 cellular response to organonitrogen compound 20.6897 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:1901652 response to peptide 20.6897 4 no
GO:1901699 cellular response to nitrogen compound 20.6897 4 no
GO:1903037 regulation of leukocyte cell-cell adhesion 20.6897 6 no
GO:1903039 positive regulation of leukocyte cell-cell adhesion 20.6897 7 no
GO:0001817 regulation of cytokine production 20.6897 4 no
GO:0009967 positive regulation of signal transduction 20.6897 5 no
GO:0010647 positive regulation of cell communication 20.6897 5 no
GO:0023056 positive regulation of signaling 20.6897 4 no
GO:0031347 regulation of defense response 20.6897 5 no
GO:0032103 positive regulation of response to external stimulus 20.6897 5 no
GO:0050776 regulation of immune response 20.6897 4 no
GO:0050778 positive regulation of immune response 20.6897 5 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:0006915 apoptotic process 17.2414 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PRUN2_HUMAN
DOID:0050155 sensory system disease 6.8966 3 no
DOID:110 lens disease 6.8966 5 no
DOID:5614 eye disease 6.8966 4 no
DOID:83 cataract 6.8966 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCL2_HUMAN [view interactions] Low throughput no no
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
ZMYM1_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
APLP1_HUMAN [view interactions] High throughput no yes
NDUV3_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2K_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
PECA1_HUMAN [view interactions] High throughput no no
TTHY_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
KLF11_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
RCN3_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
UBCP1_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
DRA_HUMAN [view interactions] High throughput no no
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF2A_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
DHRS3_HUMAN [view interactions] High throughput no yes