SNX6_HUMAN
Evidence for PS localization
Functions
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B . May contribute to transcription regulation (Probable). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX6_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.8841 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.4348 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.4348 | 4 | no |
| GO:0046872 | metal ion binding | 20.2899 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 20.2899 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.2899 | 4 | no |
| GO:0035091 | phosphatidylinositol binding | 18.8406 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 15.9420 | 4 | yes |
| GO:0005126 | cytokine receptor binding | 4.3478 | 4 | yes |
| GO:0034452 | dynactin binding | 2.8986 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.2174 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.6232 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.1739 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.1739 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.2754 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0008104 | protein localization | 47.8261 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.8261 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.3768 | 4 | yes |
| GO:0051049 | regulation of transport | 44.9275 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.5797 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.5797 | 5 | yes |
| GO:0071702 | organic substance transport | 39.1304 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.6812 | 4 | no |
| GO:0071705 | nitrogen compound transport | 37.6812 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.2319 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.7826 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.8841 | 4 | yes |
| GO:0010468 | regulation of gene expression | 31.8841 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.4348 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 28.9855 | 5 | no |
| GO:0051050 | positive regulation of transport | 28.9855 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9855 | 4 | no |
| GO:0009894 | regulation of catabolic process | 28.9855 | 4 | yes |
| GO:0022607 | cellular component assembly | 27.5362 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.5362 | 4 | no |
| GO:0010941 | regulation of cell death | 27.5362 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.5362 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.0870 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | yes |
| GO:0016197 | endosomal transport | 26.0870 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 24.6377 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.6377 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 24.6377 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 24.6377 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 23.1884 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.1884 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 23.1884 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.1884 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.1884 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.1884 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 23.1884 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 23.1884 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 23.1884 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 21.7391 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 20.2899 | 7 | no |
| GO:0032880 | regulation of protein localization | 20.2899 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.2899 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.2899 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.2899 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.2899 | 5 | no |
| GO:0048878 | chemical homeostasis | 20.2899 | 4 | no |
| GO:0030030 | cell projection organization | 20.2899 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.2899 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.2899 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.2899 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 20.2899 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 20.2899 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 20.2899 | 5 | yes |
| GO:0016482 | cytosolic transport | 18.8406 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 18.8406 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 17.3913 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 17.3913 | 7 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 17.3913 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 17.3913 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 17.3913 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 17.3913 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 17.3913 | 7 | yes |
| GO:0043066 | negative regulation of apoptotic process | 15.9420 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 15.9420 | 6 | yes |
| GO:1901699 | cellular response to nitrogen compound | 14.4928 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 13.0435 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 13.0435 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 13.0435 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 11.5942 | 5 | yes |
| GO:0010506 | regulation of autophagy | 11.5942 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 11.5942 | 6 | yes |
| GO:0045859 | regulation of protein kinase activity | 11.5942 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 11.5942 | 6 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 11.5942 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 10.1449 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 10.1449 | 7 | yes |
| GO:0031400 | negative regulation of protein modification process | 10.1449 | 7 | yes |
| GO:1901652 | response to peptide | 10.1449 | 4 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 8.6957 | 6 | yes |
| GO:0042326 | negative regulation of phosphorylation | 8.6957 | 8 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 8.6957 | 7 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 8.6957 | 7 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 8.6957 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 8.6957 | 8 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 7.2464 | 8 | yes |
| GO:1901214 | regulation of neuron death | 7.2464 | 5 | yes |
| GO:1901215 | negative regulation of neuron death | 7.2464 | 6 | yes |
| GO:1901653 | cellular response to peptide | 7.2464 | 5 | yes |
| GO:1904645 | response to amyloid-beta | 5.7971 | 5 | yes |
| GO:1904646 | cellular response to amyloid-beta | 5.7971 | 6 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 5.7971 | 6 | yes |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 4.3478 | 6 | yes |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 4.3478 | 7 | yes |
| GO:0043086 | negative regulation of catalytic activity | 4.3478 | 4 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 4.3478 | 7 | yes |
| GO:1901184 | regulation of ERBB signaling pathway | 4.3478 | 5 | yes |
| GO:1901185 | negative regulation of ERBB signaling pathway | 4.3478 | 6 | yes |
| GO:0007176 | regulation of epidermal growth factor-activated receptor activity | 2.8986 | 4 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 2.8986 | 8 | yes |
| GO:0061097 | regulation of protein tyrosine kinase activity | 2.8986 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SNX6_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.3478 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.3478 | 5 | no |
| DOID:114 | heart disease | 4.3478 | 3 | no |
| DOID:2843 | long QT syndrome | 4.3478 | 6 | no |
| DOID:1289 | neurodegenerative disease | 4.3478 | 4 | no |
| DOID:331 | central nervous system disease | 4.3478 | 3 | no |
| DOID:12377 | spinal muscular atrophy | 2.8986 | 6 | no |
| DOID:231 | motor neuron disease | 2.8986 | 5 | no |
| DOID:332 | amyotrophic lateral sclerosis | 2.8986 | 6 | no |
| DOID:10273 | heart conduction disease | 2.8986 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.8986 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TCTP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1L_HUMAN | [view interactions] | Low throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRMS1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| POTB3_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HENMT_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| F221A_HUMAN | [view interactions] | High throughput | no | yes |
| TRML2_HUMAN | [view interactions] | High throughput | no | no |
| SNX32_HUMAN | [view interactions] | High throughput | no | no |
| CAST3_HUMAN | [view interactions] | High throughput | no | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| CMKMT_HUMAN | [view interactions] | High throughput | no | no |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| BACE1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX7_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CI072_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX11_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA43A_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| EPB42_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAVR1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PKCB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN687_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| TEX28_HUMAN | [view interactions] | High throughput | no | no |
| IBPL1_HUMAN | [view interactions] | High throughput | no | no |
| PAEP_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| BMP6_HUMAN | [view interactions] | High throughput | no | no |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| PRUN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCL1_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS5_HUMAN | [view interactions] | High throughput | no | yes |
| HCLS1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| STAC2_HUMAN | [view interactions] | High throughput | no | no |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| KLHL1_HUMAN | [view interactions] | High throughput | no | no |
| S12A3_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CBCO1_HUMAN | [view interactions] | High throughput | no | no |
| TMPSC_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| SNX12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VP26B_HUMAN | [view interactions] | Computational | no | yes |