SNX6_HUMAN
Evidence for PS localization
Functions
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B . May contribute to transcription regulation (Probable). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX6_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.9398 | 4 | no |
| GO:0000166 | nucleotide binding | 30.1205 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.1205 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.9157 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.9157 | 4 | no |
| GO:0043169 | cation binding | 22.8916 | 4 | no |
| GO:0046872 | metal ion binding | 22.8916 | 5 | no |
| GO:0035091 | phosphatidylinositol binding | 14.4578 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 14.4578 | 4 | yes |
| GO:0005126 | cytokine receptor binding | 3.6145 | 4 | yes |
| GO:0034452 | dynactin binding | 2.4096 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.0602 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.0120 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8072 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.1928 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.1928 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.9880 | 4 | yes |
| GO:0008104 | protein localization | 46.9880 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.9880 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.7831 | 4 | yes |
| GO:0071702 | organic substance transport | 39.7590 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.7590 | 4 | no |
| GO:0051049 | regulation of transport | 39.7590 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.5542 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 38.5542 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 36.1446 | 5 | no |
| GO:0006996 | organelle organization | 34.9398 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.9398 | 5 | no |
| GO:0015031 | protein transport | 33.7349 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5301 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 32.5301 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.5301 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 32.5301 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 31.3253 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.3253 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.3253 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.3253 | 4 | no |
| GO:0022607 | cellular component assembly | 30.1205 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.1205 | 6 | no |
| GO:0010468 | regulation of gene expression | 30.1205 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.1205 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.1205 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 28.9157 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 27.7108 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.5060 | 5 | no |
| GO:0006886 | intracellular protein transport | 26.5060 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 26.5060 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 25.3012 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.3012 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 25.3012 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0964 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 24.0964 | 4 | yes |
| GO:0032880 | regulation of protein localization | 24.0964 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.0964 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0964 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 24.0964 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 24.0964 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 22.8916 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.8916 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.8916 | 4 | no |
| GO:0030030 | cell projection organization | 21.6867 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.6867 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.6867 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.6867 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.6867 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.6867 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.6867 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 20.4819 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 20.4819 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.4819 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.4819 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.4819 | 4 | no |
| GO:0098657 | import into cell | 20.4819 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4819 | 7 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.4819 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 20.4819 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 20.4819 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 20.4819 | 7 | yes |
| GO:0009968 | negative regulation of signal transduction | 19.2771 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 18.0723 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 18.0723 | 7 | yes |
| GO:0043066 | negative regulation of apoptotic process | 18.0723 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 18.0723 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 16.8675 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 16.8675 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 14.4578 | 6 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.4578 | 4 | yes |
| GO:0016482 | cytosolic transport | 14.4578 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.4578 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 13.2530 | 4 | yes |
| GO:0010506 | regulation of autophagy | 13.2530 | 6 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 13.2530 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 12.0482 | 8 | yes |
| GO:0051338 | regulation of transferase activity | 12.0482 | 4 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 12.0482 | 7 | yes |
| GO:0043549 | regulation of kinase activity | 12.0482 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 10.8434 | 6 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 10.8434 | 7 | yes |
| GO:1901699 | cellular response to nitrogen compound | 10.8434 | 4 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 10.8434 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 10.8434 | 7 | yes |
| GO:0031400 | negative regulation of protein modification process | 10.8434 | 7 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 9.6386 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 8.4337 | 4 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 8.4337 | 8 | yes |
| GO:0042326 | negative regulation of phosphorylation | 8.4337 | 8 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 6.0241 | 6 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 6.0241 | 7 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 4.8193 | 4 | yes |
| GO:1904645 | response to amyloid-beta | 4.8193 | 4 | yes |
| GO:1904646 | cellular response to amyloid-beta | 4.8193 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 4.8193 | 4 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 3.6145 | 8 | yes |
| GO:0051348 | negative regulation of transferase activity | 2.4096 | 5 | yes |
| GO:0061097 | regulation of protein tyrosine kinase activity | 2.4096 | 7 | yes |
| GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2.4096 | 5 | yes |
| GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2.4096 | 6 | yes |
| GO:1901184 | regulation of ERBB signaling pathway | 2.4096 | 5 | yes |
| GO:1901185 | negative regulation of ERBB signaling pathway | 2.4096 | 6 | yes |
| GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 2.4096 | 5 | yes |
| GO:0007176 | regulation of epidermal growth factor-activated receptor activity | 2.4096 | 4 | yes |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 2.4096 | 6 | yes |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 2.4096 | 7 | yes |
| GO:0033673 | negative regulation of kinase activity | 2.4096 | 6 | yes |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 2.4096 | 6 | yes |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 2.4096 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1L_HUMAN | [view interactions] | Low throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRMS1_HUMAN | [view interactions] | Low throughput | no | yes |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| KLHL1_HUMAN | [view interactions] | High throughput | no | no |
| S12A3_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CBCO1_HUMAN | [view interactions] | High throughput | no | no |
| TMPSC_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| NRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4B_HUMAN | [view interactions] | High throughput | no | yes |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| POTB3_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HENMT_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| TRML2_HUMAN | [view interactions] | High throughput | no | no |
| F221A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX32_HUMAN | [view interactions] | High throughput | no | no |
| CAST3_HUMAN | [view interactions] | High throughput | no | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| CMKMT_HUMAN | [view interactions] | High throughput | no | no |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| BACE1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX7_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CI072_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX11_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA43A_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| EPB42_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAVR1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYD8_HUMAN | [view interactions] | High throughput | no | yes |
| ZN687_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| TEX28_HUMAN | [view interactions] | High throughput | no | no |
| IBPL1_HUMAN | [view interactions] | High throughput | no | no |
| PAEP_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| BMP6_HUMAN | [view interactions] | High throughput | no | no |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| PRUN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCL1_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS5_HUMAN | [view interactions] | High throughput | no | yes |
| HCLS1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| STAC2_HUMAN | [view interactions] | High throughput | no | no |