Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRP2_HUMAN
GO:0017154 semaphorin receptor activity 38.8889 4 yes
GO:0046872 metal ion binding 22.2222 4 yes
GO:0048018 receptor ligand activity 22.2222 4 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 16.6667 5 yes
GO:0005021 vascular endothelial growth factor receptor activity 16.6667 6 yes
GO:0016301 kinase activity 16.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 16.6667 4 yes
GO:0019199 transmembrane receptor protein kinase activity 16.6667 4 yes
GO:0004713 protein tyrosine kinase activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRP2_HUMAN
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0051128 regulation of cellular component organization 83.3333 4 yes
GO:0010975 regulation of neuron projection development 72.2222 7 no
GO:0031344 regulation of cell projection organization 72.2222 5 no
GO:0045595 regulation of cell differentiation 72.2222 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 72.2222 6 no
GO:0030030 cell projection organization 72.2222 4 yes
GO:0120036 plasma membrane bounded cell projection organization 72.2222 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 66.6667 4 no
GO:0050767 regulation of neurogenesis 66.6667 6 no
GO:0050770 regulation of axonogenesis 66.6667 5 no
GO:0051960 regulation of nervous system development 66.6667 5 no
GO:0060284 regulation of cell development 66.6667 5 no
GO:2000026 regulation of multicellular organismal development 66.6667 4 no
GO:0030334 regulation of cell migration 66.6667 5 yes
GO:0031175 neuron projection development 66.6667 6 yes
GO:2000145 regulation of cell motility 66.6667 4 yes
GO:0048638 regulation of developmental growth 61.1111 4 no
GO:0007411 axon guidance 61.1111 8 yes
GO:0097485 neuron projection guidance 61.1111 7 yes
GO:0048523 negative regulation of cellular process 61.1111 4 no
GO:0001558 regulation of cell growth 55.5556 4 no
GO:0030516 regulation of axon extension 55.5556 5 no
GO:0061387 regulation of extent of cell growth 55.5556 5 no
GO:0071526 semaphorin-plexin signaling pathway 55.5556 4 yes
GO:0045597 positive regulation of cell differentiation 50.0000 5 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0001667 ameboidal-type cell migration 50.0000 4 yes
GO:0032101 regulation of response to external stimulus 44.4444 4 no
GO:0010720 positive regulation of cell development 44.4444 6 no
GO:0030155 regulation of cell adhesion 44.4444 4 no
GO:0031346 positive regulation of cell projection organization 44.4444 6 no
GO:0050769 positive regulation of neurogenesis 44.4444 6 no
GO:0050772 positive regulation of axonogenesis 44.4444 6 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 no
GO:0051962 positive regulation of nervous system development 44.4444 5 no
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 44.4444 5 yes
GO:0010721 negative regulation of cell development 38.8889 6 no
GO:0045596 negative regulation of cell differentiation 38.8889 5 no
GO:0048841 regulation of axon extension involved in axon guidance 38.8889 6 no
GO:0050920 regulation of chemotaxis 38.8889 4 no
GO:0051093 negative regulation of developmental process 38.8889 4 no
GO:0051129 negative regulation of cellular component organization 38.8889 5 no
GO:0030335 positive regulation of cell migration 38.8889 6 yes
GO:0040017 positive regulation of locomotion 38.8889 4 yes
GO:0050919 negative chemotaxis 38.8889 4 yes
GO:2000147 positive regulation of cell motility 38.8889 5 yes
GO:0010977 negative regulation of neuron projection development 33.3333 7 no
GO:0031345 negative regulation of cell projection organization 33.3333 6 no
GO:0032102 negative regulation of response to external stimulus 33.3333 5 no
GO:0040013 negative regulation of locomotion 33.3333 4 no
GO:0045926 negative regulation of growth 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0048640 negative regulation of developmental growth 33.3333 5 no
GO:0050768 negative regulation of neurogenesis 33.3333 6 no
GO:0050771 negative regulation of axonogenesis 33.3333 6 no
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 no
GO:0051961 negative regulation of nervous system development 33.3333 5 no
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 33.3333 6 no
GO:0007162 negative regulation of cell adhesion 33.3333 5 no
GO:0022604 regulation of cell morphogenesis 33.3333 5 no
GO:0001755 neural crest cell migration 33.3333 6 yes
GO:0001764 neuron migration 33.3333 4 yes
GO:0008284 positive regulation of cell population proliferation 33.3333 5 yes
GO:0021612 facial nerve structural organization 33.3333 4 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0050807 regulation of synapse organization 33.3333 5 yes
GO:0090497 mesenchymal cell migration 33.3333 5 yes
GO:1990138 neuron projection extension 33.3333 4 yes
GO:0051246 regulation of protein metabolic process 27.7778 5 no
GO:0060255 regulation of macromolecule metabolic process 27.7778 4 no
GO:0080090 regulation of primary metabolic process 27.7778 4 no
GO:0030308 negative regulation of cell growth 27.7778 5 no
GO:0030517 negative regulation of axon extension 27.7778 6 no
GO:0048843 negative regulation of axon extension involved in axon guidance 27.7778 6 no
GO:0050922 negative regulation of chemotaxis 27.7778 5 no
GO:0008360 regulation of cell shape 27.7778 6 no
GO:0051336 regulation of hydrolase activity 27.7778 4 no
GO:0010632 regulation of epithelial cell migration 27.7778 4 yes
GO:0050678 regulation of epithelial cell proliferation 27.7778 5 yes
GO:0071310 cellular response to organic substance 27.7778 4 yes
GO:0099175 regulation of postsynapse organization 27.7778 6 yes
GO:0008104 protein localization 27.7778 4 no
GO:0009893 positive regulation of metabolic process 27.7778 4 no
GO:0009966 regulation of signal transduction 27.7778 4 no
GO:0009967 positive regulation of signal transduction 27.7778 5 no
GO:0010646 regulation of cell communication 27.7778 4 no
GO:0010647 positive regulation of cell communication 27.7778 5 no
GO:0023056 positive regulation of signaling 27.7778 4 no
GO:0031323 regulation of cellular metabolic process 27.7778 4 no
GO:0031325 positive regulation of cellular metabolic process 27.7778 5 no
GO:0048584 positive regulation of response to stimulus 27.7778 4 no
GO:0051171 regulation of nitrogen compound metabolic process 27.7778 4 no
GO:0021637 trigeminal nerve structural organization 22.2222 4 no
GO:0001952 regulation of cell-matrix adhesion 22.2222 6 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0030307 positive regulation of cell growth 22.2222 5 no
GO:0045773 positive regulation of axon extension 22.2222 6 no
GO:0045927 positive regulation of growth 22.2222 4 no
GO:0048639 positive regulation of developmental growth 22.2222 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0007409 axonogenesis 22.2222 8 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0032990 cell part morphogenesis 22.2222 4 no
GO:0048812 neuron projection morphogenesis 22.2222 7 no
GO:0048858 cell projection morphogenesis 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 6 no
GO:0043087 regulation of GTPase activity 22.2222 5 no
GO:0001936 regulation of endothelial cell proliferation 22.2222 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 22.2222 7 yes
GO:0010594 regulation of endothelial cell migration 22.2222 5 yes
GO:0010595 positive regulation of endothelial cell migration 22.2222 6 yes
GO:0010634 positive regulation of epithelial cell migration 22.2222 5 yes
GO:0036484 trunk neural crest cell migration 22.2222 7 yes
GO:0036486 ventral trunk neural crest cell migration 22.2222 8 yes
GO:0048675 axon extension 22.2222 5 yes
GO:0048846 axon extension involved in axon guidance 22.2222 6 yes
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 yes
GO:0061548 ganglion development 22.2222 4 yes
GO:0061549 sympathetic ganglion development 22.2222 5 yes
GO:0097490 sympathetic neuron projection extension 22.2222 5 yes
GO:0097491 sympathetic neuron projection guidance 22.2222 8 yes
GO:1901166 neural crest cell migration involved in autonomic nervous system development 22.2222 7 yes
GO:1902284 neuron projection extension involved in neuron projection guidance 22.2222 5 yes
GO:0010631 epithelial cell migration 22.2222 5 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0043542 endothelial cell migration 22.2222 6 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0003148 outflow tract septum morphogenesis 16.6667 4 yes
GO:0021649 vestibulocochlear nerve structural organization 16.6667 4 yes
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus 16.6667 5 yes
GO:0021855 hypothalamus cell migration 16.6667 4 yes
GO:0021856 hypothalamic tangential migration using cell-axon interactions 16.6667 5 yes
GO:0034097 response to cytokine 16.6667 4 yes
GO:0061550 cranial ganglion development 16.6667 5 yes
GO:0061551 trigeminal ganglion development 16.6667 6 yes
GO:0061552 ganglion morphogenesis 16.6667 4 yes
GO:0071345 cellular response to cytokine stimulus 16.6667 5 yes
GO:0097374 sensory neuron axon guidance 16.6667 9 yes
GO:1903375 facioacoustic ganglion development 16.6667 6 yes
GO:1904835 dorsal root ganglion morphogenesis 16.6667 5 yes
GO:1990823 response to leukemia inhibitory factor 11.1111 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
VEGFC_HUMAN [view interactions] Low throughput no no
PLXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR2_HUMAN [view interactions] Low throughput no no
SEM3F_HUMAN [view entry] [view interactions] Low throughput yes no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB1_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view interactions] High throughput no no
FCG3B_HUMAN [view interactions] High throughput no no
TAZ_HUMAN [view interactions] High throughput no yes
NXPH2_HUMAN [view interactions] High throughput no no
AT1B3_HUMAN [view interactions] High throughput no yes
SIAE_HUMAN [view interactions] High throughput no yes
NAAA_HUMAN [view interactions] High throughput no yes
SIA8C_HUMAN [view interactions] High throughput no yes
DEF5_HUMAN [view interactions] High throughput no no
BRNP3_HUMAN [view interactions] High throughput no yes
SIA8D_HUMAN [view interactions] High throughput no yes
TSN11_HUMAN [view interactions] High throughput no no
LYZL1_HUMAN [view interactions] High throughput no no
PCDGD_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
O10H2_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
TRI68_HUMAN [view interactions] High throughput no yes
COKA1_HUMAN [view interactions] High throughput no no
C1QA_HUMAN [view interactions] High throughput no no
DB135_HUMAN [view interactions] High throughput no no
CSTL1_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
NKG2E_HUMAN [view interactions] High throughput no no
CEAM8_HUMAN [view interactions] High throughput no no
TMPSD_HUMAN [view interactions] High throughput no no
CCL3_HUMAN [view interactions] High throughput no no
TM169_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
SEM3A_HUMAN [view interactions] High throughput no no
SEM3C_HUMAN [view interactions] High throughput no no
SEM3E_HUMAN [view interactions] High throughput no no
SEM3G_HUMAN [view interactions] High throughput no no
SEM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SEM4F_HUMAN [view entry] [view interactions] High throughput yes no
SEM3B_HUMAN [view interactions] Computational no yes
PLXB2_HUMAN [view interactions] Computational no yes
PLXA2_HUMAN [view entry] [view interactions] Computational yes yes
GIPC1_HUMAN [view entry] [view interactions] Computational yes yes
VGFR1_HUMAN [view interactions] Computational no no
VGFR2_HUMAN [view interactions] Computational no no
VEGFD_HUMAN [view interactions] Computational no no
PLXA3_HUMAN [view entry] [view interactions] Computational yes no
PLXD1_HUMAN [view interactions] Computational no yes
PLGF_HUMAN [view interactions] Computational no no
VGFR3_HUMAN [view interactions] Computational no yes
PLXA4_HUMAN [view entry] [view interactions] Computational yes no
PLXB3_HUMAN [view interactions] Computational no yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
PLXC1_HUMAN [view interactions] Computational no no
NRCAM_HUMAN [view entry] [view interactions] Computational yes no