Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRP2_HUMAN
GO:0017154 semaphorin receptor activity 27.7778 4 yes
GO:0016301 kinase activity 22.2222 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 yes
GO:0043169 cation binding 22.2222 4 yes
GO:0046872 metal ion binding 22.2222 5 yes
GO:0048018 receptor ligand activity 22.2222 4 no
GO:0030215 semaphorin receptor binding 22.2222 4 no
GO:0004713 protein tyrosine kinase activity 16.6667 4 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 16.6667 5 yes
GO:0005021 vascular endothelial growth factor receptor activity 16.6667 6 yes
GO:0019199 transmembrane receptor protein kinase activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRP2_HUMAN
GO:0048522 positive regulation of cellular process 72.2222 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0030030 cell projection organization 61.1111 4 yes
GO:0120036 plasma membrane bounded cell projection organization 55.5556 5 yes
GO:0010975 regulation of neuron projection development 55.5556 7 no
GO:0022603 regulation of anatomical structure morphogenesis 55.5556 4 no
GO:0031344 regulation of cell projection organization 55.5556 5 no
GO:0045595 regulation of cell differentiation 55.5556 4 no
GO:0050767 regulation of neurogenesis 55.5556 6 no
GO:0050770 regulation of axonogenesis 55.5556 5 no
GO:0051960 regulation of nervous system development 55.5556 5 no
GO:0060284 regulation of cell development 55.5556 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 55.5556 6 no
GO:2000026 regulation of multicellular organismal development 55.5556 4 no
GO:0097485 neuron projection guidance 50.0000 7 yes
GO:2000145 regulation of cell motility 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0007411 axon guidance 50.0000 8 yes
GO:0030334 regulation of cell migration 50.0000 5 yes
GO:0031175 neuron projection development 50.0000 6 yes
GO:0071526 semaphorin-plexin signaling pathway 44.4444 4 yes
GO:0001558 regulation of cell growth 44.4444 4 no
GO:0030516 regulation of axon extension 44.4444 5 no
GO:0048638 regulation of developmental growth 44.4444 4 no
GO:0061387 regulation of extent of cell growth 44.4444 5 no
GO:2000147 positive regulation of cell motility 38.8889 5 yes
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0010646 regulation of cell communication 38.8889 4 no
GO:0048584 positive regulation of response to stimulus 38.8889 4 no
GO:0001667 ameboidal-type cell migration 38.8889 4 yes
GO:0030335 positive regulation of cell migration 38.8889 6 yes
GO:0040017 positive regulation of locomotion 38.8889 4 yes
GO:0042127 regulation of cell population proliferation 38.8889 4 yes
GO:0090497 mesenchymal cell migration 33.3333 5 yes
GO:1990138 neuron projection extension 33.3333 4 yes
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010720 positive regulation of cell development 33.3333 6 no
GO:0010721 negative regulation of cell development 33.3333 6 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0045596 negative regulation of cell differentiation 33.3333 5 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0048841 regulation of axon extension involved in axon guidance 33.3333 6 no
GO:0050769 positive regulation of neurogenesis 33.3333 6 no
GO:0050772 positive regulation of axonogenesis 33.3333 6 no
GO:0050920 regulation of chemotaxis 33.3333 4 no
GO:0051093 negative regulation of developmental process 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0001755 neural crest cell migration 33.3333 6 yes
GO:0001764 neuron migration 33.3333 4 yes
GO:0008284 positive regulation of cell population proliferation 33.3333 5 yes
GO:0050919 negative chemotaxis 33.3333 4 yes
GO:1902284 neuron projection extension involved in neuron projection guidance 27.7778 5 yes
GO:0030155 regulation of cell adhesion 27.7778 4 no
GO:0060255 regulation of macromolecule metabolic process 27.7778 4 no
GO:0080090 regulation of primary metabolic process 27.7778 4 no
GO:0010977 negative regulation of neuron projection development 27.7778 7 no
GO:0030308 negative regulation of cell growth 27.7778 5 no
GO:0030517 negative regulation of axon extension 27.7778 6 no
GO:0031345 negative regulation of cell projection organization 27.7778 6 no
GO:0032102 negative regulation of response to external stimulus 27.7778 5 no
GO:0040013 negative regulation of locomotion 27.7778 4 no
GO:0045926 negative regulation of growth 27.7778 4 no
GO:0048640 negative regulation of developmental growth 27.7778 5 no
GO:0048843 negative regulation of axon extension involved in axon guidance 27.7778 6 no
GO:0050768 negative regulation of neurogenesis 27.7778 6 no
GO:0050771 negative regulation of axonogenesis 27.7778 6 no
GO:0050922 negative regulation of chemotaxis 27.7778 5 no
GO:0051241 negative regulation of multicellular organismal process 27.7778 4 no
GO:0051961 negative regulation of nervous system development 27.7778 5 no
GO:0008104 protein localization 27.7778 4 no
GO:0048675 axon extension 27.7778 5 yes
GO:0048846 axon extension involved in axon guidance 27.7778 6 yes
GO:0097490 sympathetic neuron projection extension 22.2222 5 yes
GO:0097491 sympathetic neuron projection guidance 22.2222 8 yes
GO:0099175 regulation of postsynapse organization 22.2222 6 yes
GO:1901166 neural crest cell migration involved in autonomic nervous system development 22.2222 7 yes
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0030307 positive regulation of cell growth 22.2222 5 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0045773 positive regulation of axon extension 22.2222 6 no
GO:0045927 positive regulation of growth 22.2222 4 no
GO:0048639 positive regulation of developmental growth 22.2222 5 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0050808 synapse organization 22.2222 5 no
GO:0001936 regulation of endothelial cell proliferation 22.2222 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 22.2222 7 yes
GO:0008045 motor neuron axon guidance 22.2222 9 yes
GO:0010594 regulation of endothelial cell migration 22.2222 5 yes
GO:0010595 positive regulation of endothelial cell migration 22.2222 6 yes
GO:0010632 regulation of epithelial cell migration 22.2222 4 yes
GO:0010634 positive regulation of epithelial cell migration 22.2222 5 yes
GO:0021612 facial nerve structural organization 22.2222 4 yes
GO:0021637 trigeminal nerve structural organization 22.2222 4 yes
GO:0021785 branchiomotor neuron axon guidance 22.2222 10 yes
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus 22.2222 5 yes
GO:0021855 hypothalamus cell migration 22.2222 4 yes
GO:0021856 hypothalamic tangential migration using cell-axon interactions 22.2222 5 yes
GO:0036484 trunk neural crest cell migration 22.2222 7 yes
GO:0036486 ventral trunk neural crest cell migration 22.2222 8 yes
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 yes
GO:0050807 regulation of synapse organization 22.2222 5 yes
GO:0061548 ganglion development 22.2222 4 yes
GO:0061549 sympathetic ganglion development 22.2222 5 yes
GO:0071310 cellular response to organic substance 16.6667 4 yes
GO:0097374 sensory neuron axon guidance 16.6667 9 yes
GO:1903375 facioacoustic ganglion development 16.6667 6 yes
GO:1904835 dorsal root ganglion morphogenesis 16.6667 5 yes
GO:0003148 outflow tract septum morphogenesis 16.6667 4 yes
GO:0021649 vestibulocochlear nerve structural organization 16.6667 4 yes
GO:0061550 cranial ganglion development 16.6667 5 yes
GO:0061551 trigeminal ganglion development 16.6667 6 yes
GO:0061552 ganglion morphogenesis 16.6667 4 yes
GO:0071345 cellular response to cytokine stimulus 11.1111 5 yes
GO:1990823 response to leukemia inhibitory factor 11.1111 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 11.1111 6 yes
GO:0034097 response to cytokine 11.1111 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SEM3F_HUMAN [view entry] [view interactions] Low throughput yes no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
VEGFC_HUMAN [view interactions] Low throughput no no
PLXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR2_HUMAN [view interactions] Low throughput no no
SIA8C_HUMAN [view interactions] High throughput no yes
DEF5_HUMAN [view interactions] High throughput no no
BRNP3_HUMAN [view interactions] High throughput no yes
SIA8D_HUMAN [view interactions] High throughput no yes
TSN11_HUMAN [view interactions] High throughput no no
LYZL1_HUMAN [view interactions] High throughput no no
PCDGD_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
O10H2_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
TRI68_HUMAN [view interactions] High throughput no yes
COKA1_HUMAN [view interactions] High throughput no no
C1QA_HUMAN [view entry] [view interactions] High throughput yes no
DB135_HUMAN [view interactions] High throughput no no
CSTL1_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
NKG2E_HUMAN [view interactions] High throughput no no
CEAM8_HUMAN [view interactions] High throughput no no
TMPSD_HUMAN [view interactions] High throughput no no
CCL3_HUMAN [view interactions] High throughput no no
TM169_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
EZH2_HUMAN [view interactions] High throughput no no
SEM3A_HUMAN [view interactions] High throughput no no
SEM3C_HUMAN [view interactions] High throughput no no
SEM3E_HUMAN [view interactions] High throughput no no
SEM3G_HUMAN [view interactions] High throughput no no
SEM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SEM4F_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB1_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
FCG3B_HUMAN [view interactions] High throughput no no
TAZ_HUMAN [view interactions] High throughput no yes
NXPH2_HUMAN [view interactions] High throughput no no
AT1B3_HUMAN [view interactions] High throughput no yes
SIAE_HUMAN [view interactions] High throughput no yes
NAAA_HUMAN [view interactions] High throughput no yes