Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEM3F_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May play a role in cell motility and cell adhesion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003999 LIG_NRP_CendR_1 LIG 778 779 -
ELMI003999 LIG_NRP_CendR_1 LIG 778 779 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SEM3F_HUMAN
GO:0043169 cation binding 42.8571 4 no
GO:0046872 metal ion binding 42.8571 5 no
GO:0002020 protease binding 28.5714 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0031625 ubiquitin protein ligase binding 28.5714 5 no
GO:0044389 ubiquitin-like protein ligase binding 28.5714 4 no
GO:0003723 RNA binding 28.5714 4 no
GO:0004713 protein tyrosine kinase activity 28.5714 4 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 28.5714 5 no
GO:0005021 vascular endothelial growth factor receptor activity 28.5714 6 no
GO:0016301 kinase activity 28.5714 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0017154 semaphorin receptor activity 28.5714 4 no
GO:0019199 transmembrane receptor protein kinase activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SEM3F_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0043412 macromolecule modification 42.8571 4 no
GO:0043632 modification-dependent macromolecule catabolic process 42.8571 5 no
GO:0043687 post-translational protein modification 42.8571 5 no
GO:0051603 proteolysis involved in protein catabolic process 42.8571 5 no
GO:0070647 protein modification by small protein conjugation or removal 42.8571 6 no
GO:0001558 regulation of cell growth 42.8571 4 yes
GO:0001667 ameboidal-type cell migration 42.8571 4 yes
GO:0001755 neural crest cell migration 42.8571 6 yes
GO:0007411 axon guidance 42.8571 8 yes
GO:0008045 motor neuron axon guidance 42.8571 9 yes
GO:0021612 facial nerve structural organization 42.8571 4 yes
GO:0021637 trigeminal nerve structural organization 42.8571 4 yes
GO:0021785 branchiomotor neuron axon guidance 42.8571 10 yes
GO:0022603 regulation of anatomical structure morphogenesis 42.8571 4 yes
GO:0030030 cell projection organization 42.8571 4 yes
GO:0030334 regulation of cell migration 42.8571 5 yes
GO:0030335 positive regulation of cell migration 42.8571 6 yes
GO:0031175 neuron projection development 42.8571 6 yes
GO:0036484 trunk neural crest cell migration 42.8571 7 yes
GO:0036486 ventral trunk neural crest cell migration 42.8571 8 yes
GO:0040017 positive regulation of locomotion 42.8571 4 yes
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0048638 regulation of developmental growth 42.8571 4 yes
GO:0048675 axon extension 42.8571 5 yes
GO:0048846 axon extension involved in axon guidance 42.8571 6 yes
GO:0051093 negative regulation of developmental process 42.8571 4 yes
GO:0051129 negative regulation of cellular component organization 42.8571 5 yes
GO:0061548 ganglion development 42.8571 4 yes
GO:0061549 sympathetic ganglion development 42.8571 5 yes
GO:0071526 semaphorin-plexin signaling pathway 42.8571 4 yes
GO:0090497 mesenchymal cell migration 42.8571 5 yes
GO:0097485 neuron projection guidance 42.8571 7 yes
GO:0097490 sympathetic neuron projection extension 42.8571 5 yes
GO:0097491 sympathetic neuron projection guidance 42.8571 8 yes
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 yes
GO:1901166 neural crest cell migration involved in autonomic nervous system development 42.8571 7 yes
GO:1902284 neuron projection extension involved in neuron projection guidance 42.8571 5 yes
GO:1990138 neuron projection extension 42.8571 4 yes
GO:2000145 regulation of cell motility 42.8571 4 yes
GO:2000147 positive regulation of cell motility 42.8571 5 yes
GO:0006508 proteolysis 42.8571 4 no
GO:0009057 macromolecule catabolic process 42.8571 4 no
GO:0016567 protein ubiquitination 42.8571 8 no
GO:0019941 modification-dependent protein catabolic process 42.8571 6 no
GO:0032446 protein modification by small protein conjugation 42.8571 7 no
GO:0036211 protein modification process 42.8571 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043066 negative regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043069 negative regulation of programmed cell death 28.5714 5 no
GO:0043393 regulation of protein binding 28.5714 4 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0043523 regulation of neuron apoptotic process 28.5714 6 no
GO:0043524 negative regulation of neuron apoptotic process 28.5714 7 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0045927 positive regulation of growth 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0048639 positive regulation of developmental growth 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051099 positive regulation of binding 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0110053 regulation of actin filament organization 28.5714 6 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:1902903 regulation of supramolecular fiber organization 28.5714 5 no
GO:2001233 regulation of apoptotic signaling pathway 28.5714 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 28.5714 6 no
GO:0001764 neuron migration 28.5714 4 no
GO:0001936 regulation of endothelial cell proliferation 28.5714 6 no
GO:0001938 positive regulation of endothelial cell proliferation 28.5714 7 no
GO:0003148 outflow tract septum morphogenesis 28.5714 4 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0010594 regulation of endothelial cell migration 28.5714 5 no
GO:0010595 positive regulation of endothelial cell migration 28.5714 6 no
GO:0010632 regulation of epithelial cell migration 28.5714 4 no
GO:0010634 positive regulation of epithelial cell migration 28.5714 5 no
GO:0021649 vestibulocochlear nerve structural organization 28.5714 4 no
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus 28.5714 5 no
GO:0021855 hypothalamus cell migration 28.5714 4 no
GO:0021856 hypothalamic tangential migration using cell-axon interactions 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0050678 regulation of epithelial cell proliferation 28.5714 5 no
GO:0050679 positive regulation of epithelial cell proliferation 28.5714 6 no
GO:0061550 cranial ganglion development 28.5714 5 no
GO:0061551 trigeminal ganglion development 28.5714 6 no
GO:0061552 ganglion morphogenesis 28.5714 4 no
GO:0097374 sensory neuron axon guidance 28.5714 9 no
GO:1903375 facioacoustic ganglion development 28.5714 6 no
GO:1904835 dorsal root ganglion morphogenesis 28.5714 5 no
GO:0010721 negative regulation of cell development 28.5714 6 yes
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0010977 negative regulation of neuron projection development 28.5714 7 yes
GO:0030308 negative regulation of cell growth 28.5714 5 yes
GO:0030516 regulation of axon extension 28.5714 5 yes
GO:0030517 negative regulation of axon extension 28.5714 6 yes
GO:0031344 regulation of cell projection organization 28.5714 5 yes
GO:0031345 negative regulation of cell projection organization 28.5714 6 yes
GO:0032101 regulation of response to external stimulus 28.5714 4 yes
GO:0032102 negative regulation of response to external stimulus 28.5714 5 yes
GO:0040013 negative regulation of locomotion 28.5714 4 yes
GO:0045595 regulation of cell differentiation 28.5714 4 yes
GO:0045596 negative regulation of cell differentiation 28.5714 5 yes
GO:0045926 negative regulation of growth 28.5714 4 yes
GO:0048640 negative regulation of developmental growth 28.5714 5 yes
GO:0048841 regulation of axon extension involved in axon guidance 28.5714 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 28.5714 6 yes
GO:0050767 regulation of neurogenesis 28.5714 6 yes
GO:0050768 negative regulation of neurogenesis 28.5714 6 yes
GO:0050770 regulation of axonogenesis 28.5714 5 yes
GO:0050771 negative regulation of axonogenesis 28.5714 6 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0050919 negative chemotaxis 28.5714 4 yes
GO:0050920 regulation of chemotaxis 28.5714 4 yes
GO:0050922 negative regulation of chemotaxis 28.5714 5 yes
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 yes
GO:0051960 regulation of nervous system development 28.5714 5 yes
GO:0051961 negative regulation of nervous system development 28.5714 5 yes
GO:0060284 regulation of cell development 28.5714 5 yes
GO:0061387 regulation of extent of cell growth 28.5714 5 yes
GO:0099175 regulation of postsynapse organization 28.5714 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006511 ubiquitin-dependent protein catabolic process 28.5714 7 no
GO:0008104 protein localization 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0030307 positive regulation of cell growth 28.5714 5 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0032092 positive regulation of protein binding 28.5714 5 no
GO:0032231 regulation of actin filament bundle assembly 28.5714 5 no
GO:0032956 regulation of actin cytoskeleton organization 28.5714 5 no
GO:0032970 regulation of actin filament-based process 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0033365 protein localization to organelle 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
S35G2_HUMAN [view interactions] High throughput no yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
SHBG_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
SEM3C_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes