Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEM4B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SEM4B_HUMAN
GO:0017154 semaphorin receptor activity 42.8571 4 no
GO:0043169 cation binding 42.8571 4 no
GO:0046872 metal ion binding 42.8571 5 no
GO:0030215 semaphorin receptor binding 28.5714 4 yes
GO:0005096 GTPase activator activity 28.5714 4 no
GO:0030695 GTPase regulator activity 28.5714 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0004713 protein tyrosine kinase activity 28.5714 4 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 28.5714 5 no
GO:0005021 vascular endothelial growth factor receptor activity 28.5714 6 no
GO:0016301 kinase activity 28.5714 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0019199 transmembrane receptor protein kinase activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SEM4B_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0030030 cell projection organization 71.4286 4 yes
GO:0051128 regulation of cellular component organization 71.4286 4 yes
GO:0009966 regulation of signal transduction 71.4286 4 no
GO:0009967 positive regulation of signal transduction 71.4286 5 no
GO:0010646 regulation of cell communication 71.4286 4 no
GO:0010647 positive regulation of cell communication 71.4286 5 no
GO:0023056 positive regulation of signaling 71.4286 4 no
GO:0048584 positive regulation of response to stimulus 71.4286 4 no
GO:0001667 ameboidal-type cell migration 57.1429 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 57.1429 4 yes
GO:0030334 regulation of cell migration 57.1429 5 yes
GO:0031175 neuron projection development 57.1429 6 yes
GO:0031344 regulation of cell projection organization 57.1429 5 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0071526 semaphorin-plexin signaling pathway 57.1429 4 yes
GO:0120036 plasma membrane bounded cell projection organization 57.1429 5 yes
GO:2000145 regulation of cell motility 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0022607 cellular component assembly 57.1429 4 no
GO:0001755 neural crest cell migration 42.8571 6 yes
GO:0007411 axon guidance 42.8571 8 yes
GO:0010975 regulation of neuron projection development 42.8571 7 yes
GO:0030335 positive regulation of cell migration 42.8571 6 yes
GO:0040017 positive regulation of locomotion 42.8571 4 yes
GO:0045595 regulation of cell differentiation 42.8571 4 yes
GO:0050767 regulation of neurogenesis 42.8571 6 yes
GO:0050770 regulation of axonogenesis 42.8571 5 yes
GO:0051129 negative regulation of cellular component organization 42.8571 5 yes
GO:0051960 regulation of nervous system development 42.8571 5 yes
GO:0060284 regulation of cell development 42.8571 5 yes
GO:0090497 mesenchymal cell migration 42.8571 5 yes
GO:0097485 neuron projection guidance 42.8571 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 yes
GO:2000026 regulation of multicellular organismal development 42.8571 4 yes
GO:2000147 positive regulation of cell motility 42.8571 5 yes
GO:0007268 chemical synaptic transmission 42.8571 7 no
GO:0008104 protein localization 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0098916 anterograde trans-synaptic signaling 42.8571 6 no
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 no
GO:0099536 synaptic signaling 42.8571 4 no
GO:0099537 trans-synaptic signaling 42.8571 5 no
GO:0031346 positive regulation of cell projection organization 42.8571 6 no
GO:0042127 regulation of cell population proliferation 42.8571 4 no
GO:0048812 neuron projection morphogenesis 42.8571 5 no
GO:0051094 positive regulation of developmental process 42.8571 4 no
GO:0051130 positive regulation of cellular component organization 42.8571 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 42.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0010594 regulation of endothelial cell migration 28.5714 5 no
GO:0010595 positive regulation of endothelial cell migration 28.5714 6 no
GO:0010632 regulation of epithelial cell migration 28.5714 4 no
GO:0010634 positive regulation of epithelial cell migration 28.5714 5 no
GO:0021612 facial nerve structural organization 28.5714 4 no
GO:0021637 trigeminal nerve structural organization 28.5714 4 no
GO:0021649 vestibulocochlear nerve structural organization 28.5714 4 no
GO:0021785 branchiomotor neuron axon guidance 28.5714 10 no
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus 28.5714 5 no
GO:0021855 hypothalamus cell migration 28.5714 4 no
GO:0021856 hypothalamic tangential migration using cell-axon interactions 28.5714 5 no
GO:0036484 trunk neural crest cell migration 28.5714 7 no
GO:0036486 ventral trunk neural crest cell migration 28.5714 8 no
GO:0048675 axon extension 28.5714 5 no
GO:0048846 axon extension involved in axon guidance 28.5714 6 no
GO:0050678 regulation of epithelial cell proliferation 28.5714 5 no
GO:0050679 positive regulation of epithelial cell proliferation 28.5714 6 no
GO:0061548 ganglion development 28.5714 4 no
GO:0061549 sympathetic ganglion development 28.5714 5 no
GO:0061550 cranial ganglion development 28.5714 5 no
GO:0061551 trigeminal ganglion development 28.5714 6 no
GO:0061552 ganglion morphogenesis 28.5714 4 no
GO:0097374 sensory neuron axon guidance 28.5714 9 no
GO:0097490 sympathetic neuron projection extension 28.5714 5 no
GO:0097491 sympathetic neuron projection guidance 28.5714 8 no
GO:1901166 neural crest cell migration involved in autonomic nervous system development 28.5714 7 no
GO:1902284 neuron projection extension involved in neuron projection guidance 28.5714 5 no
GO:1903375 facioacoustic ganglion development 28.5714 6 no
GO:1904835 dorsal root ganglion morphogenesis 28.5714 5 no
GO:1990138 neuron projection extension 28.5714 4 no
GO:0001558 regulation of cell growth 28.5714 4 yes
GO:0010721 negative regulation of cell development 28.5714 6 yes
GO:0010977 negative regulation of neuron projection development 28.5714 7 yes
GO:0030308 negative regulation of cell growth 28.5714 5 yes
GO:0030516 regulation of axon extension 28.5714 5 yes
GO:0030517 negative regulation of axon extension 28.5714 6 yes
GO:0031345 negative regulation of cell projection organization 28.5714 6 yes
GO:0032101 regulation of response to external stimulus 28.5714 4 yes
GO:0032102 negative regulation of response to external stimulus 28.5714 5 yes
GO:0040013 negative regulation of locomotion 28.5714 4 yes
GO:0045596 negative regulation of cell differentiation 28.5714 5 yes
GO:0045926 negative regulation of growth 28.5714 4 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 yes
GO:0048638 regulation of developmental growth 28.5714 4 yes
GO:0048640 negative regulation of developmental growth 28.5714 5 yes
GO:0048841 regulation of axon extension involved in axon guidance 28.5714 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 28.5714 6 yes
GO:0050768 negative regulation of neurogenesis 28.5714 6 yes
GO:0050771 negative regulation of axonogenesis 28.5714 6 yes
GO:0050919 negative chemotaxis 28.5714 4 yes
GO:0050920 regulation of chemotaxis 28.5714 4 yes
GO:0050922 negative regulation of chemotaxis 28.5714 5 yes
GO:0051093 negative regulation of developmental process 28.5714 4 yes
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 yes
GO:0051961 negative regulation of nervous system development 28.5714 5 yes
GO:0061387 regulation of extent of cell growth 28.5714 5 yes
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010631 epithelial cell migration 28.5714 5 no
GO:0034097 response to cytokine 28.5714 4 no
GO:0043542 endothelial cell migration 28.5714 6 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0071345 cellular response to cytokine stimulus 28.5714 5 no
GO:0090287 regulation of cellular response to growth factor stimulus 28.5714 4 no
GO:0010720 positive regulation of cell development 28.5714 6 no
GO:0022604 regulation of cell morphogenesis 28.5714 5 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0035023 regulation of Rho protein signal transduction 28.5714 7 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0045597 positive regulation of cell differentiation 28.5714 5 no
GO:0050769 positive regulation of neurogenesis 28.5714 6 no
GO:0050772 positive regulation of axonogenesis 28.5714 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 28.5714 6 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0051962 positive regulation of nervous system development 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0007612 learning 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0031644 regulation of nervous system process 28.5714 5 no
GO:0033365 protein localization to organelle 28.5714 5 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 28.5714 9 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0050890 cognition 28.5714 4 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 no
GO:0099173 postsynapse organization 28.5714 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 28.5714 5 no
GO:0001764 neuron migration 28.5714 4 no
GO:0001936 regulation of endothelial cell proliferation 28.5714 6 no
GO:0001938 positive regulation of endothelial cell proliferation 28.5714 7 no
GO:0003148 outflow tract septum morphogenesis 28.5714 4 no
GO:0008045 motor neuron axon guidance 28.5714 9 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC2_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP2_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB1_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB2_HUMAN [view interactions] High throughput no yes
SREC2_HUMAN [view interactions] High throughput no yes