SEM4B_HUMAN
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SEM4B_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 50.0000 | 4 | no |
GO:0004713 | protein tyrosine kinase activity | 33.3333 | 4 | no |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 33.3333 | 5 | no |
GO:0005021 | vascular endothelial growth factor receptor activity | 33.3333 | 6 | no |
GO:0016301 | kinase activity | 33.3333 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 33.3333 | 4 | no |
GO:0017154 | semaphorin receptor activity | 33.3333 | 4 | no |
GO:0019199 | transmembrane receptor protein kinase activity | 33.3333 | 4 | no |
GO:0019900 | kinase binding | 33.3333 | 4 | no |
GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SEM4B_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 100.0000 | 4 | yes |
GO:0001667 | ameboidal-type cell migration | 66.6667 | 4 | yes |
GO:0030030 | cell projection organization | 66.6667 | 4 | yes |
GO:0031175 | neuron projection development | 66.6667 | 6 | yes |
GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 66.6667 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 66.6667 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 66.6667 | 4 | no |
GO:0009966 | regulation of signal transduction | 66.6667 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 66.6667 | 5 | no |
GO:0010646 | regulation of cell communication | 66.6667 | 4 | no |
GO:0010647 | positive regulation of cell communication | 66.6667 | 5 | no |
GO:0023056 | positive regulation of signaling | 66.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 66.6667 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 66.6667 | 4 | no |
GO:0051049 | regulation of transport | 66.6667 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 66.6667 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 66.6667 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
GO:0001755 | neural crest cell migration | 50.0000 | 6 | yes |
GO:0007411 | axon guidance | 50.0000 | 8 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | yes |
GO:0030334 | regulation of cell migration | 50.0000 | 5 | yes |
GO:0030335 | positive regulation of cell migration | 50.0000 | 6 | yes |
GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | yes |
GO:0040017 | positive regulation of locomotion | 50.0000 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 50.0000 | 5 | yes |
GO:0071526 | semaphorin-plexin signaling pathway | 50.0000 | 4 | yes |
GO:0090497 | mesenchymal cell migration | 50.0000 | 5 | yes |
GO:0097485 | neuron projection guidance | 50.0000 | 7 | yes |
GO:2000145 | regulation of cell motility | 50.0000 | 4 | yes |
GO:2000147 | positive regulation of cell motility | 50.0000 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 50.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 50.0000 | 6 | no |
GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | no |
GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 50.0000 | 4 | no |
GO:0008104 | protein localization | 50.0000 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 50.0000 | 4 | no |
GO:0001558 | regulation of cell growth | 33.3333 | 4 | yes |
GO:0010721 | negative regulation of cell development | 33.3333 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 33.3333 | 7 | yes |
GO:0010977 | negative regulation of neuron projection development | 33.3333 | 7 | yes |
GO:0030308 | negative regulation of cell growth | 33.3333 | 5 | yes |
GO:0030516 | regulation of axon extension | 33.3333 | 5 | yes |
GO:0030517 | negative regulation of axon extension | 33.3333 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 33.3333 | 6 | yes |
GO:0032101 | regulation of response to external stimulus | 33.3333 | 4 | yes |
GO:0032102 | negative regulation of response to external stimulus | 33.3333 | 5 | yes |
GO:0040013 | negative regulation of locomotion | 33.3333 | 4 | yes |
GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | yes |
GO:0045596 | negative regulation of cell differentiation | 33.3333 | 5 | yes |
GO:0045926 | negative regulation of growth | 33.3333 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | yes |
GO:0048638 | regulation of developmental growth | 33.3333 | 4 | yes |
GO:0048640 | negative regulation of developmental growth | 33.3333 | 5 | yes |
GO:0048841 | regulation of axon extension involved in axon guidance | 33.3333 | 6 | yes |
GO:0048843 | negative regulation of axon extension involved in axon guidance | 33.3333 | 6 | yes |
GO:0050767 | regulation of neurogenesis | 33.3333 | 6 | yes |
GO:0050768 | negative regulation of neurogenesis | 33.3333 | 6 | yes |
GO:0050770 | regulation of axonogenesis | 33.3333 | 5 | yes |
GO:0050771 | negative regulation of axonogenesis | 33.3333 | 6 | yes |
GO:0050919 | negative chemotaxis | 33.3333 | 4 | yes |
GO:0050920 | regulation of chemotaxis | 33.3333 | 4 | yes |
GO:0050922 | negative regulation of chemotaxis | 33.3333 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 33.3333 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 33.3333 | 4 | yes |
GO:0051960 | regulation of nervous system development | 33.3333 | 5 | yes |
GO:0051961 | negative regulation of nervous system development | 33.3333 | 5 | yes |
GO:0060284 | regulation of cell development | 33.3333 | 5 | yes |
GO:0061387 | regulation of extent of cell growth | 33.3333 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | yes |
GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | yes |
GO:0006811 | ion transport | 33.3333 | 4 | no |
GO:0007612 | learning | 33.3333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
GO:0030162 | regulation of proteolysis | 33.3333 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
GO:0031644 | regulation of nervous system process | 33.3333 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 33.3333 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 33.3333 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0043269 | regulation of ion transport | 33.3333 | 5 | no |
GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
GO:0044057 | regulation of system process | 33.3333 | 4 | no |
GO:0050890 | cognition | 33.3333 | 4 | no |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
GO:0098815 | modulation of excitatory postsynaptic potential | 33.3333 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 33.3333 | 6 | no |
GO:2000463 | positive regulation of excitatory postsynaptic potential | 33.3333 | 5 | no |
GO:0001764 | neuron migration | 33.3333 | 4 | no |
GO:0001936 | regulation of endothelial cell proliferation | 33.3333 | 6 | no |
GO:0001938 | positive regulation of endothelial cell proliferation | 33.3333 | 7 | no |
GO:0003148 | outflow tract septum morphogenesis | 33.3333 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 33.3333 | 5 | no |
GO:0010594 | regulation of endothelial cell migration | 33.3333 | 5 | no |
GO:0010595 | positive regulation of endothelial cell migration | 33.3333 | 6 | no |
GO:0010632 | regulation of epithelial cell migration | 33.3333 | 4 | no |
GO:0010634 | positive regulation of epithelial cell migration | 33.3333 | 5 | no |
GO:0021612 | facial nerve structural organization | 33.3333 | 4 | no |
GO:0021649 | vestibulocochlear nerve structural organization | 33.3333 | 4 | no |
GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus | 33.3333 | 5 | no |
GO:0021855 | hypothalamus cell migration | 33.3333 | 4 | no |
GO:0021856 | hypothalamic tangential migration using cell-axon interactions | 33.3333 | 5 | no |
GO:0034097 | response to cytokine | 33.3333 | 4 | no |
GO:0036484 | trunk neural crest cell migration | 33.3333 | 7 | no |
GO:0036486 | ventral trunk neural crest cell migration | 33.3333 | 8 | no |
GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
GO:0048675 | axon extension | 33.3333 | 5 | no |
GO:0048846 | axon extension involved in axon guidance | 33.3333 | 6 | no |
GO:0050678 | regulation of epithelial cell proliferation | 33.3333 | 5 | no |
GO:0050679 | positive regulation of epithelial cell proliferation | 33.3333 | 6 | no |
GO:0061548 | ganglion development | 33.3333 | 4 | no |
GO:0061549 | sympathetic ganglion development | 33.3333 | 5 | no |
GO:0061550 | cranial ganglion development | 33.3333 | 5 | no |
GO:0061551 | trigeminal ganglion development | 33.3333 | 6 | no |
GO:0061552 | ganglion morphogenesis | 33.3333 | 4 | no |
GO:0071345 | cellular response to cytokine stimulus | 33.3333 | 5 | no |
GO:0097374 | sensory neuron axon guidance | 33.3333 | 9 | no |
GO:0097490 | sympathetic neuron projection extension | 33.3333 | 5 | no |
GO:0097491 | sympathetic neuron projection guidance | 33.3333 | 8 | no |
GO:1901166 | neural crest cell migration involved in autonomic nervous system development | 33.3333 | 7 | no |
GO:1902284 | neuron projection extension involved in neuron projection guidance | 33.3333 | 5 | no |
GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 33.3333 | 5 | no |
GO:1903375 | facioacoustic ganglion development | 33.3333 | 6 | no |
GO:1904835 | dorsal root ganglion morphogenesis | 33.3333 | 5 | no |
GO:1990138 | neuron projection extension | 33.3333 | 4 | no |
GO:0010631 | epithelial cell migration | 33.3333 | 5 | no |
GO:0043542 | endothelial cell migration | 33.3333 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 33.3333 | 8 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0022604 | regulation of cell morphogenesis | 33.3333 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 33.3333 | 6 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
GO:0032990 | cell part morphogenesis | 33.3333 | 4 | no |
GO:0033365 | protein localization to organelle | 33.3333 | 5 | no |
GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
GO:0048812 | neuron projection morphogenesis | 33.3333 | 7 | no |
GO:0048858 | cell projection morphogenesis | 33.3333 | 5 | no |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 33.3333 | 8 | no |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 33.3333 | 9 | no |
GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0099173 | postsynapse organization | 33.3333 | 4 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 33.3333 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIPC2_HUMAN | [view interactions] | Low throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLXB1_HUMAN | [view interactions] | High throughput | no | yes |
PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
SREC2_HUMAN | [view interactions] | High throughput | no | yes |
PLXB3_HUMAN | [view interactions] | Computational | no | yes |