VPS35_HUMAN
Evidence for PS localization
Functions
(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 620 | Asp | Asn | Parkinsondisease17(PARK17) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS35_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.0930 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.9302 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.9302 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.9302 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 8.1395 | 4 | yes |
| GO:0031748 | D1 dopamine receptor binding | 4.6512 | 6 | yes |
| GO:0050780 | dopamine receptor binding | 4.6512 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS35_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.8372 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.8372 | 4 | yes |
| GO:0008104 | protein localization | 46.5116 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.5116 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.5116 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.5116 | 4 | yes |
| GO:0071702 | organic substance transport | 45.3488 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.1860 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.0233 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 43.0233 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 41.8605 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.5349 | 4 | yes |
| GO:0006996 | organelle organization | 38.3721 | 4 | yes |
| GO:0015031 | protein transport | 38.3721 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.3721 | 5 | yes |
| GO:0010468 | regulation of gene expression | 37.2093 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.8837 | 4 | yes |
| GO:0051049 | regulation of transport | 34.8837 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.7209 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5581 | 5 | yes |
| GO:0022607 | cellular component assembly | 32.5581 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.3953 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 31.3953 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.3953 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.2326 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.0698 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9070 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 27.9070 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.9070 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.7442 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 26.7442 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 25.5814 | 5 | yes |
| GO:0010941 | regulation of cell death | 25.5814 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 25.5814 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.5814 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.5814 | 6 | yes |
| GO:0006886 | intracellular protein transport | 24.4186 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 24.4186 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 24.4186 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 24.4186 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2558 | 5 | yes |
| GO:0016197 | endosomal transport | 23.2558 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.2558 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.0930 | 5 | yes |
| GO:0051050 | positive regulation of transport | 22.0930 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 22.0930 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.0930 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.0930 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.0930 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.0930 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.9302 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 20.9302 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.9302 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9302 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.9302 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.9302 | 4 | no |
| GO:0006897 | endocytosis | 20.9302 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.9302 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 19.7674 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 19.7674 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 19.7674 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.7674 | 6 | yes |
| GO:0016482 | cytosolic transport | 18.6047 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 18.6047 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 18.6047 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 17.4419 | 6 | yes |
| GO:0032880 | regulation of protein localization | 17.4419 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 17.4419 | 5 | yes |
| GO:0080134 | regulation of response to stress | 17.4419 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 16.2791 | 5 | yes |
| GO:0010506 | regulation of autophagy | 16.2791 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 16.2791 | 6 | yes |
| GO:0042176 | regulation of protein catabolic process | 16.2791 | 5 | yes |
| GO:0051046 | regulation of secretion | 16.2791 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 15.1163 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 15.1163 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 15.1163 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 15.1163 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 15.1163 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 13.9535 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 13.9535 | 4 | yes |
| GO:0032456 | endocytic recycling | 13.9535 | 5 | yes |
| GO:0033365 | protein localization to organelle | 13.9535 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 13.9535 | 6 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 13.9535 | 4 | yes |
| GO:1901214 | regulation of neuron death | 13.9535 | 5 | yes |
| GO:0007005 | mitochondrion organization | 12.7907 | 5 | yes |
| GO:0051223 | regulation of protein transport | 12.7907 | 5 | yes |
| GO:1901215 | negative regulation of neuron death | 12.7907 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 12.7907 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 11.6279 | 6 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 11.6279 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 11.6279 | 5 | yes |
| GO:0034330 | cell junction organization | 11.6279 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 11.6279 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 11.6279 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 11.6279 | 5 | yes |
| GO:0009895 | negative regulation of catabolic process | 10.4651 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 10.4651 | 7 | yes |
| GO:0051051 | negative regulation of transport | 10.4651 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 10.4651 | 5 | yes |
| GO:0007034 | vacuolar transport | 9.3023 | 4 | yes |
| GO:0007041 | lysosomal transport | 9.3023 | 5 | yes |
| GO:0031347 | regulation of defense response | 9.3023 | 5 | yes |
| GO:0034329 | cell junction assembly | 9.3023 | 5 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 9.3023 | 6 | yes |
| GO:0050808 | synapse organization | 9.3023 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 9.3023 | 5 | yes |
| GO:0010822 | positive regulation of mitochondrion organization | 8.1395 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 8.1395 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 8.1395 | 6 | yes |
| GO:0050727 | regulation of inflammatory response | 8.1395 | 5 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 8.1395 | 6 | yes |
| GO:0007416 | synapse assembly | 6.9767 | 6 | yes |
| GO:0032387 | negative regulation of intracellular transport | 6.9767 | 5 | yes |
| GO:0033238 | regulation of cellular amine metabolic process | 6.9767 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 6.9767 | 4 | yes |
| GO:0042053 | regulation of dopamine metabolic process | 6.9767 | 6 | yes |
| GO:0042069 | regulation of catecholamine metabolic process | 6.9767 | 5 | yes |
| GO:0050905 | neuromuscular process | 6.9767 | 4 | yes |
| GO:0051222 | positive regulation of protein transport | 6.9767 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 6.9767 | 6 | yes |
| GO:0072657 | protein localization to membrane | 6.9767 | 4 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 6.9767 | 6 | yes |
| GO:0007033 | vacuole organization | 5.8140 | 5 | yes |
| GO:0016055 | Wnt signaling pathway | 5.8140 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 5.8140 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 5.8140 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 5.8140 | 5 | yes |
| GO:0090140 | regulation of mitochondrial fission | 5.8140 | 5 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 5.8140 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 5.8140 | 5 | yes |
| GO:0008637 | apoptotic mitochondrial changes | 4.6512 | 6 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 4.6512 | 6 | yes |
| GO:0031348 | negative regulation of defense response | 4.6512 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 4.6512 | 6 | yes |
| GO:0090141 | positive regulation of mitochondrial fission | 4.6512 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 4.6512 | 6 | yes |
| GO:1903179 | regulation of dopamine biosynthetic process | 4.6512 | 6 | yes |
| GO:0006839 | mitochondrial transport | 3.4884 | 4 | yes |
| GO:0031648 | protein destabilization | 3.4884 | 4 | yes |
| GO:0033240 | positive regulation of cellular amine metabolic process | 3.4884 | 6 | yes |
| GO:0036010 | protein localization to endosome | 3.4884 | 6 | yes |
| GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 3.4884 | 7 | yes |
| GO:0045915 | positive regulation of catecholamine metabolic process | 3.4884 | 6 | yes |
| GO:0045964 | positive regulation of dopamine metabolic process | 3.4884 | 7 | yes |
| GO:0050728 | negative regulation of inflammatory response | 3.4884 | 6 | yes |
| GO:0061356 | regulation of Wnt protein secretion | 3.4884 | 4 | yes |
| GO:0061357 | positive regulation of Wnt protein secretion | 3.4884 | 5 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 3.4884 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 3.4884 | 4 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 3.4884 | 7 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 3.4884 | 5 | yes |
| GO:0099074 | mitochondrion to lysosome transport | 3.4884 | 5 | yes |
| GO:0099075 | mitochondrion-derived vesicle mediated transport | 3.4884 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 3.4884 | 6 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 3.4884 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 3.4884 | 5 | yes |
| GO:1902950 | regulation of dendritic spine maintenance | 3.4884 | 7 | yes |
| GO:1903181 | positive regulation of dopamine biosynthetic process | 3.4884 | 7 | yes |
| GO:1905606 | regulation of presynapse assembly | 3.4884 | 7 | yes |
| GO:0007040 | lysosome organization | 2.3256 | 7 | yes |
| GO:0032459 | regulation of protein oligomerization | 2.3256 | 6 | yes |
| GO:0032460 | negative regulation of protein oligomerization | 2.3256 | 7 | yes |
| GO:0032462 | regulation of protein homooligomerization | 2.3256 | 7 | yes |
| GO:0032463 | negative regulation of protein homooligomerization | 2.3256 | 8 | yes |
| GO:0035418 | protein localization to synapse | 2.3256 | 6 | yes |
| GO:0048520 | positive regulation of behavior | 2.3256 | 5 | yes |
| GO:0050795 | regulation of behavior | 2.3256 | 4 | yes |
| GO:0050882 | voluntary musculoskeletal movement | 2.3256 | 4 | yes |
| GO:0060159 | regulation of dopamine receptor signaling pathway | 2.3256 | 5 | yes |
| GO:0060161 | positive regulation of dopamine receptor signaling pathway | 2.3256 | 6 | yes |
| GO:0062237 | protein localization to postsynapse | 2.3256 | 7 | yes |
| GO:0080171 | lytic vacuole organization | 2.3256 | 6 | yes |
| GO:0090325 | regulation of locomotion involved in locomotory behavior | 2.3256 | 4 | yes |
| GO:0090326 | positive regulation of locomotion involved in locomotory behavior | 2.3256 | 5 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 2.3256 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 2.3256 | 4 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 2.3256 | 5 | yes |
| GO:1902822 | regulation of late endosome to lysosome transport | 2.3256 | 7 | yes |
| GO:1902823 | negative regulation of late endosome to lysosome transport | 2.3256 | 7 | yes |
| GO:1903335 | regulation of vacuolar transport | 2.3256 | 6 | yes |
| GO:1903336 | negative regulation of vacuolar transport | 2.3256 | 6 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:1904350 | regulation of protein catabolic process in the vacuole | 2.3256 | 6 | yes |
| GO:1904351 | negative regulation of protein catabolic process in the vacuole | 2.3256 | 7 | yes |
| GO:1905165 | regulation of lysosomal protein catabolic process | 2.3256 | 7 | yes |
| GO:1905166 | negative regulation of lysosomal protein catabolic process | 2.3256 | 8 | yes |
| GO:2000331 | regulation of terminal button organization | 2.3256 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VPS35_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.1395 | 3 | yes |
| DOID:1289 | neurodegenerative disease | 5.8140 | 4 | yes |
| DOID:0050890 | synucleinopathy | 4.6512 | 5 | yes |
| DOID:14330 | Parkinsons disease | 4.6512 | 6 | yes |
| DOID:0060892 | late onset Parkinsons disease | 3.4884 | 7 | yes |
| DOID:574 | peripheral nervous system disease | 2.3256 | 3 | no |
| DOID:870 | neuropathy | 2.3256 | 4 | no |
| DOID:0060894 | early-onset Parkinsons disease | 2.3256 | 7 | no |
| DOID:936 | brain disease | 2.3256 | 4 | no |
| DOID:0060897 | Parkinsons disease 17 | 2.3256 | 8 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SORT_HUMAN | [view interactions] | Low throughput | no | yes |
| SORL_HUMAN | [view interactions] | Low throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COMD1_HUMAN | [view interactions] | Low throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DNM1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AIMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NRAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MMP14_HUMAN | [view interactions] | Low throughput | no | yes |
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WAC2C_HUMAN | [view interactions] | Low throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP26B_HUMAN | [view interactions] | Low throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| WASH3_HUMAN | [view interactions] | High throughput | no | no |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| STAB2_HUMAN | [view interactions] | High throughput | no | no |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEL1_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| NELFB_HUMAN | [view interactions] | High throughput | no | no |
| TMM52_HUMAN | [view interactions] | High throughput | no | no |
| Z518B_HUMAN | [view interactions] | High throughput | no | yes |
| TBC13_HUMAN | [view interactions] | High throughput | no | yes |
| PCD20_HUMAN | [view interactions] | High throughput | no | no |
| NAT14_HUMAN | [view interactions] | High throughput | no | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLIT3_HUMAN | [view interactions] | High throughput | no | yes |
| ITB5_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| IMA7_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| TB22A_HUMAN | [view interactions] | High throughput | no | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTHD1_HUMAN | [view interactions] | High throughput | no | no |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VEGFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB17_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| ZBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| CF20D_HUMAN | [view interactions] | High throughput | no | no |
| LOXL3_HUMAN | [view interactions] | High throughput | no | no |
| LRC73_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| GPSM3_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| CITE1_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| CF410_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR62_HUMAN | [view interactions] | High throughput | no | no |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUN3B_HUMAN | [view interactions] | High throughput | no | no |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| NOB1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| COMD9_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| N4BP2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR74_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| CSPP1_HUMAN | [view interactions] | High throughput | no | no |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| ZN318_HUMAN | [view interactions] | High throughput | no | yes |
| TM165_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| GNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS36_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| PP14C_HUMAN | [view interactions] | High throughput | no | no |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| TRM6_HUMAN | [view interactions] | High throughput | no | yes |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| AN32E_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYHR1_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| OXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP13A_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP43_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| FKB10_HUMAN | [view interactions] | High throughput | no | yes |
| IRF4_HUMAN | [view interactions] | High throughput | no | no |
| FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NT5D3_HUMAN | [view interactions] | High throughput | no | no |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
| WASH6_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC5_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR27_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COMD3_HUMAN | [view interactions] | High throughput | no | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MON2_HUMAN | [view interactions] | Computational | no | no |
| PI3R4_HUMAN | [view interactions] | Computational | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VPS54_HUMAN | [view interactions] | Computational | no | no |
| SNX7_HUMAN | [view interactions] | Computational | no | yes |
| AT132_HUMAN | [view interactions] | Computational | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WLS_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLPL9_HUMAN | [view interactions] | Computational | no | yes |
| BECN1_HUMAN | [view interactions] | Computational | no | yes |
| VP26C_HUMAN | [view interactions] | Computational | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3C3_HUMAN | [view interactions] | Computational | no | yes |
| GOLP3_HUMAN | [view interactions] | Computational | no | no |
| SORC2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX8_HUMAN | [view interactions] | Computational | no | yes |
| PINK1_HUMAN | [view interactions] | Computational | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| SORC1_HUMAN | [view interactions] | Computational | no | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |