Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD1_HUMAN
GO:0046872 metal ion binding 33.3333 4 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0004930 G protein-coupled receptor activity 23.8095 4 yes
GO:0004952 dopamine neurotransmitter receptor activity 14.2857 5 yes
GO:0035240 dopamine binding 14.2857 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DRD1_HUMAN
GO:0080090 regulation of primary metabolic process 76.1905 4 yes
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 71.4286 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 yes
GO:0048523 negative regulation of cellular process 61.9048 4 yes
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0010243 response to organonitrogen compound 57.1429 4 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0009893 positive regulation of metabolic process 52.3810 4 yes
GO:0051049 regulation of transport 52.3810 4 yes
GO:0099177 regulation of trans-synaptic signaling 47.6190 4 yes
GO:0010647 positive regulation of cell communication 47.6190 5 yes
GO:0022607 cellular component assembly 47.6190 4 yes
GO:0023056 positive regulation of signaling 47.6190 4 yes
GO:0050804 modulation of chemical synaptic transmission 47.6190 5 yes
GO:0071702 organic substance transport 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0008104 protein localization 42.8571 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 yes
GO:0014070 response to organic cyclic compound 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0050890 cognition 42.8571 4 yes
GO:0051050 positive regulation of transport 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 38.0952 5 no
GO:0044057 regulation of system process 38.0952 4 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.0952 5 no
GO:0060341 regulation of cellular localization 38.0952 4 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.0952 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 38.0952 4 yes
GO:0010468 regulation of gene expression 38.0952 5 yes
GO:0032101 regulation of response to external stimulus 38.0952 4 yes
GO:0043269 regulation of ion transport 38.0952 5 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0071417 cellular response to organonitrogen compound 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:1901699 cellular response to nitrogen compound 33.3333 4 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 33.3333 5 yes
GO:0007612 learning 33.3333 4 yes
GO:0009416 response to light stimulus 33.3333 4 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0032102 negative regulation of response to external stimulus 33.3333 5 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 yes
GO:1904062 regulation of cation transmembrane transport 28.5714 6 yes
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0050795 regulation of behavior 28.5714 4 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0060548 negative regulation of cell death 28.5714 5 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 yes
GO:0006811 ion transport 28.5714 4 yes
GO:0008306 associative learning 28.5714 5 yes
GO:0008542 visual learning 28.5714 4 yes
GO:0010959 regulation of metal ion transport 28.5714 6 yes
GO:0034762 regulation of transmembrane transport 28.5714 4 yes
GO:0034765 regulation of ion transmembrane transport 28.5714 5 yes
GO:0042325 regulation of phosphorylation 28.5714 7 yes
GO:0071407 cellular response to organic cyclic compound 23.8095 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 23.8095 7 yes
GO:0032870 cellular response to hormone stimulus 23.8095 4 no
GO:0097305 response to alcohol 23.8095 4 no
GO:0048878 chemical homeostasis 23.8095 4 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0007600 sensory perception 23.8095 4 no
GO:0051047 positive regulation of secretion 23.8095 5 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 no
GO:0043086 negative regulation of catalytic activity 23.8095 4 no
GO:0043549 regulation of kinase activity 23.8095 5 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0045859 regulation of protein kinase activity 23.8095 6 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0051223 regulation of protein transport 23.8095 5 no
GO:0070201 regulation of establishment of protein localization 23.8095 6 no
GO:0016192 vesicle-mediated transport 23.8095 4 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0042981 regulation of apoptotic process 23.8095 6 no
GO:0043067 regulation of programmed cell death 23.8095 5 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0006576 cellular biogenic amine metabolic process 23.8095 5 yes
GO:0006584 catecholamine metabolic process 23.8095 6 yes
GO:0006812 cation transport 23.8095 5 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 23.8095 4 yes
GO:0009308 amine metabolic process 23.8095 4 yes
GO:0009712 catechol-containing compound metabolic process 23.8095 5 yes
GO:0015031 protein transport 23.8095 4 yes
GO:0018958 phenol-containing compound metabolic process 23.8095 4 yes
GO:0034329 cell junction assembly 23.8095 5 yes
GO:0034330 cell junction organization 23.8095 4 yes
GO:0042417 dopamine metabolic process 23.8095 7 yes
GO:0044106 cellular amine metabolic process 23.8095 4 yes
GO:0050806 positive regulation of synaptic transmission 23.8095 5 yes
GO:0051924 regulation of calcium ion transport 23.8095 7 yes
GO:0051952 regulation of amine transport 23.8095 5 yes
GO:0071867 response to monoamine 19.0476 5 yes
GO:0071868 cellular response to monoamine stimulus 19.0476 5 yes
GO:0071869 response to catecholamine 19.0476 4 yes
GO:0071870 cellular response to catecholamine stimulus 19.0476 5 yes
GO:2000145 regulation of cell motility 19.0476 4 yes
GO:0001975 response to amphetamine 19.0476 6 yes
GO:0006886 intracellular protein transport 19.0476 4 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 19.0476 4 yes
GO:0014075 response to amine 19.0476 5 yes
GO:0030334 regulation of cell migration 19.0476 5 yes
GO:0033365 protein localization to organelle 19.0476 5 yes
GO:0043266 regulation of potassium ion transport 19.0476 7 yes
GO:0043270 positive regulation of ion transport 19.0476 5 yes
GO:0048148 behavioral response to cocaine 19.0476 4 yes
GO:0050805 negative regulation of synaptic transmission 19.0476 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 19.0476 6 yes
GO:0060134 prepulse inhibition 19.0476 6 yes
GO:0071875 adrenergic receptor signaling pathway 14.2857 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 14.2857 5 yes
GO:0007416 synapse assembly 14.2857 6 yes
GO:0007613 memory 14.2857 4 yes
GO:0010628 positive regulation of gene expression 14.2857 6 yes
GO:0017157 regulation of exocytosis 14.2857 5 yes
GO:0031279 regulation of cyclase activity 14.2857 4 yes
GO:0033238 regulation of cellular amine metabolic process 14.2857 5 yes
GO:0040017 positive regulation of locomotion 14.2857 4 yes
GO:0042053 regulation of dopamine metabolic process 14.2857 6 yes
GO:0042069 regulation of catecholamine metabolic process 14.2857 5 yes
GO:0045761 regulation of adenylate cyclase activity 14.2857 5 yes
GO:0050808 synapse organization 14.2857 5 yes
GO:0051282 regulation of sequestering of calcium ion 14.2857 4 yes
GO:0051339 regulation of lyase activity 14.2857 4 yes
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 14.2857 4 yes
GO:0051580 regulation of neurotransmitter uptake 14.2857 4 yes
GO:0051584 regulation of dopamine uptake involved in synaptic transmission 14.2857 6 yes
GO:0051588 regulation of neurotransmitter transport 14.2857 5 yes
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission 14.2857 5 yes
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway 14.2857 4 yes
GO:0060291 long-term synaptic potentiation 9.5238 4 yes
GO:0090659 walking behavior 9.5238 4 yes
GO:1903305 regulation of regulated secretory pathway 9.5238 6 yes
GO:1904064 positive regulation of cation transmembrane transport 9.5238 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 9.5238 7 yes
GO:1904936 interneuron migration 9.5238 5 yes
GO:2000147 positive regulation of cell motility 9.5238 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 9.5238 5 yes
GO:0001508 action potential 9.5238 4 yes
GO:0001764 neuron migration 9.5238 4 yes
GO:0006936 muscle contraction 9.5238 4 yes
GO:0006939 smooth muscle contraction 9.5238 5 yes
GO:0007628 adult walking behavior 9.5238 5 yes
GO:0008344 adult locomotory behavior 9.5238 4 yes
GO:0014821 phasic smooth muscle contraction 9.5238 6 yes
GO:0015844 monoamine transport 9.5238 5 yes
GO:0015850 organic hydroxy compound transport 9.5238 5 yes
GO:0015872 dopamine transport 9.5238 6 yes
GO:0021826 substrate-independent telencephalic tangential migration 9.5238 6 yes
GO:0021830 interneuron migration from the subpallium to the cortex 9.5238 8 yes
GO:0021843 substrate-independent telencephalic tangential interneuron migration 9.5238 7 yes
GO:0021853 cerebral cortex GABAergic interneuron migration 9.5238 6 yes
GO:0021885 forebrain cell migration 9.5238 4 yes
GO:0022029 telencephalon cell migration 9.5238 5 yes
GO:0030335 positive regulation of cell migration 9.5238 6 yes
GO:0030432 peristalsis 9.5238 7 yes
GO:0034764 positive regulation of transmembrane transport 9.5238 5 yes
GO:0034767 positive regulation of ion transmembrane transport 9.5238 6 yes
GO:0043268 positive regulation of potassium ion transport 9.5238 6 yes
GO:0046928 regulation of neurotransmitter secretion 9.5238 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 9.5238 5 yes
GO:0051928 positive regulation of calcium ion transport 9.5238 6 yes
GO:0051937 catecholamine transport 9.5238 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
DJC14_HUMAN [view interactions] Low throughput no yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
COPG1_HUMAN [view interactions] Low throughput no yes
COPG2_HUMAN [view interactions] Low throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
PE2R1_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP10_HUMAN [view interactions] Low throughput no no
AGTR1_HUMAN [view interactions] Low throughput no no
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
VPS35_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
HRH3_HUMAN [view interactions] Low throughput no no
ADA_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
MD2L1_HUMAN [view interactions] High throughput no no
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KAT5_HUMAN [view interactions] High throughput no yes
GNAL_HUMAN [view interactions] Computational no yes
SC6A3_HUMAN [view entry] [view interactions] Computational yes yes
CALY_HUMAN [view entry] [view interactions] Computational yes yes
GBG1_HUMAN [view interactions] Computational no no
PPR1B_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes