Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD1_HUMAN
GO:0043169 cation binding 37.5000 4 yes
GO:0004930 G protein-coupled receptor activity 31.2500 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 25.0000 4 yes
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0004952 dopamine neurotransmitter receptor activity 18.7500 5 yes
GO:0035240 dopamine binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DRD1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 81.2500 4 yes
GO:0010646 regulation of cell communication 81.2500 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0009966 regulation of signal transduction 75.0000 4 no
GO:0031323 regulation of cellular metabolic process 68.7500 4 yes
GO:0048523 negative regulation of cellular process 68.7500 4 yes
GO:0050804 modulation of chemical synaptic transmission 68.7500 5 yes
GO:0051049 regulation of transport 68.7500 4 yes
GO:0099177 regulation of trans-synaptic signaling 68.7500 4 yes
GO:0010243 response to organonitrogen compound 68.7500 4 yes
GO:0010647 positive regulation of cell communication 68.7500 5 yes
GO:0023056 positive regulation of signaling 68.7500 4 yes
GO:0048585 negative regulation of response to stimulus 56.2500 4 yes
GO:0051246 regulation of protein metabolic process 56.2500 5 yes
GO:0009893 positive regulation of metabolic process 56.2500 4 no
GO:0009967 positive regulation of signal transduction 56.2500 5 no
GO:0048584 positive regulation of response to stimulus 56.2500 4 no
GO:0008104 protein localization 56.2500 4 yes
GO:0050890 cognition 50.0000 4 yes
GO:0044057 regulation of system process 50.0000 4 no
GO:0010648 negative regulation of cell communication 50.0000 5 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0023057 negative regulation of signaling 50.0000 4 yes
GO:0032101 regulation of response to external stimulus 43.7500 4 yes
GO:0043269 regulation of monoatomic ion transport 43.7500 5 yes
GO:0051050 positive regulation of transport 43.7500 4 yes
GO:0071702 organic substance transport 43.7500 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:0009889 regulation of biosynthetic process 43.7500 4 no
GO:0009892 negative regulation of metabolic process 43.7500 4 no
GO:0010468 regulation of gene expression 43.7500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.7500 5 no
GO:0031325 positive regulation of cellular metabolic process 43.7500 5 no
GO:0031326 regulation of cellular biosynthetic process 43.7500 5 no
GO:0051046 regulation of secretion 43.7500 5 no
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:1903530 regulation of secretion by cell 43.7500 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 43.7500 4 yes
GO:0014070 response to organic cyclic compound 43.7500 4 yes
GO:0032102 negative regulation of response to external stimulus 37.5000 5 yes
GO:0034762 regulation of transmembrane transport 37.5000 4 yes
GO:0050806 positive regulation of synaptic transmission 37.5000 5 yes
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 37.5000 6 yes
GO:0071310 cellular response to organic substance 37.5000 4 yes
GO:0071417 cellular response to organonitrogen compound 37.5000 4 yes
GO:0071705 nitrogen compound transport 37.5000 4 yes
GO:1901699 cellular response to nitrogen compound 37.5000 4 yes
GO:1901701 cellular response to oxygen-containing compound 37.5000 4 yes
GO:0051051 negative regulation of transport 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 37.5000 5 yes
GO:0007612 learning 37.5000 4 yes
GO:0010959 regulation of metal ion transport 37.5000 6 yes
GO:0019220 regulation of phosphate metabolic process 37.5000 6 yes
GO:0031399 regulation of protein modification process 31.2500 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 31.2500 5 yes
GO:0051952 regulation of amine transport 31.2500 5 yes
GO:0098916 anterograde trans-synaptic signaling 31.2500 6 yes
GO:0099536 synaptic signaling 31.2500 4 yes
GO:0099537 trans-synaptic signaling 31.2500 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 31.2500 6 yes
GO:0009968 negative regulation of signal transduction 31.2500 5 no
GO:0043933 protein-containing complex organization 31.2500 4 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0065003 protein-containing complex assembly 31.2500 5 no
GO:1902532 negative regulation of intracellular signal transduction 31.2500 6 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0031644 regulation of nervous system process 31.2500 5 no
GO:0032870 cellular response to hormone stimulus 31.2500 4 no
GO:0032880 regulation of protein localization 31.2500 5 no
GO:0044087 regulation of cellular component biogenesis 31.2500 4 no
GO:0050708 regulation of protein secretion 31.2500 5 no
GO:0050795 regulation of behavior 31.2500 4 no
GO:0051094 positive regulation of developmental process 31.2500 4 no
GO:0051223 regulation of protein transport 31.2500 5 no
GO:0070201 regulation of establishment of protein localization 31.2500 6 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0051047 positive regulation of secretion 31.2500 5 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0051726 regulation of cell cycle 31.2500 4 no
GO:0055074 calcium ion homeostasis 31.2500 4 no
GO:0055080 monoatomic cation homeostasis 31.2500 4 no
GO:0009894 regulation of catabolic process 31.2500 4 no
GO:0007268 chemical synaptic transmission 31.2500 7 yes
GO:0008306 associative learning 31.2500 5 yes
GO:0008542 visual learning 31.2500 4 yes
GO:0009416 response to light stimulus 31.2500 4 yes
GO:0033365 protein localization to organelle 25.0000 5 yes
GO:0034329 cell junction assembly 25.0000 5 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0042325 regulation of phosphorylation 25.0000 7 yes
GO:0042417 dopamine metabolic process 25.0000 7 yes
GO:0043266 regulation of potassium ion transport 25.0000 7 yes
GO:0050805 negative regulation of synaptic transmission 25.0000 5 yes
GO:0051924 regulation of calcium ion transport 25.0000 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 25.0000 7 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0006996 organelle organization 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0002791 regulation of peptide secretion 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0031348 negative regulation of defense response 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0046883 regulation of hormone secretion 25.0000 4 no
GO:0046903 secretion 25.0000 4 no
GO:0051048 negative regulation of secretion 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090087 regulation of peptide transport 25.0000 5 no
GO:0090257 regulation of muscle system process 25.0000 5 no
GO:1903531 negative regulation of secretion by cell 25.0000 5 no
GO:1903828 negative regulation of protein localization 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006873 intracellular monoatomic ion homeostasis 25.0000 4 no
GO:0006874 intracellular calcium ion homeostasis 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0030003 intracellular monoatomic cation homeostasis 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0048168 regulation of neuronal synaptic plasticity 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0060078 regulation of postsynaptic membrane potential 25.0000 4 no
GO:0060079 excitatory postsynaptic potential 25.0000 5 no
GO:1903532 positive regulation of secretion by cell 25.0000 5 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0050905 neuromuscular process 25.0000 4 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0097305 response to alcohol 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 yes
GO:0006576 biogenic amine metabolic process 25.0000 5 yes
GO:0006584 catecholamine metabolic process 25.0000 6 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 25.0000 4 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 25.0000 4 yes
GO:0009308 amine metabolic process 25.0000 4 yes
GO:0009712 catechol-containing compound metabolic process 25.0000 5 yes
GO:0015031 protein transport 25.0000 4 yes
GO:0018958 phenol-containing compound metabolic process 25.0000 4 yes
GO:0030334 regulation of cell migration 25.0000 5 yes
GO:0040017 positive regulation of locomotion 18.7500 4 yes
GO:0043085 positive regulation of catalytic activity 18.7500 4 yes
GO:0043270 positive regulation of monoatomic ion transport 18.7500 5 yes
GO:0048148 behavioral response to cocaine 18.7500 4 yes
GO:0051282 regulation of sequestering of calcium ion 18.7500 4 yes
GO:0051580 regulation of neurotransmitter uptake 18.7500 6 yes
GO:0051584 regulation of dopamine uptake involved in synaptic transmission 18.7500 7 yes
GO:0051588 regulation of neurotransmitter transport 18.7500 5 yes
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission 18.7500 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 18.7500 6 yes
GO:0060134 prepulse inhibition 18.7500 6 yes
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway 18.7500 4 yes
GO:0071407 cellular response to organic cyclic compound 18.7500 5 yes
GO:0071867 response to monoamine 18.7500 5 yes
GO:0071868 cellular response to monoamine stimulus 18.7500 5 yes
GO:0071869 response to catecholamine 18.7500 4 yes
GO:0071870 cellular response to catecholamine stimulus 18.7500 5 yes
GO:0071875 adrenergic receptor signaling pathway 18.7500 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 18.7500 5 yes
GO:0001975 response to amphetamine 18.7500 6 yes
GO:0006886 intracellular protein transport 18.7500 4 yes
GO:0007613 memory 18.7500 4 yes
GO:0014075 response to amine 18.7500 5 yes
GO:0030335 positive regulation of cell migration 12.5000 6 yes
GO:0030432 peristalsis 12.5000 7 yes
GO:0031279 regulation of cyclase activity 12.5000 4 yes
GO:0033238 regulation of amine metabolic process 12.5000 4 yes
GO:0034764 positive regulation of transmembrane transport 12.5000 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 12.5000 6 yes
GO:0035150 regulation of tube size 12.5000 4 yes
GO:0035249 synaptic transmission, glutamatergic 12.5000 8 yes
GO:0035296 regulation of tube diameter 12.5000 5 yes
GO:0042053 regulation of dopamine metabolic process 12.5000 6 yes
GO:0042069 regulation of catecholamine metabolic process 12.5000 5 yes
GO:0042311 vasodilation 12.5000 6 yes
GO:0043268 positive regulation of potassium ion transport 12.5000 6 yes
GO:0045761 regulation of adenylate cyclase activity 12.5000 5 yes
GO:0050808 synapse organization 12.5000 5 yes
GO:0051169 nuclear transport 12.5000 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 12.5000 5 yes
GO:0051339 regulation of lyase activity 12.5000 4 yes
GO:0051928 positive regulation of calcium ion transport 12.5000 6 yes
GO:0051937 catecholamine transport 12.5000 6 yes
GO:0060291 long-term synaptic potentiation 12.5000 4 yes
GO:0060292 long-term synaptic depression 12.5000 4 yes
GO:0090659 walking behavior 12.5000 4 yes
GO:0097746 blood vessel diameter maintenance 12.5000 5 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 12.5000 6 yes
GO:1904064 positive regulation of cation transmembrane transport 12.5000 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 12.5000 7 yes
GO:1904936 interneuron migration 12.5000 5 yes
GO:2000147 positive regulation of cell motility 12.5000 5 yes
GO:2001222 regulation of neuron migration 12.5000 6 yes
GO:0001764 neuron migration 12.5000 4 yes
GO:0003018 vascular process in circulatory system 12.5000 4 yes
GO:0006913 nucleocytoplasmic transport 12.5000 5 yes
GO:0006936 muscle contraction 12.5000 4 yes
GO:0006939 smooth muscle contraction 12.5000 5 yes
GO:0007416 synapse assembly 12.5000 6 yes
GO:0007628 adult walking behavior 12.5000 5 yes
GO:0008344 adult locomotory behavior 12.5000 4 yes
GO:0014821 phasic smooth muscle contraction 12.5000 6 yes
GO:0015844 monoamine transport 12.5000 5 yes
GO:0015850 organic hydroxy compound transport 12.5000 5 yes
GO:0015872 dopamine transport 12.5000 7 yes
GO:0021826 substrate-independent telencephalic tangential migration 12.5000 6 yes
GO:0021830 interneuron migration from the subpallium to the cortex 12.5000 8 yes
GO:0021843 substrate-independent telencephalic tangential interneuron migration 12.5000 7 yes
GO:0021853 cerebral cortex GABAergic interneuron migration 12.5000 6 yes
GO:0021885 forebrain cell migration 12.5000 4 yes
GO:0022029 telencephalon cell migration 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
DJC14_HUMAN [view interactions] Low throughput no yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
COPG1_HUMAN [view interactions] Low throughput no yes
COPG2_HUMAN [view interactions] Low throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
PE2R1_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP10_HUMAN [view interactions] Low throughput no no
AGTR1_HUMAN [view interactions] Low throughput no no
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
VPS35_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
HRH3_HUMAN [view interactions] Low throughput no no
ADA_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KAT5_HUMAN [view interactions] High throughput no yes