Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB17_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development . May also play a role in cell migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB17_HUMAN
GO:0043168 anion binding 64.2857 4 yes
GO:0000166 nucleotide binding 57.1429 4 yes
GO:0017076 purine nucleotide binding 57.1429 5 yes
GO:0032555 purine ribonucleotide binding 57.1429 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 57.1429 4 yes
GO:0016462 pyrophosphatase activity 50.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 yes
GO:0005525 GTP binding 35.7143 5 yes
GO:0019001 guanyl nucleotide binding 35.7143 6 yes
GO:0032561 guanyl ribonucleotide binding 35.7143 5 yes
GO:0003924 GTPase activity 28.5714 7 yes
GO:0005524 ATP binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0019003 GDP binding 21.4286 5 yes
GO:0016887 ATP hydrolysis activity 21.4286 7 no
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0003723 RNA binding 21.4286 4 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAB17_HUMAN
GO:0008104 protein localization 64.2857 4 yes
GO:0015031 protein transport 57.1429 4 yes
GO:0071702 organic substance transport 57.1429 4 yes
GO:0071705 nitrogen compound transport 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051246 regulation of protein metabolic process 57.1429 5 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0006886 intracellular protein transport 35.7143 4 yes
GO:0022607 cellular component assembly 35.7143 4 yes
GO:0009889 regulation of biosynthetic process 35.7143 4 no
GO:0009891 positive regulation of biosynthetic process 35.7143 5 no
GO:0010468 regulation of gene expression 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 35.7143 6 no
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 no
GO:0031328 positive regulation of cellular biosynthetic process 35.7143 6 no
GO:0043254 regulation of protein-containing complex assembly 35.7143 5 no
GO:0048523 negative regulation of cellular process 35.7143 4 no
GO:0048584 positive regulation of response to stimulus 35.7143 4 no
GO:0051129 negative regulation of cellular component organization 35.7143 5 no
GO:0042981 regulation of apoptotic process 35.7143 5 no
GO:0043067 regulation of programmed cell death 35.7143 4 no
GO:0051049 regulation of transport 28.5714 4 yes
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010628 positive regulation of gene expression 28.5714 7 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0033365 protein localization to organelle 28.5714 5 no
GO:0042176 regulation of protein catabolic process 28.5714 5 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0031344 regulation of cell projection organization 21.4286 5 yes
GO:0032456 endocytic recycling 21.4286 4 yes
GO:0098657 import into cell 21.4286 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 yes
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0031333 negative regulation of protein-containing complex assembly 21.4286 6 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0045732 positive regulation of protein catabolic process 21.4286 6 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0090150 establishment of protein localization to membrane 21.4286 4 no
GO:1903829 positive regulation of protein localization 21.4286 5 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:1901565 organonitrogen compound catabolic process 21.4286 4 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0050807 regulation of synapse organization 14.2857 5 yes
GO:0051650 establishment of vesicle localization 14.2857 4 yes
GO:0051963 regulation of synapse assembly 14.2857 6 yes
GO:0060491 regulation of cell projection assembly 14.2857 5 yes
GO:0060627 regulation of vesicle-mediated transport 14.2857 4 yes
GO:0070925 organelle assembly 14.2857 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 14.2857 6 yes
GO:1901888 regulation of cell junction assembly 14.2857 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB7A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACVR1_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
GTPB1_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
GEMI6_HUMAN [view interactions] High throughput no yes
BOLA1_HUMAN [view interactions] High throughput no yes
CHMP6_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
FAM9B_HUMAN [view interactions] High throughput no no
CSTP1_HUMAN [view interactions] High throughput no yes
BOLA3_HUMAN [view interactions] High throughput no yes
NUDT3_HUMAN [view interactions] High throughput no yes
S10A8_HUMAN [view interactions] High throughput no no
PSPC1_HUMAN [view interactions] High throughput no yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
LIMD1_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
SMU1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
RU2A_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
P5CS_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
BRDT_HUMAN [view interactions] High throughput no no
SMD3_HUMAN [view interactions] High throughput no yes
MTREX_HUMAN [view interactions] High throughput no yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
FXL19_HUMAN [view interactions] High throughput no no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
CC127_HUMAN [view entry] [view interactions] High throughput yes yes
HKDC1_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2B_HUMAN [view interactions] High throughput no no
MOCS1_HUMAN [view interactions] High throughput no yes
PGTB2_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
CL12A_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes