Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB17_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development . May also play a role in cell migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB17_HUMAN
GO:0016462 pyrophosphatase activity 58.3333 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 58.3333 4 yes
GO:0017076 purine nucleotide binding 58.3333 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 58.3333 6 yes
GO:0032555 purine ribonucleotide binding 58.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 58.3333 4 yes
GO:0003924 GTPase activity 33.3333 7 yes
GO:0005525 GTP binding 33.3333 5 yes
GO:0019001 guanyl nucleotide binding 33.3333 5 yes
GO:0032561 guanyl ribonucleotide binding 33.3333 5 yes
GO:0019003 GDP binding 25.0000 4 yes
GO:0005524 ATP binding 25.0000 5 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAB17_HUMAN
GO:0008104 protein localization 58.3333 4 yes
GO:0071702 organic substance transport 50.0000 4 yes
GO:0071705 nitrogen compound transport 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0015031 protein transport 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 41.6667 4 yes
GO:0051128 regulation of cellular component organization 41.6667 4 yes
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0006886 intracellular protein transport 41.6667 4 yes
GO:0022607 cellular component assembly 41.6667 4 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1901565 organonitrogen compound catabolic process 33.3333 4 no
GO:0016192 vesicle-mediated transport 33.3333 4 yes
GO:0051049 regulation of transport 25.0000 4 yes
GO:0098876 vesicle-mediated transport to the plasma membrane 25.0000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 yes
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0030163 protein catabolic process 25.0000 4 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0090150 establishment of protein localization to membrane 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0016197 endosomal transport 25.0000 4 yes
GO:0031344 regulation of cell projection organization 25.0000 5 yes
GO:0032456 endocytic recycling 25.0000 5 yes
GO:0050807 regulation of synapse organization 16.6667 5 yes
GO:0051650 establishment of vesicle localization 16.6667 4 yes
GO:0051963 regulation of synapse assembly 16.6667 6 yes
GO:0060627 regulation of vesicle-mediated transport 16.6667 4 yes
GO:0070925 organelle assembly 16.6667 5 yes
GO:1901888 regulation of cell junction assembly 16.6667 5 yes
GO:0006897 endocytosis 16.6667 5 yes
GO:0010975 regulation of neuron projection development 16.6667 7 yes
GO:0030030 cell projection organization 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB7A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACVR1_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
BOLA1_HUMAN [view interactions] High throughput no yes
GEMI6_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
GTPB1_HUMAN [view interactions] High throughput no yes
CHMP6_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
FAM9B_HUMAN [view interactions] High throughput no no
CK049_HUMAN [view interactions] High throughput no yes
BOLA3_HUMAN [view interactions] High throughput no yes
NUDT3_HUMAN [view interactions] High throughput no yes
S10A8_HUMAN [view interactions] High throughput no no
SF3A3_HUMAN [view interactions] High throughput no yes
P5CS_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
SMU1_HUMAN [view interactions] High throughput no yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
HKDC1_HUMAN [view interactions] High throughput no no
CC127_HUMAN [view entry] [view interactions] High throughput yes yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
FXL19_HUMAN [view interactions] High throughput no no
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
MTREX_HUMAN [view interactions] High throughput no yes
SMD3_HUMAN [view interactions] High throughput no yes
BRDT_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B4_HUMAN [view interactions] High throughput no yes
RU2A_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
LIMD1_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2B_HUMAN [view interactions] High throughput no no
MOCS1_HUMAN [view interactions] High throughput no yes
PGTB2_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
CL12A_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes