ODB2_HUMAN
Evidence for PS localization
Functions
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ODB2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.2500 | 4 | yes |
| GO:0003723 | RNA binding | 29.1667 | 4 | no |
| GO:0000166 | nucleotide binding | 27.0833 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.9167 | 5 | no |
| GO:0043169 | cation binding | 22.9167 | 4 | no |
| GO:0046872 | metal ion binding | 22.9167 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 20.8333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.8333 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 12.5000 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 12.5000 | 4 | yes |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4.1667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ODB2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 39.5833 | 4 | no |
| GO:0006996 | organelle organization | 35.4167 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.4167 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 29.1667 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 27.0833 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 27.0833 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.0833 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.9167 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 22.9167 | 4 | no |
| GO:0008104 | protein localization | 22.9167 | 4 | no |
| GO:0010646 | regulation of cell communication | 22.9167 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.8333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.8333 | 4 | no |
| GO:0009063 | amino acid catabolic process | 14.5833 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 14.5833 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 14.5833 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 14.5833 | 4 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 10.4167 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 10.4167 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| F136A_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| PRS35_HUMAN | [view interactions] | High throughput | no | no |
| PRGR_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOSB2_HUMAN | [view interactions] | High throughput | no | no |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDM4_HUMAN | [view interactions] | High throughput | no | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FOXQ1_HUMAN | [view interactions] | High throughput | no | no |
| TAL1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CECR2_HUMAN | [view interactions] | High throughput | no | yes |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DJB13_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2B_HUMAN | [view interactions] | High throughput | no | yes |
| RBM5_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| MCEE_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT6_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| RAB17_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| MICU3_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM18_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| CI170_HUMAN | [view interactions] | High throughput | no | no |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| GDAH_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| PHS2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| FABD_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHD2_HUMAN | [view interactions] | High throughput | no | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| GATM_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM27_HUMAN | [view interactions] | High throughput | no | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| UBP16_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LIPT_HUMAN | [view interactions] | High throughput | no | no |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| CDO1_HUMAN | [view interactions] | High throughput | no | no |
| PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE2_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| CAH5B_HUMAN | [view interactions] | High throughput | no | yes |