ODB2_HUMAN
Evidence for PS localization
Functions
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ODB2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 29.6296 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.3704 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.3704 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 11.1111 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 11.1111 | 4 | yes |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 7.4074 | 4 | yes |
| GO:0016407 | acetyltransferase activity | 3.7037 | 5 | yes |
| GO:0031406 | carboxylic acid binding | 3.7037 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 3.7037 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ODB2_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 37.0370 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 37.0370 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 35.1852 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 31.4815 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.4815 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.4815 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 27.7778 | 4 | no |
| GO:0006996 | organelle organization | 25.9259 | 4 | no |
| GO:0022607 | cellular component assembly | 24.0741 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.2222 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.3704 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.3704 | 5 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 20.3704 | 6 | no |
| GO:0036211 | protein modification process | 20.3704 | 4 | no |
| GO:0016054 | organic acid catabolic process | 18.5185 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 18.5185 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 16.6667 | 4 | yes |
| GO:0009063 | cellular amino acid catabolic process | 12.9630 | 4 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 11.1111 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 11.1111 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ODB2_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 3.7037 | 3 | no |
| DOID:700 | mitochondrial metabolism disease | 3.7037 | 3 | no |
| DOID:574 | peripheral nervous system disease | 3.7037 | 3 | no |
| DOID:870 | neuropathy | 3.7037 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| PRS35_HUMAN | [view interactions] | High throughput | no | no |
| PRGR_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOSB2_HUMAN | [view interactions] | High throughput | no | no |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDM4_HUMAN | [view interactions] | High throughput | no | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FOXQ1_HUMAN | [view interactions] | High throughput | no | no |
| TAL1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CECR2_HUMAN | [view interactions] | High throughput | no | yes |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DJB13_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2B_HUMAN | [view interactions] | High throughput | no | yes |
| RBM5_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| MCEE_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDT6_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| RAB17_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| MICU3_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM18_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| CI170_HUMAN | [view interactions] | High throughput | no | no |
| SPEB_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| PHS2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| FABD_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHD2_HUMAN | [view interactions] | High throughput | no | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| GATM_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM27_HUMAN | [view interactions] | High throughput | no | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| UBP16_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LIPT_HUMAN | [view interactions] | High throughput | no | no |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE2_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
| CDO1_HUMAN | [view interactions] | High throughput | no | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| CAH5B_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| F136A_HUMAN | [view interactions] | High throughput | no | yes |
| BCAT1_HUMAN | [view interactions] | Computational | no | no |
| MMSA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AOXA_HUMAN | [view interactions] | Computational | no | no |
| ECHD1_HUMAN | [view interactions] | Computational | no | no |
| BCAT2_HUMAN | [view interactions] | Computational | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ODPB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL9A1_HUMAN | [view interactions] | Computational | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PCCB_HUMAN | [view interactions] | Computational | no | yes |
| ACOX1_HUMAN | [view interactions] | Computational | no | yes |
| ACADS_HUMAN | [view interactions] | Computational | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL1B1_HUMAN | [view interactions] | Computational | no | yes |
| ACDSB_HUMAN | [view interactions] | Computational | no | yes |
| ACOX3_HUMAN | [view interactions] | Computational | no | yes |
| ACSA_HUMAN | [view interactions] | Computational | no | no |
| GABT_HUMAN | [view interactions] | Computational | no | yes |
| GCSH_HUMAN | [view interactions] | Computational | no | yes |
| ODBA_HUMAN | [view interactions] | Computational | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHTK1_HUMAN | [view interactions] | Computational | no | no |
| SDHL_HUMAN | [view interactions] | Computational | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 3HIDH_HUMAN | [view interactions] | Computational | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDSL_HUMAN | [view interactions] | Computational | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AGT2_HUMAN | [view interactions] | Computational | no | no |
| ACS2L_HUMAN | [view interactions] | Computational | no | yes |
| ACSS3_HUMAN | [view interactions] | Computational | no | no |
| ACAD8_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |