MECR_HUMAN
Evidence for PS localization
Functions
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed, PubMed, PubMed). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 232 | Gly | Glu | Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) | - |
| 258 | Arg | Trp | Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) | - |
| 285 | Tyr | Cys | Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MECR_HUMAN |
|---|---|---|---|---|
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 26.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 20.0000 | 4 | yes |
| GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MECR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 40.0000 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 40.0000 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 33.3333 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 33.3333 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.6667 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 26.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 26.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 26.6667 | 4 | no |
| GO:0006633 | fatty acid biosynthetic process | 20.0000 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 20.0000 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 20.0000 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 20.0000 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| PPARA_HUMAN | [view interactions] | Low throughput | no | yes |
| RXRA_HUMAN | [view interactions] | Low throughput | no | yes |
| HNF4A_HUMAN | [view interactions] | Low throughput | no | no |
| MECR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| T2R41_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX30_HUMAN | [view interactions] | High throughput | no | no |
| RN133_HUMAN | [view interactions] | High throughput | no | no |
| DMRT1_HUMAN | [view interactions] | High throughput | no | no |
| NR2E1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| HTAI2_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| HTD2_HUMAN | [view interactions] | Computational | no | yes |
| PPT2_HUMAN | [view interactions] | Computational | no | no |
| RT4I1_HUMAN | [view interactions] | Computational | no | yes |
| ECHM_HUMAN | [view interactions] | Computational | no | yes |
| OXSM_HUMAN | [view interactions] | Computational | no | yes |
| LIPT2_HUMAN | [view interactions] | Computational | no | yes |
| ACDSB_HUMAN | [view interactions] | Computational | no | yes |
| ACADL_HUMAN | [view interactions] | Computational | no | no |
| ACADV_HUMAN | [view interactions] | Computational | no | yes |
| ACOX3_HUMAN | [view interactions] | Computational | no | yes |
| LIPT_HUMAN | [view interactions] | Computational | no | no |
| ACOX1_HUMAN | [view interactions] | Computational | no | yes |
| ACADS_HUMAN | [view interactions] | Computational | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MIC10_HUMAN | [view interactions] | Computational | no | yes |
| THIM_HUMAN | [view interactions] | Computational | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TREA_HUMAN | [view interactions] | Computational | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | Computational | yes | no |