Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MECR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed, PubMed, PubMed). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
232 Gly Glu Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) -
258 Arg Trp Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) -
285 Tyr Cys Dystonia,childhood-onset,withopticatrophyandbasalgangliaabnormalities(DYTOABG) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MECR_HUMAN
GO:0043168 anion binding 28.5714 4 no
GO:0000166 nucleotide binding 21.4286 4 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 14.2857 4 yes
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MECR_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0008104 protein localization 35.7143 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010646 regulation of cell communication 35.7143 4 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0051128 regulation of cellular component organization 35.7143 4 no
GO:0006996 organelle organization 35.7143 4 no
GO:0019752 carboxylic acid metabolic process 28.5714 5 yes
GO:0043436 oxoacid metabolic process 28.5714 4 yes
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0006631 fatty acid metabolic process 21.4286 4 yes
GO:0032787 monocarboxylic acid metabolic process 21.4286 6 yes
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0015031 protein transport 21.4286 4 no
GO:0017157 regulation of exocytosis 21.4286 5 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0045921 positive regulation of exocytosis 21.4286 6 no
GO:0051046 regulation of secretion 21.4286 5 no
GO:0051047 positive regulation of secretion 21.4286 5 no
GO:0051049 regulation of transport 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:1903530 regulation of secretion by cell 21.4286 4 no
GO:1903532 positive regulation of secretion by cell 21.4286 5 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0007264 small GTPase-mediated signal transduction 21.4286 5 no
GO:0016601 Rac protein signal transduction 21.4286 6 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0016482 cytosolic transport 21.4286 4 no
GO:0006873 intracellular monoatomic ion homeostasis 21.4286 4 no
GO:0030003 intracellular monoatomic cation homeostasis 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0051452 intracellular pH reduction 21.4286 4 no
GO:0055080 monoatomic cation homeostasis 21.4286 4 no
GO:0080090 regulation of primary metabolic process 21.4286 4 no
GO:1901565 organonitrogen compound catabolic process 21.4286 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:0006633 fatty acid biosynthetic process 14.2857 5 yes
GO:0008610 lipid biosynthetic process 14.2857 4 yes
GO:0016053 organic acid biosynthetic process 14.2857 4 yes
GO:0046394 carboxylic acid biosynthetic process 14.2857 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RARA_HUMAN [view interactions] Low throughput no no
PPARA_HUMAN [view interactions] Low throughput no yes
RXRA_HUMAN [view interactions] Low throughput no yes
HNF4A_HUMAN [view interactions] Low throughput no no
MECR_HUMAN [view entry] [view interactions] Low throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
YAP1_HUMAN [view interactions] High throughput no yes
T2R41_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
IPYR2_HUMAN [view interactions] High throughput no yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
SNX30_HUMAN [view interactions] High throughput no no
RN133_HUMAN [view interactions] High throughput no no
DMRT1_HUMAN [view interactions] High throughput no no
NR2E1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
RF1ML_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV2_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
UB2D2_HUMAN [view interactions] High throughput no yes
HTAI2_HUMAN [view interactions] High throughput no yes
GLRX2_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
MOB1B_HUMAN [view interactions] High throughput no yes
DNPEP_HUMAN [view interactions] High throughput no yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes