Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DC1I1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002939 LIG_KLC1_WD_1 LIG 81 88 -
ELMI002940 LIG_KLC1_WD_1 LIG 124 133 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DC1I1_HUMAN
GO:0017076 purine nucleotide binding 36.5854 4 no
GO:0032555 purine ribonucleotide binding 36.5854 4 no
GO:0035639 purine ribonucleoside triphosphate binding 36.5854 4 no
GO:0016462 pyrophosphatase activity 28.0488 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.0488 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.0488 6 no
GO:0003723 RNA binding 28.0488 4 no
GO:0005524 ATP binding 24.3902 5 no
GO:0030554 adenyl nucleotide binding 24.3902 5 no
GO:0032559 adenyl ribonucleotide binding 24.3902 5 no
GO:0019900 kinase binding 23.1707 4 no
GO:0015631 tubulin binding 18.2927 4 yes
GO:0008017 microtubule binding 14.6341 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DC1I1_HUMAN
GO:0048522 positive regulation of cellular process 59.7561 4 no
GO:0060255 regulation of macromolecule metabolic process 47.5610 4 no
GO:0051128 regulation of cellular component organization 47.5610 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.3415 4 no
GO:0080090 regulation of primary metabolic process 46.3415 4 no
GO:0006996 organelle organization 45.1220 4 no
GO:0031323 regulation of cellular metabolic process 45.1220 4 no
GO:0009893 positive regulation of metabolic process 42.6829 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.2439 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.0244 5 no
GO:0010646 regulation of cell communication 37.8049 4 no
GO:0033043 regulation of organelle organization 37.8049 5 no
GO:0031325 positive regulation of cellular metabolic process 36.5854 5 no
GO:0048523 negative regulation of cellular process 35.3659 4 no
GO:0051130 positive regulation of cellular component organization 35.3659 5 no
GO:0051246 regulation of protein metabolic process 31.7073 5 no
GO:0009966 regulation of signal transduction 31.7073 4 no
GO:0007010 cytoskeleton organization 31.7073 5 no
GO:0022607 cellular component assembly 29.2683 4 no
GO:0008104 protein localization 28.0488 4 no
GO:0009889 regulation of biosynthetic process 28.0488 4 no
GO:0031326 regulation of cellular biosynthetic process 28.0488 5 no
GO:0010638 positive regulation of organelle organization 28.0488 6 no
GO:0010556 regulation of macromolecule biosynthetic process 26.8293 5 no
GO:0051247 positive regulation of protein metabolic process 25.6098 6 no
GO:1902531 regulation of intracellular signal transduction 25.6098 5 no
GO:0044087 regulation of cellular component biogenesis 25.6098 4 no
GO:0030030 cell projection organization 24.3902 4 no
GO:0031399 regulation of protein modification process 24.3902 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.3902 5 no
GO:0043085 positive regulation of catalytic activity 23.1707 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.1707 5 no
GO:0010647 positive regulation of cell communication 21.9512 5 no
GO:0023056 positive regulation of signaling 21.9512 4 no
GO:0060341 regulation of cellular localization 21.9512 4 no
GO:0051338 regulation of transferase activity 21.9512 4 no
GO:0009892 negative regulation of metabolic process 21.9512 4 no
GO:0051049 regulation of transport 20.7317 4 no
GO:0071310 cellular response to organic substance 20.7317 4 no
GO:0010468 regulation of gene expression 20.7317 5 no
GO:0048584 positive regulation of response to stimulus 20.7317 4 no
GO:0051726 regulation of cell cycle 20.7317 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 15.8537 4 yes
GO:0051650 establishment of vesicle localization 14.6341 4 yes
GO:0099111 microtubule-based transport 13.4146 4 yes
GO:0010970 transport along microtubule 13.4146 4 yes
GO:0072384 organelle transport along microtubule 12.1951 4 yes
GO:0047496 vesicle transport along microtubule 9.7561 5 yes
GO:0099518 vesicle cytoskeletal trafficking 9.7561 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in DC1I1_HUMAN
DOID:0050700 cardiomyopathy 2.4390 4 no
DOID:0060036 intrinsic cardiomyopathy 2.4390 5 no
DOID:114 heart disease 2.4390 3 no
DOID:2843 long QT syndrome 2.4390 6 no
DOID:1289 neurodegenerative disease 2.4390 4 no
DOID:331 central nervous system disease 2.4390 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FRS1L_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPHK2_HUMAN [view interactions] Low throughput no no
EMIL1_HUMAN [view interactions] Low throughput no no
ECM29_HUMAN [view interactions] Low throughput no no
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DAZL_HUMAN [view interactions] Low throughput no no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
BICL1_HUMAN [view interactions] Low throughput no yes
BICD2_HUMAN [view interactions] Low throughput no yes
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
TBB1_HUMAN [view interactions] Low throughput no yes
BICD1_HUMAN [view interactions] Low throughput no yes
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDE1_HUMAN [view interactions] Low throughput no yes
NUDC_HUMAN [view interactions] Low throughput no yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
HAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYLT1_HUMAN [view interactions] Low throughput no no
DYLT3_HUMAN [view interactions] Low throughput no yes
CMC2_HUMAN [view entry] [view interactions] Low throughput yes yes
GLRB_HUMAN [view entry] [view interactions] Low throughput yes no
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
KLC3_HUMAN [view interactions] Low throughput no no
TBB3_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA5_HUMAN [view interactions] Low throughput no no
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI58_HUMAN [view interactions] Low throughput no no
AMRA1_HUMAN [view interactions] Low throughput no yes
BECN1_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
MCRS1_HUMAN [view interactions] Low throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
NUCL_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
ZN276_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
NUP85_HUMAN [view interactions] High throughput no yes
PDIP3_HUMAN [view interactions] High throughput no no
SARNP_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
ARP10_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
PFD6_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
PFD2_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
PFD3_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RAD50_HUMAN [view interactions] High throughput no yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
K1C19_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
PPM1A_HUMAN [view interactions] High throughput no yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
TTC1_HUMAN [view interactions] High throughput no yes
BPL1_HUMAN [view interactions] High throughput no yes
BT3L4_HUMAN [view interactions] High throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
WDCP_HUMAN [view interactions] High throughput no yes
CADM4_HUMAN [view interactions] High throughput no yes
F110A_HUMAN [view interactions] High throughput no yes
FA83D_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
CRCM_HUMAN [view interactions] High throughput no no
KAT7_HUMAN [view interactions] High throughput no yes
RPGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RUN3B_HUMAN [view interactions] High throughput no no
TAOK1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB7_HUMAN [view interactions] High throughput no no
NAGK_HUMAN [view interactions] High throughput no no
CPSF5_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
RCC1_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ZW10_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD2_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
ACADM_HUMAN [view interactions] High throughput no yes
RBPMS_HUMAN [view interactions] High throughput no no
SRRM3_HUMAN [view interactions] High throughput no no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
BICL2_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
DC2I2_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
CO039_HUMAN [view interactions] High throughput no yes
SAMD1_HUMAN [view interactions] High throughput no no
MGAP_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] Computational yes yes
TBB2A_HUMAN [view entry] [view interactions] Computational yes yes
RAB7B_HUMAN [view interactions] Computational no no
RB3GP_HUMAN [view entry] [view interactions] Computational yes yes
ANDR_HUMAN [view interactions] Computational no no
DLRB2_HUMAN [view entry] [view interactions] Computational yes no
PRGR_HUMAN [view interactions] Computational no no
RAB7A_HUMAN [view entry] [view interactions] Computational yes yes
NUDC3_HUMAN [view interactions] Computational no yes
DC2L1_HUMAN [view interactions] Computational no no
DYT2B_HUMAN [view interactions] Computational no no
RAB18_HUMAN [view entry] [view interactions] Computational yes yes
TPR_HUMAN [view interactions] Computational no yes
RBGPR_HUMAN [view entry] [view interactions] Computational yes yes
MCR_HUMAN [view entry] [view interactions] Computational yes yes
RILP_HUMAN [view interactions] Computational no no