DC1I1_HUMAN
Evidence for PS localization
Functions
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002939 | LIG_KLC1_WD_1 | LIG | 81 | 88 | - |
| ELMI002940 | LIG_KLC1_WD_1 | LIG | 124 | 133 | - |
| ELMI002939 | LIG_KLC1_WD_1 | LIG | 81 | 88 | - |
| ELMI002940 | LIG_KLC1_WD_1 | LIG | 124 | 133 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DC1I1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 39.1892 | 4 | no |
| GO:0000166 | nucleotide binding | 35.1351 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.1351 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.1351 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1351 | 4 | no |
| GO:0003723 | RNA binding | 29.7297 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.6757 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.6757 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.6757 | 6 | no |
| GO:0005524 | ATP binding | 25.6757 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.6757 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.6757 | 5 | no |
| GO:0019900 | kinase binding | 24.3243 | 4 | no |
| GO:0019901 | protein kinase binding | 20.2703 | 5 | no |
| GO:0015631 | tubulin binding | 18.9189 | 4 | yes |
| GO:0008017 | microtubule binding | 14.8649 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DC1I1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.1622 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.6486 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.2973 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.5946 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.5946 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.2432 | 4 | no |
| GO:0006996 | organelle organization | 40.5405 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.5405 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 39.1892 | 4 | no |
| GO:0033043 | regulation of organelle organization | 37.8378 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 36.4865 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.4865 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.1351 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.1351 | 5 | no |
| GO:0007010 | cytoskeleton organization | 33.7838 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.7838 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.7838 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 29.7297 | 6 | no |
| GO:0022607 | cellular component assembly | 29.7297 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
| GO:0009966 | regulation of signal transduction | 28.3784 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.6757 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.3243 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.3243 | 5 | no |
| GO:0008104 | protein localization | 24.3243 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.3243 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.3243 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 24.3243 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.3243 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.9730 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.9730 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.9730 | 6 | no |
| GO:0032880 | regulation of protein localization | 22.9730 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.9730 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9730 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9730 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.9730 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.6216 | 5 | no |
| GO:0030030 | cell projection organization | 21.6216 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.6216 | 5 | no |
| GO:0051726 | regulation of cell cycle | 21.6216 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 20.2703 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 20.2703 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.2703 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.2703 | 4 | no |
| GO:0051049 | regulation of transport | 20.2703 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.2703 | 5 | no |
| GO:0010970 | transport along microtubule | 18.9189 | 4 | yes |
| GO:0099111 | microtubule-based transport | 18.9189 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 14.8649 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 13.5135 | 4 | yes |
| GO:0047496 | vesicle transport along microtubule | 9.4595 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 9.4595 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAZL_HUMAN | [view interactions] | Low throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BICL1_HUMAN | [view interactions] | Low throughput | no | yes |
| BICD2_HUMAN | [view interactions] | Low throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| TBB1_HUMAN | [view interactions] | Low throughput | no | yes |
| BICD1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDE1_HUMAN | [view interactions] | Low throughput | no | yes |
| NUDC_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | Low throughput | no | no |
| DYLT3_HUMAN | [view interactions] | Low throughput | no | yes |
| S2513_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | Low throughput | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI58_HUMAN | [view interactions] | Low throughput | no | no |
| AMRA1_HUMAN | [view interactions] | Low throughput | no | yes |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| MCRS1_HUMAN | [view interactions] | Low throughput | no | yes |
| FRS1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPHK2_HUMAN | [view interactions] | Low throughput | no | no |
| EMIL1_HUMAN | [view interactions] | Low throughput | no | no |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| BPL1_HUMAN | [view interactions] | High throughput | no | yes |
| BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| CADM4_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| FA83D_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| RPGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUN3B_HUMAN | [view interactions] | High throughput | no | no |
| TAOK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| SRRM3_HUMAN | [view interactions] | High throughput | no | no |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICL2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO039_HUMAN | [view interactions] | High throughput | no | yes |
| SAMD1_HUMAN | [view interactions] | High throughput | no | no |
| MGAP_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN276_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP85_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |