FRS1L_HUMAN
Evidence for PS localization
Functions
Important modulator of glutamate signaling pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FRS1L_HUMAN |
|---|---|---|---|---|
| GO:0001540 | amyloid-beta binding | 50.0000 | 4 | no |
| GO:0004970 | ionotropic glutamate receptor activity | 50.0000 | 5 | no |
| GO:0004971 | AMPA glutamate receptor activity | 50.0000 | 6 | no |
| GO:0005216 | ion channel activity | 50.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 50.0000 | 6 | no |
| GO:0005261 | cation channel activity | 50.0000 | 5 | no |
| GO:0008066 | glutamate receptor activity | 50.0000 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 50.0000 | 4 | no |
| GO:0015267 | channel activity | 50.0000 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 50.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 50.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | no |
| GO:0022836 | gated channel activity | 50.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 50.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FRS1L_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| ABITM_HUMAN | [view interactions] | Computational | no | yes |