FRS1L_HUMAN
Evidence for PS localization
Functions
Important modulator of glutamate signaling pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FRS1L_HUMAN |
|---|---|---|---|---|
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | no |
| GO:0022836 | gated channel activity | 50.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | no |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 50.0000 | 4 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | no |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | no |
| GO:0004970 | glutamate-gated receptor activity | 50.0000 | 4 | no |
| GO:0004971 | AMPA glutamate receptor activity | 50.0000 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 50.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | no |
| GO:0008066 | glutamate receptor activity | 50.0000 | 4 | no |
| GO:0015267 | channel activity | 50.0000 | 4 | no |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 50.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FRS1L_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 75.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 75.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 75.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | no |
| GO:0035249 | synaptic transmission, glutamatergic | 50.0000 | 8 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | no |
| GO:0099536 | synaptic signaling | 50.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |