Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RPGP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RPGP1_HUMAN
GO:0016462 pyrophosphatase activity 41.1765 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 41.1765 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 41.1765 6 yes
GO:0003924 GTPase activity 35.2941 7 yes
GO:0019900 kinase binding 29.4118 4 no
GO:0019901 protein kinase binding 29.4118 5 no
GO:0046872 metal ion binding 29.4118 4 no
GO:0017076 purine nucleotide binding 29.4118 4 no
GO:0032555 purine ribonucleotide binding 29.4118 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0031267 small GTPase binding 23.5294 5 yes
GO:0051020 GTPase binding 23.5294 4 yes
GO:0001664 G protein-coupled receptor binding 23.5294 4 no
GO:0005525 GTP binding 23.5294 5 no
GO:0019001 guanyl nucleotide binding 23.5294 5 no
GO:0032561 guanyl ribonucleotide binding 23.5294 5 no
GO:0030695 GTPase regulator activity 17.6471 4 yes
GO:0005096 GTPase activator activity 11.7647 4 yes
GO:0042803 protein homodimerization activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RPGP1_HUMAN
GO:0048523 negative regulation of cellular process 76.4706 4 yes
GO:0010646 regulation of cell communication 70.5882 4 yes
GO:0031323 regulation of cellular metabolic process 70.5882 4 no
GO:0009966 regulation of signal transduction 64.7059 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.8235 4 no
GO:0080090 regulation of primary metabolic process 58.8235 4 no
GO:0051128 regulation of cellular component organization 58.8235 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 58.8235 4 no
GO:0043085 positive regulation of catalytic activity 52.9412 4 yes
GO:1902531 regulation of intracellular signal transduction 52.9412 5 yes
GO:0048522 positive regulation of cellular process 52.9412 4 no
GO:0051049 regulation of transport 52.9412 4 no
GO:0051246 regulation of protein metabolic process 47.0588 5 no
GO:0009893 positive regulation of metabolic process 47.0588 4 no
GO:0031325 positive regulation of cellular metabolic process 47.0588 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.1765 5 no
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 no
GO:0051247 positive regulation of protein metabolic process 41.1765 6 no
GO:0001932 regulation of protein phosphorylation 41.1765 7 no
GO:0001934 positive regulation of protein phosphorylation 41.1765 8 no
GO:0008104 protein localization 41.1765 4 no
GO:0010562 positive regulation of phosphorus metabolic process 41.1765 6 no
GO:0010604 positive regulation of macromolecule metabolic process 41.1765 5 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 no
GO:0031399 regulation of protein modification process 41.1765 6 no
GO:0031401 positive regulation of protein modification process 41.1765 7 no
GO:0042325 regulation of phosphorylation 41.1765 7 no
GO:0042327 positive regulation of phosphorylation 41.1765 8 no
GO:0045937 positive regulation of phosphate metabolic process 41.1765 7 no
GO:0051338 regulation of transferase activity 35.2941 4 no
GO:0051347 positive regulation of transferase activity 35.2941 5 no
GO:0060627 regulation of vesicle-mediated transport 35.2941 4 no
GO:0099177 regulation of trans-synaptic signaling 35.2941 4 no
GO:0051336 regulation of hydrolase activity 35.2941 4 yes
GO:0051345 positive regulation of hydrolase activity 35.2941 5 yes
GO:0050804 modulation of chemical synaptic transmission 35.2941 5 no
GO:0051051 negative regulation of transport 35.2941 4 no
GO:0051130 positive regulation of cellular component organization 29.4118 5 no
GO:0031344 regulation of cell projection organization 29.4118 5 yes
GO:0044087 regulation of cellular component biogenesis 29.4118 4 yes
GO:0071310 cellular response to organic substance 29.4118 4 yes
GO:0006996 organelle organization 29.4118 4 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010038 response to metal ion 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0031324 negative regulation of cellular metabolic process 29.4118 5 no
GO:0033674 positive regulation of kinase activity 29.4118 6 no
GO:0043549 regulation of kinase activity 29.4118 5 no
GO:0045859 regulation of protein kinase activity 29.4118 6 no
GO:0045860 positive regulation of protein kinase activity 29.4118 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0051588 regulation of neurotransmitter transport 23.5294 5 no
GO:0051726 regulation of cell cycle 23.5294 4 no
GO:1903305 regulation of regulated secretory pathway 23.5294 6 no
GO:1903530 regulation of secretion by cell 23.5294 4 no
GO:1904062 regulation of cation transmembrane transport 23.5294 6 no
GO:2000300 regulation of synaptic vesicle exocytosis 23.5294 5 no
GO:2001257 regulation of cation channel activity 23.5294 6 no
GO:0010647 positive regulation of cell communication 23.5294 5 no
GO:0023056 positive regulation of signaling 23.5294 4 no
GO:0043408 regulation of MAPK cascade 23.5294 6 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0006886 intracellular protein transport 23.5294 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0042127 regulation of cell population proliferation 23.5294 4 yes
GO:0045595 regulation of cell differentiation 23.5294 4 yes
GO:0051129 negative regulation of cellular component organization 23.5294 5 yes
GO:0070848 response to growth factor 23.5294 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 yes
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0010243 response to organonitrogen compound 23.5294 4 no
GO:0010564 regulation of cell cycle process 23.5294 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 23.5294 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 23.5294 9 no
GO:0014070 response to organic cyclic compound 23.5294 4 no
GO:0017157 regulation of exocytosis 23.5294 5 no
GO:0021762 substantia nigra development 23.5294 4 no
GO:0022898 regulation of transmembrane transporter activity 23.5294 4 no
GO:0032412 regulation of ion transmembrane transporter activity 23.5294 5 no
GO:0034762 regulation of transmembrane transport 23.5294 4 no
GO:0034765 regulation of ion transmembrane transport 23.5294 5 no
GO:0043269 regulation of ion transport 23.5294 5 no
GO:0044057 regulation of system process 23.5294 4 no
GO:0046928 regulation of neurotransmitter secretion 23.5294 4 no
GO:0051046 regulation of secretion 23.5294 5 no
GO:0031345 negative regulation of cell projection organization 17.6471 6 yes
GO:0043087 regulation of GTPase activity 17.6471 5 yes
GO:0043547 positive regulation of GTPase activity 17.6471 6 yes
GO:0045596 negative regulation of cell differentiation 17.6471 5 yes
GO:0051093 negative regulation of developmental process 17.6471 4 yes
GO:0051241 negative regulation of multicellular organismal process 17.6471 4 yes
GO:0060491 regulation of cell projection assembly 17.6471 5 yes
GO:0071363 cellular response to growth factor stimulus 17.6471 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 17.6471 6 yes
GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 17.6471 7 yes
GO:0008285 negative regulation of cell population proliferation 11.7647 5 yes
GO:0032530 regulation of microvillus organization 11.7647 7 yes
GO:0032534 regulation of microvillus assembly 11.7647 7 yes
GO:0045664 regulation of neuron differentiation 11.7647 5 yes
GO:0045665 negative regulation of neuron differentiation 11.7647 6 yes
GO:0050678 regulation of epithelial cell proliferation 11.7647 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 11.7647 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.7647 6 yes
GO:0051100 negative regulation of binding 11.7647 4 yes
GO:0090630 activation of GTPase activity 11.7647 7 yes
GO:1903697 negative regulation of microvillus assembly 11.7647 8 yes
GO:1904424 regulation of GTP binding 11.7647 4 yes
GO:1904425 negative regulation of GTP binding 11.7647 5 yes
GO:1904441 regulation of thyroid gland epithelial cell proliferation 11.7647 6 yes
GO:1904442 negative regulation of thyroid gland epithelial cell proliferation 11.7647 5 yes
GO:1990792 cellular response to glial cell derived neurotrophic factor 11.7647 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in RPGP1_HUMAN
DOID:0050700 cardiomyopathy 11.7647 4 no
DOID:0060036 intrinsic cardiomyopathy 11.7647 5 no
DOID:114 heart disease 11.7647 3 no
DOID:2843 long QT syndrome 11.7647 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAP1B_HUMAN [view entry] [view interactions] Low throughput yes no
AFAD_HUMAN [view interactions] Low throughput no yes
CNR1_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
FBW1B_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
BRAF_HUMAN [view interactions] Low throughput no yes
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
CDK1_HUMAN [view interactions] Low throughput no no
RPGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G2_HUMAN [view interactions] High throughput no yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
IDLC_HUMAN [view interactions] High throughput no no
KLF11_HUMAN [view interactions] High throughput no no
MEX3B_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
ATE1_HUMAN [view interactions] High throughput no yes
GILT_HUMAN [view interactions] High throughput no no
CLH2_HUMAN [view interactions] High throughput no no
RPGP2_HUMAN [view interactions] High throughput no yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
SKAP2_HUMAN [view interactions] High throughput no no
ZN330_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
RET_HUMAN [view interactions] Computational no yes