Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RPGP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RPGP1_HUMAN
GO:0019900 kinase binding 32.0000 4 no
GO:0016462 pyrophosphatase activity 28.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.0000 6 yes
GO:0043168 anion binding 28.0000 4 no
GO:0019901 protein kinase binding 28.0000 5 no
GO:0043169 cation binding 28.0000 4 no
GO:0046872 metal ion binding 28.0000 5 no
GO:0003924 GTPase activity 24.0000 7 yes
GO:0000166 nucleotide binding 24.0000 4 no
GO:0017076 purine nucleotide binding 24.0000 5 no
GO:0032555 purine ribonucleotide binding 24.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.0000 4 no
GO:0019887 protein kinase regulator activity 24.0000 4 no
GO:0031267 small GTPase binding 20.0000 5 yes
GO:0051020 GTPase binding 20.0000 4 yes
GO:0030695 GTPase regulator activity 12.0000 4 yes
GO:0005096 GTPase activator activity 8.0000 4 yes
GO:0042803 protein homodimerization activity 8.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RPGP1_HUMAN
GO:0048523 negative regulation of cellular process 84.0000 4 yes
GO:0031323 regulation of cellular metabolic process 76.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 72.0000 4 no
GO:0010646 regulation of cell communication 68.0000 4 yes
GO:0080090 regulation of primary metabolic process 68.0000 4 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0051049 regulation of transport 60.0000 4 no
GO:0009966 regulation of signal transduction 56.0000 4 yes
GO:0051246 regulation of protein metabolic process 56.0000 5 no
GO:0051128 regulation of cellular component organization 52.0000 4 yes
GO:0031399 regulation of protein modification process 52.0000 6 no
GO:1902531 regulation of intracellular signal transduction 48.0000 5 yes
GO:0008104 protein localization 48.0000 4 no
GO:0009893 positive regulation of metabolic process 48.0000 4 no
GO:0019220 regulation of phosphate metabolic process 48.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 48.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 48.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 44.0000 5 no
GO:0051051 negative regulation of transport 40.0000 4 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0043085 positive regulation of catalytic activity 36.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 36.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 36.0000 4 no
GO:0141124 intracellular signaling cassette 36.0000 4 no
GO:0009892 negative regulation of metabolic process 36.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 36.0000 5 no
GO:0031401 positive regulation of protein modification process 36.0000 7 no
GO:0051247 positive regulation of protein metabolic process 36.0000 6 no
GO:0031344 regulation of cell projection organization 32.0000 5 yes
GO:0045595 regulation of cell differentiation 32.0000 4 yes
GO:0048584 positive regulation of response to stimulus 32.0000 4 no
GO:0009889 regulation of biosynthetic process 32.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 32.0000 5 no
GO:0034762 regulation of transmembrane transport 32.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 32.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 32.0000 6 no
GO:0042327 positive regulation of phosphorylation 32.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.0000 7 no
GO:0051338 regulation of transferase activity 32.0000 4 no
GO:0060341 regulation of cellular localization 32.0000 4 no
GO:0051336 regulation of hydrolase activity 28.0000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.0000 6 yes
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0023056 positive regulation of signaling 28.0000 4 no
GO:0010468 regulation of gene expression 28.0000 6 no
GO:0032880 regulation of protein localization 28.0000 5 no
GO:0043549 regulation of kinase activity 28.0000 5 no
GO:0045859 regulation of protein kinase activity 28.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 28.0000 6 no
GO:0031400 negative regulation of protein modification process 28.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 28.0000 7 no
GO:0051248 negative regulation of protein metabolic process 28.0000 6 no
GO:0044087 regulation of cellular component biogenesis 24.0000 4 yes
GO:0051129 negative regulation of cellular component organization 24.0000 5 yes
GO:0051345 positive regulation of hydrolase activity 24.0000 5 yes
GO:0009967 positive regulation of signal transduction 24.0000 5 no
GO:0051130 positive regulation of cellular component organization 24.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 24.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.0000 5 no
GO:0021762 substantia nigra development 24.0000 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 24.0000 5 no
GO:0043269 regulation of monoatomic ion transport 24.0000 5 no
GO:0051347 positive regulation of transferase activity 24.0000 5 no
GO:0051726 regulation of cell cycle 24.0000 4 no
GO:0010038 response to metal ion 24.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 24.0000 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 24.0000 5 no
GO:0051050 positive regulation of transport 24.0000 4 no
GO:0031345 negative regulation of cell projection organization 20.0000 6 yes
GO:0051093 negative regulation of developmental process 20.0000 4 yes
GO:0071363 cellular response to growth factor stimulus 20.0000 4 yes
GO:0042127 regulation of cell population proliferation 16.0000 4 yes
GO:0045596 negative regulation of cell differentiation 16.0000 5 yes
GO:0045664 regulation of neuron differentiation 16.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 16.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 12.0000 5 yes
GO:0043087 regulation of GTPase activity 12.0000 5 yes
GO:0043547 positive regulation of GTPase activity 12.0000 6 yes
GO:0050678 regulation of epithelial cell proliferation 12.0000 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 12.0000 6 yes
GO:0060491 regulation of cell projection assembly 12.0000 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 12.0000 6 yes
GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 12.0000 7 yes
GO:0032530 regulation of microvillus organization 8.0000 7 yes
GO:0032534 regulation of microvillus assembly 8.0000 7 yes
GO:0045665 negative regulation of neuron differentiation 8.0000 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 8.0000 6 yes
GO:1903697 negative regulation of microvillus assembly 8.0000 8 yes
GO:1904441 regulation of thyroid gland epithelial cell proliferation 8.0000 6 yes
GO:1904442 negative regulation of thyroid gland epithelial cell proliferation 8.0000 5 yes
GO:1990790 response to glial cell derived neurotrophic factor 8.0000 4 yes
GO:1990792 cellular response to glial cell derived neurotrophic factor 8.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAP1B_HUMAN [view entry] [view interactions] Low throughput yes no
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
CNR1_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
FBW1B_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
MEX3A_HUMAN [view interactions] Low throughput no no
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
CDK1_HUMAN [view interactions] Low throughput no no
RPGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G2_HUMAN [view interactions] High throughput no yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
IDLC_HUMAN [view interactions] High throughput no no
KLF11_HUMAN [view interactions] High throughput no no
MEX3B_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
VP26C_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
DSCR9_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
ATE1_HUMAN [view interactions] High throughput no yes
GILT_HUMAN [view interactions] High throughput no no
CLH2_HUMAN [view interactions] High throughput no no
RPGP2_HUMAN [view interactions] High throughput no yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
SKAP2_HUMAN [view interactions] High throughput no no
ZN330_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes