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RAP1B_HUMAN

GO
G2C
SynaptomeDB

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAP1B_HUMAN
GO:0000166 nucleotide binding 43.0769 4 yes
GO:0017076 purine nucleotide binding 43.0769 5 yes
GO:0032555 purine ribonucleotide binding 43.0769 4 yes
GO:0043168 anion binding 43.0769 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.5385 4 yes
GO:0016462 pyrophosphatase activity 35.3846 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 35.3846 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 35.3846 6 yes
GO:0003924 GTPase activity 29.2308 7 yes
GO:0005525 GTP binding 27.6923 5 yes
GO:0019001 guanyl nucleotide binding 27.6923 6 yes
GO:0032561 guanyl ribonucleotide binding 27.6923 5 yes
GO:0043169 cation binding 27.6923 4 no
GO:0046872 metal ion binding 27.6923 5 no
GO:0019003 GDP binding 18.4615 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAP1B_HUMAN
GO:0051128 regulation of cellular component organization 55.3846 4 yes
GO:0048522 positive regulation of cellular process 50.7692 4 yes
GO:0008104 protein localization 47.6923 4 no
GO:0048523 negative regulation of cellular process 43.0769 4 yes
GO:0006996 organelle organization 41.5385 4 no
GO:0022607 cellular component assembly 41.5385 4 no
GO:0010646 regulation of cell communication 40.0000 4 yes
GO:0071702 organic substance transport 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0044087 regulation of cellular component biogenesis 36.9231 4 yes
GO:0051049 regulation of transport 36.9231 4 yes
GO:0080090 regulation of primary metabolic process 36.9231 4 no
GO:0071705 nitrogen compound transport 35.3846 4 no
GO:0009966 regulation of signal transduction 33.8462 4 yes
GO:0015031 protein transport 32.3077 4 no
GO:0031323 regulation of cellular metabolic process 32.3077 4 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0048584 positive regulation of response to stimulus 29.2308 4 yes
GO:0009893 positive regulation of metabolic process 29.2308 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.2308 5 no
GO:0010647 positive regulation of cell communication 27.6923 5 yes
GO:0023056 positive regulation of signaling 27.6923 4 yes
GO:0060627 regulation of vesicle-mediated transport 27.6923 4 yes
GO:1902531 regulation of intracellular signal transduction 27.6923 5 yes
GO:0051130 positive regulation of cellular component organization 26.1538 5 yes
GO:0009889 regulation of biosynthetic process 26.1538 4 no
GO:0009892 negative regulation of metabolic process 26.1538 4 no
GO:0031326 regulation of cellular biosynthetic process 26.1538 5 no
GO:0009967 positive regulation of signal transduction 24.6154 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 24.6154 5 no
GO:0051129 negative regulation of cellular component organization 24.6154 5 no
GO:2000145 regulation of cell motility 24.6154 4 no
GO:0006886 intracellular protein transport 24.6154 4 no
GO:0141124 intracellular signaling cassette 23.0769 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0030334 regulation of cell migration 23.0769 5 no
GO:0051046 regulation of secretion 21.5385 5 yes
GO:1903530 regulation of secretion by cell 21.5385 4 yes
GO:0032880 regulation of protein localization 21.5385 5 no
GO:0060341 regulation of cellular localization 21.5385 4 no
GO:0010468 regulation of gene expression 21.5385 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.5385 5 no
GO:0031324 negative regulation of cellular metabolic process 21.5385 5 no
GO:0097435 supramolecular fiber organization 21.5385 4 no
GO:1902533 positive regulation of intracellular signal transduction 18.4615 6 yes
GO:0007264 small GTPase-mediated signal transduction 16.9231 5 yes
GO:0017157 regulation of exocytosis 16.9231 5 yes
GO:0034330 cell junction organization 16.9231 4 yes
GO:0043408 regulation of MAPK cascade 16.9231 6 yes
GO:0071310 cellular response to organic substance 16.9231 4 yes
GO:0044089 positive regulation of cellular component biogenesis 15.3846 5 yes
GO:0046903 secretion 15.3846 4 yes
GO:0043254 regulation of protein-containing complex assembly 13.8462 5 yes
GO:1901701 cellular response to oxygen-containing compound 13.8462 4 yes
GO:0050804 modulation of chemical synaptic transmission 12.3077 5 yes
GO:0051051 negative regulation of transport 12.3077 4 yes
GO:0099177 regulation of trans-synaptic signaling 12.3077 4 yes
GO:1901888 regulation of cell junction assembly 12.3077 5 yes
GO:0010243 response to organonitrogen compound 10.7692 4 yes
GO:0014070 response to organic cyclic compound 10.7692 4 yes
GO:0043410 positive regulation of MAPK cascade 9.2308 7 yes
GO:0050808 synapse organization 9.2308 5 yes
GO:0051048 negative regulation of secretion 9.2308 5 yes
GO:0071417 cellular response to organonitrogen compound 9.2308 4 yes
GO:1901699 cellular response to nitrogen compound 9.2308 4 yes
GO:1903305 regulation of regulated secretory pathway 9.2308 6 yes
GO:1903531 negative regulation of secretion by cell 9.2308 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 7.6923 6 yes
GO:0045055 regulated exocytosis 7.6923 4 yes
GO:0045920 negative regulation of exocytosis 7.6923 6 yes
GO:0046928 regulation of neurotransmitter secretion 7.6923 5 yes
GO:0051588 regulation of neurotransmitter transport 7.6923 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 7.6923 7 yes
GO:0071407 cellular response to organic cyclic compound 7.6923 5 yes
GO:0017156 calcium-ion regulated exocytosis 6.1538 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 6.1538 8 yes
GO:2000300 regulation of synaptic vesicle exocytosis 6.1538 6 yes
GO:0014074 response to purine-containing compound 4.6154 5 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 4.6154 7 yes
GO:0046683 response to organophosphorus 4.6154 4 yes
GO:0051591 response to cAMP 4.6154 4 yes
GO:0099563 modification of synaptic structure 4.6154 6 yes
GO:1903306 negative regulation of regulated secretory pathway 4.6154 7 yes
GO:2000301 negative regulation of synaptic vesicle exocytosis 4.6154 7 yes
GO:0001885 endothelial cell development 3.0769 5 yes
GO:0002064 epithelial cell development 3.0769 4 yes
GO:0032486 Rap protein signal transduction 3.0769 6 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 3.0769 4 yes
GO:0033623 regulation of integrin activation 3.0769 6 yes
GO:0033625 positive regulation of integrin activation 3.0769 7 yes
GO:0045955 negative regulation of calcium ion-dependent exocytosis 3.0769 8 yes
GO:0061028 establishment of endothelial barrier 3.0769 6 yes
GO:0071320 cellular response to cAMP 3.0769 5 yes
GO:0099010 modification of postsynaptic structure 3.0769 7 yes
GO:2000114 regulation of establishment of cell polarity 3.0769 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RPTOR_HUMAN [view interactions] Low throughput no yes
KRIT1_HUMAN [view interactions] Low throughput no no
HEG1_HUMAN [view interactions] Low throughput no yes
RAP1B_HUMAN [view entry] [view interactions] Low throughput yes no
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
RAIN_HUMAN [view interactions] Low throughput no no
GRP2_HUMAN [view interactions] Low throughput no yes
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
RASF5_HUMAN [view interactions] Low throughput no yes
RGL2_HUMAN [view interactions] Low throughput no yes
GNDS_HUMAN [view interactions] Low throughput no yes
RPGF3_HUMAN [view interactions] Low throughput no yes
RPGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
SHSA2_HUMAN [view interactions] High throughput no no
DHB13_HUMAN [view interactions] High throughput no yes
MYLK4_HUMAN [view interactions] High throughput no no
ACADL_HUMAN [view interactions] High throughput no no
T4S18_HUMAN [view interactions] High throughput no no
STAM1_HUMAN [view interactions] High throughput no yes
EAF1_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
TPGS2_HUMAN [view interactions] High throughput no yes
PED1A_HUMAN [view interactions] High throughput no yes
WDR46_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
ITB8_HUMAN [view interactions] High throughput no no
CB39L_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
CDKAL_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
CBCO1_HUMAN [view interactions] High throughput no no
I20RB_HUMAN [view interactions] High throughput no no
TECTB_HUMAN [view interactions] High throughput no no
DERL2_HUMAN [view interactions] High throughput no yes
CLM2_HUMAN [view interactions] High throughput no no
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
KLK10_HUMAN [view interactions] High throughput no no
FGF4_HUMAN [view interactions] High throughput no no
ICE2_HUMAN [view interactions] High throughput no no
NGRN_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
VIPR1_HUMAN [view interactions] High throughput no yes
PADI3_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
TRI31_HUMAN [view interactions] High throughput no no
E2F4_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PP14B_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
MOGS_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
PDXK_HUMAN [view entry] [view interactions] High throughput yes yes
PHF5A_HUMAN [view interactions] High throughput no yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
UBP5_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
SMAP1_HUMAN [view interactions] High throughput no yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB4_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
A2MG_HUMAN [view interactions] High throughput no yes
HEM1_HUMAN [view interactions] High throughput no yes
APLP1_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
SCG1_HUMAN [view interactions] High throughput no no
CSAD_HUMAN [view interactions] High throughput no yes
DDAH2_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
KMT2B_HUMAN [view interactions] High throughput no no
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
CAB45_HUMAN [view interactions] High throughput no no
TLE1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
U119A_HUMAN [view interactions] High throughput no no
ZN135_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TCAB1_HUMAN [view interactions] High throughput no yes
NRBP2_HUMAN [view interactions] High throughput no yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP32_HUMAN [view interactions] High throughput no yes
RT35_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
DMXL1_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC1_HUMAN [view entry] [view interactions] High throughput yes yes
PACC1_HUMAN [view interactions] High throughput no no
GRPR_HUMAN [view interactions] High throughput no no
PLPR1_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
CAV2_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ZFHX4_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
RGS2_HUMAN [view interactions] High throughput no no
RAB7B_HUMAN [view interactions] High throughput no no
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
NEK7_HUMAN [view interactions] High throughput no yes
M3K14_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MTUS2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
RSLAA_HUMAN [view interactions] High throughput no yes
PLTP_HUMAN [view interactions] High throughput no no
RD3_HUMAN [view interactions] High throughput no no
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
M3K4_HUMAN [view interactions] High throughput no yes
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
GAR1_HUMAN [view interactions] High throughput no yes
P33MX_HUMAN [view interactions] High throughput no yes
NCK5L_HUMAN [view interactions] High throughput no yes
SEN2_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHM1_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
RGL1_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
PACE1_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
MAGF1_HUMAN [view entry] [view interactions] High throughput yes yes
MED28_HUMAN [view interactions] High throughput no yes